TWAS hub - CYB561D1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0712	0.0281	1.3e-03	-0.003	NA	-0.003	NA	-0.002	8.3e-01	NA	7.7e-01	NA	0.72000
2	YFS	Blood	0.0400	0.0112	7.9e-07	0.019	0.022	0.019	NA	0.011	5.0e-07	7.7e-08	5.8e-07	NA	0.00009

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
LDL Cholesterol	13.9	22.0	44.0	6.6	0.3
Impedance of leg (left)	8.0	39.1	72.1	8.5	2.5
Impedance of leg (right)	7.5	36.2	67.9	8.2	2.1
Qualifications: None of the above	7.5	16.0	21.5	4.6	3.2
Impedance of whole body	6.7	34.3	59.3	7.7	3.0
Intelligence (Savage-Jansen 2018)	6.3	19.4	37.5	-6.1	-1.2
Multivitamins +/- minerals	6.0	7.6	11.2	-2.0	-3.3
Fluid intelligence score	5.9	12.3	23.4	-4.8	-1.1
Verbal and Numeric Reasoning (VNR)	5.7	13.7	27.3	-5.2	-0.2
Impedance of arm (right)	5.5	25.7	45.6	6.8	2.4
Number of live births	5.4	7.6	10.2	2.2	3.2
Qualifications: College or University degree	5.1	15.9	27.0	-5.2	-2.2
Neck or shoulder pain in last month	5.1	7.2	12.4	3.5	1.4
Sensitivity / hurt feelings	4.5	7.8	8.0	-2.7	-2.8
Impedance of arm (left)	4.4	20.6	34.9	5.9	2.5
Chronotype (morning person)	4.3	9.9	16.3	-1.8	-4.0
Noisy workplace	4.3	5.4	10.4	3.2	0.6
Back pain experienced in last month	4.3	6.2	6.5	2.4	2.5
Type 2 Diabetes (T2D) (2012)	4.0	4.6	9.1	0.3	3.0
Exposure to tobacco smoke outside home	3.9	5.2	6.7	1.9	2.6
Medication: Ventolin 100micrograms inhaler	3.8	4.8	5.7	-2.4	-2.0
Alcohol intake versus 10 years previously	3.6	5.4	8.0	-1.6	-2.8
Birth weight of first child	3.6	6.5	9.5	-3.1	-1.9
Commuting to job workplace: Walk	3.6	3.8	4.8	-2.2	-1.7
Bipolar Disorder (2011)	3.5	3.4	6.8	0.0	-2.6
Alcohol drinker status: Previous	3.5	4.0	6.5	-1.3	-2.5
Comparative body size at age 10	3.4	9.4	15.8	-4.0	1.7
Father’s age at death	3.3	4.5	8.9	-3.0	-0.2
Leg pain on walking	3.3	4.1	4.2	2.0	2.0
Number of full brothers	3.2	4.0	5.1	2.2	1.7
Respiratory disease	3.1	6.9	9.3	-3.1	-2.1
Pack years adult smoking proportion	2.9	4.4	8.5	2.9	0.6
Qualifications: O levels/GCSEs or equivalent	2.9	4.6	4.8	-2.2	-2.1
Pain type(s) experienced in last month: Hip pain	2.9	3.7	6.4	1.0	2.5
Stomach or abdominal pain in last month	2.8	3.5	5.6	2.4	1.2
Falls in the last year	2.8	3.8	4.1	2.0	1.9
Hair/balding pattern: Pattern 3	2.8	4.1	6.9	-1.1	-2.6
Length of working week for main job	2.8	3.1	3.5	-1.9	-1.6
BMI	2.7	15.4	29.3	-5.4	1.3
Asthma (self-reported)	2.7	5.3	6.2	-2.1	-2.5
Pack years of smoking	2.7	3.9	7.2	2.7	0.8
High blood pressure (mother)	2.6	3.6	3.9	-2.0	-1.8
Asthma	2.6	5.2	5.8	-2.1	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.7	3.0	1.6	1.7
Townsend deprivation index at recruitment	2.5	3.5	3.6	-1.9	-1.9
Diverticular disease/diverticulitis (self-reported)	2.5	2.9	3.3	-1.6	-1.8
Bipolar Disorder (2018)	2.4	3.8	6.0	-2.4	-1.3
Illnesses of mother	2.4	3.0	3.3	1.8	1.6
Smoking status: Previous	2.4	3.7	5.7	-2.4	-1.3
Smoking status: Current	2.4	3.9	6.0	2.4	1.3
