TWAS hub - ADD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0830	0.0340	3.5e-03	-0.002	NA	-0.002	NA	-0.001	4.9e-01	NA	5.4e-01	NA	3.6e-01
2	GTEx	Lung	0.0873	0.0379	2.1e-03	0.016	NA	0.012	NA	0.010	2.0e-02	NA	3.5e-02	NA	5.4e-02
3	GTEx	Whole Blood	0.0710	0.0350	8.5e-03	0.001	NA	0.006	NA	0.006	2.5e-01	NA	8.4e-02	NA	8.9e-02
4	YFS	Blood	0.0426	0.0138	8.0e-07	0.023	0.025	0.023	0.027	0.026	3.2e-08	7.2e-09	2.9e-08	2.4e-09	6.2e-09
5	TCGA	Pheochromocytoma and Paraganglioma	0.1570	0.0820	2.2e-03	0.101	0.048	0.064	NA	0.061	8.2e-05	5.4e-03	1.5e-03	NA	1.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5
Overall health rating	7.7	16.4	43.5	-2.7	6.6	-4.5	3.4
Qualifications: O levels/GCSEs or equivalent	4.9	7.8	16.0	2.4	-3.5	4.0	-2.2
Unable to work because of sickness or disability	4.8	6.3	16.5	-2.3	4.1	-1.7	2.6
Qualifications: College or University degree	4.6	14.6	32.8	3.3	-5.1	5.7	-1.8
Noisy workplace	4.5	5.5	10.6	-2.6	3.1	-3.3	0.8
Qualifications: None of the above	4.2	8.9	18.9	-2.4	4.3	-4.1	1.8
Breastfed as a baby	4.2	5.2	11.9	3.4	-1.8	2.7	-1.9
Pack years adult smoking proportion	4.1	6.3	18.9	-0.7	3.3	-4.3	1.1
Average weekly champagne plus white wine intake	4.1	5.7	12.6	2.0	-3.6	2.6	-2.2
Wears glasses or contact lenses	4.1	4.7	15.0	3.9	-2.7	0.1	-1.0
Ever had prostate specific antigen (PSA) test	4.1	4.8	13.3	2.9	-3.6	0.6	-1.3
Father’s age at death	4.0	5.4	14.3	1.6	-3.8	1.5	-2.8
Pack years of smoking	3.8	5.6	18.6	-0.3	2.9	-4.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	3.7	6.0	14.2	-3.1	3.8	-1.3	2.2
Mother’s age at death	3.7	4.6	10.1	2.4	-3.2	1.2	-2.3
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	16.6	-4.1	3.0	1.0	1.2
Chest pain or discomfort	3.5	5.0	13.9	-1.6	3.7	-2.0	2.1
Age at last live birth	3.5	5.0	16.3	1.0	-4.0	1.2	-2.6
Qualifications: A levels/AS levels or equivalent	3.2	7.1	16.2	2.6	-3.1	4.0	-1.7
Serious illness, injury or assault of a close relative in last 2 years	3.2	3.6	9.9	-1.0	2.7	-0.3	3.1
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.8	9.8	-1.8	3.1	-0.5	2.4
Health satisfaction	3.1	4.1	8.4	-1.8	2.6	-2.9	1.5
Mineral and other dietary supplements	3.1	4.2	9.6	-1.5	3.1	-2.6	1.5
Illnesses of siblings	3.0	4.2	12.6	-0.6	-3.6	0.7	-2.7
Mean time to correctly identify matches	2.9	5.5	13.8	3.7	-3.5	0.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.7	8.0	-2.6	2.8	-1.2	1.5
Alcohol usually taken with meals	2.8	4.5	10.1	1.3	-3.2	2.7	-1.8
Financial difficulties in last 2 years	2.8	3.7	7.3	-0.9	2.5	-2.7	2.0
Angina	2.7	3.6	10.8	-0.1	3.3	-2.0	1.7
Relative age voice broke	2.7	4.1	8.5	1.8	-2.4	2.9	-1.7
Medication: Cholesterol lowering	2.7	4.2	11.6	-0.9	3.4	-1.2	2.7
