Best TWAS P=5.19e-08 · Best GWAS P=1.4e-07 conditioned to 0.0972
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | GBAP1 | 0.21 | 0.26 | lasso | 7 | 0.26 | 1.3e-20 | 4.9 | 5.1 | 3.1e-07 | 0.72 | 0.05 | 0.94 | FALSE |
2 | GTEx | Brain Cerebellum | THBS3 | 0.17 | 0.15 | enet | 6 | 0.16 | 2.0e-05 | 5.1 | -5.4 | 5.2e-08 | -0.77 | 0.03 | 0.94 | TRUE |
3 | GTEx | Brain Cerebellum | EFNA1 | 0.20 | 0.09 | enet | 13 | 0.06 | 9.2e-03 | -5.2 | 5.3 | 1.1e-07 | 0.79 | 0.02 | 0.93 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | SLC50A1 | 0.08 | 0.07 | lasso | 6 | 0.07 | 3.9e-06 | -5.2 | -5.3 | 1.4e-07 | -0.82 | 0.03 | 0.97 | FALSE |
5 | GTEx | Prostate | GBAP1 | 0.47 | 0.30 | lasso | 7 | 0.32 | 1.1e-08 | 4.9 | 5.2 | 1.9e-07 | 0.66 | 0.04 | 0.95 | FALSE |
6 | GTEx | Small Intestine Terminal Ileum | GBAP1 | 0.20 | 0.13 | lasso | 10 | 0.11 | 1.8e-03 | -5.2 | 5.4 | 7.8e-08 | 0.72 | 0.03 | 0.81 | FALSE |
7 | GTEx | Spleen | THBS3 | 0.23 | 0.10 | enet | 17 | 0.08 | 4.6e-03 | -4.5 | -5.4 | 7.9e-08 | -0.84 | 0.03 | 0.85 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TRIM46 | 0.03 | 0.00 | blup | 33 | 0.02 | 3.6e-03 | -4.0 | -5.2 | 2.1e-07 | -0.70 | 0.01 | 0.53 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | THBS3 | 0.02 | 0.03 | lasso | 4 | 0.03 | 2.1e-04 | 4.9 | -5.1 | 2.8e-07 | -0.63 | 0.02 | 0.95 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GBAP1 | 0.03 | 0.01 | blup | 26 | 0.02 | 1.9e-03 | -5.2 | 5.4 | 8.2e-08 | 0.70 | 0.01 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAG1AP1 | 0.07 | 0.05 | blup | 77 | 0.05 | 3.8e-06 | -4.7 | -5.3 | 1.4e-07 | -0.83 | 0.03 | 0.96 | FALSE |