TWAS hub - BAI1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.195	0.0602	0.00091	0.031	NA	0.056	NA	0.015	2.6e-03	NA	8.0e-05	NA	2.8e-02
2	GTEx	Testis	0.176	0.0610	0.00086	0.129	NA	0.151	NA	0.139	2.5e-06	NA	3.2e-07	NA	1.0e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Multivitamins +/- minerals	9.9	12.6	18.7	-4.3	-2.6
Alcohol intake frequency.	8.3	19.2	22.0	4.1	4.7
Schizophrenia (2014)	7.7	16.9	33.6	-5.8	0.4
Mineral and other dietary supplements	7.4	10.0	15.5	3.9	2.1
Schizophrenia (2018)	7.1	14.8	29.5	-5.4	0.1
Supplements: Zinc	6.3	6.9	9.5	-3.1	-2.1
Bipolar Disorder or Schizophrenia	6.0	14.7	29.2	-5.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.9	7.0	13.8	-0.5	-3.7
Vitamin and mineral supplements	5.8	7.9	12.1	3.5	1.9
Average weekly fortified wine intake	5.7	6.7	7.6	-2.4	-2.8
Qualifications: College or University degree	5.7	17.9	33.1	-1.6	-5.8
Qualifications: O levels/GCSEs or equivalent	5.6	9.0	17.6	-0.6	-4.2
Risk taking	5.3	7.8	8.2	-2.9	-2.7
Supplements: Calcium	5.3	5.9	9.3	-3.0	-1.6
Qualifications: A levels/AS levels or equivalent	5.1	11.4	21.5	-1.1	-4.6
Qualifications: None of the above	5.0	10.7	20.9	0.6	4.6
Bipolar Disorder (2011)	4.7	4.5	7.5	-2.7	-1.3
Waist circumference	4.7	17.2	20.0	4.5	3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.6	5.4	5.8	-2.4	2.2
Overall health rating	4.4	9.6	11.6	2.7	3.4
Age at first live birth	4.3	7.7	9.8	-2.4	-3.1
Supplements: Fish oil (including cod liver oil)	4.3	5.6	10.5	-3.2	-0.9
Alcohol drinker status: Never	4.1	4.9	6.2	1.9	2.5
Arm fat mass (left)	4.0	16.2	17.7	4.2	3.8
Fed-up feelings	3.7	6.7	12.5	0.9	3.5
Age at First Birth	3.6	5.3	7.5	-2.7	-1.7
Arm fat mass (right)	3.6	14.6	15.6	4.0	3.7
Supplements: Glucosamine	3.5	4.5	6.4	-1.6	-2.5
BMI	3.4	19.8	25.8	5.1	3.7
Chronotype (morning person)	3.3	7.7	12.8	-3.6	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	5.2	1.9	2.3
Body mass index (BMI)	3.3	14.0	16.9	4.1	3.3
Hip circumference	3.3	14.2	16.9	4.1	3.4
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.3	7.8	1.7	2.8
Alcohol drinker status: Previous	3.3	3.7	5.6	1.4	2.4
Neuroticism (Nagel 2018)	3.2	7.5	14.4	0.8	3.8
Trunk fat percentage	3.2	12.7	14.5	3.8	3.3
Arm fat percentage (right)	3.2	12.6	13.2	3.6	3.5
Leg fat mass (left)	3.2	12.5	14.3	3.8	3.3
Depressed Affect (Nagel 2018)	3.1	6.6	12.8	0.6	3.6
Trunk fat mass	3.1	13.4	14.3	3.8	3.5
Whole body fat mass	3.1	13.0	14.7	3.8	3.4
Leg fat mass (right)	3.1	12.2	12.6	3.5	3.4
Age at last live birth	3.1	4.5	7.3	-2.7	-1.3
Lupus	3.0	4.5	6.6	-2.6	1.6
Body fat percentage	3.0	11.7	13.2	3.6	3.2
Arm fat percentage (left)	3.0	11.9	13.0	3.6	3.3
Fasting Glucose	2.9	3.5	5.2	2.3	-1.3
Weight	2.9	14.4	14.5	3.8	3.8
Medication: Ibuprofen	2.9	3.4	6.9	2.6	-0.1
Leg fat percentage (right)	2.7	9.6	10.0	3.0	3.2
Worry too long after embarrassment	2.6	4.4	8.7	0.1	3.0
Leg fat percentage (left)	2.6	9.5	10.8	3.3	2.9