Age at first live birth	2.7	4.9	13.9	2.1	-3.7	0.3	-2.4
Loneliness, isolation	2.7	3.7	8.3	-1.2	2.9	-1.5	2.6
Commuting to job workplace: Cycle	2.7	3.2	11.7	1.5	-1.1	3.4	-1.1
Body mass index (BMI)	2.6	11.2	36.1	-3.5	6.0	-2.5	1.2
Had menopause	2.6	3.2	10.0	3.2	-1.9	0.7	-1.4
Mouth/teeth dental problems: Dentures	2.6	4.4	9.6	0.0	3.0	-3.1	1.8
Heart disease (mother)	2.5	3.0	7.8	1.8	-1.7	-2.8	-1.1
Illness, injury, bereavement, stress in last 2 years	2.5	3.1	7.5	0.5	-2.7	0.9	-2.6
Supplements: Fish oil (including cod liver oil)	2.5	3.2	9.7	1.3	-3.1	1.6	-1.4
Qualifications: CSEs or equivalent	2.4	3.2	10.1	-3.2	2.0	-0.0	1.3
Arm fat percentage (left)	2.4	9.5	31.1	-2.3	5.6	-2.9	1.8
Leg fat percentage (left)	2.4	8.8	30.6	-2.8	5.5	-2.2	0.8
Stomach or abdominal pain in last month	2.3	2.9	6.1	-2.5	2.5	-0.2	1.5
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	11.6	0.3	-3.4	1.7	-2.1
Angina (self-reported)	2.3	3.0	10.0	0.1	3.2	-1.7	1.5
Medication: Gliclazide	2.3	2.6	5.2	-2.3	1.3	-2.3	1.0
Arm fat percentage (right)	2.2	8.8	27.6	-2.4	5.3	-2.9	1.5
Body fat percentage	2.2	8.7	27.8	-2.5	5.3	-2.8	1.4
Leg fat percentage (right)	2.2	8.0	26.2	-2.8	5.1	-2.3	0.7
Exposure to tobacco smoke outside home	2.2	2.9	7.0	-2.1	2.6	-1.2	1.4
Number of self-reported non-cancer illnesses	2.2	3.8	10.1	-1.4	3.2	-2.2	1.4
Ulcerative Colitis (UC)	2.1	3.9	10.7	-0.1	3.3	-1.0	2.8
Past tobacco smoking	2.1	3.9	14.0	-0.5	-0.8	3.7	-2.2
Mouth/teeth dental problems	2.1	3.3	9.2	1.2	-1.9	3.0	-1.5
Length of working week for main job	2.1	2.3	5.6	-2.4	1.5	-1.4	1.3
Had major operations	2.1	2.4	8.4	2.9	-1.6	1.0	-0.6
Commuting to job workplace: Walk	2.1	2.2	10.3	0.5	0.6	0.4	3.2
Asthma (self-reported)	2.1	4.3	11.1	-1.5	3.3	-1.4	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	11.8	0.2	-2.7	3.4	-1.8
Vascular/heart problems diagnosed by doctor	2.1	5.6	11.1	0.3	-3.3	3.1	-2.8
Leg fat mass (left)	2.1	8.3	25.6	-3.2	5.1	-2.2	0.9
Chronotype (morning person)	2.0	4.7	12.7	-1.5	3.6	-1.6	2.5
Supplements: Glucosamine	2.0	2.6	7.1	1.6	-2.7	1.6	-1.0
Waist circumference	2.0	7.1	21.3	-2.3	4.6	-2.6	1.5
Falls in the last year	2.0	2.7	8.4	-1.5	2.9	0.6	1.5
Wheeze or whistling in the chest in last year	2.0	3.6	13.1	-1.9	3.6	-0.7	0.9
Leg fat mass (right)	2.0	7.9	22.9	-3.4	4.8	-2.1	0.8
Smoking status: Previous	2.0	2.9	11.5	0.8	0.2	-3.4	1.6
Ever had bowel cancer screening	2.0	2.4	7.7	2.8	-0.1	1.9	-0.8
Pain experienced in last month	2.0	3.3	6.0	2.1	-1.6	2.4	-1.9
Heart attack/myocardial infarction (self-reported)	2.0	2.6	7.7	-0.1	2.8	-1.1	2.1
Irritable Bowel Disease (IBD)	1.9	4.6	16.9	-0.4	4.1	-0.4	2.4
Smoking Status	1.9	4.5	16.5	-0.9	2.2	-4.1	0.6
