TWAS hub - RAG1AP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0667	0.0377	3.5e-03	0.003	0.000	0.000	NA	0.000	1.3e-01	2.9e-01	3.1e-01	NA	3.3e-01
2	TCGA	Brain Lower Grade Glioma	0.0709	0.0402	8.4e-06	0.047	0.048	0.045	NA	0.045	4.3e-06	3.8e-06	6.8e-06	NA	6.5e-06
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.1700	0.0770	3.2e-03	0.002	0.040	0.038	NA	0.007	2.3e-01	1.1e-03	1.4e-03	NA	9.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Breast Cancer	14.0	33.6	43.4	-6.6	-6.0	-4.6
Mouth/teeth dental problems: Dentures	12.2	20.7	35.5	4.4	6.0	2.7
Mouth/teeth dental problems	9.2	14.1	27.7	-3.4	-5.3	-1.7
Impedance of leg (left)	8.7	42.4	50.7	7.0	7.1	5.2
Impedance of leg (right)	7.9	38.4	50.1	6.5	7.1	4.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	7.5	8.9	11.5	3.2	3.4	2.2
Irritable Bowel Disease (IBD)	7.2	17.3	37.5	3.2	6.1	2.0
Crohns Disease (2012)	7.0	11.3	20.2	2.9	4.5	2.3
Pain experienced in last month	6.3	10.6	13.4	3.1	3.0	3.7
Crohns Disease (2017)	5.8	12.8	26.4	2.7	5.1	2.1
Smoking status: Previous	5.7	8.5	21.0	1.5	4.6	1.5
Leg fat-free mass (right)	5.5	29.4	35.8	-6.0	-5.7	-4.4
Leg predicted mass (right)	5.5	29.3	35.8	-6.0	-5.7	-4.4
Medication: Atorvastatin	5.5	6.8	11.4	2.6	3.4	1.6
Diabetes (self-reported)	5.3	8.1	10.6	3.2	2.5	2.7
Leg fat-free mass (left)	5.2	27.4	33.5	-5.8	-5.5	-4.3
Leg predicted mass (left)	5.2	27.6	33.9	-5.8	-5.5	-4.3
Medication: Gliclazide	5.2	5.9	8.1	2.1	2.9	2.3
Gout (self-reported)	4.9	6.8	10.5	-3.0	-3.2	-0.7
Medication: Allopurinol	4.9	6.5	10.6	-3.3	-2.9	-0.6
High blood pressure (mother)	4.7	6.6	12.6	-2.5	-3.5	-1.0
Medication for cholesterol, blood pressure or diabetes	4.7	7.7	9.8	-3.1	-2.9	-2.3
Ulcerative Colitis (UC)	4.5	8.4	20.7	2.0	4.5	0.8
Whole body fat-free mass	4.5	25.6	39.1	-6.2	-4.2	-4.5
Whole body water mass	4.5	25.8	39.4	-6.3	-4.2	-4.5
Trunk fat-free mass	4.4	25.2	42.1	-6.5	-3.5	-4.6
Basal metabolic rate	4.4	24.4	34.2	-5.8	-4.5	-4.3
Past tobacco smoking	4.3	7.9	18.2	-2.0	-4.3	-1.2
Trunk predicted mass	4.3	24.4	41.1	-6.4	-3.4	-4.6
Miserableness	4.3	7.4	12.2	2.7	3.5	1.6
Ever used hormone-replacement therapy (HRT)	4.1	5.3	6.1	-2.2	-2.2	-2.5
Knee pain experienced in last month	4.1	6.4	6.7	-2.6	-2.4	-2.6
Medication: Aspirin	4.0	5.3	9.2	3.0	1.5	2.1
Impedance of whole body	4.0	20.1	31.2	5.6	3.9	3.7
Depressed Affect (Nagel 2018)	3.9	8.2	16.6	2.4	4.1	1.6
Hair/balding pattern: Pattern 2	3.8	4.8	6.6	2.6	1.7	2.2
Medication: Aspirin	3.8	4.9	8.7	2.9	1.9	1.6
Type 2 Diabetes (T2D) (2018)	3.7	6.8	8.9	2.5	2.4	3.0
Frequency of depressed mood in last 2 weeks	3.7	5.1	7.8	2.7	2.8	0.7
Mean Putamen Volume	3.6	4.1	5.4	1.8	1.9	2.3
Severe depression (siblings)	3.6	4.0	6.0	2.4	1.5	2.0
Hayfever, allergic rhinitis or eczema	3.5	7.5	11.9	2.7	3.5	1.9