Had other major operations	2.5	3.0	3.5	1.9	1.6
Neuroticism	2.3	5.6	10.5	0.8	3.2
Hearing difficulty/problems with background noise	2.3	3.7	6.4	1.0	2.5
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	5.1	-0.4	-2.3
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	4.6	-1.2	-2.1
Neuroticism score	2.2	4.6	7.0	1.5	2.6
Medication: Cholesterol lowering	2.2	3.4	4.9	2.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.5	-1.9	-1.2
Smoking Status	2.1	4.9	9.9	0.1	-3.1
Prospective memory result	2.1	2.5	4.1	-2.0	1.0
Financial situation satisfaction	2.1	2.6	4.7	2.2	0.7
Schizophrenia vs Biploar Disorder	2.0	2.7	4.1	-1.1	2.0
Number of treatments/medications taken	2.0	3.6	4.0	1.8	2.0
Medication: Simvastatin	2.0	2.9	3.6	1.9	1.5
Mouth/teeth dental problems: Dentures	2.0	3.3	6.6	0.2	2.6
Coronary Artery Disease (CAD)	1.9	2.3	2.7	1.6	1.4
Loneliness, isolation	1.9	2.6	3.9	1.2	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.0	-0.0	-2.0
Qualifications: nursing, teaching	1.9	3.0	4.3	-1.3	-2.1
Depression (Nagel 2018)	1.8	2.7	4.7	0.8	2.2
Serious illness, injury or assault to yourself	1.8	2.2	4.4	2.1	-0.2
Eye problems/disorders: None of the above	1.8	2.1	3.6	-0.7	-1.9
Medication: Paracetamol	1.8	2.7	3.3	1.8	1.5
Age started oral contraceptive pill	1.8	2.3	4.2	-2.1	0.6
Mean Putamen Volume	1.7	1.9	2.9	1.7	1.0
Blood clot in the leg (DVT)	1.7	2.2	4.2	2.0	-0.4
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	6.2	2.5	-0.5
Worry (Nagel 2018)	1.6	3.3	6.3	0.6	2.5
Crohns Disease (2017)	1.6	3.6	6.4	0.9	2.5
Major Depression (MDD)	1.6	1.9	3.7	-0.2	1.9
Health satisfaction	1.6	2.0	2.4	1.6	1.3
Shortness of breath walking on level ground	1.6	1.9	3.3	0.7	1.8
Comparative height size at age 10	1.6	8.8	15.4	1.5	3.9
Smoking status: Previous	1.6	2.4	4.8	-0.1	-2.2
Diastolic blood pressure, automated reading	1.6	5.1	10.0	0.4	3.2
Frequency of depressed mood in last 2 weeks	1.5	2.1	4.1	0.1	2.0
Past tobacco smoking	1.5	2.8	5.6	-0.1	2.4
Breast cancer (self-reported)	1.5	1.8	2.8	1.7	0.8
Hearing aid user	1.5	1.7	1.8	-1.3	-1.3
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.4	0.6	1.8
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	3.9	2.0	-0.2
Heart disease (siblings)	1.5	1.8	3.4	0.5	-1.9
Arm predicted mass (left)	1.5	7.8	9.2	3.0	2.5
Sensitivity / hurt feelings	1.4	2.5	4.8	0.4	2.2
Taking other prescription medications	1.4	2.2	2.6	1.6	1.3
Leg predicted mass (left)	1.4	7.4	8.6	2.9	2.5
Number of incorrect matches in round	1.4	2.4	3.3	-1.8	-1.2
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	1.8	-1.4	1.2
Hair/balding pattern: Pattern 3	1.4	2.0	3.7	1.9	0.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	3.5	-1.9	-1.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.1	-0.3	1.8
Arm fat-free mass (left)	1.4	6.9	8.3	2.9	2.3
Neuroticism (2016)	1.3	1.9	3.1	-0.8	1.8
Ulcerative Colitis	1.3	1.9	3.4	-1.8	-0.7
Lung FVC	1.3	6.5	8.3	-2.2	-2.9
Leg fat-free mass (left)	1.3	7.1	8.4	2.9	2.4