Heart attack	1.9	2.5	7.7	0.0	2.8	-1.0	1.9
Asthma	1.9	3.8	9.8	-1.2	3.1	-1.6	2.3
Arm fat mass (right)	1.9	8.0	24.9	-3.0	5.0	-2.2	1.2
Chronic bronchitis/emphysema (mother)	1.9	2.2	8.3	-0.7	1.1	-2.9	1.0
Medication: Ibuprofen	1.9	2.2	6.1	-1.1	2.0	0.0	2.5
Handedness (chirality/laterality): Left-handed	1.9	2.2	5.1	2.3	-2.1	1.0	-0.9
Arm fat mass (left)	1.9	7.9	24.4	-2.8	4.9	-2.3	1.2
Financial situation satisfaction	1.9	2.3	5.2	-2.2	1.0	-2.3	0.8
Myopia	1.9	2.7	9.1	1.0	-1.0	3.0	-1.6
Reaction Time	1.8	3.5	8.5	2.9	-2.7	0.8	-1.0
Blood White Count	1.8	13.0	41.7	-1.0	6.5	-3.7	2.9
Respiratory disease	1.8	4.1	11.7	-1.9	3.4	-1.5	1.7
Hearing difficulty/problems: Yes	1.8	2.7	10.0	-0.2	1.8	-0.4	3.2
Trunk fat percentage	1.8	7.4	24.0	-2.4	4.9	-2.3	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	5.5	-1.3	1.8	-0.9	2.4
Shortness of breath walking on level ground	1.8	2.2	8.0	0.0	2.8	-1.7	0.4
Whole body fat mass	1.8	7.6	22.3	-2.8	4.7	-2.6	1.0
Number of full sisters	1.8	2.2	6.8	-2.0	2.6	0.4	-0.4
Illnesses of father: Heart disease	1.8	2.5	6.7	-0.9	2.6	-0.2	2.3
Average weekly beer plus cider intake	1.8	2.6	6.2	-2.0	0.8	-2.5	1.5
Age at First Birth	1.7	2.5	6.3	1.8	-2.5	-0.1	-1.6
Forced vital capacity (FVC)	1.7	6.7	18.3	1.1	-4.3	2.9	-2.4
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	15.9	0.6	-4.0	2.7	-2.2
Birth weight of first child	1.7	3.0	6.2	0.9	-1.8	2.2	-2.5
Medication: Amlodipine	1.7	2.3	6.4	1.0	2.5	0.1	2.1
High blood pressure (siblings)	1.7	2.5	6.9	0.7	2.6	-0.3	2.3
Forced vital capacity (FVC), Best measure	1.7	6.2	19.4	0.3	-4.4	2.2	-2.6
Depression (Nagel 2018)	1.6	2.3	5.7	-2.1	2.4	-1.2	0.5
Cardiovascular Disease	1.6	5.3	13.2	-0.6	3.6	-2.3	2.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	16.3	0.2	-4.0	1.8	-2.3
Worry too long after embarrassment	1.6	2.7	10.6	1.4	-3.3	-0.4	-1.1
Knee pain experienced in last month	1.6	2.4	4.3	-0.7	1.9	-2.1	2.0
Mood swings	1.6	2.9	4.4	-1.5	2.0	-2.0	2.1
Basal cell carcinoma (self-reported)	1.6	1.9	6.0	1.2	-0.4	2.4	1.4
Heart disease (siblings)	1.6	2.0	4.2	-0.8	2.0	-1.6	1.6
Lung FVC	1.5	7.6	19.4	0.5	-4.4	4.1	-1.1
Age when periods started (menarche)	1.5	3.6	11.2	3.3	-2.4	0.8	-0.2
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	6.4	-0.8	-0.7	0.8	-2.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.5	-2.1	2.1	-0.3	0.3
Medication: Ramipril	1.5	2.0	6.5	-0.9	1.4	-0.8	2.5
Medication for pain relief, constipation, heartburn	1.5	2.5	4.6	1.8	-2.1	0.6	-2.2
Osteoarthritis (self-reported)	1.5	2.0	4.3	-0.8	2.1	-1.0	1.9
Verbal and Numeric Reasoning (VNR)	1.4	3.3	9.7	1.0	-3.1	1.9	-1.4
Serious illness, injury or assault to yourself	1.4	1.7	5.1	-0.2	2.3	-1.5	1.1
