Best TWAS P=1.17e-09 · Best GWAS P=5.54e-09 conditioned to 1.52e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | SYPL2 | 0.28 | 0.04 | lasso | 5 | 0.09 | 2.7e-03 | 5.5 | 6.1 | 1.2e-09 | 0.03 | 0.03 | 0.95 | TRUE |
2 | GTEx | Brain Cerebellum | SYPL2 | 0.16 | 0.02 | enet | 9 | 0.03 | 5.1e-02 | 5.4 | 5.5 | 3.6e-08 | 0.03 | 0.03 | 0.91 | FALSE |
3 | GTEx | Liver | SYPL2 | 0.34 | 0.27 | lasso | 5 | 0.30 | 4.6e-09 | 5.5 | 5.6 | 2.5e-08 | 0.02 | 0.03 | 0.97 | FALSE |
4 | GTEx | Muscle Skeletal | CYB561D1 | 0.07 | 0.00 | lasso | 3 | 0.00 | 7.2e-01 | 5.1 | -5.2 | 2.0e-07 | -0.01 | 0.05 | 0.83 | FALSE |
5 | GTEx | Ovary | SYPL2 | 0.39 | 0.44 | lasso | 5 | 0.46 | 8.8e-13 | 5.1 | -5.5 | 4.9e-08 | -0.02 | 0.03 | 0.97 | FALSE |
6 | GTEx | Ovary | ATXN7L2 | 0.18 | 0.18 | enet | 17 | 0.13 | 5.6e-04 | 5.2 | -5.4 | 8.4e-08 | -0.02 | 0.04 | 0.91 | FALSE |
7 | GTEx | Testis | SYPL2 | 0.45 | 0.50 | enet | 22 | 0.54 | 5.0e-28 | 5.4 | -5.5 | 3.8e-08 | -0.02 | 0.04 | 0.96 | FALSE |
8 | GTEx | Testis | ATXN7L2 | 0.28 | 0.34 | lasso | 4 | 0.33 | 3.7e-15 | 5.3 | -5.3 | 1.1e-07 | -0.02 | 0.04 | 0.96 | FALSE |
9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AMIGO1 | 0.10 | 0.14 | enet | 10 | 0.11 | 2.8e-09 | 4.3 | 5.2 | 1.8e-07 | 0.03 | 0.77 | 0.22 | FALSE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SYPL2 | 0.03 | 0.05 | lasso | 4 | 0.05 | 6.6e-06 | 5.4 | 5.5 | 3.4e-08 | 0.02 | 0.03 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AMIGO1 | 0.06 | 0.00 | blup | 46 | 0.02 | 9.5e-03 | 4.3 | 5.8 | 9.2e-09 | 0.04 | 0.03 | 0.37 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SYPL2 | 0.08 | 0.08 | blup | 44 | 0.10 | 1.9e-10 | 5.6 | 5.6 | 2.3e-08 | 0.03 | 0.02 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | ATXN7L2 | 0.06 | 0.06 | lasso | 3 | 0.05 | 6.6e-06 | 5.6 | -5.6 | 2.5e-08 | -0.03 | 0.01 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | SYPL2 | 0.07 | 0.04 | blup | 45 | 0.03 | 4.9e-04 | 5.6 | -5.5 | 4.3e-08 | -0.02 | 0.02 | 0.98 | FALSE |