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chr3:49,016,056-50,833,360

Best TWAS P=1.42e-08 · Best GWAS P=2.19e-08 conditioned to 0.067

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RBM6	0.16	0.19	lasso	9	0.19	1.2e-22	-5.3	-5.4	7.6e-08	0.98	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	RBM6	0.25	0.35	lasso	9	0.35	1.8e-29	-5.3	-5.3	8.7e-08	0.94	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	-5.3	-5.4	5.9e-08	0.94	0.04	0.96	FALSE
4	GTEx	Adrenal Gland	RBM6	0.12	0.05	enet	18	0.05	5.9e-03	-5.3	-5.3	1.4e-07	0.97	0.04	0.93	FALSE
5	GTEx	Artery Aorta	RBM6	0.32	0.36	lasso	6	0.41	3.3e-24	-5.3	-5.3	1.1e-07	0.96	0.04	0.96	FALSE
6	GTEx	Artery Aorta	APEH	0.05	0.03	enet	8	0.01	9.1e-02	-5.3	-5.4	6.3e-08	0.93	0.06	0.86	FALSE
7	GTEx	Artery Tibial	RBM6	0.24	0.31	enet	24	0.30	5.8e-24	-5.3	-5.4	5.9e-08	0.95	0.04	0.96	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RBM6	0.19	0.28	lasso	5	0.32	7.4e-09	5.4	-5.3	1.1e-07	0.92	0.04	0.96	FALSE
9	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	-5.3	5.6	2.7e-08	-0.91	0.06	0.94	FALSE
10	GTEx	Brain Cortex	RBM6	0.21	0.25	lasso	4	0.29	8.8e-09	-5.3	-5.1	2.8e-07	0.92	0.04	0.96	FALSE
11	GTEx	Brain Putamen basal ganglia	RBM6	0.15	0.22	lasso	4	0.12	7.4e-04	-5.3	-5.3	1.1e-07	0.97	0.05	0.92	FALSE
12	GTEx	Breast Mammary Tissue	RBM6	0.25	0.35	enet	26	0.38	7.4e-21	-5.3	-5.4	7.8e-08	0.96	0.04	0.96	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RBM6	0.23	0.27	enet	16	0.26	2.7e-08	5.1	-5.4	7.8e-08	0.96	0.04	0.96	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	RBM6	0.27	0.21	enet	14	0.23	5.0e-08	-5.3	-5.4	8.4e-08	0.96	0.04	0.96	FALSE
15	GTEx	Colon Sigmoid	RBM6	0.25	0.19	enet	7	0.13	2.3e-05	-5.3	-5.4	6.8e-08	0.96	0.04	0.96	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	-5.6	-5.1	2.7e-07	0.92	0.04	0.96	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	MST1R	0.18	0.02	lasso	9	0.06	2.4e-03	5.4	5.1	2.9e-07	-0.76	0.05	0.68	FALSE
18	GTEx	Esophagus Muscularis	RBM6	0.22	0.29	lasso	7	0.30	1.1e-18	-5.3	-5.5	3.6e-08	0.98	0.03	0.97	FALSE
19	GTEx	Heart Atrial Appendage	RBM6	0.34	0.36	lasso	6	0.35	1.2e-16	-5.3	-5.4	8.0e-08	0.96	0.04	0.96	FALSE
20	GTEx	Heart Left Ventricle	RBM6	0.09	0.08	enet	10	0.11	3.0e-06	-5.3	-5.4	5.9e-08	0.95	0.06	0.94	FALSE
21	GTEx	Liver	RBM6	0.21	0.11	enet	6	0.09	1.4e-03	5.0	-5.4	8.1e-08	0.95	0.05	0.90	FALSE
22	GTEx	Lung	RBM6	0.17	0.20	lasso	6	0.24	4.6e-18	-5.3	-5.5	4.2e-08	0.95	0.04	0.96	FALSE
23	GTEx	Lung	MST1R	0.06	0.04	lasso	3	0.04	7.5e-04	-5.3	5.4	6.9e-08	-0.95	0.05	0.92	FALSE