High blood pressure	1.4	3.9	8.5	-0.3	2.4	-2.9	2.2
Trunk fat mass	1.4	6.1	18.7	-2.5	4.3	-2.2	1.1
Peak expiratory flow (PEF)	1.4	3.3	7.7	-0.4	-2.8	1.6	-2.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.5	-0.3	1.0	-2.1	1.8
Alcohol intake frequency.	1.4	3.2	13.1	-1.7	3.6	-0.0	0.5
Medication: Aspirin	1.4	1.9	5.1	-0.2	2.0	0.4	2.3
BMI	1.3	7.7	23.3	-3.0	4.8	-2.3	1.0
Taking other prescription medications	1.3	2.0	9.0	0.1	3.0	-0.3	0.9
Number of incorrect matches in round	1.3	2.1	6.0	0.7	-2.0	2.5	-0.1
Illnesses of mother	1.3	1.7	7.7	0.1	-0.2	2.8	-0.8
Medication: Omeprazole	1.3	1.5	5.0	-1.0	2.2	-0.1	1.2
Leg pain on walking	1.3	1.6	4.3	-2.1	1.9	0.7	-0.2
Supplements: Vitamin C	1.3	1.6	4.3	-1.0	-1.5	-2.1	-0.4
Hypertension (Self-reported)	1.3	3.7	7.1	-0.2	2.3	-2.7	2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.5	-2.1	-1.0	-0.8	-0.8
Medication: Aspirin	1.3	1.7	4.5	0.0	2.0	-0.3	2.1
Hearing aid user	1.3	1.4	3.2	-1.2	1.8	0.1	1.6
Medication: Atorvastatin	1.3	1.6	7.6	0.3	0.3	-2.8	0.3
Prostate Cancer	1.2	1.7	4.0	2.0	-1.2	-1.3	-1.2
Ulcerative Colitis	1.2	1.8	6.7	0.2	2.6	-1.2	0.9
Current tobacco smoking	1.2	1.9	7.1	-1.1	2.7	-1.0	0.4
Tense / ‘highly strung’	1.2	2.0	6.9	-2.6	1.4	-0.6	0.9
Headache pain in last month	1.2	2.0	5.2	-2.3	2.0	-0.9	0.4
Gout (self-reported)	1.2	1.7	3.0	-1.7	1.3	1.0	1.7
Pulse wave peak to peak time	1.2	1.4	3.2	0.5	-1.8	0.8	-1.6
Average weekly red wine intake	1.2	1.7	5.1	1.9	-2.3	-0.2	-0.1
Diabetes diagnosed by doctor	1.2	1.9	5.8	-1.1	2.4	-1.2	0.9
Qualifications: nursing, teaching	1.2	1.8	3.8	1.3	-1.8	1.9	-0.6
Medication: Blood pressure	1.2	2.3	4.2	0.5	2.0	-1.9	1.8
Supplements: Calcium	1.2	1.4	5.5	0.6	-2.3	0.4	-0.9
Alcohol drinker status: Previous	1.2	1.4	5.1	-0.4	2.3	-1.2	0.7
Intelligence (Savage-Jansen 2018)	1.1	3.5	9.8	1.1	-3.1	2.4	-1.0
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.5	-0.5	2.5	-1.1	1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	3.6	0.0	1.9	0.7	1.5
Medication: Co-codamol	1.1	1.2	3.2	-1.8	1.4	1.0	0.3
Townsend deprivation index at recruitment	1.1	1.5	5.9	-1.3	2.4	-0.2	0.5
Diabetes (self-reported)	1.1	1.8	5.4	-1.3	2.3	-0.9	1.0
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.6	-2.2	0.2	0.6	1.3
Neck or shoulder pain in last month	1.1	1.6	3.3	-1.7	1.8	-1.2	0.6
Back pain experienced in last month	1.1	1.7	4.3	-1.4	2.1	-0.9	1.1
Breast cancer (self-reported)	1.1	1.3	3.6	-1.6	-0.4	1.9	0.3
High cholesterol (Self-reported)	1.1	2.0	5.4	-0.2	2.3	-1.6	1.5
Risk taking	1.1	1.6	3.2	-1.7	1.1	0.8	1.8
Crohns Disease (2017)	1.0	2.3	8.8	-0.7	3.0	0.8	1.2
LDL Cholesterol	1.0	1.5	6.9	-0.1	2.6	-0.0	0.8