Worrier / anxious feelings	1.3	2.5	4.3	0.8	2.1
Arm fat-free mass (right)	1.3	6.5	10.1	3.2	1.7
Number of children fathered	1.3	1.4	1.9	-1.4	-1.0
Miserableness	1.3	2.3	3.4	1.1	1.8
Basal metabolic rate	1.3	7.0	8.4	2.9	2.4
Maternal smoking around birth	1.2	1.7	3.2	1.8	-0.4
Medication: Levothyroxine sodium	1.2	2.1	3.8	2.0	-0.6
Allergy	1.2	2.7	5.1	-0.5	2.3
Diabetes (self-reported)	1.2	1.9	2.8	1.7	0.9
Wheeze or whistling in the chest in last year	1.2	2.1	2.7	1.2	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.4	1.6	0.6
Mood swings	1.2	2.2	4.3	0.4	2.1
Eye problems/disorders: Glaucoma	1.2	1.5	1.6	-1.2	1.3
Commuting to job workplace: Cycle	1.2	1.4	1.7	1.1	-1.3
Bipolar Disorder (2018)	1.1	1.7	3.0	-1.7	-0.6
Systolic blood pressure, automated reading	1.1	3.3	6.2	-0.7	2.5
Hayfever, allergic rhinitis or eczema	1.1	2.4	4.3	-0.7	-2.1
Breastfed as a baby	1.1	1.4	1.8	-1.3	-1.0
Migraine (self-reported)	1.1	1.4	2.4	1.6	0.5
Arm predicted mass (right)	1.1	5.7	8.0	2.8	1.8
Family relationship satisfaction	1.1	1.3	1.6	-1.0	-1.3
Leg pain on walking	1.1	1.3	2.5	0.4	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.2	0.6	1.5
Leg predicted mass (right)	1.1	5.6	7.4	2.7	2.0
Cardiovascular Disease	1.0	3.5	4.9	1.4	2.2
Age when periods started (menarche)	1.0	2.5	3.8	-1.1	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	1.7	1.2	1.3
Exposure to tobacco smoke at home	1.0	1.1	2.2	-0.2	1.5
Peak expiratory flow (PEF)	1.0	2.2	4.4	-0.2	-2.1
Headache pain in last month	1.0	1.8	2.3	1.5	1.1
Mean time to correctly identify matches	1.0	1.9	3.8	-1.9	0.2
Pulse rate, automated reading	1.0	3.4	5.7	2.4	1.0
Leg fat-free mass (right)	1.0	5.6	7.3	2.7	2.0
Long-standing illness, disability or infirmity	1.0	1.6	2.6	0.7	1.6
Medication: Bendroflumethiazide	1.0	1.5	2.9	1.7	0.3
Primary Biliary Cirrhosis	0.9	1.4	1.8	1.3	1.0
Severe depression (siblings)	0.9	1.0	2.1	-0.1	1.4
Hand grip strength (right)	0.9	2.4	4.7	-0.3	2.2
Relative age voice broke	0.9	1.3	1.4	-1.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.4	1.5	-0.1
Glaucoma (self-reported)	0.9	1.1	1.7	-1.3	0.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	1.4	-1.0	-1.2
Medication: Blood pressure	0.9	1.6	2.0	1.4	1.1
Medication: Seretide 50 evohaler	0.9	1.0	1.6	1.3	-0.6
Heart disease (mother)	0.9	1.1	1.3	-1.2	0.9
Back pain experienced in last month	0.9	1.3	2.3	-0.6	1.5
Whole body water mass	0.9	5.1	6.5	2.5	1.9
Ever smoked	0.9	1.7	3.2	-0.3	-1.8
Alzheimer’s Disease (in mother)	0.8	1.0	1.0	1.0	1.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.1	1.5	0.2
Hypothyroidism (self reported)	0.8	1.9	3.7	1.9	0.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	1.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.9	0.5	1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	1.3	0.2
Angina	0.8	1.1	1.2	1.0	-1.1
Townsend deprivation index at recruitment	0.8	1.1	1.1	1.0	1.0
