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chr4:1,947,324-3,943,984

Best TWAS P=7.22e-15 · Best GWAS P=1.02e-13 conditioned to 0.286

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Pancreas	GRK4	0.14	0.05	lasso	9	0.03	3.0e-02	7.3	-7.8	7.2e-15	-0.89	0.02	0.97	TRUE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	GRK4	0.18	0.23	blup	76	0.21	3.8e-12	7.3	-7.7	9.5e-15	-0.94	0.02	0.98	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	GRK4	0.37	0.23	lasso	9	0.22	2.2e-08	7.4	-7.7	1.9e-14	-0.98	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	GRK4	0.17	0.24	lasso	6	0.24	1.2e-17	7.3	-7.5	5.1e-14	-0.97	0.02	0.98	FALSE
4	GTEx	Artery Aorta	GRK4	0.29	0.38	enet	11	0.40	1.3e-23	7.2	-7.5	5.2e-14	-0.97	0.02	0.98	FALSE
34	GTEx	Thyroid	MFSD10	0.15	0.11	lasso	8	0.13	3.6e-10	6.8	-7.5	6.2e-14	-0.88	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRK4	0.11	0.17	lasso	7	0.18	6.7e-36	7.3	-7.5	7.2e-14	-0.98	0.02	0.98	FALSE
16	GTEx	Colon Transverse	GRK4	0.27	0.25	enet	18	0.25	2.4e-12	7.3	-7.4	1.0e-13	-0.96	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	GRK4	0.30	0.39	lasso	6	0.41	1.2e-35	7.2	-7.4	1.1e-13	-0.98	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	GRK4	0.32	0.38	lasso	4	0.40	5.5e-22	7.3	-7.4	1.1e-13	-0.98	0.02	0.98	FALSE
14	GTEx	Cells Transformed fibroblasts	GRK4	0.32	0.35	lasso	7	0.37	3.1e-29	7.3	-7.4	1.1e-13	-0.98	0.01	0.99	FALSE
26	GTEx	Pituitary	GRK4	0.17	0.00	enet	6	-0.01	5.6e-01	7.4	-7.4	1.1e-13	-0.99	0.02	0.77	FALSE
30	GTEx	Spleen	GRK4	0.24	0.16	lasso	5	0.12	4.8e-04	7.3	-7.4	1.2e-13	-0.93	0.02	0.91	FALSE
11	GTEx	Breast Mammary Tissue	GRK4	0.27	0.32	enet	11	0.32	5.3e-17	7.2	-7.4	1.3e-13	-0.97	0.02	0.98	FALSE
21	GTEx	Lung	GRK4	0.26	0.36	lasso	4	0.36	3.3e-29	7.2	-7.4	1.3e-13	-0.97	0.02	0.98	FALSE
9	GTEx	Brain Cerebellum	GRK4	0.41	0.36	lasso	7	0.34	7.7e-11	7.2	-7.4	1.4e-13	-0.92	0.02	0.98	FALSE
10	GTEx	Brain Cortex	GRK4	0.25	0.26	lasso	4	0.25	1.7e-07	7.3	-7.4	1.4e-13	-0.93	0.04	0.96	FALSE
12	GTEx	Breast Mammary Tissue (Female)	GRK4	0.23	0.24	lasso	3	0.24	1.1e-07	7.3	-7.4	1.4e-13	-0.98	0.02	0.98	FALSE
35	GTEx	Thyroid	GRK4	0.50	0.47	lasso	9	0.48	6.4e-41	7.3	-7.4	1.4e-13	-0.97	0.02	0.98	FALSE
19	GTEx	Esophagus Muscularis	GRK4	0.29	0.30	enet	7	0.30	2.5e-18	7.2	-7.4	1.7e-13	-0.95	0.02	0.98	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	GRK4	0.38	0.43	lasso	4	0.42	9.6e-25	7.3	-7.4	1.8e-13	-0.96	0.02	0.98	FALSE
40	METSIM	Adipose	GRK4	0.20	0.26	lasso	6	0.25	9.9e-38	7.1	-7.3	2.0e-13	-0.96	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GRK4	0.23	0.32	lasso	5	0.31	1.0e-13	7.3	-7.3	2.0e-13	-0.94	0.02	0.98	FALSE
