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chr1:109,316,076-110,742,615

Best TWAS P=1.17e-09 · Best GWAS P=5.54e-09 conditioned to 1.52e-08

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Cerebellar Hemisphere	SYPL2	0.28	0.04	lasso	5	0.09	2.7e-03	5.5	6.1	1.2e-09	0.03	0.03	0.95	TRUE
11	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AMIGO1	0.06	0.00	blup	46	0.02	9.5e-03	4.3	5.8	9.2e-09	0.04	0.03	0.37	FALSE
12	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYPL2	0.08	0.08	blup	44	0.10	1.9e-10	5.6	5.6	2.3e-08	0.03	0.02	0.98	FALSE
3	GTEx	Liver	SYPL2	0.34	0.27	lasso	5	0.30	4.6e-09	5.5	5.6	2.5e-08	0.02	0.03	0.97	FALSE
13	The Cancer Genome Atlas	Thyroid Carcinoma	ATXN7L2	0.06	0.06	lasso	3	0.05	6.6e-06	5.6	-5.6	2.5e-08	-0.03	0.01	0.98	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYPL2	0.03	0.05	lasso	4	0.05	6.6e-06	5.4	5.5	3.4e-08	0.02	0.03	0.96	FALSE
2	GTEx	Brain Cerebellum	SYPL2	0.16	0.02	enet	9	0.03	5.1e-02	5.4	5.5	3.6e-08	0.03	0.03	0.91	FALSE
7	GTEx	Testis	SYPL2	0.45	0.50	enet	22	0.54	5.0e-28	5.4	-5.5	3.8e-08	-0.02	0.04	0.96	FALSE
14	The Cancer Genome Atlas	Thyroid Carcinoma	SYPL2	0.07	0.04	blup	45	0.03	4.9e-04	5.6	-5.5	4.3e-08	-0.02	0.02	0.98	FALSE
5	GTEx	Ovary	SYPL2	0.39	0.44	lasso	5	0.46	8.8e-13	5.1	-5.5	4.9e-08	-0.02	0.03	0.97	FALSE
6	GTEx	Ovary	ATXN7L2	0.18	0.18	enet	17	0.13	5.6e-04	5.2	-5.4	8.4e-08	-0.02	0.04	0.91	FALSE
8	GTEx	Testis	ATXN7L2	0.28	0.34	lasso	4	0.33	3.7e-15	5.3	-5.3	1.1e-07	-0.02	0.04	0.96	FALSE
9	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AMIGO1	0.10	0.14	enet	10	0.11	2.8e-09	4.3	5.2	1.8e-07	0.03	0.77	0.22	FALSE
4	GTEx	Muscle Skeletal	CYB561D1	0.07	0.00	lasso	3	0.00	7.2e-01	5.1	-5.2	2.0e-07	-0.01	0.05	0.83	FALSE