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.6	1.9	0.8	0.0	1.2
Waist Hip Ratio (WHR)	1.0	4.3	8.2	0.3	2.5	-2.7	2.9
Vitamin and mineral supplements	1.0	1.3	3.3	-0.4	1.8	-1.2	1.3
Severe depression (siblings)	1.0	1.1	4.6	0.3	0.5	0.6	2.1
Pain all over the body in last month	1.0	1.1	4.0	0.1	2.0	-0.1	1.1
Medication: Lansoprazole	1.0	1.1	2.2	1.4	0.2	1.2	-1.5
Prospective memory result	1.0	1.3	5.3	-0.1	-1.1	-2.3	0.0
Standing height	1.0	9.9	36.8	1.1	-6.1	2.1	-2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.3	1.0	1.5	-0.1	1.8
Medication for cholesterol	1.0	1.5	3.9	-0.7	-2.0	1.6	-0.7
Guilty feelings	1.0	1.5	5.3	1.4	-2.3	-0.0	-0.0
Commuting to job workplace: Public transport	1.0	1.2	3.1	1.8	-1.2	1.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.4	-0.3	2.1	-0.1	1.2
Alzheimer’s Disease (in father)	0.9	1.0	2.2	0.7	-0.0	1.5	1.5
Bipolar Disorder (2011)	0.9	0.8	3.4	0.9	-0.0	1.9	0.1
Rheumatoid Arthritis	0.9	1.2	2.9	1.7	-1.4	-1.0	-0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.5	2.1	-0.5	0.2	-1.0
Fed-up feelings	0.9	1.6	7.2	-0.7	-0.1	-2.7	-0.3
Pulse rate	0.9	1.5	4.6	-2.1	1.4	-0.8	0.5
Depression (self-reported)	0.9	1.1	3.3	0.2	1.4	-1.8	0.6
Glaucoma (self-reported)	0.9	1.1	2.7	0.7	-1.6	1.4	-0.6
Miserableness	0.9	1.5	4.4	-0.8	0.5	-1.5	2.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.4	0.6	0.8	1.1	1.8
Medication: Paracetamol	0.9	1.5	4.7	-2.2	1.3	-0.8	0.6
Irritability	0.9	1.5	4.3	-2.1	0.6	-1.7	0.0
Depressed Affect (Nagel 2018)	0.8	1.6	7.9	0.2	0.2	-2.8	0.2
Primary Biliary Cirrhosis	0.8	1.1	4.2	0.1	0.8	0.8	-2.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.3	-1.5	1.3	-0.4	1.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	-1.3	1.4	0.2	1.0
Diabetes (mother)	0.8	1.0	2.8	0.2	1.7	-1.4	-0.1
Average weekly fortified wine intake	0.8	0.9	3.7	0.2	0.8	0.5	1.9
Chronic bronchitis/emphysema (father)	0.8	0.9	2.9	-1.7	0.6	-1.1	0.2
Nervous feelings	0.8	1.5	3.9	-1.3	-1.5	-0.0	-2.0
Weight	0.8	3.7	9.0	-2.7	3.0	-1.5	0.2
Impedance of arm (right)	0.8	3.7	11.2	2.4	-3.3	1.0	-0.7
Happiness	0.8	1.0	4.0	-2.0	-0.8	-0.4	-0.4
Lung cancer (father)	0.8	0.9	2.5	0.4	-1.1	-1.0	-1.6
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	-0.4	1.3	-0.6	1.5
Loud music exposure frequency	0.8	0.9	1.8	-1.4	0.9	0.9	-1.1
Medication: Paracetamol	0.8	1.3	4.0	-2.0	1.3	-0.9	-0.2
Eye problems/disorders: None of the above	0.8	0.9	4.3	-2.1	-0.2	0.4	-0.3
Medication: Blood pressure	0.8	1.4	3.2	0.2	1.8	-1.0	1.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.3	-1.4	1.5	-0.5	-0.3
Illnesses of siblings: Diabetes	0.8	1.0	4.5	-0.2	2.1	0.5	-0.1