Diabetes diagnosed by doctor	3.5	5.8	6.6	2.4	2.3	2.6
Medication: Ramipril	3.4	4.4	6.0	2.4	2.1	1.6
Financial situation satisfaction	3.4	4.2	4.9	2.2	2.0	1.9
Blood Red Count	3.3	32.3	69.4	4.3	8.3	-3.0
Allergy or Eczema	3.3	8.7	12.0	3.1	3.5	2.1
Allergy	3.3	7.5	14.2	-2.2	-3.8	-1.8
Pulse wave reflection index	3.3	4.0	8.0	1.7	2.8	1.1
Commuting to job workplace: Public transport	3.3	4.0	6.3	-2.4	-2.5	-0.2
Alzheimer’s Disease (in father)	3.2	3.5	5.1	-2.0	-2.3	-1.2
Supplements: Glucosamine	3.2	4.2	6.4	-1.9	-1.6	-2.5
Medication: Blood pressure	3.2	5.7	8.7	3.0	2.5	1.5
Arm fat-free mass (left)	3.2	16.1	27.4	-5.2	-2.8	-3.6
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	10.0	-2.3	-1.7	-3.2
Arm predicted mass (right)	3.0	15.1	26.9	-5.2	-2.4	-3.6
Family relationship satisfaction	3.0	3.7	4.7	2.2	2.0	1.6
Arm predicted mass (left)	3.0	15.4	27.0	-5.2	-2.6	-3.5
Body Mass Index (BMI) (2010)	2.9	3.9	4.8	-2.0	-2.2	-1.8
Lung FVC	2.9	14.6	20.7	-4.5	-4.5	-1.8
Weight	2.9	14.5	20.7	-3.8	-4.5	-2.9
Number of full brothers	2.9	3.7	4.2	2.0	1.6	2.0
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	5.3	2.3	1.5	1.7
Smoking Status	2.8	6.7	10.3	3.2	2.5	1.9
Nervous feelings	2.8	5.2	6.6	-2.3	-2.6	-2.0
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.5	5.1	-1.1	-2.3	-2.0
Eye problems/disorders: None of the above	2.8	3.2	7.0	-1.3	-2.7	-0.9
Alcohol drinker status: Never	2.8	3.4	5.8	-1.9	-0.8	-2.4
Risk taking	2.8	4.1	7.3	2.2	2.7	-0.3
Blood Platelet Count	2.7	31.2	55.8	5.5	7.5	2.8
Fed-up feelings	2.7	5.0	9.1	1.9	3.0	1.4
Medication: Cholesterol lowering	2.7	4.2	5.6	2.1	2.4	1.6
Forced vital capacity (FVC)	2.6	10.2	19.1	-4.4	-2.5	-2.3
Happiness	2.6	3.2	6.1	2.5	1.4	1.3
Mouth/teeth dental problems: Bleeding gums	2.6	3.3	4.8	1.3	2.2	1.9
Arm fat-free mass (right)	2.6	13.1	24.1	-4.9	-2.1	-3.3
Waist Hip Ratio (WHR)	2.5	11.1	15.4	3.8	3.9	1.8
Age when periods started (menarche)	2.5	6.0	8.7	2.7	1.4	3.0
Chest pain or discomfort	2.5	3.6	7.1	1.6	2.7	1.1
Ever had hysterectomy (womb removed)	2.4	2.7	5.2	-1.2	-1.2	-2.3
Hip circumference	2.4	10.3	13.3	-3.1	-3.6	-2.8
Medication: Ibuprofen	2.4	2.9	5.4	-0.8	-1.6	-2.3
Mood swings	2.4	4.3	7.8	2.0	2.8	1.1
Arm fat mass (left)	2.3	9.4	21.5	-1.8	-4.6	-1.8
Arm fat mass (right)	2.2	9.2	21.3	-1.8	-4.6	-1.8
Pulse wave peak to peak time	2.2	2.5	3.8	-2.0	-1.4	-1.3
Illnesses of siblings: Diabetes	2.2	2.7	4.2	-2.1	-0.3	-1.9
Loneliness, isolation	2.2	3.1	6.7	1.4	2.6	0.8
Bipolar Disorder (2018)	2.1	3.4	6.4	1.6	2.5	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.7	4.2	2.0	2.1	0.2
Hair/balding pattern: Pattern 4	2.1	5.0	8.8	-2.2	-3.0	-1.1
Blood clot in the leg (DVT)	2.1	2.7	4.8	1.1	2.2	1.5
Mean time to correctly identify matches	2.1	3.9	8.4	1.6	0.8	2.9