Whole body water mass	2.4	13.5	25.4	-5.0	-1.3
Trunk predicted mass	2.3	13.3	23.4	-4.8	-1.8
Whole body fat-free mass	2.3	13.2	24.9	-5.0	-1.2
Leg fat-free mass (right)	2.3	12.4	24.1	-4.9	-0.8
Myopia	2.3	3.3	6.6	-2.6	-0.1
Body Mass Index (BMI) (2010)	2.2	3.0	5.7	0.5	2.4
Leg fat-free mass (left)	2.2	11.4	22.4	-4.7	-0.7
Serious illness, injury or assault to yourself	2.2	2.7	3.0	1.7	1.5
Leg predicted mass (left)	2.2	11.4	22.5	-4.7	-0.6
Trunk fat-free mass	2.2	12.9	22.7	-4.8	-1.8
Arm predicted mass (right)	2.2	11.3	21.0	-4.6	-1.3
Leg predicted mass (right)	2.2	11.7	22.9	-4.8	-0.7
Medication: Atorvastatin	2.2	2.7	5.2	2.3	0.4
Qualifications: A levels/AS levels or equivalent	2.1	4.6	6.2	-2.5	-1.7
Arm fat-free mass (right)	2.1	10.7	20.2	-4.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	3.9	-2.0	-1.0
Irritability	2.1	3.5	4.1	-1.7	-2.0
Ever depressed for a whole week	2.1	2.6	4.5	-0.8	-2.1
Exposure to tobacco smoke at home	2.0	2.3	4.0	0.8	2.0
Pain experienced in last month	2.0	3.3	4.9	-2.2	-1.4
Major Depression (MDD)	1.9	2.4	2.6	-1.6	-1.4
Trunk fat percentage	1.9	7.5	13.8	1.1	3.7
Birth weight	1.9	4.1	8.1	-2.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	2.7	-1.2	-1.6
Body fat percentage	1.8	7.2	13.2	1.1	3.6
Family relationship satisfaction	1.8	2.3	4.2	-0.6	-2.0
Commuting to job workplace: Public transport	1.8	2.1	2.3	-1.5	-1.4
Ever smoked	1.8	3.2	6.3	-2.5	-0.4
Basal metabolic rate	1.8	10.0	19.6	-4.4	-0.6
Average weekly beer plus cider intake	1.8	2.5	5.0	2.2	-0.2
Arm predicted mass (left)	1.8	8.9	17.5	-4.2	-0.6
Current tobacco smoking	1.7	2.8	4.5	2.1	1.1
Age at last live birth	1.7	2.4	3.9	-1.0	-2.0
Illnesses of siblings: Diabetes	1.7	2.1	3.6	1.9	0.7
Handedness (chirality/laterality): Left-handed	1.7	2.0	2.3	-1.3	-1.5
Arm fat-free mass (left)	1.7	8.5	16.5	-4.1	-0.7
Bipolar Disorder or Schizophrenia	1.6	3.8	4.8	-1.7	-2.2
Worry (Nagel 2018)	1.6	3.3	4.4	-1.5	-2.1
Supplements: Zinc	1.6	1.8	2.3	-1.1	-1.5
Tense / ‘highly strung’	1.6	2.6	2.9	-1.7	-1.5
Leg fat percentage (right)	1.6	5.9	9.9	1.3	3.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.6	1.9	-0.4
Leg fat percentage (left)	1.6	5.8	10.2	1.2	3.2
Cholesterol lowering medication	1.6	2.4	4.6	2.1	0.4
Body mass index (BMI)	1.5	6.2	10.7	-3.3	1.3
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.0	1.7	0.7
Supplements: Glucosamine	1.4	1.8	3.4	-1.8	-0.4
Medication: Allopurinol	1.4	1.9	2.3	-1.2	-1.5
Chest pain or discomfort	1.4	2.0	2.4	1.6	1.3
Supplements: Vitamin C	1.4	1.6	3.2	-0.2	1.8
Qualifications: nursing, teaching	1.4	2.2	4.5	-2.1	0.2
Average weekly champagne plus white wine intake	1.4	1.9	3.7	-1.9	0.3
Illnesses of father: High blood pressure	1.4	1.7	2.1	-1.5	-1.2
Alzheimer’s Disease (in father)	1.3	1.5	2.5	1.6	0.6
Crohns Disease (2012)	1.3	2.1	4.2	0.0	-2.0
Lupus	1.3	2.0	3.2	-1.8	-0.9
High blood pressure (siblings)	1.3	1.8	3.6	-0.3	-1.9
