Hub : Genes

JRK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.322	0.0450	0.0e+00	0.315	0.282	0.314	0.319	0.315	4.1e-39	1.8e-34	5.8e-39	1.1e-39	3.9e-39
2	GTEx	Adipose Subcutaneous	0.208	0.0580	9.6e-07	0.130	NA	0.105	NA	0.121	9.6e-11	NA	7.0e-09	NA	4.0e-10
3	GTEx	Cells Transformed fibroblasts	0.130	0.0450	5.5e-05	0.044	NA	0.039	NA	0.049	2.9e-04	NA	6.5e-04	NA	1.5e-04
4	GTEx	Heart Atrial Appendage	0.129	0.0540	6.2e-03	0.140	NA	0.137	NA	0.133	7.3e-07	NA	1.0e-06	NA	1.5e-06
5	GTEx	Heart Left Ventricle	0.325	0.0584	3.3e-13	0.357	NA	0.357	NA	0.350	7.0e-20	NA	7.2e-20	NA	1.8e-19
6	GTEx	Muscle Skeletal	0.295	0.0433	0.0e+00	0.278	NA	0.263	NA	0.288	2.1e-27	NA	9.7e-26	NA	1.7e-28
7	GTEx	Skin Sun Exposed Lower leg	0.138	0.0410	5.1e-06	0.016	NA	0.054	NA	0.027	1.6e-02	NA	2.6e-05	NA	2.7e-03
8	GTEx	Stomach	0.257	0.0620	4.9e-09	0.203	NA	0.247	NA	0.172	4.6e-10	NA	3.8e-12	NA	1.2e-08
9	GTEx	Uterus	0.361	0.1100	1.9e-03	0.017	NA	0.017	NA	0.017	1.4e-01	NA	1.5e-01	NA	1.4e-01
10	ROSMAP	Brain Pre-frontal Cortex	0.159	0.0371	9.6e-10	0.114	0.066	0.120	0.089	0.128	1.7e-14	6.7e-09	3.9e-15	1.4e-11	3.7e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.6	2.5	5.1	2.1	1.5	-0.5	2.2	1.4	1.8	2.0	1.4	-0.7	-1.2
Bipolar Disorder or Schizophrenia	4.1	10.0	17.4	4.1	3.8	0.1	4.2	3.7	3.9	3.1	2.2	-2.8	-0.9
Depressed Affect (Nagel 2018)	1.2	2.6	11.6	-3.4	-1.4	0.2	-0.7	-0.9	-1.6	-1.2	-1.6	0.4	2.1
Depression (Nagel 2018)	0.3	0.5	1.9	-0.7	0.1	0.8	0.2	0.3	0.1	0.0	-1.1	-0.6	1.4
Intelligence (Savage-Jansen 2018)	1.2	3.8	10.4	-0.3	-1.4	-2.7	-1.6	-1.9	-1.2	1.1	2.4	1.9	-3.2
Neuroticism (Nagel 2018)	1.5	3.5	11.0	-2.9	-1.2	1.0	-0.5	-0.7	-1.2	-2.2	-2.5	0.1	3.3
Schizophrenia (2018)	4.1	8.5	16.0	3.5	3.6	0.5	4.0	3.6	3.6	2.4	1.6	-3.0	-0.2
Schizophrenia vs Biploar Disorder	1.5	1.9	4.7	1.6	1.2	2.2	1.3	1.3	1.1	0.1	-1.5	-1.7	1.1
Worry (Nagel 2018)	0.8	1.8	8.3	-0.6	0.3	1.0	0.9	0.4	0.2	-1.6	-2.0	-0.6	2.9
Alzheimer’s Disease (in mother)	3.3	3.8	6.8	1.5	2.5	1.7	2.0	2.5	2.3	1.9	-0.5	-2.6	0.9
Alzheimer’s Disease (in father)	0.6	0.7	1.6	1.1	-0.4	1.2	-0.4	-0.3	-0.3	-0.9	-1.0	-0.1	1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	0.8	0.7	1.2	0.5	0.9	0.6	0.2	-1.0	-1.0	1.1
Crohns Disease (2017)	1.9	4.2	7.0	2.5	2.5	0.9	2.2	2.3	2.4	2.6	0.5	-2.3	0.2
Irritable Bowel Disease (IBD)	1.1	2.5	3.9	1.9	1.9	1.2	1.6	1.8	2.0	1.5	-0.4	-1.5	1.3
Ulcerative Colitis (UC)	0.4	0.7	3.0	0.9	0.6	1.0	0.5	0.6	0.7	-0.4	-0.9	-0.2	1.7
Major Depression (MDD)	0.1	0.1	1.2	1.1	0.0	0.3	0.0	0.0	0.0	0.0	-0.2	0.0	-0.1
Reaction Time	2.7	5.1	8.7	2.3	2.2	2.6	2.1	2.3	2.2	-1.0	-2.9	-1.9	2.3
Verbal and Numeric Reasoning (VNR)	1.3	3.2	8.4	-0.9	-1.1	-2.9	-1.3	-1.5	-1.0	0.9	2.5	1.4	-2.7
Breast Cancer	0.5	1.2	1.8	-1.0	-1.2	-1.2	-0.8	-1.3	-1.2	0.5	1.3	0.8	-1.2
Ovarian Cancer	0.9	1.1	3.4	-1.2	-0.8	0.3	-1.9	-1.1	-0.9	-1.5	-0.9	0.6	0.2
Prostate Cancer	0.5	0.6	1.8	0.2	0.8	-0.7	0.5	0.8	0.7	1.3	1.1	-1.0	-0.4
Age at First Birth	0.5	0.7	1.5	-0.9	-0.9	-1.0	-0.7	-0.9	-0.8	-0.9	0.7	1.2	-0.1
Bipolar Disorder (2011)	6.6	6.3	13.7	3.7	2.9	-0.2	2.7	2.8	3.1	2.5	2.3	-1.8	-1.3
Body Mass Index (BMI) (2010)	1.0	1.4	3.8	0.8	0.3	1.9	0.6	0.4	0.2	-1.0	-2.0	-1.0	1.8
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.1	-0.0	-0.7	-0.0	0.5	-0.1	0.3	0.8	-0.4	-0.9
Crohns Disease (2012)	0.7	1.1	2.9	0.6	0.9	-0.9	0.9	0.8	0.8	1.7	1.4	-0.7	-1.2
Mean Putamen Volume	1.8	2.1	3.4	1.1	1.8	-0.6	1.8	1.5	1.9	1.3	1.4	-1.1	-1.5
Fasting Glucose	0.8	0.9	5.6	0.2	0.4	-1.1	-0.0	0.0	0.3	-0.4	1.3	-0.1	-2.4
HbA1C	1.3	1.5	3.1	0.7	1.4	-0.4	1.8	1.3	1.3	0.8	1.2	-1.6	-1.2
HDL Cholesterol	3.0	5.0	9.7	2.0	3.0	0.4	2.6	3.1	3.1	1.5	0.3	-2.8	0.1
LDL Cholesterol	0.2	0.4	1.0	1.0	0.4	0.1	0.3	0.6	0.4	0.7	0.8	-0.9	-0.0
Lupus	0.3	0.4	1.0	-0.2	-1.0	-0.2	-0.7	-0.8	-0.9	0.2	0.8	0.8	0.3
Neuroticism (2016)	0.8	1.1	2.4	-1.3	-1.2	-0.3	-1.6	-1.2	-1.3	-0.9	-0.2	0.7	0.9
Primary Biliary Cirrhosis	0.0	0.1	0.2	-0.0	0.0	0.2	0.0	-0.2	0.0	-0.5	-0.3	0.2	-0.3