Mouth/teeth dental problems	0.8	1.3	2.4	-0.3	-1.6
Fluid intelligence score	0.8	1.7	2.5	1.6	-0.9
Pulse rate	0.8	1.4	2.4	0.7	1.6
Noisy workplace	0.8	1.0	1.0	1.0	1.0
Depression (self-reported)	0.8	1.0	1.5	1.2	0.7
Pulse wave reflection index	0.8	1.0	1.9	0.0	-1.4
Neck or shoulder pain in last month	0.8	1.2	1.3	-1.0	1.2
Whole body fat-free mass	0.8	4.8	6.1	2.5	1.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.3	-1.3
Number of operations (self-reported)	0.8	1.2	2.4	1.6	-0.0
Lung FEV1/FVC ratio	0.7	3.4	6.8	2.6	0.1
Average weekly spirits intake	0.7	0.9	1.6	-0.3	-1.3
Medication: Ramipril	0.7	1.0	1.9	1.4	0.2
Alcohol intake versus 10 years previously	0.7	1.1	1.8	0.6	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.2	-1.5	-0.1
Medication: Paracetamol	0.7	1.2	1.6	1.3	0.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	-0.1	-1.2
Emphysema/chronic bronchitis	0.7	0.8	1.5	0.4	1.2
Medication: Allopurinol	0.7	0.9	1.4	0.6	1.2
Ever taken oral contraceptive pill	0.7	0.8	0.8	0.9	-0.8
High cholesterol (Self-reported)	0.7	1.2	1.5	1.2	0.9
Irritable Bowel Disease (IBD)	0.6	1.4	2.8	0.2	1.7
Rheumatoid Arthritis	0.6	0.8	1.3	0.5	1.1
Hand grip strength (left)	0.6	1.7	2.6	-0.9	1.6
Diabetes (father)	0.6	0.7	1.4	-1.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	1.9	-1.4	-0.8
Trunk fat-free mass	0.6	3.3	4.0	2.0	1.6
Trunk predicted mass	0.6	3.2	3.7	1.9	1.6
Medication: Amlodipine	0.6	0.8	1.5	0.4	1.2
Angina (self-reported)	0.6	0.8	0.8	0.9	-0.9
Hypertension (Self-reported)	0.6	1.6	3.1	0.3	1.8
Ever had bowel cancer screening	0.6	0.7	1.3	-0.3	1.1
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.0	-1.0	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	0.2	1.2
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.3	1.5	-0.7
Alzheimer’s Disease (in father)	0.5	0.6	1.0	0.5	-1.0
Blood Red Count	0.5	5.2	5.9	2.4	2.1
Heel T-Score	0.5	4.2	5.0	-1.8	-2.2
Relative age of first facial hair	0.5	1.0	1.6	-0.7	-1.3
Qualifications: CSEs or equivalent	0.5	0.6	0.7	0.8	0.7
High blood pressure	0.5	1.5	2.4	0.7	1.5
Falls in the last year	0.5	0.7	0.9	-0.9	0.7
Asthma	0.5	1.1	2.1	-0.2	-1.5
Medication: Lansoprazole	0.5	0.6	0.6	-0.8	0.7
Lung cancer (father)	0.5	0.5	0.6	-0.8	-0.7
Tense / ‘highly strung’	0.5	0.8	1.1	-0.7	1.0
Gout (self-reported)	0.5	0.7	1.3	-0.1	1.2
Comparative body size at age 10	0.5	1.3	1.6	-1.0	1.3
Knee pain experienced in last month	0.5	0.8	0.9	-0.9	0.8
Diabetes diagnosed by doctor	0.5	0.8	1.5	1.2	0.2
Osteoarthritis (self-reported)	0.5	0.6	1.1	0.4	1.0
Medication: Atorvastatin	0.5	0.7	1.2	0.4	1.1
Illnesses of father: High blood pressure	0.5	0.7	0.9	-0.7	0.9
Reaction Time	0.4	0.8	1.6	-1.2	0.1
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.9	1.4	-0.5
HDL Cholesterol	0.4	0.6	1.2	0.1	-1.1
Triglycerides	0.4	0.7	1.3	0.3	1.1
Waist Hip Ratio (WHR)	0.4	1.8	3.3	1.8	0.6
Allergy or Eczema	0.4	1.1	2.0	-0.5	-1.4
Medication for hormone replacement therapy	0.4	0.5	0.7	0.8	-0.6