Worry (Nagel 2018)	2.0	4.3	8.2	-1.9	-1.1	-2.9
Ulcerative Colitis	2.0	2.9	8.0	0.8	2.8	0.5
Hypothyroidism (self reported)	2.0	4.7	8.1	-1.9	-1.5	-2.8
Lung FEV1/FVC ratio	2.0	10.0	24.0	4.9	-0.6	2.4
Medication: Metformin	2.0	2.9	4.1	2.0	1.6	1.4
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	5.0	1.2	2.2	1.2
Depression (Nagel 2018)	1.9	2.9	5.9	1.6	2.4	0.1
Body mass index (BMI)	1.9	8.3	18.4	-1.9	-4.3	-1.7
Forced vital capacity (FVC), Best measure	1.9	6.9	12.7	-3.6	-2.1	-1.8
Illnesses of father: None of the above (group 1)	1.9	2.3	3.6	1.6	1.9	0.8
Ever smoked	1.9	3.4	7.5	1.4	2.7	0.8
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.3	1.3	2.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	5.0	1.3	2.2	0.5
Qualifications: College or University degree	1.8	5.5	8.5	-2.4	-1.6	-2.9
Arm fat percentage (left)	1.8	7.0	20.2	-0.2	-4.5	-0.8
Back pain experienced in last month	1.8	2.6	5.7	-0.8	-2.4	-1.2
High cholesterol (Self-reported)	1.8	3.3	6.5	1.5	2.5	1.0
Diastolic blood pressure, automated reading	1.8	5.4	9.4	-2.0	-3.1	-1.7
Supplements: Calcium	1.8	1.9	2.1	1.3	1.4	1.5
Major Depression (MDD)	1.7	2.1	5.0	1.0	0.6	2.2
Current tobacco smoking	1.7	2.8	4.8	2.2	0.3	1.9
Impedance of arm (right)	1.7	8.2	17.1	4.1	0.5	2.7
Pulse wave Arterial Stiffness index	1.7	1.9	2.7	1.6	1.3	1.2
Commuting to job workplace: Car/motor vehicle	1.7	1.9	2.5	1.6	1.6	0.9
Illnesses of father: Heart disease	1.7	2.3	5.9	-1.0	-2.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	2.5	1.2	1.6	1.3
Eye problems/disorders: Cataract	1.7	2.0	3.6	1.3	1.9	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.1	3.5	-1.1	-1.9	-1.2
Mineral and other dietary supplements	1.7	2.2	3.9	1.5	0.7	2.0
LDL Cholesterol	1.6	2.5	6.9	0.5	2.6	0.5
Supplements: Zinc	1.6	1.7	2.9	-1.5	0.2	-1.7
Arm fat percentage (right)	1.6	6.5	19.2	0.1	-4.4	-0.4
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	7.8	-2.5	-2.8	-1.4
Medication: Omeprazole	1.6	1.9	3.6	1.5	1.9	-0.1
Number of self-reported non-cancer illnesses	1.6	2.7	4.0	2.0	1.5	1.4
Cardiovascular Disease	1.5	5.1	11.4	3.4	1.3	1.5
Medication for hormone replacement therapy	1.5	1.7	2.3	-1.1	-1.5	-1.2
Maternal smoking around birth	1.5	2.2	3.9	1.6	-0.1	2.0
Wheeze or whistling in the chest in last year	1.5	2.7	7.8	0.7	2.8	0.1
Emphysema/chronic bronchitis	1.5	1.7	4.3	0.7	2.1	0.5
Smoking status: Current	1.5	2.5	4.9	2.2	-0.0	1.6
Average weekly champagne plus white wine intake	1.5	2.1	4.2	-1.0	-2.0	-1.0
Birth weight	1.4	2.9	5.2	-2.3	-1.1	-1.5
Comparative height size at age 10	1.4	7.9	14.1	-2.9	-0.9	-3.8
Ever depressed for a whole week	1.4	1.7	2.8	1.7	-0.2	1.5
Blood White Count	1.3	9.9	13.2	3.6	2.9	2.9
Height	1.3	25.5	46.9	-6.8	-3.1	-4.5
Diabetes (mother)	1.3	1.7	3.0	1.1	0.8	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	6.8	-2.3	-2.6	-0.9