Rheumatoid Arthritis	0.3	0.4	1.1	0.4	0.6	0.4	0.7	0.7	0.5	0.9	0.1	-1.0	0.3
Schizophrenia (2014)	4.2	9.3	14.4	3.8	3.5	0.0	3.8	3.7	3.6	3.2	2.3	-3.0	-0.5
Triglycerides	0.2	0.4	0.9	-0.5	-1.0	0.3	-0.5	-0.6	-0.9	-0.4	-0.2	0.0	1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	-1.1	-1.0	-0.8	-0.8	-1.3	-0.8	-1.2	0.1	0.6	0.0
Ulcerative Colitis	0.4	0.5	1.6	1.3	0.3	0.9	0.1	0.2	0.4	-0.1	-1.0	-0.1	1.3
Blood Eosinophil Count	0.4	2.8	4.9	2.2	2.1	1.5	1.1	1.9	1.9	1.7	-0.2	-2.1	0.6
Blood Platelet Count	1.5	17.1	31.6	3.1	4.9	4.5	3.7	5.0	4.6	0.1	-3.4	-5.6	3.7
Blood Red Count	0.1	0.6	1.6	0.1	0.1	0.9	-1.0	0.2	0.1	-1.2	-1.2	-0.2	1.1
Blood White Count	0.2	1.2	3.5	0.2	1.5	0.8	0.7	1.9	1.5	0.2	-0.6	-1.4	0.6
Heel T-Score	0.6	5.0	13.5	1.7	1.8	-1.2	3.3	1.8	2.0	3.7	2.3	-1.0	-2.1
BMI	1.0	5.7	12.2	-3.4	-2.1	1.6	-2.3	-1.9	-2.4	-1.9	-3.5	0.8	2.8
Height	0.7	12.7	37.7	0.4	-0.0	5.0	-1.1	0.0	-0.4	-4.9	-6.1	-1.5	6.0
Waist Hip Ratio (WHR)	0.2	0.8	1.7	0.8	1.1	-1.1	0.5	0.8	1.3	0.7	0.8	-0.6	-0.9
Systolic Blood Pressure	0.2	1.2	2.9	-0.1	-1.7	-0.7	0.5	-1.4	-1.6	1.0	0.7	1.6	-0.4
Smoking Status	1.1	2.6	5.8	0.8	2.1	0.3	2.3	2.4	2.3	-0.3	-0.1	-2.0	1.1
Allergy or Eczema	1.8	4.7	11.6	-2.5	-1.4	-3.4	-2.2	-1.6	-1.5	0.7	2.8	1.4	-2.8
Cardiovascular Disease	0.2	0.5	2.0	-0.2	0.2	1.0	0.7	0.5	0.3	0.6	-0.9	-0.7	1.4
Hypothyroidism (self reported)	0.2	0.4	0.9	0.2	0.9	-0.0	0.8	0.9	1.0	0.3	0.6	-0.5	-0.2
Respiratory disease	1.2	2.7	10.1	1.5	-0.1	-1.8	-0.7	-0.5	0.0	1.2	2.7	1.3	-3.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	2.1	-1.5	0.1	-0.8	0.2	0.2	0.1	0.4	0.4	-0.0	-0.0
Lung FEV1/FVC ratio	0.7	3.6	9.2	0.4	2.0	-0.7	3.0	2.1	2.2	2.5	1.1	-1.8	-1.3
Lung FVC	0.8	4.1	8.9	-1.0	-1.5	-2.3	-0.8	-1.3	-1.2	2.8	3.0	1.9	-2.8
Neuroticism	0.4	0.9	2.9	-1.5	-0.0	0.8	-0.1	0.2	-0.2	-0.8	-1.2	-0.6	1.7
Chronotype (morning person)	0.3	0.7	3.0	0.2	-0.0	1.7	0.2	-0.2	-0.2	-0.9	-1.3	-0.6	1.0
Hair Pigment	0.2	4.5	7.9	-0.9	-1.9	-2.7	-1.9	-2.1	-1.6	1.1	2.8	2.3	-2.8
Tanning	0.0	0.3	1.5	0.1	-0.3	-0.4	-0.3	-0.0	-0.1	1.2	0.7	0.5	0.4
Hand grip strength (left)	0.3	0.8	2.8	0.4	-0.5	1.7	-0.2	-0.6	-0.7	-0.8	-1.7	-0.1	0.5
Number of treatments/medications taken	0.3	0.6	2.5	-0.7	-0.4	0.7	-0.3	-0.1	-0.3	-0.2	-1.6	-0.3	1.4
Average weekly spirits intake	2.9	3.7	10.6	0.6	0.5	-2.3	1.9	0.5	0.8	2.8	3.3	0.2	-2.7
Sensitivity / hurt feelings	0.5	0.9	3.5	-1.9	-0.9	0.3	-1.1	-0.5	-0.8	-0.8	-0.5	0.6	1.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.7	-1.3	-0.5	-0.4	-0.5	-0.2	-0.5	1.2	0.7	0.3	0.0
Hearing difficulty/problems: Yes	1.3	1.9	2.8	-0.7	-1.5	-1.5	-1.1	-1.5	-1.5	1.0	1.7	1.6	-1.6
Relative age of first facial hair	0.7	1.4	5.9	0.7	0.2	-1.3	-0.5	-0.1	0.2	0.6	2.3	0.2	-2.4
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	9.2	-0.6	-0.8	-2.1	-0.5	-1.0	-0.8	1.0	2.5	1.4	-3.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.1	-0.5	-0.2	1.5	-0.4	-0.0	-0.3	-1.2	-1.6	-0.3	2.0
Ever had hysterectomy (womb removed)	1.3	1.4	4.3	2.1	1.4	1.2	1.0	1.3	1.4	0.7	-0.6	-1.0	0.6
Systolic blood pressure, automated reading	0.2	0.7	1.5	-0.3	-1.2	-0.7	0.3	-1.0	-1.1	1.0	0.2	1.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	0.2	-0.1	-0.6	0.4	-0.2	0.0	0.9	0.2	0.7	-0.7
Angina	0.8	1.0	2.9	-0.2	-0.7	-1.3	0.2	-0.4	-0.5	1.2	1.6	0.9	-1.7
Medication for hormone replacement therapy	1.0	1.2	3.8	1.5	1.1	0.7	0.4	1.2	1.2	2.0	0.1	-0.7	-0.5
Vitamin and mineral supplements	0.6	0.8	2.5	-1.0	-0.4	1.4	-0.4	-0.4	-0.5	-0.8	-1.6	-0.0	1.2
Supplements: Zinc	2.9	3.1	6.7	1.1	2.3	0.5	2.2	2.6	2.3	0.6	0.6	-2.5	0.9
Medication: Co-codamol	1.1	1.3	2.6	-0.7	-1.6	-0.5	-1.3	-1.6	-1.5	0.4	0.2	1.5	-0.5
Medication: Metformin	0.2	0.2	0.7	-0.2	0.1	0.8	-0.2	0.3	0.2	-0.6	-0.6	-0.4	0.7
Diabetes (father)	0.3	0.3	1.0	-1.0	-0.3	-0.2	-0.2	-0.8	-0.6	-0.3	-0.5	0.5	-0.7
Diabetes (mother)	0.2	0.3	0.8	0.1	-0.4	0.2	-0.8	-0.2	-0.3	-0.8	-0.7	0.1	0.9
Severe depression (siblings)	3.3	3.7	5.5	2.2	2.3	1.1	2.4	2.3	2.3	2.1	-0.2	-2.3	0.2