Chronic bronchitis/emphysema (father)	0.4	0.4	0.5	0.7	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	0.2	1.0
Forced vital capacity (FVC)	0.4	1.4	1.8	-1.0	-1.3
Financial difficulties in last 2 years	0.4	0.5	0.8	-0.5	-0.9
Impedance of arm (right)	0.4	1.9	3.8	-2.0	-0.1
Loud music exposure frequency	0.4	0.5	0.7	0.5	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.4	-0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	0.7	-0.9	-0.8
Medication: Omeprazole	0.4	0.5	0.9	0.3	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	-0.9	0.3
Illnesses of siblings: Diabetes	0.4	0.5	0.5	0.7	-0.6
Average weekly red wine intake	0.4	0.6	1.2	0.1	-1.1
Friendships satisfaction	0.4	0.4	0.5	0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	0.9	-0.9	-0.7
Average weekly champagne plus white wine intake	0.4	0.6	1.1	-0.2	-1.0
Mother’s age at death	0.4	0.5	0.9	-1.0	0.4
Fractured/broken bones in last 5 years	0.4	0.6	0.8	0.9	-0.5
Cholesterol lowering medication	0.4	0.6	1.1	0.5	1.0
Pain experienced in last month	0.4	0.6	1.1	0.3	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-1.0	-0.1
Prostate Cancer	0.3	0.5	0.8	0.2	-0.9
Blood Platelet Count	0.3	3.9	6.8	1.0	2.6
Systolic Blood Pressure	0.3	1.3	1.4	-1.1	1.2
Medication: Metformin	0.3	0.4	0.7	0.8	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	0.7	-0.5
Medication: Atenolol	0.3	0.3	0.6	-0.1	0.8
Sitting height	0.3	2.1	2.2	1.4	1.5
Alcohol usually taken with meals	0.3	0.4	0.8	-0.3	-0.9
Nervous feelings	0.3	0.6	0.7	0.6	0.9
Heart attack	0.3	0.3	0.6	0.8	-0.3
Father’s age at death	0.3	0.4	0.7	0.8	0.4
Pulse wave Arterial Stiffness index	0.3	0.4	0.4	-0.5	0.7
High blood pressure (siblings)	0.3	0.4	0.7	-0.8	0.3
Pulse wave peak to peak time	0.3	0.3	0.4	0.6	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.1	0.9
Commuting to job workplace: Walk	0.3	0.3	0.6	0.2	0.8
Medication for cholesterol	0.3	0.4	0.7	-0.8	-0.2
Asthma (self-reported)	0.3	0.6	1.3	-0.2	-1.1
Osteoporosis (self-reported)	0.3	0.4	0.5	0.5	0.7
Medication: Gliclazide	0.3	0.4	0.4	-0.6	-0.6
Medication: Blood pressure	0.3	0.6	0.6	-0.7	0.8
Ever depressed for a whole week	0.3	0.4	0.6	-0.8	0.5
Breast Cancer	0.2	0.4	0.5	0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.6	0.1
Blood White Count	0.2	1.7	2.9	0.8	1.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.5	0.7	0.6
Tanning	0.2	2.3	3.7	-1.9	1.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.3	-0.5
Diabetes (mother)	0.2	0.3	0.6	-0.1	0.8
Pack years adult smoking proportion	0.2	0.3	0.5	-0.7	0.2
Impedance of leg (right)	0.2	1.0	1.5	-1.2	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.3	-0.5	-0.5
Impedance of leg (left)	0.2	1.2	1.3	-1.1	-1.1
Pain all over the body in last month	0.2	0.2	0.4	0.3	0.6
Illnesses of siblings	0.2	0.3	0.5	-0.3	0.7
Time employed in main current job	0.2	0.3	0.4	-0.6	0.4