Long-standing illness, disability or infirmity	0.8	1.1	2.3	-1.4	1.5	-1.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.3	-1.8	-1.5	0.7	-0.8
Ever smoked	0.8	1.5	3.1	1.4	0.3	-1.4	1.8
Diastolic blood pressure, automated reading	0.8	2.3	5.2	-1.7	2.3	-1.9	0.2
Bipolar Disorder (2018)	0.7	1.2	3.8	2.0	0.4	1.2	0.6
Major Depression (MDD)	0.7	0.9	2.1	0.4	1.5	0.9	1.2
Ovarian Cancer	0.7	0.9	2.2	1.0	1.5	0.2	1.2
Triglycerides	0.7	1.1	3.4	-0.9	1.9	0.4	1.0
Neuroticism	0.7	1.6	6.8	0.3	-1.0	-2.6	0.2
Average weekly spirits intake	0.7	0.9	2.4	1.0	0.6	1.5	0.9
Relative age of first facial hair	0.7	1.5	4.1	1.7	-2.0	0.8	-0.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	2.4	0.5	1.6	0.9	0.8
Supplements: Zinc	0.7	0.7	2.4	0.7	-0.6	-1.5	0.7
Diabetes (father)	0.7	0.9	3.1	1.8	1.1	0.3	0.3
Maternal smoking around birth	0.7	1.1	2.3	-1.3	0.9	-0.7	1.5
Medication: Levothyroxine sodium	0.7	1.1	2.1	1.2	1.4	0.2	-1.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.1	-1.2	0.7	-0.8	-1.4
Blood clot in the leg (DVT)	0.7	0.8	3.4	0.1	1.9	-0.6	0.7
Medication: Allopurinol	0.7	0.9	2.7	-0.6	1.2	0.6	1.6
Medication: Seretide 50 evohaler	0.7	0.8	2.5	0.8	-0.9	-1.6	-0.3
Pulse rate, automated reading	0.7	2.2	7.7	-1.3	2.8	-0.9	-0.7
Eye problems/disorders: Cataract	0.7	0.8	3.0	1.7	0.3	-0.3	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.0	-0.6	1.7	-0.3	0.7
Medication: Lisinopril	0.7	0.9	3.2	0.5	1.0	-1.8	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.8	-1.7	0.6	-0.9	0.5
Alzheimer’s Disease (in mother)	0.6	0.7	2.1	0.9	-1.5	-0.7	0.0
Crohns Disease (2012)	0.6	1.0	4.1	0.1	2.0	0.6	0.7
Lupus	0.6	1.0	3.2	1.8	-0.5	1.1	-0.5
Blood Platelet Count	0.6	7.4	33.1	-1.0	5.8	-1.1	-1.3
Number of treatments/medications taken	0.6	1.1	3.1	0.8	1.8	-1.1	0.6
Systolic blood pressure, automated reading	0.6	1.7	4.0	0.3	2.0	-1.4	1.5
Sitting height	0.6	4.4	16.9	-0.8	-4.1	0.8	-1.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.5	-0.7	1.2	0.3	1.2
Medication: Simvastatin	0.6	0.9	2.9	-0.3	1.7	0.3	1.2
Neuroticism score	0.6	1.3	5.2	-0.9	0.3	-2.3	0.6
Time employed in main current job	0.6	0.7	1.7	-1.0	0.6	-1.3	0.7
Impedance of arm (left)	0.6	3.0	7.6	2.6	-2.8	0.6	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.2	0.6	1.5	-0.2	1.5
Hair/balding pattern: Pattern 4	0.6	1.5	4.8	0.2	-1.0	1.3	-2.2
Number of full brothers	0.6	0.7	1.9	-0.9	0.9	0.3	1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.8	-0.8	1.4	-0.9	-0.7
Alcohol drinker status: Never	0.6	0.7	2.4	-1.6	1.0	0.3	0.5
Neuroticism (Nagel 2018)	0.5	1.1	2.9	-0.1	-1.7	-1.5	-0.7
Systolic Blood Pressure	0.5	2.7	5.2	-0.2	2.0	-2.1	2.3
Hand grip strength (left)	0.5	1.3	4.0	-1.5	-0.4	2.0	-0.0
Multivitamins +/- minerals	0.5	0.6	1.7	0.8	-1.3	0.7	-0.6