Pack years adult smoking proportion	1.2	1.8	3.1	-1.8	-1.7	-0.9	-1.0	-1.6	-1.6	-1.6	-0.2	1.5	0.1
Impedance of leg (right)	2.3	11.2	19.5	4.0	4.4	2.5	3.2	4.3	4.4	-0.2	-1.4	-4.1	1.8
Leg fat-free mass (left)	1.7	9.0	14.2	-3.8	-3.4	0.8	-3.6	-3.4	-3.7	-3.0	-2.8	2.2	2.1
Trunk fat percentage	1.6	6.5	23.9	-0.9	-0.2	3.3	-0.6	-0.0	-0.4	-2.6	-4.9	-1.3	4.5
Hand grip strength (right)	1.0	2.8	9.6	0.7	-0.8	3.1	-0.5	-0.9	-1.1	-2.0	-2.9	0.2	1.6
Townsend deprivation index at recruitment	0.8	1.1	2.2	-1.1	-1.3	-0.2	-1.5	-1.4	-1.3	-0.5	-0.2	1.2	-0.8
Current tobacco smoking	0.5	0.9	2.0	0.3	1.2	-0.3	0.9	1.4	1.4	0.5	0.2	-1.3	0.8
Average weekly fortified wine intake	0.5	0.6	2.1	0.5	0.6	-1.4	0.2	0.4	0.7	0.7	1.4	0.2	-0.6
Maternal smoking around birth	0.5	0.8	2.4	-0.1	0.7	-1.4	0.5	0.5	0.8	-0.2	1.1	0.3	-1.5
Fed-up feelings	2.1	3.8	12.4	-3.5	-1.9	0.3	-1.7	-1.3	-2.1	-2.0	-1.7	0.7	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	-1.2	-0.6	-0.3	-0.5	-0.5	-0.7	-0.1	-0.5	-0.0	0.9
Relative age voice broke	1.1	1.7	8.2	0.5	-0.0	-1.6	0.1	-0.4	0.1	0.6	2.2	1.0	-2.9
Taking other prescription medications	0.3	0.4	1.3	-1.1	-0.7	-0.6	-0.1	-0.7	-0.7	-0.2	-0.2	0.9	0.1
Age when periods started (menarche)	0.1	0.3	0.6	-0.0	-0.8	0.0	-0.4	-0.8	-0.7	0.3	0.5	0.3	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.4	-0.0	0.0	-0.9	0.1	-0.1	0.1	1.6	0.7	-0.0	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.7	0.5	0.8	-0.8	1.5	0.7	0.8	1.6	1.3	-0.4	-1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.4	-0.4	-0.2	-0.4	-0.1	-0.3	-0.1	-1.2	0.1	-0.1	-0.2
Qualifications: CSEs or equivalent	1.1	1.5	2.8	-1.7	-1.5	-1.0	-1.6	-1.5	-1.6	0.1	0.5	0.9	-0.9
Serious illness, injury or assault to yourself	0.3	0.4	1.3	-0.6	-0.3	-1.1	0.2	-0.3	-0.2	0.4	1.0	0.5	-0.9
High blood pressure	0.3	0.8	2.2	-0.3	0.4	0.3	1.5	0.8	0.5	1.3	-0.2	-0.9	1.3
Hayfever, allergic rhinitis or eczema	3.0	6.5	17.1	-2.2	-1.0	-4.1	-1.7	-1.3	-1.1	1.9	4.1	1.1	-3.8
Multivitamins +/- minerals	0.5	0.6	1.9	1.0	0.5	-0.9	0.4	0.6	0.6	0.8	1.4	-0.6	-0.5
Stomach or abdominal pain in last month	0.3	0.4	1.9	0.7	-0.4	0.5	0.2	-0.4	-0.4	-1.4	-0.6	0.6	-0.3
Supplements: Glucosamine	1.7	2.2	6.9	0.3	-0.6	-2.1	0.2	-0.7	-0.3	1.2	2.6	1.2	-2.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	0.0	-0.9	0.2	-0.7	-0.8	-0.7	-1.1	-0.6	1.2	0.4
Medication: Atenolol	0.9	1.1	3.2	-1.8	-1.4	-0.5	-0.8	-0.8	-1.2	-0.5	-0.3	1.2	0.8
Medication: Levothyroxine sodium	0.2	0.4	1.0	-0.6	-0.4	-0.4	-0.6	-0.6	-0.4	-1.0	0.5	0.7	-0.4
Sitting height	0.9	6.4	15.0	-1.4	-1.7	2.5	-2.4	-1.6	-1.9	-3.8	-3.9	0.3	3.5
Chronic bronchitis/emphysema (father)	3.1	3.7	6.6	2.6	2.1	2.4	1.7	1.8	2.0	0.3	-1.8	-2.5	0.6
High blood pressure (mother)	0.9	1.3	5.0	-0.2	-1.4	-0.9	-0.4	-1.6	-1.4	0.1	0.2	2.2	-0.4
Body mass index (BMI)	0.7	3.0	6.9	-2.6	-1.7	0.8	-1.9	-1.6	-1.8	-1.2	-2.3	0.8	1.8
Impedance of leg (left)	2.6	12.5	21.2	4.4	4.6	2.6	3.6	4.6	4.6	-0.2	-1.2	-4.4	1.7
Leg predicted mass (left)	1.7	9.2	14.3	-3.8	-3.4	0.8	-3.8	-3.4	-3.7	-3.0	-2.8	2.2	2.1
Trunk fat mass	1.8	7.8	27.1	-1.5	-0.6	3.5	-1.2	-0.5	-0.9	-3.1	-5.2	-0.9	4.8
Waist circumference	0.7	2.6	8.6	-1.3	-0.3	1.7	-1.2	-0.2	-0.4	-1.4	-2.9	-0.6	2.9
Number of incorrect matches in round	0.8	1.4	3.7	-0.1	0.9	0.3	1.8	1.1	1.0	-1.0	-1.4	-0.6	1.9
Past tobacco smoking	1.0	1.9	3.9	-1.1	-1.5	-1.2	-1.2	-1.9	-1.6	-0.0	1.1	2.0	-1.3
Alcohol usually taken with meals	2.1	3.4	5.9	2.4	2.0	2.3	1.9	2.3	2.2	0.3	-1.0	-1.6	1.3
Nervous feelings	0.2	0.3	1.5	-0.2	-0.1	0.6	-0.1	0.0	-0.1	-0.9	-0.9	0.2	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.3	-0.9	-1.2	0.1	-1.8	-1.1	-1.2	0.0	-0.2	0.9	0.7
Hearing difficulty/problems with background noise	1.4	2.3	3.3	-1.1	-1.8	1.1	-1.7	-1.6	-1.8	-1.1	-1.6	1.3	1.7
Hair/balding pattern: Pattern 2	2.3	2.9	7.5	-1.7	-2.1	-1.2	-2.7	-1.9	-2.2	-1.1	0.4	1.6	0.2
Had menopause	0.1	0.2	0.9	0.3	0.4	-0.2	0.3	0.3	0.3	0.1	-0.5	-0.3	0.9