6	GTEx	Artery Coronary	GRK4	0.27	0.24	lasso	3	0.22	6.7e-08	7.3	-7.3	2.1e-13	-0.95	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	GRK4	0.22	0.39	lasso	6	0.38	4.1e-39	7.3	-7.3	2.1e-13	-0.93	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	GRK4	0.12	0.13	lasso	6	0.14	6.0e-15	7.3	-7.3	2.3e-13	-0.98	0.02	0.98	FALSE
7	GTEx	Artery Tibial	GRK4	0.34	0.35	lasso	4	0.35	1.1e-28	7.2	-7.3	2.5e-13	-0.94	0.03	0.97	FALSE
23	GTEx	Nerve Tibial	GRK4	0.29	0.38	lasso	3	0.39	4.6e-29	7.2	-7.3	2.6e-13	-0.96	0.02	0.98	FALSE
15	GTEx	Colon Sigmoid	GRK4	0.26	0.30	lasso	2	0.28	2.6e-10	7.3	-7.3	2.7e-13	-0.93	0.02	0.98	FALSE
31	GTEx	Stomach	GRK4	0.22	0.19	lasso	7	0.19	2.6e-09	7.4	-7.3	2.7e-13	-0.99	0.01	0.99	FALSE
18	GTEx	Esophagus Mucosa	GRK4	0.28	0.35	lasso	4	0.34	3.1e-23	7.2	-7.3	3.1e-13	-0.94	0.03	0.97	FALSE
69	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	GRK4	0.11	0.12	lasso	1	0.10	8.4e-04	7.3	-7.3	3.9e-13	-0.97	0.01	0.92	FALSE
64	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GRK4	0.08	0.09	lasso	1	0.06	4.2e-03	7.2	-7.2	4.5e-13	-0.94	0.02	0.80	FALSE
3	GTEx	Adrenal Gland	GRK4	0.38	0.25	lasso	5	0.29	5.1e-11	7.3	-7.2	4.7e-13	-0.89	0.02	0.98	FALSE
13	GTEx	Cells Transformed fibroblasts	NOP14	0.12	0.06	enet	11	0.09	2.9e-07	5.3	-7.2	5.6e-13	-0.77	0.04	0.96	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GRK4	0.09	0.12	blup	76	0.12	1.7e-06	7.1	-7.2	5.7e-13	-0.94	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRK4	0.10	0.14	enet	16	0.14	4.6e-15	7.3	-7.2	6.1e-13	-0.95	0.02	0.98	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	GRK4	0.12	0.14	lasso	4	0.14	1.8e-17	7.2	-7.2	7.6e-13	-0.96	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GRK4	0.13	0.10	blup	76	0.11	8.4e-08	7.3	-7.1	1.6e-12	-0.91	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Rectum Adenocarcinoma	GRK4	0.27	0.10	blup	76	0.13	7.3e-04	7.3	-7.0	2.1e-12	-0.88	0.03	0.83	FALSE
29	GTEx	Skin Sun Exposed Lower leg	GRK4	0.37	0.45	enet	30	0.46	1.3e-41	7.2	-7.0	2.9e-12	-0.94	0.03	0.97	FALSE
38	GTEx	Vagina	GRK4	0.27	0.12	lasso	4	0.11	1.6e-03	6.5	-7.0	3.1e-12	-0.88	0.04	0.80	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GRK4	0.09	0.10	lasso	4	0.14	1.4e-11	7.2	-7.0	3.6e-12	-0.93	0.03	0.97	FALSE
50	The Cancer Genome Atlas	Esophageal Carcinoma	GRK4	0.28	0.32	lasso	8	0.34	1.7e-11	7.3	-6.8	1.3e-11	-0.90	0.03	0.97	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GRK4	0.09	0.18	lasso	5	0.20	1.5e-22	7.4	-6.8	1.3e-11	-0.94	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	GRK4	0.13	0.19	lasso	2	0.19	6.1e-22	7.1	-6.8	1.4e-11	-0.93	0.02	0.98	FALSE