Medication: Atenolol	0.5	0.6	2.5	-0.1	0.7	-1.6	-0.3
High blood pressure (mother)	0.5	0.6	1.6	-0.9	0.8	0.5	1.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	0.7	1.4	-0.9	-0.2
Hip circumference	0.5	2.2	4.7	-2.0	2.2	-1.2	-0.9
Comparative body size at age 10	0.5	1.4	4.1	-1.5	2.0	0.3	0.7
Emphysema/chronic bronchitis	0.5	0.5	1.4	-1.2	-0.1	0.6	-1.0
Migraine (self-reported)	0.5	0.6	1.3	-1.1	0.9	-0.4	-0.8
Osteoporosis (self-reported)	0.5	0.6	2.5	1.6	-0.1	-0.2	0.8
Illnesses of father: None of the above (group 1)	0.5	0.7	2.0	-0.1	-1.1	0.0	-1.4
Smoking status: Current	0.5	0.9	3.4	-0.7	1.8	-0.7	-0.0
Ever taken oral contraceptive pill	0.5	0.6	1.7	0.0	-1.3	-0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	0.3	1.4	-0.8	0.6
Impedance of whole body	0.5	2.6	6.3	2.1	-2.5	1.3	-0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	1.6	1.2	0.8	0.9	1.1
Schizophrenia (2014)	0.4	0.9	2.7	0.0	1.6	-0.5	1.3
Height	0.4	7.9	28.7	1.4	-5.4	0.3	-2.9
Lung FEV1/FVC ratio	0.4	1.9	6.7	0.7	-2.6	-0.3	-1.4
Sensitivity / hurt feelings	0.4	0.7	1.9	-1.4	1.0	-0.9	0.3
Medication for hormone replacement therapy	0.4	0.5	1.2	0.2	0.9	1.1	-0.6
Impedance of leg (right)	0.4	1.9	4.9	1.0	-2.2	1.7	-0.9
Impedance of leg (left)	0.4	1.8	3.9	1.4	-1.5	2.0	-0.8
Fluid intelligence score	0.4	0.9	1.8	1.4	-0.6	1.3	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	0.6	-0.7	1.0	1.0
Number of children fathered	0.4	0.5	1.6	-1.3	0.3	0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.2	0.3	1.1	0.6	0.7
Friendships satisfaction	0.4	0.4	1.0	-1.0	0.7	0.8	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.2	0.8	-1.1	-0.6	0.3
Cholesterol lowering medication	0.4	0.5	1.7	0.9	0.2	-1.3	-0.3
Worry (Nagel 2018)	0.3	0.6	2.0	-0.5	-1.4	-0.5	-0.5
Mean Putamen Volume	0.3	0.3	1.0	0.2	-0.6	1.0	-0.3
HbA1C	0.3	0.3	1.3	0.5	-0.1	1.1	-0.2
Blood Eosinophil Count	0.3	2.2	8.8	-3.0	1.1	-0.6	-0.8
Hypothyroidism (self reported)	0.3	0.7	1.5	-0.3	1.2	-1.1	-0.9
Medication: Metformin	0.3	0.5	1.0	-0.7	0.6	-1.0	0.7
Hand grip strength (right)	0.3	0.7	2.7	-1.7	-0.5	0.3	0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	-0.5	0.9	0.4	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	-1.3	0.1	0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	-0.5	-0.2	1.3	-1.0
Allergy	0.3	0.8	2.2	0.6	-1.5	0.8	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.8	-0.1	1.4	0.8	0.2
Exposure to tobacco smoke at home	0.3	0.4	1.1	-0.8	0.1	-1.0	-0.0
Pulse wave reflection index	0.3	0.4	1.2	1.1	0.1	-0.5	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.9	0.5	0.6	-0.0	-1.4
Birth weight	0.3	0.6	1.9	0.1	-1.4	1.1	-0.1
Suffer from ‘nerves’	0.3	0.4	0.8	-0.9	-0.5	0.7	0.8