Had other major operations	0.2	0.2	0.5	-0.1	0.5	0.0	0.7	0.5	0.5	-0.1	-0.5	-0.5	0.2
Forced vital capacity (FVC)	0.7	2.9	5.9	-1.6	-2.3	0.3	-2.0	-2.2	-2.4	-1.4	-0.7	1.9	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.9	0.6	0.9	-0.7	1.7	0.8	0.9	2.0	1.4	-0.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-0.9	-0.0	-0.1	0.6	0.0	-0.2	-1.1	-0.6	-0.4	1.2
Qualifications: None of the above	2.1	4.6	14.1	0.2	0.8	3.3	0.8	1.1	0.5	-1.6	-3.5	-1.8	3.8
Financial difficulties in last 2 years	1.6	2.2	4.2	-1.3	-1.3	-1.6	-1.4	-1.3	-1.2	1.1	2.1	1.3	-1.9
Mouth/teeth dental problems	1.1	1.7	3.5	1.2	1.4	-0.5	1.8	1.5	1.6	1.9	0.8	-1.1	-0.7
Heart attack	0.1	0.1	0.3	0.1	0.3	0.3	0.4	0.5	0.3	0.0	-0.5	-0.4	0.5
Allergy	2.3	5.3	16.8	0.7	0.5	3.5	1.2	0.8	0.4	-1.9	-4.1	-1.0	4.0
Pain all over the body in last month	1.3	1.4	4.4	-2.1	-1.1	-0.7	-0.9	-1.0	-1.3	-1.8	0.1	0.5	0.5
Diabetes (self-reported)	0.6	0.9	1.7	0.4	1.1	0.7	0.9	1.3	1.3	0.1	-0.8	-0.9	1.1
Hayfever/allergic rhinitis (self-reported)	8.2	10.8	19.9	-3.1	-3.3	-4.5	-3.1	-3.4	-3.2	0.7	3.8	3.3	-3.2
Medication: Ramipril	0.3	0.3	1.1	-0.5	-0.7	-0.4	-0.1	-0.7	-0.6	-1.1	-0.3	0.8	-0.2
Medication: Simvastatin	0.1	0.1	0.3	0.2	0.2	0.2	-0.4	0.2	0.2	0.5	-0.5	-0.1	0.5
Fluid intelligence score	0.7	1.5	3.5	-1.2	-1.1	-1.9	-1.3	-1.3	-1.0	0.0	1.3	1.2	-1.4
Illnesses of siblings	0.5	0.7	2.9	0.2	0.6	1.1	0.3	0.6	0.6	-1.7	-1.0	-0.6	0.9
Neuroticism score	1.0	2.1	6.2	-2.5	-1.5	0.1	-1.6	-1.2	-1.6	-1.6	-1.0	0.9	1.3
Weight	1.5	7.4	19.0	-2.7	-1.8	2.5	-2.6	-1.7	-2.1	-3.1	-4.4	0.5	3.8
Impedance of arm (right)	1.0	4.6	7.5	2.3	1.7	2.7	1.7	1.7	1.6	-1.4	-2.6	-2.4	2.7
Arm fat percentage (right)	0.9	3.5	12.8	-1.4	-0.7	2.4	-0.8	-0.5	-0.9	-1.4	-3.6	-0.5	3.2
Trunk fat-free mass	1.1	6.2	11.9	-2.9	-2.5	1.1	-3.5	-2.5	-2.8	-2.8	-2.4	1.8	1.9
Hip circumference	1.4	6.0	14.1	-2.4	-1.9	2.1	-2.6	-1.8	-2.2	-2.3	-3.8	0.7	3.3
Time employed in main current job	1.0	1.2	2.1	0.8	0.8	1.3	1.4	0.8	0.7	-0.4	-1.5	-1.0	1.5
Alcohol intake versus 10 years previously	0.2	0.3	1.4	-0.8	0.4	-0.5	1.2	0.4	0.4	0.5	0.3	-0.5	-0.2
Father’s age at death	0.5	0.7	2.2	0.7	-0.4	1.3	-0.3	-0.4	-0.4	-1.1	-1.5	0.7	0.5
Worrier / anxious feelings	2.4	4.5	7.4	1.2	2.5	1.6	2.7	2.7	2.6	0.3	-1.3	-2.5	2.2
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	8.0	-2.8	-2.6	-1.3	-2.0	-2.5	-2.7	-0.5	0.3	1.8	-0.5
Falls in the last year	0.1	0.2	0.6	0.2	-0.1	0.1	0.6	0.2	-0.0	0.8	0.6	-0.1	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.0	0.2	0.1	0.7	0.2	0.3	0.7	-0.5	0.2	-0.3
Number of live births	0.9	1.3	3.8	-0.8	-1.2	0.4	-1.9	-1.1	-1.4	-1.3	-0.6	0.7	1.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.8	-1.5	-1.8	-0.3	-1.5	-1.8	-1.9	-0.1	0.3	1.5	-0.8
Pulse rate	0.2	0.4	1.0	-0.6	0.3	0.4	0.8	0.4	0.2	0.4	-1.0	-0.6	1.0
Happiness	2.5	3.0	9.5	-3.1	-2.1	-1.3	-0.8	-1.9	-2.1	-1.3	0.3	1.8	-0.7
Noisy workplace	0.6	0.7	1.2	-0.3	-1.0	0.2	-1.1	-1.0	-1.1	-1.1	-0.8	0.8	0.0
Qualifications: A levels/AS levels or equivalent	2.5	5.4	16.0	-1.3	-0.9	-4.0	0.1	-1.2	-0.7	1.1	3.9	2.0	-3.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.2	0.8	0.1	-1.0	-0.1	-0.1	0.2	0.4	1.7	0.3	-1.8
Mouth/teeth dental problems: Dentures	1.2	2.1	4.5	-1.4	-2.0	0.4	-1.7	-2.0	-2.1	-0.2	-0.6	1.7	-0.0
Asthma	0.4	0.9	2.7	1.4	-0.0	-0.7	-0.5	-0.2	0.1	0.6	1.6	0.6	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.3	-1.2	-0.4	-0.8	-0.1	-0.5	-0.4	0.5	-0.4	0.5	-0.4
Medication: Cholesterol lowering	0.3	0.4	1.0	0.4	0.7	0.6	-0.0	0.9	0.8	1.0	-0.4	-0.6	0.6
Depression (self-reported)	0.0	0.0	0.3	-0.1	0.0	-0.5	-0.0	-0.0	0.0	-0.3	0.1	0.2	-0.2
Medication: Lansoprazole	2.3	2.6	5.3	-1.8	-2.3	-0.8	-1.6	-2.2	-2.2	0.4	-0.6	2.0	0.0
Prospective memory result	0.7	0.9	2.5	1.5	0.6	0.9	0.5	0.3	0.5	-1.6	-1.2	-0.7	0.6
Lung cancer (father)	0.2	0.3	0.8	-0.3	0.3	0.1	0.7	0.4	0.2	0.4	-0.7	-0.5	0.9