High cholesterol (Self-reported)	1.3	2.4	3.4	1.8	1.2
Blood Red Count	1.2	11.7	16.2	-4.0	-2.7
Ever had hysterectomy (womb removed)	1.2	1.3	2.0	0.8	-1.4
Relative age voice broke	1.2	1.8	3.5	-1.9	-0.3
Pulse rate	1.2	2.0	4.0	0.3	-2.0
Medication: Cholesterol lowering	1.2	1.9	3.2	1.8	0.7
Lung cancer (father)	1.2	1.4	2.7	1.6	0.4
Illnesses of father: Heart disease	1.2	1.7	1.8	-1.3	-1.3
Hearing aid user	1.2	1.4	1.6	1.1	1.3
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.6	-0.8	-1.6
Systolic Blood Pressure	1.1	5.5	10.0	-1.0	-3.2
Average weekly fortified wine intake	1.1	1.3	2.4	-1.5	-0.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.1	0.7	-1.4
Nervous feelings	1.1	2.0	2.2	-1.5	-1.4
Depression (self-reported)	1.1	1.3	2.3	0.5	1.5
Age at first live birth	1.1	1.9	3.6	-0.5	-1.9
Pulse wave peak to peak time	1.1	1.3	1.5	-1.1	-1.2
Medication: Blood pressure	1.1	2.0	2.2	-1.5	-1.3
Alcohol intake frequency.	1.1	2.5	3.3	-1.3	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.6	1.6	0.1
Osteoarthritis (self-reported)	1.1	1.4	2.3	-0.7	1.5
Medication: Aspirin	1.1	1.4	2.4	1.5	0.7
Medication: Lisinopril	1.1	1.4	2.8	-1.7	-0.2
Schizophrenia vs Biploar Disorder	1.0	1.3	2.7	1.6	0.1
Heel T-Score	1.0	7.9	15.3	-3.9	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	2.2	-1.4	1.5
Trunk fat mass	1.0	4.1	8.1	-0.5	2.8
Past tobacco smoking	1.0	1.8	2.9	1.7	0.8
Neuroticism score	1.0	2.0	2.8	-1.7	-1.1
Weight	1.0	4.8	7.6	-2.8	1.4
Pulse wave Arterial Stiffness index	1.0	1.1	1.4	0.9	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	2.4	-0.9	-1.5
Number of full sisters	1.0	1.2	2.1	1.5	0.5
Medication: Aspirin	1.0	1.3	2.3	1.5	0.6
Arm fat percentage (left)	1.0	4.0	7.3	-0.8	2.7
Eye problems/disorders: Cataract	1.0	1.2	2.3	1.5	0.3
Osteoporosis (self-reported)	1.0	1.3	1.6	0.9	1.3
Fractured/broken bones in last 5 years	1.0	1.2	1.7	1.3	-0.9
Irritable Bowel Disease (IBD)	0.9	2.1	3.6	-0.7	-1.9
Coronary Artery Disease (CAD)	0.9	1.1	2.1	1.4	0.2
Ulcerative Colitis	0.9	1.4	2.2	0.7	-1.5
Waist circumference	0.9	3.3	5.7	-2.4	0.9
Arm fat percentage (right)	0.9	3.5	7.0	-0.3	2.6
Medication: Lansoprazole	0.9	1.0	1.9	1.4	0.4
Arm fat mass (right)	0.9	3.6	3.7	-1.9	1.9
Eye problems/disorders: None of the above	0.9	1.0	1.5	-1.2	-0.7
Whole body fat mass	0.9	3.9	7.6	-0.4	2.8
Medication for cholesterol	0.9	1.4	2.1	-1.4	0.9
Arm fat mass (left)	0.9	3.7	3.9	-1.9	2.0
Heart disease (siblings)	0.9	1.1	1.5	1.2	0.8
Schizophrenia (2018)	0.8	1.6	3.1	-0.3	-1.8
Crohns Disease (2017)	0.8	1.7	2.4	-1.0	-1.6
Breast Cancer	0.8	1.9	2.8	1.7	1.0
Fasting Glucose	0.8	1.0	1.7	-1.3	-0.5
Cardiovascular Disease	0.8	2.5	4.9	-0.2	-2.2
Hypothyroidism (self reported)	0.8	1.8	1.8	-1.3	-1.4
Neuroticism	0.8	2.0	3.5	-1.9	-0.7
Systolic blood pressure, automated reading	0.8	2.2	2.9	-1.7	-1.2
Financial difficulties in last 2 years	0.8	1.1	2.0	-1.4	-0.3