Medication: Seretide 50 evohaler	1.3	1.5	2.2	0.4	1.5	1.5
Long-standing illness, disability or infirmity	1.3	2.0	2.9	1.5	1.7	0.9
Ever taken oral contraceptive pill	1.3	1.4	3.7	1.9	0.2	0.8
Reaction Time	1.2	2.2	5.9	0.8	0.4	2.4
Prostate Cancer	1.2	1.7	3.3	1.8	0.7	1.1
Neuroticism (2016)	1.2	1.7	4.9	-0.5	0.3	-2.2
Heel T-Score	1.2	9.7	24.0	-2.0	-4.9	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	7.0	-1.0	-2.6	-0.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.4	-0.7	-0.4	-1.8
Depression (self-reported)	1.2	1.5	2.7	1.7	0.9	1.0
Prospective memory result	1.2	1.4	1.9	-1.1	-1.4	-1.1
Impedance of arm (left)	1.2	5.7	12.9	3.6	0.3	2.0
Asthma (self-reported)	1.2	2.4	4.3	1.1	2.1	1.3
Osteoarthritis (self-reported)	1.2	1.5	2.4	-1.4	-0.3	-1.5
Neuroticism	1.1	2.6	6.5	1.0	2.5	-0.6
Asthma	1.1	2.2	4.3	1.0	2.1	1.2
Tense / ‘highly strung’	1.1	1.9	3.8	0.5	2.0	-1.3
Shortness of breath walking on level ground	1.1	1.3	3.5	-0.6	-0.3	-1.9
Migraine (self-reported)	1.1	1.3	3.0	-0.0	-1.0	-1.7
Whole body fat mass	1.1	4.5	12.3	-0.7	-3.5	-0.8
Had major operations	1.1	1.3	2.5	1.1	1.6	0.3
Commuting to job workplace: Walk	1.1	1.2	2.3	-1.2	-1.5	0.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.0	1.4	1.3	-0.3
Bipolar Disorder or Schizophrenia	1.0	2.5	3.6	1.9	1.8	0.9
Alzheimer’s Disease (in mother)	1.0	1.1	1.2	1.0	1.1	-1.1
Triglycerides	1.0	1.7	3.2	-0.4	1.3	-1.8
Tanning	1.0	12.6	16.7	3.7	4.1	2.7
Qualifications: CSEs or equivalent	1.0	1.3	1.7	1.3	0.9	1.1
Serious illness, injury or assault to yourself	1.0	1.2	2.2	1.2	1.5	-0.3
Medication: Levothyroxine sodium	1.0	1.8	4.5	-0.7	-0.6	-2.1
Trunk fat mass	1.0	4.4	13.0	-0.4	-3.6	-0.4
Hearing difficulty/problems with background noise	1.0	1.5	3.1	0.6	1.1	-1.8
Had other major operations	1.0	1.2	2.1	1.4	-0.4	1.1
Lung cancer (father)	1.0	1.2	2.6	1.0	1.6	0.0
Peak expiratory flow (PEF)	1.0	2.4	6.7	0.1	-2.6	-0.7
Loud music exposure frequency	1.0	1.1	2.2	-0.3	-1.5	-1.0
Average weekly beer plus cider intake	1.0	1.4	3.1	-1.1	0.0	-1.8
BMI	0.9	5.0	14.9	-0.3	-3.9	-0.1
Respiratory disease	0.9	2.0	3.5	1.2	1.9	1.1
Systolic blood pressure, automated reading	0.9	2.5	5.9	-1.1	-2.4	-0.6
Trunk fat percentage	0.9	3.7	8.9	1.3	-3.0	0.7
Time employed in main current job	0.9	1.0	2.1	-0.9	-1.4	-0.5
Number of live births	0.9	1.3	2.9	0.9	1.7	0.4
Qualifications: A levels/AS levels or equivalent	0.9	2.1	4.2	-2.0	-0.1	-1.4
Illnesses of mother	0.9	1.1	1.9	0.9	1.4	-0.8
Comparative body size at age 10	0.9	2.5	3.3	-1.5	-1.8	-1.4
Leg pain on walking	0.9	1.1	1.3	-1.1	-0.9	-1.1
Hypertension (Self-reported)	0.9	2.5	4.4	2.1	0.7	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.8	1.4	1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.8	-2.2	-0.5	-0.8