Illnesses of mother	0.5	0.7	2.2	-1.1	-0.7	-0.6	-1.0	-0.7	-0.6	-1.5	0.3	0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	-0.9	-0.8	-0.2	-0.3	-0.6	-0.8	0.6	0.3	0.3	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	-0.0	-0.5	0.6	-0.1	-0.5	-0.5	-0.8	-1.0	-0.2	1.0
Impedance of arm (left)	1.0	4.5	8.1	2.2	1.6	2.7	1.4	1.7	1.5	-1.6	-2.5	-2.3	2.9
Arm fat mass (right)	1.3	5.3	16.2	-2.0	-1.2	2.5	-1.7	-1.1	-1.5	-2.4	-4.0	-0.0	3.6
Trunk predicted mass	1.0	5.9	10.9	-2.8	-2.4	1.2	-3.3	-2.4	-2.6	-2.8	-2.5	1.7	2.0
Standing height	0.9	9.4	26.7	-0.6	-0.8	4.0	-1.9	-0.8	-1.2	-4.5	-5.2	-0.5	4.8
Length of working week for main job	0.6	0.7	2.0	-1.4	-1.1	-0.2	-0.7	-1.2	-1.1	-0.4	0.0	0.7	-0.3
Exposure to tobacco smoke at home	1.1	1.2	3.3	0.4	1.1	1.8	0.9	1.3	0.9	0.1	-1.3	-1.2	1.1
Breastfed as a baby	0.5	0.6	1.2	-0.7	-0.8	-0.6	-0.5	-0.9	-0.8	-0.4	1.1	0.7	-0.9
Tense / ‘highly strung’	0.2	0.3	0.6	-0.2	0.3	-0.5	0.5	0.3	0.4	0.8	0.6	-0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.6	0.1	-0.9	0.1	0.2	0.2	-0.1	0.8	0.2	0.4
Hair/balding pattern: Pattern 4	0.5	1.3	3.2	1.4	1.1	1.8	0.9	1.1	1.0	0.7	-0.9	-1.3	0.8
Birth weight of first child	0.1	0.2	1.1	0.0	-0.3	0.7	0.2	-0.4	-0.4	-0.1	-1.0	-0.2	0.4
Peak expiratory flow (PEF)	1.5	3.4	6.2	-1.8	-1.7	-2.3	-0.8	-1.8	-1.6	1.3	2.5	1.6	-2.5
Pulse wave reflection index	1.0	1.2	3.0	-0.8	-1.3	-0.1	-1.7	-1.4	-1.3	-1.5	-0.3	0.9	0.5
Ever highly irritable/argumentative for 2 days	2.7	3.2	4.9	-1.7	-2.1	-1.8	-2.0	-2.2	-2.2	0.0	1.5	1.9	-1.3
Loud music exposure frequency	1.2	1.4	2.9	-1.1	-1.3	0.1	-1.7	-1.4	-1.4	-1.3	-0.8	1.0	0.6
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	6.5	-0.0	-0.3	-2.2	-0.5	-0.6	-0.1	1.5	2.2	1.2	-2.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.5	-1.0	-1.0	0.4	-1.4	-1.0	-1.0	-1.6	-0.8	0.8	1.0
Blood clot in the leg (DVT)	0.6	0.8	2.2	-0.4	-0.9	-0.3	-1.5	-1.2	-0.8	-0.7	0.2	1.1	-1.1
Medication: Paracetamol	0.2	0.4	1.1	-0.8	-0.5	-0.5	-1.1	-0.7	-0.6	-0.5	-0.1	0.5	0.1
Headache pain in last month	2.0	3.4	5.5	-1.3	-2.1	0.9	-1.7	-2.1	-2.3	-2.3	-2.3	1.8	0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.6	-1.0	-1.4	-1.6	-1.3	-1.6	-1.4	-1.3	1.6	1.6	-1.9
Glaucoma (self-reported)	0.2	0.2	1.0	-0.4	0.2	-0.7	1.0	0.4	0.3	0.4	0.5	-0.2	0.2
Gout (self-reported)	1.3	1.8	3.8	-1.3	-1.7	-1.4	-1.4	-1.7	-1.7	-0.3	0.5	1.9	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.2	0.6	-0.2	0.3	0.5	0.6	-0.6	0.5	-0.2	-0.3
Medication: Amlodipine	0.1	0.2	0.7	-0.2	-0.1	0.3	0.4	0.3	0.1	0.2	-0.7	-0.2	0.8
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.5	1.6	1.2	0.5	1.2	1.1	1.2	0.2	-0.2	-1.1	0.3
Birth weight	0.9	2.0	4.0	-1.1	-2.0	-0.9	-1.4	-2.0	-2.0	-1.1	0.5	1.7	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.3	0.0	0.0	-0.0	0.5	-0.1	-0.1	-1.1	-0.3	-0.1	-0.4
High blood pressure (siblings)	0.8	1.1	3.6	-0.9	-0.7	-1.4	0.2	-0.7	-0.8	1.9	1.6	0.5	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.7	1.7	-1.2	-1.2	0.4	-0.7	-1.0	-1.3	-0.5	-0.5	0.7	0.2
Body fat percentage	1.4	5.4	19.6	-1.0	0.1	3.0	-0.5	0.3	-0.1	-2.1	-4.4	-1.3	4.2
Leg fat percentage (right)	1.0	3.7	12.5	-0.8	0.8	2.4	-0.0	0.9	0.6	-1.6	-3.5	-1.5	3.4
Arm fat-free mass (right)	1.1	5.6	11.1	-2.8	-2.3	0.8	-3.3	-2.4	-2.6	-2.8	-2.3	1.6	1.8
Exposure to tobacco smoke outside home	0.4	0.5	1.7	-0.3	0.2	0.6	-0.4	0.5	0.2	-1.3	-1.0	-0.8	0.9
Comparative body size at age 10	0.4	1.0	3.9	-1.1	-0.6	1.1	0.0	-0.5	-0.8	0.2	-2.0	0.5	1.5
Number of full brothers	1.5	1.9	3.7	-1.9	-1.6	-1.5	-1.4	-1.3	-1.6	0.6	1.6	0.9	-1.0
Worry too long after embarrassment	3.3	5.6	16.8	-0.2	0.1	3.6	-0.5	0.2	-0.2	-3.0	-4.0	-1.0	4.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	-0.5	-0.6	-1.1	-0.4	-0.6	-0.3	-0.7	0.9	1.3	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	1.2	-0.1	0.2	0.1	-0.5	0.4	0.3	-0.3	-0.6	-0.3	1.1
Number of children fathered	0.3	0.4	1.2	1.1	0.2	0.9	0.0	-0.0	0.0	-0.2	-1.0	-0.7	0.4
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.7	9.5	2.5	2.3	0.8	3.1	2.2	2.5	1.1	0.1	-1.4	0.2