32	GTEx	Testis	GRK4	0.36	0.18	enet	22	0.28	1.3e-12	7.3	-6.7	1.8e-11	-0.82	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRK4	0.19	0.23	blup	77	0.22	4.2e-24	7.3	-6.7	2.5e-11	-0.85	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GRK4	0.16	0.18	lasso	6	0.20	1.9e-11	5.5	-6.6	3.8e-11	-0.88	0.06	0.94	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	C4orf10	0.18	0.06	lasso	3	0.07	2.2e-07	7.4	-6.6	3.9e-11	-0.95	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	GRK4	0.08	0.07	blup	77	0.09	4.4e-06	5.8	-6.6	4.0e-11	-0.91	0.06	0.94	FALSE
36	GTEx	Thyroid	NOP14-AS1	0.18	0.09	lasso	8	0.11	1.3e-08	7.3	-6.6	4.4e-11	-0.94	0.02	0.98	FALSE
39	GTEx	Whole Blood	GRK4	0.08	0.10	lasso	4	0.10	1.0e-09	7.3	-6.5	6.8e-11	-0.89	0.04	0.96	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	MFSD10	0.07	0.02	enet	6	0.08	7.2e-08	7.3	-6.4	1.2e-10	-0.72	0.01	0.98	FALSE
22	GTEx	Lung	HTT	0.06	0.00	lasso	4	0.00	5.8e-01	6.4	-6.4	1.3e-10	-0.80	0.07	0.61	FALSE
24	GTEx	Ovary	GRK4	0.25	0.19	lasso	8	0.18	3.6e-05	7.3	-6.2	6.3e-10	-0.88	0.03	0.88	FALSE
37	GTEx	Uterus	GRK4	0.31	0.24	enet	29	0.32	2.5e-07	7.4	-5.9	3.1e-09	-0.90	0.02	0.96	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	C4orf44	0.03	0.04	lasso	4	0.05	2.9e-06	4.7	-5.9	3.3e-09	-0.34	0.25	0.71	FALSE
33	GTEx	Thyroid	NOP14	0.09	0.04	lasso	5	0.03	4.5e-03	5.4	-5.9	4.8e-09	-0.85	0.19	0.76	FALSE
43	YFS	Blood	ADD1	0.04	0.02	bslmm	401	0.03	2.4e-09	6.8	5.7	1.0e-08	0.48	0.44	0.56	FALSE
5	GTEx	Artery Aorta	NOP14-AS1	0.11	0.01	lasso	5	0.07	1.7e-04	-2.6	5.7	1.4e-08	0.52	0.24	0.41	FALSE
27	GTEx	Prostate	GRK4	0.38	0.19	enet	27	0.25	5.3e-07	7.2	-5.6	2.6e-08	-0.75	0.02	0.96	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	NOP14	0.09	0.12	blup	57	0.13	1.4e-12	5.5	-5.5	3.2e-08	-0.85	0.13	0.87	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C4orf44	0.03	0.02	blup	42	0.02	8.0e-04	4.6	-5.5	5.0e-08	-0.30	0.31	0.12	FALSE
8	GTEx	Brain Cerebellar Hemisphere	GRK4	0.33	0.30	enet	25	0.35	8.2e-10	6.8	-5.4	5.8e-08	-0.79	0.02	0.97	FALSE
41	METSIM	Adipose	MFSD10	0.16	0.03	enet	48	0.05	2.1e-08	-2.0	-5.3	1.1e-07	-0.45	0.32	0.51	FALSE
44	YFS	Blood	FAM193A	0.02	0.00	enet	18	0.01	5.8e-04	7.1	-5.2	2.0e-07	-0.59	0.03	0.90	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RNF4	0.14	0.02	blup	47	0.07	3.1e-04	-1.6	-5.2	2.4e-07	-0.20	0.00	0.00	FALSE
20	GTEx	Lung	ADD1	0.09	0.02	enet	6	0.01	3.5e-02	-3.7	-5.1	3.0e-07	-0.70	0.18	0.68	FALSE