Hub : Traits :

Eye problems/disorders: Glaucoma

29 significantly associated models · 9 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	164933115	166462417	2	1	2.6e-30	1.4e-32	1.0e+00	100	TMCO1
2	4	7060959	8640389	2	1	9.3e-11	1.1e-13	5.8e-08	47	AFAP1-AS1
3	9	21303958	22819407	2	1	5.3e-16	8.5e-18	1.2e-03	86	CDKN2B
4	11	46891901	48287931	1	1	2.2e-08	5.5e-07	5.4e-02	85	PTPMT1
5	14	60168943	61664530	1	1	1.5e-09	2.9e-09	1.1e-02	82	C14orf39
6	17	9114358	10799013	1	1	1.2e-08	1.9e-13	3.2e-06	60	GAS7

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Glaucoma (self-reported)	39.58	6	5	11.1	1.00	1.8e-05	AFAP1-AS1 C14orf39 CDKN2B GAS7 PTPMT1 TMCO1
Coronary Artery Disease (CAD)	13.30	1	1	2.2	0.00	1.0e+00	CDKN2B
Angina	12.52	1	1	2.2	0.00	1.0e+00	CDKN2B
Angina (self-reported)	12.40	1	1	2.2	0.00	1.0e+00	CDKN2B
Illnesses of father: Heart disease	11.87	1	1	2.2	0.00	1.0e+00	CDKN2B
Heart attack/myocardial infarction (self-reported)	10.27	1	1	2.2	0.00	1.0e+00	CDKN2B
Heart attack	9.97	1	1	2.2	0.00	1.0e+00	CDKN2B
Eye problems/disorders: None of the above	6.21	2	0	0.0	0.00	1.0e+00	AFAP1-AS1 TMCO1
Heart disease (mother)	6.20	1	1	2.2	0.00	1.0e+00	CDKN2B
Standing height	5.57	4	4	8.9	0.20	8.0e-01	AFAP1-AS1 C14orf39 GAS7 PTPMT1
Medication: Aspirin	5.52	1	1	2.2	0.00	1.0e+00	CDKN2B
Medication: Aspirin	5.33	1	1	2.2	0.00	1.0e+00	CDKN2B
Height	5.26	4	4	8.9	0.25	7.5e-01	AFAP1-AS1 C14orf39 GAS7 PTPMT1
Illnesses of father: None of the above (group 1)	5.10	1	1	2.2	0.00	1.0e+00	CDKN2B
Trunk predicted mass	4.62	3	1	2.2	0.00	1.0e+00	C14orf39 GAS7 PTPMT1
Trunk fat-free mass	4.51	3	1	2.2	0.00	1.0e+00	C14orf39 GAS7 PTPMT1
Myopia	4.27	2	0	0.0	0.00	1.0e+00	C14orf39 TMCO1
Arm predicted mass (left)	4.10	2	1	2.2	0.00	1.0e+00	C14orf39 PTPMT1
Arm fat-free mass (left)	4.00	2	1	2.2	0.00	1.0e+00	C14orf39 PTPMT1
Medication: Atorvastatin	3.98	1	1	2.2	0.00	1.0e+00	CDKN2B
Sitting height	3.91	3	3	6.7	0.00	1.0e+00	AFAP1-AS1 C14orf39 GAS7
Whole body fat-free mass	3.85	2	1	2.2	0.00	1.0e+00	C14orf39 PTPMT1
Father's age at death	3.79	1	0	0.0	0.00	1.0e+00	CDKN2B
Whole body water mass	3.79	2	1	2.2	0.00	1.0e+00	C14orf39 PTPMT1
Arm predicted mass (right)	3.63	2	1	2.2	0.00	1.0e+00	C14orf39 PTPMT1
Forced expiratory volume in 1-second (FEV1), predicted	3.62	3	0	0.0	0.00	1.0e+00	AFAP1-AS1 C14orf39 GAS7
Basal cell carcinoma (self-reported)	3.60	1	0	0.0	0.00	1.0e+00	CDKN2B
Arm fat-free mass (right)	3.42	2	1	2.2	0.00	1.0e+00	C14orf39 PTPMT1
Basal metabolic rate	3.36	2	1	2.2	0.00	1.0e+00	C14orf39 PTPMT1
Heel bone mineral density (BMD) T-score, automated (left)	3.31	2	0	0.0	0.00	1.0e+00	C14orf39 GAS7
HDL Cholesterol	3.26	1	1	2.2	0.00	1.0e+00	PTPMT1
Age when periods started (menarche)	3.16	1	1	2.2	0.00	1.0e+00	C14orf39
Comparative height size at age 10	3.09	3	1	2.2	0.00	1.0e+00	C14orf39 GAS7 PTPMT1
Heel bone mineral density (BMD) T-score, automated (right)	3.01	1	0	0.0	0.00	1.0e+00	C14orf39