Age at first live birth	0.2	0.3	1.1	-0.1	0.2	-1.0	1.0	0.4	0.5	0.2	0.8	0.0	-0.4
Pulse wave peak to peak time	0.2	0.2	0.4	0.1	0.6	-0.3	0.1	0.6	0.5	0.6	0.6	0.0	-0.6
Health satisfaction	1.7	2.3	4.5	-2.1	-2.0	-1.2	-0.5	-2.0	-2.1	-0.3	-0.0	1.8	-0.7
Shortness of breath walking on level ground	0.6	0.7	2.4	-1.5	-1.0	-0.6	-0.4	-1.1	-1.1	0.1	-0.1	0.7	-0.2
Qualifications: College or University degree	4.0	12.6	32.0	-1.6	-2.4	-5.7	-1.3	-2.7	-2.0	1.3	5.5	3.9	-5.1
Eye problems/disorders: None of the above	1.8	2.1	3.7	-1.9	-1.8	-1.0	-1.6	-1.8	-1.6	0.2	0.6	1.9	-1.1
Mouth/teeth dental problems: Loose teeth	3.1	3.7	6.9	1.6	1.6	2.6	1.5	1.7	1.5	-2.0	-2.2	-1.7	2.3
Emphysema/chronic bronchitis	0.6	0.7	2.7	0.7	0.9	0.2	0.8	0.6	0.9	1.6	0.6	-0.4	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	0.8	0.7	-0.3	0.5	0.8	0.8	0.0	1.0	-0.5	-0.4
Neck or shoulder pain in last month	0.5	0.7	2.9	-1.7	-0.8	-0.5	-1.0	-0.7	-1.0	0.5	-0.2	0.0	0.7
Medication: Blood pressure	0.6	1.0	2.3	0.1	0.5	1.2	1.2	0.8	0.5	0.7	-1.4	-1.0	1.5
Angina (self-reported)	0.7	0.9	2.5	-0.2	-0.7	-1.1	-0.0	-0.5	-0.6	1.2	1.2	1.0	-1.6
Migraine (self-reported)	0.5	0.6	1.0	-0.7	-0.8	-0.8	-1.0	-1.0	-1.0	-0.2	0.1	0.9	-0.9
Medication: Ibuprofen	0.5	0.6	1.9	-1.4	-0.6	-1.0	-0.6	-0.7	-0.6	-0.1	-0.3	0.9	-0.6
Medication: Allopurinol	2.6	3.5	5.9	-2.1	-2.3	-2.0	-1.9	-2.3	-2.3	-0.8	0.6	2.4	-0.1
Medication: Omeprazole	1.5	1.8	4.2	1.6	0.9	2.0	0.7	0.8	0.9	0.2	-2.0	-1.1	1.7
Medication: Seretide 50 evohaler	0.5	0.6	1.8	1.0	0.6	-0.6	0.5	0.5	0.7	1.4	0.9	-0.5	-1.0
Mean time to correctly identify matches	3.1	5.9	11.8	2.2	2.2	2.9	2.0	2.3	2.1	-1.1	-3.4	-2.1	3.0
Heart disease (mother)	1.1	1.3	2.7	1.3	1.3	1.2	1.0	1.2	1.1	1.6	-0.4	-1.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.1	0.2	-0.2	-0.6	0.1	-0.1	-0.1	-0.6	1.0	0.5	-1.0
Whole body fat mass	1.5	6.2	21.9	-1.4	-0.5	3.1	-1.2	-0.3	-0.8	-2.5	-4.7	-0.9	4.3
Leg fat mass (right)	1.1	4.4	15.0	-1.8	-0.5	2.4	-1.3	-0.4	-0.8	-2.2	-3.9	-0.5	3.5
Arm predicted mass (right)	0.9	4.7	9.3	-2.6	-1.9	1.0	-3.0	-1.9	-2.2	-2.6	-2.3	1.2	2.1
Pulse rate, automated reading	0.4	1.2	3.7	-1.9	-0.7	0.3	-0.9	-0.6	-0.9	-1.4	-1.5	0.3	1.1
Alcohol intake frequency.	0.3	0.7	1.3	-0.5	1.1	-0.5	0.9	0.9	1.0	1.1	0.3	-0.8	-0.8
Comparative height size at age 10	0.5	2.8	6.8	-1.6	-1.4	1.6	-1.5	-1.3	-1.7	-1.9	-2.6	0.4	2.0
Number of full sisters	3.7	4.5	7.8	-2.4	-2.8	-1.5	-2.8	-2.5	-2.7	-0.6	1.0	2.3	-1.1
Suffer from ‘nerves’	2.9	4.6	8.4	-2.2	-2.3	0.5	-2.4	-2.2	-2.4	-2.9	-2.1	1.6	1.9
Overall health rating	0.5	1.1	3.1	-1.8	-0.8	0.4	-0.1	-0.5	-1.0	-1.1	-1.6	-0.0	1.6
Chest pain or discomfort	0.1	0.2	0.7	0.1	-0.3	-0.4	-0.2	-0.4	-0.4	0.0	0.7	0.4	-0.9
Had major operations	0.2	0.2	0.6	-0.5	0.1	-0.6	-0.6	0.2	0.2	0.8	0.7	-0.0	-0.2
Age at last live birth	0.2	0.3	1.4	-0.9	-0.4	-0.3	0.2	-0.3	-0.3	-1.2	-0.3	0.4	0.5
Family relationship satisfaction	1.7	2.1	3.2	-1.8	-1.7	-1.4	-0.6	-1.7	-1.7	0.0	1.1	1.7	-1.4
Leg pain on walking	3.4	4.2	8.1	-2.3	-2.7	-1.1	-2.4	-2.8	-2.7	-1.3	-0.0	2.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.1	0.7	0.7	1.4	0.2	0.6	0.6	-0.3	-1.3	-0.6	0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.3	0.1	0.1	1.0	-0.2	0.1	-0.1	-1.1	-1.1	-0.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.2	0.0	0.5	0.4	1.4	0.4	0.4	-0.6	-1.5	-0.5	1.2
Medication: Aspirin	0.2	0.2	0.6	-0.3	-0.8	-0.2	-0.3	-0.6	-0.7	-0.0	-0.1	0.7	-0.2
Supplements: Vitamin C	1.0	1.1	2.7	1.4	1.6	-0.3	1.1	1.4	1.6	0.6	0.5	-0.7	-0.2
Knee pain experienced in last month	1.4	2.2	4.8	-2.2	-1.6	-2.0	-1.0	-1.2	-1.6	1.2	1.4	1.3	-1.1
Hypertension (Self-reported)	0.3	0.8	3.0	-0.2	0.3	0.7	1.3	0.7	0.4	0.9	-0.8	-0.9	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.4	0.1	0.9	1.2	1.0	0.9	0.7	0.8	-1.2	-1.2	1.2
Illnesses of father: Heart disease	2.0	2.8	7.2	-1.0	-1.4	-2.2	-0.6	-1.5	-1.3	1.3	2.2	1.6	-2.7
Illnesses of siblings: Diabetes	0.8	0.9	2.1	-0.7	-0.6	-1.5	-0.5	-0.5	-0.5	1.1	1.4	0.6	-1.4