Irritability	0.9	1.5	3.6	0.8	1.9	0.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.6	-0.7	-1.6	-0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	2.7	-0.2	-0.9	-1.6
Fasting Glucose	0.8	0.9	2.6	-0.2	1.6	-0.3
Hair Pigment	0.8	24.2	64.0	1.0	8.0	2.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	1.4	1.1	0.1
Multivitamins +/- minerals	0.8	1.0	2.0	-0.9	-1.4	-0.4
Heart attack	0.8	1.0	2.2	0.8	0.5	1.5
Standing height	0.8	8.4	17.1	-4.1	-1.1	-2.6
Length of working week for main job	0.8	0.9	1.9	0.5	0.7	1.4
Suffer from ‘nerves’	0.8	1.3	2.4	-1.1	-0.3	-1.6
Breast cancer (self-reported)	0.8	1.0	1.2	1.1	1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.9	-0.5	-2.0	-0.8
Wears glasses or contact lenses	0.8	0.9	1.7	1.3	0.2	1.0
Hearing aid user	0.8	0.9	1.4	-1.2	0.1	-1.1
Number of operations (self-reported)	0.8	1.2	2.1	1.4	0.5	1.1
Age started oral contraceptive pill	0.8	1.0	1.5	-1.2	-0.4	-1.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.4	-2.1	-0.5	-1.4
Neuroticism (Nagel 2018)	0.7	1.5	4.2	0.5	2.0	-0.4
Age at First Birth	0.7	1.0	2.4	0.5	-1.5	-0.4
Rheumatoid Arthritis	0.7	1.0	1.2	-1.1	0.9	-1.1
Number of treatments/medications taken	0.7	1.3	2.7	1.6	0.6	1.0
Vitamin and mineral supplements	0.7	0.9	1.6	1.0	1.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	4.3	-0.4	-2.1	-0.2
Neuroticism score	0.7	1.4	3.5	0.5	1.9	-0.6
Noisy workplace	0.7	0.9	1.0	1.0	1.0	0.9
Medication: Lansoprazole	0.7	0.8	1.8	0.1	1.3	-0.9
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.3	0.2	1.5	0.6
Body fat percentage	0.7	2.8	6.5	1.3	-2.5	0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	0.7	1.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.0	-1.0	-0.6	-1.4
HbA1C	0.6	0.6	1.8	-0.1	1.3	0.3
Sensitivity / hurt feelings	0.6	1.0	1.8	0.6	0.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.1	-0.9	-1.0	-0.4
Hand grip strength (right)	0.6	1.7	4.4	-2.1	-0.5	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	-0.3	-1.3	0.5
Chronic bronchitis/emphysema (father)	0.6	0.8	2.2	-1.5	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.0	0.7	1.4	0.3
Breastfed as a baby	0.6	0.8	1.6	0.6	1.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	0.9	-0.8	-0.9	-0.7
Health satisfaction	0.6	0.7	1.1	-0.7	-0.7	-1.1
Qualifications: nursing, teaching	0.6	0.9	1.9	-0.9	-0.4	-1.4
Osteoporosis (self-reported)	0.6	0.7	0.9	1.0	0.9	0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.7	-1.3	-0.9	-0.9
Schizophrenia (2014)	0.5	1.1	2.7	1.7	0.5	0.6
Townsend deprivation index at recruitment	0.5	0.7	1.4	0.6	1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	0.2	-1.2	-0.6
Had menopause	0.5	0.6	1.4	-1.2	-0.5	-0.3
Fluid intelligence score	0.5	1.0	1.5	-1.2	-0.8	-0.9
