Best TWAS P=2.84e-08 · Best GWAS P=1.15e-06 conditioned to 0.933
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RNF123 | 0.14 | 0.10 | blup | 324 | 0.12 | 4.7e-14 | -4.9 | -5.1 | 2.9e-07 | 0.63 | 0.07 | 0.92 | FALSE |
| 2 | GTEx | Artery Tibial | MST1R | 0.06 | 0.02 | lasso | 5 | 0.02 | 1.5e-02 | -4.7 | -5.5 | 5.0e-08 | 0.55 | 0.09 | 0.47 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | FAM212A | 0.25 | 0.17 | lasso | 21 | 0.20 | 8.1e-06 | 4.1 | -5.1 | 3.0e-07 | 0.69 | 0.15 | 0.64 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | RNF123 | 0.06 | 0.04 | lasso | 2 | 0.02 | 4.0e-02 | -4.8 | -5.2 | 1.7e-07 | 0.56 | 0.07 | 0.76 | FALSE |
| 5 | GTEx | Testis | RBM6 | 0.28 | 0.14 | enet | 19 | 0.17 | 7.7e-08 | -4.7 | 5.2 | 1.7e-07 | -0.71 | 0.10 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TRAIP | 0.02 | 0.01 | enet | 8 | 0.01 | 3.1e-02 | -4.9 | -5.5 | 2.8e-08 | 0.88 | 0.01 | 0.57 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UBA7 | 0.02 | 0.01 | blup | 30 | 0.02 | 5.3e-03 | -4.6 | 5.2 | 2.3e-07 | -0.70 | 0.01 | 0.76 | FALSE |