Smoking status: Previous	0.8	1.3	2.2	1.1	1.2	1.2	1.0	1.4	1.3	0.1	-0.9	-1.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	6.1	-0.4	-1.2	0.7	-0.8	-1.2	-1.2	-2.5	-1.6	1.1	1.0
Whole body fat-free mass	1.3	7.1	12.3	-3.3	-2.9	0.9	-3.5	-2.9	-3.1	-2.8	-2.5	2.0	1.9
Leg fat-free mass (right)	1.7	9.0	14.3	-3.8	-3.5	0.6	-3.6	-3.4	-3.8	-3.0	-2.5	2.2	1.9
Arm fat percentage (left)	1.0	3.9	13.5	-1.4	-0.7	2.4	-1.1	-0.5	-0.9	-1.6	-3.7	-0.4	3.4
Average weekly red wine intake	0.4	0.6	3.0	1.7	0.6	1.1	0.7	0.3	0.5	-0.5	-0.7	0.1	-0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-1.0	-1.2	-0.0	-0.5	-1.0	-1.1	-0.7	-0.1	0.7	0.7
Mood swings	1.1	2.1	9.4	-3.1	-1.7	-1.0	-0.9	-1.3	-1.7	-0.9	0.1	1.1	0.4
Loneliness, isolation	0.3	0.4	1.4	-1.2	-0.5	0.5	-1.1	-0.1	-0.5	0.7	-0.2	0.2	0.3
Long-standing illness, disability or infirmity	0.5	0.7	1.4	-1.2	-1.2	-0.5	-1.1	-1.0	-1.1	-0.5	0.2	0.6	0.2
Ever had bowel cancer screening	0.4	0.4	1.0	-0.2	0.6	-0.3	1.0	0.9	0.7	0.8	0.9	-0.4	-0.1
Diabetes diagnosed by doctor	0.7	1.1	2.1	0.6	1.1	1.0	0.9	1.3	1.3	-0.1	-0.9	-1.1	1.5
Ever had stillbirth, spontaneous miscarriage or termination	3.5	3.7	8.4	-2.9	-1.8	-2.7	-1.4	-1.6	-1.8	-1.1	2.0	1.7	-1.4
Friendships satisfaction	1.4	1.7	2.9	-1.5	-1.3	-1.3	-1.3	-1.1	-1.3	0.8	1.2	1.7	-1.3
Qualifications: nursing, teaching	0.6	1.0	2.3	0.3	0.8	-1.5	1.3	0.5	0.9	0.7	1.5	0.2	-1.0
Commuting to job workplace: Walk	3.3	3.5	6.7	-0.9	-1.3	-2.4	-1.4	-1.4	-1.0	2.6	2.3	1.9	-2.5
Eye problems/disorders: Cataract	0.1	0.1	0.5	0.6	0.4	-0.0	-0.1	0.3	0.2	-0.2	0.2	-0.7	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.2	-0.7	-0.3	-0.9	-0.0	-0.3	-0.4	-0.1	1.5	0.3	-1.1
Medication for cholesterol	0.9	1.4	4.8	-1.6	-1.0	-0.7	-1.2	-1.3	-1.2	-2.2	-0.1	0.9	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.9	1.0	0.9	0.8	1.0	0.9	0.8	0.1	-0.3	-0.9	0.9
Back pain experienced in last month	1.0	1.4	4.4	1.0	1.0	2.1	0.7	0.8	0.8	-0.4	-1.6	-1.1	1.4
Mineral and other dietary supplements	3.5	4.7	9.9	-2.3	-2.0	1.1	-2.4	-2.0	-2.1	-3.2	-2.9	1.2	1.6
Breast cancer (self-reported)	0.2	0.2	0.4	0.4	0.6	-0.1	0.2	0.4	0.5	-0.6	0.3	-0.3	-0.6
Asthma (self-reported)	0.4	0.8	2.3	1.2	-0.2	-0.8	-0.9	-0.4	-0.1	0.5	1.5	0.8	-1.5
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.4	0.1	0.2	-0.7	0.1	0.1	-0.3	-0.5	-0.1	0.3
Osteoarthritis (self-reported)	0.9	1.1	4.0	-0.4	0.1	-1.3	1.1	-0.1	0.0	2.0	1.4	-0.3	-1.6
Medication: Aspirin	0.1	0.1	0.2	-0.0	-0.4	-0.2	0.1	-0.2	-0.2	0.3	0.2	0.4	-0.4
Medication: Gliclazide	0.5	0.5	3.2	-0.2	-0.5	0.5	0.1	-0.3	-0.3	-1.8	-1.0	0.5	0.4
Illnesses of father: None of the above (group 1)	1.3	1.6	2.7	-1.6	-1.2	-1.6	-1.4	-1.2	-1.2	-1.3	1.0	1.5	0.1
Smoking status: Current	0.5	0.8	1.7	0.2	1.1	-0.0	0.9	1.3	1.2	-0.1	-0.2	-1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	7.3	-1.5	-1.4	-1.9	-0.4	-1.1	-1.2	2.7	2.0	1.1	-1.9
Whole body water mass	1.3	7.2	12.7	-3.4	-2.9	0.8	-3.6	-2.9	-3.2	-2.8	-2.3	2.0	1.8
Leg predicted mass (right)	1.7	8.8	14.1	-3.7	-3.5	0.6	-3.6	-3.4	-3.8	-2.9	-2.4	2.2	1.9
Arm fat mass (left)	1.4	5.9	16.8	-2.3	-1.5	2.4	-2.1	-1.4	-1.8	-2.6	-4.1	0.2	3.6
Number of self-reported non-cancer illnesses	0.2	0.3	1.7	-0.3	0.0	-0.6	0.7	0.1	0.2	1.3	0.7	-0.1	-0.4
Average weekly champagne plus white wine intake	0.6	0.8	2.3	-0.7	-0.3	-1.5	-0.0	-0.4	-0.3	1.2	1.3	0.7	-1.2
Miserableness	1.1	1.8	6.1	-2.5	-1.7	-0.9	-1.5	-1.4	-1.7	-0.5	0.1	1.0	0.6
Guilty feelings	3.2	4.7	8.9	-3.0	-2.4	-1.3	-2.6	-2.3	-2.5	-2.6	-0.6	2.2	0.3
Wears glasses or contact lenses	0.4	0.4	1.9	-1.4	-0.4	-0.9	-0.1	-0.3	-0.2	0.3	0.8	0.6	-0.4
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.8	-0.8	0.0	-0.6	-0.7	-0.9	-0.1	0.0	0.4	-0.1
Hearing aid user	0.3	0.4	1.0	-1.0	-0.2	-0.7	-0.5	-0.3	-0.3	0.6	0.8	0.4	-0.8
Mother’s age at death	0.2	0.3	1.5	0.4	0.2	0.5	-0.1	0.2	0.2	0.5	-0.8	-0.1	1.2