Worrier / anxious feelings	0.5	0.9	1.2	-1.1	-0.7	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	1.0	1.2	-0.0
Headache pain in last month	0.5	0.8	1.8	0.8	0.2	-1.4
Medication: Amlodipine	0.5	0.7	1.3	1.1	0.7	0.6
Worry too long after embarrassment	0.5	0.8	1.8	-0.1	1.3	-0.7
Number of full sisters	0.5	0.6	0.9	0.9	-0.2	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	0.9	-1.0	-0.6	-0.8
Commuting to job workplace: Cycle	0.5	0.6	1.2	-0.3	0.8	-1.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	-0.6	-1.2	-0.5
Heart disease (siblings)	0.5	0.6	1.3	0.5	-0.5	1.1
Alcohol drinker status: Previous	0.5	0.6	1.0	0.8	1.0	0.1
Leg fat mass (left)	0.5	1.8	5.1	-0.2	-2.3	-0.3
Schizophrenia (2018)	0.4	0.7	2.1	1.4	0.1	0.4
Average weekly spirits intake	0.4	0.6	1.5	0.2	-1.2	0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.5	0.2	0.3	-1.2
Pack years adult smoking proportion	0.4	0.6	0.9	0.4	-0.9	-0.9
High blood pressure	0.4	1.0	2.3	1.5	0.2	0.9
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.1	0.7	-1.1
Medication: Atenolol	0.4	0.5	1.1	-0.3	-1.0	0.6
Waist circumference	0.4	1.6	2.6	-0.7	-1.6	-1.3
Number of incorrect matches in round	0.4	0.7	1.1	-0.4	-1.0	-1.0
Father’s age at death	0.4	0.5	1.2	-1.1	0.5	0.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	-1.0	-0.8	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	0.5	0.6	0.9
High blood pressure (siblings)	0.4	0.6	1.6	-0.5	-1.3	0.1
Leg fat mass (right)	0.4	1.4	4.2	-0.1	-2.0	-0.2
Overall health rating	0.4	0.8	2.0	1.4	-0.1	0.6
Mother’s age at death	0.4	0.5	1.3	0.0	0.6	-1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.4	0.6	-0.5	0.8	-0.7
Fractured/broken bones in last 5 years	0.4	0.5	0.7	0.2	0.8	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.3	0.3	1.2
HDL Cholesterol	0.3	0.5	1.2	-0.2	-1.1	-0.5
Relative age of first facial hair	0.3	0.6	1.3	0.5	-0.4	1.1
Angina	0.3	0.4	0.8	0.9	0.5	0.4
Average weekly fortified wine intake	0.3	0.4	0.8	-0.6	-0.9	0.0
Illnesses of siblings	0.3	0.4	0.9	0.0	0.5	-1.0
Pulse rate	0.3	0.5	1.1	-0.5	-0.2	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.8	0.5	0.3
Exposure to tobacco smoke at home	0.3	0.4	0.8	0.9	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	0.0	-0.5	-1.1
Birth weight of first child	0.3	0.6	0.9	-0.4	-0.8	1.0
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.7	-0.1	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	-1.2	0.2	0.2
Heart disease (mother)	0.3	0.3	0.7	-0.3	-0.8	0.5
Guilty feelings	0.3	0.5	1.3	-0.3	0.2	-1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	-0.0	-0.4	-0.9
Illnesses of father: High blood pressure	0.3	0.4	1.0	-0.1	-0.3	-1.0
Leg fat percentage (left)	0.3	1.1	2.3	1.5	-0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.5	-1.2	-0.7	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	0.7	-0.0	-0.8	0.1
