[Hub]/) : Traits : Eye problems/disorders: Glaucoma : ← →

chr4:7,060,959-8,640,389

Best TWAS P=9.34e-11 · Best GWAS P=1.1e-13 conditioned to 5.8e-08

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Brain Cerebellar Hemisphere	AFAP1-AS1	0.33	0.16	lasso	7	0.16	5.9e-05	-6.3	-6.5	9.3e-11	-0.37	0.30	0.10	TRUE
3	GTEx	Brain Cerebellum	AFAP1	0.47	0.19	lasso	4	0.19	2.8e-06	6.0	-6.5	1.1e-10	-0.48	0.20	0.63	FALSE
12	METSIM	Adipose	AFAP1	0.05	0.03	enet	13	0.03	1.3e-05	-5.6	-6.2	4.9e-10	-0.31	0.85	0.06	FALSE
1	GTEx	Brain Cerebellar Hemisphere	AFAP1	0.60	0.28	lasso	11	0.34	1.1e-09	-6.3	-6.2	5.7e-10	-0.38	0.76	0.13	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	AFAP1	0.47	0.46	lasso	4	0.45	2.8e-27	-5.6	-5.7	1.6e-08	-0.31	1.00	0.00	FALSE
8	GTEx	Skin Sun Exposed Lower leg	AFAP1	0.50	0.45	lasso	8	0.46	4.2e-42	-5.6	-5.7	1.6e-08	-0.32	1.00	0.00	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	AFAP1-AS1	0.33	0.30	lasso	6	0.29	4.0e-16	-5.6	-5.6	1.9e-08	-0.32	1.00	0.00	FALSE
9	GTEx	Skin Sun Exposed Lower leg	AFAP1-AS1	0.34	0.26	lasso	5	0.24	8.3e-20	-5.6	-5.6	1.9e-08	-0.33	1.00	0.00	FALSE
10	GTEx	Whole Blood	AFAP1	0.45	0.48	enet	44	0.50	1.3e-52	-5.6	-5.6	2.5e-08	-0.30	1.00	0.00	FALSE
13	NTR	Blood	AFAP1	0.13	0.12	lasso	6	0.13	3.1e-39	-5.6	-5.5	3.7e-08	-0.32	1.00	0.00	FALSE
11	GTEx	Whole Blood	AFAP1-AS1	0.36	0.33	lasso	8	0.33	2.6e-31	-5.6	-5.5	4.4e-08	-0.31	1.00	0.00	FALSE
5	GTEx	Esophagus Mucosa	AFAP1-AS1	0.36	0.28	lasso	8	0.29	5.9e-20	-5.4	-5.2	2.3e-07	-0.29	1.00	0.00	FALSE
4	GTEx	Esophagus Mucosa	AFAP1	0.48	0.40	enet	29	0.43	3.9e-31	-5.6	-5.2	2.5e-07	-0.27	1.00	0.00	FALSE