Hip circumference	0.8	3.6	6.1	-1.0	2.5
Pulse rate, automated reading	0.8	2.7	3.8	2.0	-1.2
Loneliness, isolation	0.8	1.0	2.1	0.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.0	-1.4	-1.2
Guilty feelings	0.8	1.2	1.7	-1.3	0.8
Age started oral contraceptive pill	0.8	1.0	1.9	0.4	1.4
Neuroticism (Nagel 2018)	0.7	1.7	2.3	-1.5	-1.0
Mean Putamen Volume	0.7	0.8	1.0	1.0	-0.7
Rheumatoid Arthritis	0.7	0.9	1.8	0.2	-1.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	0.2	-1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.4	1.2	0.5
Age when periods started (menarche)	0.7	1.6	2.2	1.5	1.0
Hair/balding pattern: Pattern 2	0.7	0.9	1.0	-1.0	-1.0
Time employed in main current job	0.7	0.9	1.2	1.1	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.0	-1.0	-0.8
Medication for pain relief, constipation, heartburn	0.7	1.1	1.9	-1.4	0.6
Leg fat mass (right)	0.7	2.8	5.2	-0.7	2.3
Miserableness	0.7	1.2	2.4	1.6	0.2
Mother’s age at death	0.7	0.8	1.4	-1.2	0.6
Leg fat mass (left)	0.7	2.7	4.8	-0.8	2.2
Prostate Cancer	0.6	0.8	1.6	-0.2	-1.2
HbA1C	0.6	0.7	0.9	-0.7	-0.9
Vitamin and mineral supplements	0.6	0.9	1.4	1.2	0.6
Qualifications: CSEs or equivalent	0.6	0.9	1.1	0.8	-1.0
Hearing difficulty/problems with background noise	0.6	1.0	1.8	0.5	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	1.6	-1.3	1.0
Diabetes (self-reported)	0.6	0.9	1.8	0.1	1.3
Medication: Simvastatin	0.6	0.9	1.5	1.2	0.5
Number of children fathered	0.6	0.7	1.0	1.0	0.6
Medication: Ibuprofen	0.6	0.7	1.5	-0.0	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.1	1.0	0.6
Friendships satisfaction	0.6	0.7	1.3	-0.5	-1.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	1.2	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.3	-1.1	0.4
Commuting to job workplace: Cycle	0.6	0.7	1.1	-1.0	0.6
Ulcerative Colitis (UC)	0.5	1.0	1.6	-0.5	-1.3
Reaction Time	0.5	0.9	1.8	1.4	-0.2
Primary Biliary Cirrhosis	0.5	0.8	1.3	1.1	-0.5
Blood Platelet Count	0.5	5.6	10.2	3.2	1.0
Hand grip strength (left)	0.5	1.3	2.1	-0.7	-1.5
Medication: Metformin	0.5	0.7	0.7	0.8	0.9
Diabetes (father)	0.5	0.7	1.2	1.1	0.4
Diabetes (mother)	0.5	0.7	1.2	0.4	1.1
Hand grip strength (right)	0.5	1.3	2.5	-0.1	-1.6
High blood pressure	0.5	1.4	1.8	-1.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	0.4	-1.0
Worrier / anxious feelings	0.5	0.9	1.3	-0.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	0.2	-1.1
Peak expiratory flow (PEF)	0.5	1.3	2.3	1.5	-0.5
Pulse wave reflection index	0.5	0.6	0.9	0.6	0.9
Headache pain in last month	0.5	0.8	1.1	1.1	0.7
Gout (self-reported)	0.5	0.7	1.4	-0.3	-1.2
Medication: Amlodipine	0.5	0.6	1.0	0.6	-1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	1.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	-0.5	-1.0
Wheeze or whistling in the chest in last year	0.5	0.8	1.6	-1.3	0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-1.0	-0.5