Ovarian Cancer	0.2	0.3	0.4	-0.7	0.2	0.6
Lupus	0.2	0.4	0.9	-0.4	-0.1	-1.0
Chronotype (morning person)	0.2	0.4	1.1	0.0	1.0	-0.4
Hand grip strength (left)	0.2	0.6	1.2	-1.1	0.6	-0.1
Medication: Co-codamol	0.2	0.2	0.3	0.0	-0.5	0.5
Sitting height	0.2	1.2	2.4	-1.6	0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	0.8	-0.1	0.5
Pain all over the body in last month	0.2	0.2	0.3	-0.6	-0.2	-0.4
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	-0.2	0.4	-0.7
Leg fat percentage (right)	0.2	0.8	1.7	1.3	-0.7	0.3
Number of children fathered	0.2	0.2	0.3	0.1	-0.5	0.6
Age at first live birth	0.2	0.3	0.4	-0.6	-0.7	-0.2
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.8	-0.2	-0.3
Angina (self-reported)	0.2	0.3	0.6	0.8	0.5	0.2
Age at last live birth	0.2	0.3	0.6	-0.8	0.2	0.5
Supplements: Vitamin C	0.2	0.2	0.4	-0.3	0.7	-0.3
Medication for cholesterol	0.2	0.4	0.7	-0.7	0.8	0.1
Medication: Blood pressure	0.2	0.4	1.2	-0.2	-1.1	-0.2
Myopia	0.2	0.2	0.4	0.5	0.3	0.7
Cholesterol lowering medication	0.2	0.3	0.6	0.5	0.8	0.1
Pack years of smoking	0.2	0.3	0.5	0.4	-0.4	-0.7
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.3	0.1	-0.7
Blood Eosinophil Count	0.1	0.6	1.1	1.1	0.5	-0.5
Systolic Blood Pressure	0.1	0.5	1.2	1.1	-0.3	0.4
Diabetes (father)	0.1	0.1	0.2	-0.4	-0.4	0.2
Taking other prescription medications	0.1	0.1	0.1	0.4	0.1	0.4
Alcohol usually taken with meals	0.1	0.2	0.6	-0.0	0.3	-0.8
Financial difficulties in last 2 years	0.1	0.1	0.1	-0.1	-0.4	0.4
Medication: Simvastatin	0.1	0.1	0.2	0.2	0.4	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.6	0.4	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.6	-0.2	-0.3
Medication: Paracetamol	0.1	0.2	0.2	-0.5	-0.4	-0.3
Pulse rate, automated reading	0.1	0.5	0.7	-0.6	-0.8	-0.6
Alcohol intake frequency.	0.1	0.1	0.2	0.2	-0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.2	-0.3	-0.5	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.0	-0.2	-0.5
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	-0.2	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.4	-0.0	0.4
Medication: Lisinopril	0.1	0.2	0.4	-0.3	-0.1	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Relative age voice broke	0.0	0.0	0.0	-0.1	-0.1	0.1
Qualifications: None of the above	0.0	0.0	0.1	-0.1	-0.1	-0.3
Falls in the last year	0.0	0.0	0.1	0.0	0.3	-0.0
Glaucoma (self-reported)	0.0	0.0	0.1	-0.1	0.1	-0.3
Average weekly red wine intake	0.0	0.1	0.1	0.0	0.4	0.2
Friendships satisfaction	0.0	0.0	0.1	-0.2	0.1	-0.2
Eye problems/disorders: Glaucoma	0.0	0.1	0.1	-0.1	0.2	-0.3
Medication: Paracetamol	0.0	0.0	0.1	-0.2	0.0	-0.2
Unable to work because of sickness or disability	0.0	0.0	0.1	0.3	0.1	0.2

Hub : Genes

RAG1AP1

Models

Trait associations