Family relationship satisfaction	0.3	0.4	1.0	-0.5	-0.6	0.7	1.0
Medication: Bendroflumethiazide	0.3	0.5	2.0	-0.1	1.4	-0.4	-0.4
Ever depressed for a whole week	0.3	0.3	1.2	0.0	-0.3	-0.6	1.1
Schizophrenia (2018)	0.2	0.3	1.1	0.0	0.7	0.2	1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.6	-0.4	0.5	0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.3	-0.7	0.3	-0.8
HDL Cholesterol	0.2	0.3	0.9	0.2	-0.9	-0.8	-0.1
Blood Red Count	0.2	1.5	4.7	-1.6	0.4	-2.2	-0.5
Tanning	0.2	2.3	5.7	-2.4	2.0	-1.0	0.8
Leg fat-free mass (left)	0.2	1.1	3.6	-1.9	1.1	-0.7	-0.2
Leg predicted mass (left)	0.2	1.1	3.8	-2.0	1.1	-0.7	-0.1
Hearing difficulty/problems with background noise	0.2	0.2	1.0	-0.2	0.0	0.4	1.0
Number of live births	0.2	0.3	1.0	-0.4	-1.0	0.3	-0.0
Arm predicted mass (right)	0.2	0.9	3.0	-1.7	1.2	-0.2	-0.3
Comparative height size at age 10	0.2	1.0	3.7	0.2	-1.9	0.8	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.0	-1.0	0.5	-0.3	-0.1
Basal metabolic rate	0.2	0.9	3.6	-1.9	0.9	-0.4	-0.4
Arm fat-free mass (left)	0.2	1.2	4.3	-2.1	1.3	-0.2	-0.4
Number of operations (self-reported)	0.2	0.3	0.8	0.9	-0.0	0.4	-0.6
Fractured/broken bones in last 5 years	0.2	0.3	0.9	1.0	0.5	0.6	-0.1
Arm predicted mass (left)	0.2	1.2	4.5	-2.1	1.2	-0.1	-0.4
Breast Cancer	0.1	0.2	0.6	0.6	-0.2	0.8	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.4	0.3	-0.1	0.2	-0.6
Fasting Glucose	0.1	0.1	0.4	0.0	-0.7	-0.1	-0.5
Neuroticism (2016)	0.1	0.2	0.4	0.3	-0.6	-0.3	0.6
Heel T-Score	0.1	1.1	4.1	0.9	-0.5	2.0	-0.4
Allergy or Eczema	0.1	0.2	0.6	-0.5	0.8	0.5	0.1
Hair Pigment	0.1	2.1	4.7	1.6	0.1	-2.2	1.8
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.4	0.7	0.5	0.6
Had other major operations	0.1	0.1	0.4	-0.4	-0.0	-0.1	0.6
Trunk fat-free mass	0.1	0.7	1.3	-1.1	-1.1	0.3	-1.0
Trunk predicted mass	0.1	0.7	1.3	-1.1	-1.2	0.4	-1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	-0.6	0.5	0.2	-0.4
Arm fat-free mass (right)	0.1	0.7	2.4	-1.6	0.8	0.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.7	0.8	-0.1	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	-0.5	-0.5	-0.2	-0.5
Whole body fat-free mass	0.1	0.5	2.0	-1.4	-0.0	-0.1	-0.6
Leg fat-free mass (right)	0.1	0.7	2.6	-1.6	1.0	-0.4	-0.2
Whole body water mass	0.1	0.5	2.0	-1.4	0.0	-0.2	-0.6
Leg predicted mass (right)	0.1	0.8	2.7	-1.6	1.0	-0.4	-0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	-0.7	-0.0	0.4	0.0
Age started oral contraceptive pill	0.1	0.1	0.3	0.2	-0.4	-0.6	0.0
Worrier / anxious feelings	0.0	0.1	0.4	-0.1	-0.7	-0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.2	-0.4	-0.3	0.1	-0.0

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