Mean time to correctly identify matches	0.5	1.0	1.8	1.3	0.4
Heart disease (mother)	0.5	0.6	1.2	0.2	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	1.1	0.1
Diabetes diagnosed by doctor	0.5	0.8	1.4	-0.4	1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.3	1.2	-0.6
Mineral and other dietary supplements	0.5	0.6	1.2	0.2	1.1
Breast cancer (self-reported)	0.5	0.6	1.0	-0.5	-1.0
HDL Cholesterol	0.4	0.7	1.4	-1.2	-0.0
Blood Eosinophil Count	0.4	3.0	6.1	-2.5	0.0
Waist Hip Ratio (WHR)	0.4	1.8	3.3	-0.5	-1.8
Allergy or Eczema	0.4	0.9	1.3	-1.1	0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.0	-0.6	1.0
Relative age of first facial hair	0.4	0.8	1.5	1.2	0.3
Medication: Co-codamol	0.4	0.5	0.8	0.9	0.4
Taking other prescription medications	0.4	0.7	1.3	-1.2	-0.1
Medication: Atenolol	0.4	0.5	0.9	0.3	-0.9
Pain all over the body in last month	0.4	0.4	0.6	-0.8	-0.4
Breastfed as a baby	0.4	0.5	0.7	-0.8	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.1	-0.6	-1.1
Knee pain experienced in last month	0.4	0.7	1.0	1.0	0.6
Hypertension (Self-reported)	0.4	1.1	1.3	-1.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.3	-0.7	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.1	1.0	1.1
Supplements: Calcium	0.4	0.4	0.5	0.7	-0.6
Ovarian Cancer	0.3	0.3	0.6	0.8	0.3
Age at First Birth	0.3	0.5	0.9	-1.0	-0.2
Schizophrenia (2014)	0.3	0.7	1.3	-0.2	-1.1
Blood White Count	0.3	1.9	3.8	-0.2	2.0
Maternal smoking around birth	0.3	0.5	0.5	0.7	0.7
Sitting height	0.3	1.8	3.1	-0.7	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	-0.9	-0.2
Glaucoma (self-reported)	0.3	0.3	0.6	-0.7	0.3
Medication: Omeprazole	0.3	0.3	0.4	0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	-0.8	-0.3
Medication: Gliclazide	0.3	0.4	0.8	0.0	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.5	0.7	0.4
Depression (Nagel 2018)	0.2	0.4	0.7	-0.8	-0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	0.6	0.5
Triglycerides	0.2	0.3	0.6	-0.1	0.8
Smoking Status	0.2	0.4	0.7	-0.9	0.4
Lung FVC	0.2	1.0	1.7	0.5	1.3
Hair Pigment	0.2	5.1	5.2	2.2	2.3
Tanning	0.2	2.5	2.6	-1.6	-1.6
Number of treatments/medications taken	0.2	0.4	0.8	0.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	-0.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.6	-0.8	0.6
Heart attack	0.2	0.3	0.4	0.6	0.5
Allergy	0.2	0.5	0.7	0.8	-0.5
Medication: Ramipril	0.2	0.3	0.6	0.7	-0.2
Illnesses of siblings	0.2	0.2	0.3	-0.5	0.5
Happiness	0.2	0.3	0.3	-0.5	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.4	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.7	0.1
Medication: Paracetamol	0.2	0.3	0.5	0.7	0.2
Angina (self-reported)	0.2	0.3	0.5	0.7	-0.2
Suffer from ‘nerves’	0.2	0.4	0.7	0.9	0.1
Average weekly red wine intake	0.2	0.4	0.7	0.8	0.2
Mood swings	0.2	0.4	0.4	-0.7	0.6
Financial situation satisfaction	0.2	0.2	0.3	0.5	-0.4
Medication: Blood pressure	0.2	0.3	0.6	0.7	0.2
