[Hub]/) : Traits : Eye problems/disorders: Glaucoma : ← →

chr4:7,060,959-8,640,389

Best TWAS P=9.34e-11 · Best GWAS P=1.1e-13 conditioned to 5.8e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cerebellar Hemisphere AFAP1 0.60 0.28 lasso 11 0.34 1.1e-09 -6.3 -6.2 5.7e-10 -0.38 0.76 0.13 FALSE
2 GTEx Brain Cerebellar Hemisphere AFAP1-AS1 0.33 0.16 lasso 7 0.16 5.9e-05 -6.3 -6.5 9.3e-11 -0.37 0.30 0.10 TRUE
3 GTEx Brain Cerebellum AFAP1 0.47 0.19 lasso 4 0.19 2.8e-06 6.0 -6.5 1.1e-10 -0.48 0.20 0.63 FALSE
4 GTEx Esophagus Mucosa AFAP1 0.48 0.40 enet 29 0.43 3.9e-31 -5.6 -5.2 2.5e-07 -0.27 1.00 0.00 FALSE
5 GTEx Esophagus Mucosa AFAP1-AS1 0.36 0.28 lasso 8 0.29 5.9e-20 -5.4 -5.2 2.3e-07 -0.29 1.00 0.00 FALSE
6 GTEx Skin Not Sun Exposed Suprapubic AFAP1 0.47 0.46 lasso 4 0.45 2.8e-27 -5.6 -5.7 1.6e-08 -0.31 1.00 0.00 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic AFAP1-AS1 0.33 0.30 lasso 6 0.29 4.0e-16 -5.6 -5.6 1.9e-08 -0.32 1.00 0.00 FALSE
8 GTEx Skin Sun Exposed Lower leg AFAP1 0.50 0.45 lasso 8 0.46 4.2e-42 -5.6 -5.7 1.6e-08 -0.32 1.00 0.00 FALSE
9 GTEx Skin Sun Exposed Lower leg AFAP1-AS1 0.34 0.26 lasso 5 0.24 8.3e-20 -5.6 -5.6 1.9e-08 -0.33 1.00 0.00 FALSE
10 GTEx Whole Blood AFAP1 0.45 0.48 enet 44 0.50 1.3e-52 -5.6 -5.6 2.5e-08 -0.30 1.00 0.00 FALSE
11 GTEx Whole Blood AFAP1-AS1 0.36 0.33 lasso 8 0.33 2.6e-31 -5.6 -5.5 4.4e-08 -0.31 1.00 0.00 FALSE
12 METSIM Adipose AFAP1 0.05 0.03 enet 13 0.03 1.3e-05 -5.6 -6.2 4.9e-10 -0.31 0.85 0.06 FALSE
13 NTR Blood AFAP1 0.13 0.12 lasso 6 0.13 3.1e-39 -5.6 -5.5 3.7e-08 -0.32 1.00 0.00 FALSE