Number of live births	0.2	0.3	0.6	-0.1	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.2	-0.5	-1.1
Illnesses of mother	0.2	0.2	0.3	0.6	-0.3
Impedance of arm (left)	0.2	1.1	2.2	-1.5	-0.2
Exposure to tobacco smoke outside home	0.2	0.3	0.4	-0.4	0.6
Supplements: Vitamin C	0.2	0.2	0.3	-0.6	0.2
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.5	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.2	-0.9
Wears glasses or contact lenses	0.2	0.2	0.2	0.4	0.5
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.3	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	-0.1	0.7
Unable to work because of sickness or disability	0.2	0.2	0.4	-0.6	0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.7	-0.3
Pack years of smoking	0.2	0.3	0.5	-0.7	0.2
Impedance of whole body	0.2	1.0	1.7	-1.3	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.5	-0.0
Ulcerative Colitis (UC)	0.1	0.3	0.3	-0.5	0.5
Ovarian Cancer	0.1	0.1	0.2	-0.4	-0.1
Crohns Disease (2012)	0.1	0.2	0.3	0.4	0.5
Blood Eosinophil Count	0.1	1.1	2.1	-0.4	1.4
Respiratory disease	0.1	0.3	0.4	0.3	-0.6
Hair Pigment	0.1	3.1	6.0	0.6	-2.4
Hearing difficulty/problems: Yes	0.1	0.1	0.1	-0.3	-0.3
Current tobacco smoking	0.1	0.1	0.1	0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.5	0.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.1	0.4
High blood pressure (mother)	0.1	0.2	0.3	0.6	-0.2
Had menopause	0.1	0.1	0.1	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.3	-0.6
Standing height	0.1	1.0	1.9	0.2	1.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.8	0.0
Birth weight of first child	0.1	0.1	0.2	0.4	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	-0.1
Birth weight	0.1	0.3	0.4	0.3	0.7
Forced vital capacity (FVC), Best measure	0.1	0.5	0.8	-0.9	-0.5
Number of full brothers	0.1	0.1	0.2	-0.4	0.2
Number of full sisters	0.1	0.1	0.1	-0.3	-0.3
Suffer from ‘nerves’	0.1	0.2	0.4	0.6	0.3
Medication: Aspirin	0.1	0.2	0.2	-0.3	0.4
Illnesses of father: Heart disease	0.1	0.2	0.2	0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	0.3	0.5
Medication: Aspirin	0.1	0.1	0.1	0.3	0.2
Smoking status: Current	0.1	0.1	0.2	0.1	-0.4
Guilty feelings	0.1	0.2	0.2	0.3	0.5
Commuting to job workplace: Public transport	0.1	0.2	0.2	-0.3	-0.5
Irritability	0.1	0.1	0.2	0.5	-0.1
Myopia	0.1	0.2	0.3	0.1	0.6
HbA1C	0.0	0.0	0.0	-0.1	-0.1
LDL Cholesterol	0.0	0.0	0.0	0.1	-0.1
Height	0.0	0.4	0.7	-0.3	0.8
Medication: Co-codamol	0.0	0.0	0.0	0.2	-0.0
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.3	0.0
Happiness	0.0	0.1	0.1	0.0	0.3
Length of working week for main job	0.0	0.0	0.0	-0.0	-0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	-0.1	-0.0
Chest pain or discomfort	0.0	0.0	0.1	0.2	0.1
Had major operations	0.0	0.1	0.1	-0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.0	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	0.2	-0.0
Medication: Lisinopril	0.0	0.0	0.1	0.3	0.1

Hub : Genes

BAI1

Models

Trait associations