Medication for cholesterol	2.93	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Type 2 Diabetes (T2D) (2012)	2.86	1	0	0.0	0.00	1.0e+00	CDKN2B
Age at last live birth	2.79	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Medication: Cholesterol lowering	2.74	1	0	0.0	0.00	1.0e+00	CDKN2B
Leg predicted mass (right)	2.73	1	1	2.2	0.00	1.0e+00	C14orf39
Leg fat-free mass (right)	2.72	1	1	2.2	0.00	1.0e+00	C14orf39
Long-standing illness, disability or infirmity	2.68	1	0	0.0	0.00	1.0e+00	CDKN2B
Age at first live birth	2.67	2	0	0.0	0.00	1.0e+00	AFAP1-AS1 GAS7
Average weekly spirits intake	2.59	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Heel T-Score	2.58	2	2	4.4	0.00	1.0e+00	C14orf39 GAS7
Leg fat-free mass (left)	2.58	1	1	2.2	0.00	1.0e+00	C14orf39
Systolic Blood Pressure	2.56	2	2	4.4	0.00	1.0e+00	AFAP1-AS1 PTPMT1
Shortness of breath walking on level ground	2.56	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Medication: Metformin	2.52	1	0	0.0	0.00	1.0e+00	CDKN2B
Leg predicted mass (left)	2.52	1	1	2.2	0.00	1.0e+00	C14orf39
Waist Hip Ratio (WHR)	2.44	3	0	0.0	0.00	1.0e+00	C14orf39 PTPMT1 TMCO1
Hand grip strength (right)	2.44	2	0	0.0	0.00	1.0e+00	AFAP1-AS1 C14orf39
Hand grip strength (left)	2.39	2	0	0.0	0.00	1.0e+00	AFAP1-AS1 C14orf39
Hearing difficulty/problems: Yes	2.36	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Medication: Atenolol	2.33	1	0	0.0	0.00	1.0e+00	CDKN2B
Breast cancer (self-reported)	2.31	1	0	0.0	0.00	1.0e+00	CDKN2B
Smoking Status	2.16	1	0	0.0	0.00	1.0e+00	C14orf39
Medication: Simvastatin	2.16	1	0	0.0	0.00	1.0e+00	CDKN2B
Severe depression (siblings)	1.98	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Diastolic blood pressure, automated reading	1.97	2	0	0.0	0.00	1.0e+00	CDKN2B PTPMT1
Breast Cancer	1.95	1	0	0.0	0.00	1.0e+00	CDKN2B
Systolic blood pressure, automated reading	1.95	2	0	0.0	0.00	1.0e+00	AFAP1-AS1 PTPMT1
Forced vital capacity (FVC)	1.95	1	0	0.0	0.00	1.0e+00	GAS7
Weight	1.93	1	1	2.2	0.00	1.0e+00	C14orf39
Neuroticism score	1.91	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Illnesses of mother	1.88	1	0	0.0	0.00	1.0e+00	CDKN2B
Lung FEV1/FVC ratio	1.83	1	1	2.2	0.00	1.0e+00	AFAP1-AS1
Vascular/heart problems diagnosed by doctor	1.80	2	0	0.0	0.00	1.0e+00	CDKN2B PTPMT1
Chest pain or discomfort	1.79	1	0	0.0	0.00	1.0e+00	CDKN2B
Heart disease (siblings)	1.74	1	0	0.0	0.00	1.0e+00	CDKN2B
Forced expiratory volume in 1-second (FEV1)	1.60	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Blood White Count	1.59	2	1	2.2	0.00	1.0e+00	CDKN2B PTPMT1
Respiratory disease	1.55	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Osteoarthritis (self-reported)	1.54	1	0	0.0	0.00	1.0e+00	GAS7
Chronotype (morning person)	1.53	1	0	0.0	0.00	1.0e+00	C14orf39
Hypertension (Self-reported)	1.52	1	0	0.0	0.00	1.0e+00	PTPMT1
Cholesterol lowering medication	1.52	1	0	0.0	0.00	1.0e+00	CDKN2B