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.1	0.8
Risk taking	0.2	0.4	0.7	-0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.6	0.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.4	0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.4	-0.1
Height	0.1	1.1	2.2	0.1	-1.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.5	0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.6	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.3	0.3
Angina	0.1	0.2	0.3	0.5	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.2	-0.5	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.5	-0.1
Alcohol usually taken with meals	0.1	0.2	0.3	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.4	0.3
Had menopause	0.1	0.2	0.2	0.4	-0.3
Had other major operations	0.1	0.1	0.2	-0.5	-0.2
Mouth/teeth dental problems	0.1	0.1	0.1	-0.4	-0.2
Prospective memory result	0.1	0.1	0.2	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.5	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.2	0.5	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	-0.6	-0.1
Worry too long after embarrassment	0.1	0.2	0.2	-0.4	0.4
Shortness of breath walking on level ground	0.1	0.1	0.2	0.5	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.1	-0.5
Comparative height size at age 10	0.1	0.6	0.7	0.8	0.6
Had major operations	0.1	0.1	0.1	0.4	0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.2	0.5
Wears glasses or contact lenses	0.1	0.1	0.2	-0.4	0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.5	0.0
Medication: Paracetamol	0.1	0.2	0.4	0.1	-0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.5	0.0
Neuroticism (2016)	0.0	0.0	0.1	0.1	0.3
Lung FEV1/FVC ratio	0.0	0.0	0.0	-0.1	0.0
Average weekly spirits intake	0.0	0.0	0.0	-0.2	-0.1
Medication for hormone replacement therapy	0.0	0.0	0.1	0.2	-0.1
Severe depression (siblings)	0.0	0.0	0.0	0.2	-0.2
Fed-up feelings	0.0	0.0	0.0	0.0	0.1
Number of incorrect matches in round	0.0	0.0	0.0	0.2	-0.1
Forced vital capacity (FVC)	0.0	0.1	0.2	0.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.3	0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.3	0.6	0.1
Standing height	0.0	0.2	0.4	0.6	-0.1
Loud music exposure frequency	0.0	0.1	0.1	-0.1	-0.3
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.2	0.3
Health satisfaction	0.0	0.0	0.1	0.2	-0.3
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.2	-0.2
Migraine (self-reported)	0.0	0.1	0.1	0.2	-0.2
Overall health rating	0.0	0.0	0.0	-0.2	-0.2
Ever had bowel cancer screening	0.0	0.0	0.1	-0.3	0.0
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.3	0.2
Alcohol drinker status: Never	0.0	0.0	0.0	0.2	-0.2
Number of operations (self-reported)	0.0	0.1	0.1	0.3	-0.0
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.4	0.3
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.3	0.1

Hub : Genes

CYB561D1

Models

Trait associations