Financial situation satisfaction	1.0	1.2	3.9	-2.0	-1.1	-0.1	-1.0	-1.1	-1.1	-1.4	-0.9	0.9	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.7	0.4	0.2	-0.5	0.9	0.2	0.3	0.2	0.2	-0.3	-0.1
Commuting to job workplace: Public transport	0.9	1.1	2.3	0.2	1.2	0.9	1.0	1.3	1.1	-0.2	-0.8	-1.5	1.5
Eye problems/disorders: Glaucoma	0.9	1.0	2.4	0.5	0.9	0.8	1.5	1.0	1.0	-0.5	-1.0	-1.3	1.2
Medication: Blood pressure	0.1	0.1	0.6	-0.5	-0.3	-0.3	0.5	0.0	-0.2	0.3	0.2	-0.0	0.8
Pain type(s) experienced in last month: Hip pain	1.1	1.4	6.1	-2.5	-1.4	-0.3	-0.8	-1.2	-1.6	-0.8	-0.7	0.6	0.4
Supplements: Fish oil (including cod liver oil)	3.1	4.1	9.3	1.9	2.2	-0.0	2.4	2.4	2.3	3.0	1.6	-1.8	-0.1
High cholesterol (Self-reported)	0.3	0.6	2.0	1.4	0.7	0.9	0.2	0.6	0.7	1.1	-0.5	-0.2	0.6
Medication: Bendroflumethiazide	0.6	0.8	4.7	-0.6	-0.1	0.6	0.2	0.5	0.0	0.3	-1.1	-1.2	2.2
Medication: Paracetamol	0.2	0.3	0.7	-0.6	-0.4	-0.1	-0.8	-0.5	-0.5	-0.6	-0.6	0.3	0.5
Medication: Lisinopril	0.8	1.0	3.5	0.8	0.5	1.3	0.5	0.3	0.3	-1.0	-1.9	-1.0	1.2
Medication: Atorvastatin	0.4	0.5	2.2	0.1	-0.5	1.5	-0.9	-0.1	-0.4	0.3	-1.0	0.4	1.0
Illnesses of father: High blood pressure	1.3	1.6	3.5	-1.3	-0.8	-1.5	-0.6	-0.8	-0.9	1.2	1.9	1.1	-1.8
Alcohol drinker status: Never	0.8	1.0	3.4	1.1	1.2	-0.6	0.2	0.8	1.2	1.8	0.6	-0.5	-0.8
Ever smoked	1.2	2.0	4.8	0.7	1.5	1.3	0.9	2.1	1.6	0.0	-0.6	-2.2	1.6
Basal metabolic rate	1.4	7.6	11.8	-3.3	-2.7	1.3	-3.4	-2.7	-3.0	-3.1	-3.0	1.6	2.5
Leg fat percentage (left)	1.0	3.6	11.6	-0.6	0.9	2.4	0.3	1.1	0.7	-1.5	-3.4	-1.7	3.3
Arm fat-free mass (left)	1.1	5.8	10.5	-3.1	-2.4	0.9	-3.2	-2.4	-2.7	-2.6	-2.3	1.5	2.0
Number of operations (self-reported)	0.1	0.1	0.2	-0.0	-0.4	0.1	-0.2	-0.4	-0.4	0.0	-0.4	0.3	0.1
Average weekly beer plus cider intake	0.5	0.7	1.5	0.8	0.5	1.0	0.2	0.5	0.4	-0.9	-1.2	-1.2	0.8
Irritability	0.9	1.5	3.6	-1.9	-1.4	-1.1	-1.4	-1.4	-1.5	-0.7	0.6	0.8	-0.7
Risk taking	3.0	4.4	15.6	0.1	0.2	-2.9	2.0	-0.1	0.4	1.7	4.0	0.5	-3.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	-0.6	0.1	-0.9	0.5	0.2	0.2	1.0	1.1	-0.0	-0.1
Fractured/broken bones in last 5 years	2.7	3.5	6.9	-1.1	-1.4	-2.6	-0.3	-1.5	-1.1	1.9	2.5	2.3	-2.5
Age started oral contraceptive pill	2.9	3.6	6.5	1.4	2.3	1.9	1.7	2.4	2.1	1.0	-0.8	-2.6	2.1
Diastolic blood pressure, automated reading	0.3	0.9	2.0	-0.7	-1.4	-0.2	-0.4	-1.3	-1.4	0.2	-0.7	1.1	1.0
Ever depressed for a whole week	0.3	0.4	1.3	-0.7	-0.3	0.2	0.7	-0.2	-0.4	-1.1	-0.5	-0.1	1.0
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.5	-0.8	0.2	-0.5	-0.7	-0.7	-0.5	-0.6	0.7	0.9
Commuting to job workplace: Cycle	5.5	6.7	11.1	-2.2	-3.2	-2.6	-2.0	-3.3	-3.0	-0.0	2.1	3.3	-2.5
Myopia	1.3	1.9	5.7	-1.6	-0.4	-1.9	-0.7	-0.0	-0.3	2.1	2.4	0.8	-1.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.9	0.6	-0.4	-0.0	-1.5	-0.9	-0.5	-1.7	-0.1	0.9	-1.2
Cholesterol lowering medication	0.3	0.4	1.3	0.9	-0.2	0.9	-0.5	-0.1	-0.1	0.1	-1.0	0.0	1.1
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	5.7	1.4	1.2	2.4	0.8	1.2	1.2	0.1	-2.4	-1.2	2.3
Pain experienced in last month	0.2	0.3	0.7	0.6	0.3	-0.8	0.0	0.2	0.4	0.3	0.9	0.4	-0.7
Supplements: Calcium	0.8	0.9	1.9	0.7	1.4	-0.6	1.1	1.4	1.3	0.2	1.2	-0.8	-0.2
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	0.7	1.2	0.1	0.4	1.3	1.1	1.4	0.3	-1.1	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.3	0.1	0.4	0.2	0.3	0.1	-0.5	-0.7	-0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.5	-0.8	-1.2	-0.6	-1.9	-1.4	-1.1	-0.5	0.4	1.3	-1.3
Heart disease (siblings)	1.0	1.3	2.4	-1.4	-1.5	-1.1	-1.0	-1.3	-1.5	0.3	0.4	1.2	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.7	-0.8	0.2	-0.2	0.5	0.2	0.1	-0.3	-0.2	-0.5	0.3
Pack years of smoking	1.0	1.5	2.6	-1.6	-1.6	-0.8	-1.0	-1.5	-1.5	-1.2	-0.2	1.4	0.0
Impedance of whole body	1.7	8.7	14.2	3.8	3.4	2.7	2.9	3.4	3.4	-0.7	-1.9	-3.6	2.3
Leg fat mass (left)	1.0	4.1	13.8	-1.7	-0.4	2.3	-1.1	-0.3	-0.7	-2.1	-3.7	-0.6	3.4
Arm predicted mass (left)	1.2	6.0	11.0	-3.1	-2.4	0.9	-3.3	-2.4	-2.7	-2.7	-2.4	1.7	2.0