Fed-up feelings	1.51	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Cardiovascular Disease	1.50	1	0	0.0	0.00	1.0e+00	TMCO1
Neuroticism	1.49	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Forced expiratory volume in 1-second (FEV1), Best measure	1.48	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
High blood pressure	1.46	1	0	0.0	0.00	1.0e+00	PTPMT1
Arm fat percentage (left)	1.40	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Arm fat percentage (right)	1.38	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Nervous feelings	1.29	1	0	0.0	0.00	1.0e+00	C14orf39
Impedance of leg (right)	1.19	1	0	0.0	0.00	1.0e+00	C14orf39
Fluid intelligence score	1.18	1	0	0.0	0.00	1.0e+00	PTPMT1
Hip circumference	1.18	1	1	2.2	0.00	1.0e+00	C14orf39
Verbal and Numeric Reasoning (VNR)	1.14	1	0	0.0	0.00	1.0e+00	PTPMT1
Wheeze or whistling in the chest in last year	1.14	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Impedance of leg (left)	1.05	1	0	0.0	0.00	1.0e+00	C14orf39
Waist circumference	1.03	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Trunk fat mass	1.01	1	0	0.0	0.00	1.0e+00	C14orf39
Birth weight of first child	0.99	1	0	0.0	0.00	1.0e+00	PTPMT1
Body fat percentage	0.99	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Trunk fat percentage	0.98	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Body mass index (BMI)	0.98	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Arm fat mass (right)	0.97	2	0	0.0	0.00	1.0e+00	AFAP1-AS1 C14orf39
Leg fat percentage (left)	0.87	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Arm fat mass (left)	0.86	1	0	0.0	0.00	1.0e+00	AFAP1-AS1
Impedance of whole body	0.80	1	0	0.0	0.00	1.0e+00	C14orf39
Impedance of arm (right)	0.67	1	0	0.0	0.00	1.0e+00	CDKN2B
Hair Pigment	0.59	2	1	2.2	0.00	1.0e+00	CDKN2B PTPMT1
Blood Red Count	0.49	1	0	0.0	0.00	1.0e+00	C14orf39
Blood Platelet Count	0.46	1	0	0.0	0.00	1.0e+00	CDKN2B

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	2	0.081	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	1	0.034	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	2	0.053	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	2	0.134	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	1	0.024	1.2
GTEx	Colon Sigmoid	1	0.068	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	2	0.060	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	1	0.035	1.2
GTEx	Muscle Skeletal	1	0.035	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	3	0.082	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	2	0.100	1.2
NTR	Blood	1	0.042	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.2
GTEx	Brain Cerebellum	1	0.050	1.1
GTEx	Brain Frontal Cortex BA9	0	0.000	1.1
GTEx	Brain Putamen basal ganglia	0	0.000	1.1
GTEx	Thyroid	0	0.000	1.1
METSIM	Adipose	1	0.022	1.1
YFS	Blood	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1