24	GTEx	Muscle Skeletal	RBM6	0.11	0.15	enet	13	0.15	3.1e-14	-5.3	-5.5	4.8e-08	0.96	0.04	0.96	FALSE
25	GTEx	Nerve Tibial	RBM6	0.41	0.42	enet	19	0.41	8.8e-31	-5.3	-5.3	9.0e-08	0.96	0.04	0.96	FALSE
26	GTEx	Pancreas	RBM6	0.23	0.20	lasso	4	0.22	1.3e-09	-5.3	-5.3	9.3e-08	0.96	0.04	0.96	FALSE
27	GTEx	Prostate	RBM6	0.14	0.12	enet	15	0.05	1.8e-02	-5.3	-5.6	2.5e-08	0.93	0.05	0.87	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	RBM6	0.16	0.17	enet	24	0.23	1.2e-12	-5.6	-5.5	3.0e-08	0.95	0.04	0.96	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	MST1R	0.05	0.07	enet	7	0.05	7.1e-04	-5.3	5.3	1.1e-07	-0.97	0.04	0.94	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	FAM212A	0.05	0.04	enet	21	0.01	1.1e-01	-5.3	5.3	1.2e-07	-0.97	0.05	0.92	FALSE
31	GTEx	Skin Sun Exposed Lower leg	RBM6	0.23	0.27	lasso	8	0.29	7.6e-24	-5.3	-5.3	9.6e-08	0.96	0.04	0.96	FALSE
32	GTEx	Skin Sun Exposed Lower leg	MST1R	0.06	0.07	lasso	2	0.06	1.1e-05	5.1	5.2	2.5e-07	-0.91	0.04	0.95	FALSE
33	GTEx	Small Intestine Terminal Ileum	MST1R	0.20	0.05	lasso	5	0.10	3.6e-03	4.8	5.4	8.1e-08	-0.90	0.07	0.71	FALSE
34	GTEx	Spleen	RBM6	0.36	0.39	lasso	8	0.40	2.0e-11	-5.3	-5.4	5.3e-08	0.94	0.04	0.96	FALSE
35	GTEx	Stomach	RBM6	0.16	0.22	lasso	11	0.19	2.1e-09	-5.3	-5.3	1.1e-07	0.97	0.04	0.96	FALSE
36	GTEx	Testis	MON1A	0.08	0.06	enet	13	0.05	2.4e-03	4.8	-5.2	2.4e-07	0.88	0.11	0.74	FALSE
37	GTEx	Thyroid	RBM6	0.25	0.35	lasso	15	0.36	1.9e-28	-5.3	-5.3	9.0e-08	0.95	0.04	0.96	FALSE
38	GTEx	Whole Blood	RBM6	0.14	0.19	lasso	3	0.18	2.4e-16	-5.3	-5.3	9.7e-08	0.97	0.04	0.96	FALSE
39	METSIM	Adipose	MST1R	0.03	0.02	blup	331	0.02	1.7e-03	5.0	5.2	2.4e-07	-0.83	0.13	0.85	FALSE
40	METSIM	Adipose	RBM6	0.22	0.34	lasso	15	0.34	1.7e-52	-5.3	-5.5	3.1e-08	1.00	0.04	0.96	FALSE
41	NTR	Blood	RBM6	0.06	0.14	enet	36	0.13	7.9e-40	-5.3	-5.4	8.0e-08	0.96	0.04	0.96	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	5.4	5.6	2.7e-08	-0.88	0.04	0.94	FALSE
43	YFS	Blood	RBM6	0.28	0.43	enet	57	0.44	4.0e-160	-5.3	-5.1	2.7e-07	0.96	0.04	0.96	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RBM6	0.06	0.09	enet	27	0.10	9.3e-09	-5.3	-5.2	2.3e-07	0.96	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RBM6	0.09	0.13	blup	79	0.12	1.6e-06	-5.3	-5.5	4.0e-08	0.96	0.04	0.96	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RBM6	0.04	0.05	blup	79	0.05	2.0e-06	5.1	-5.4	7.0e-08	0.94	0.04	0.96	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MST1R	0.03	0.04	blup	32	0.05	4.0e-06	5.1	5.4	5.4e-08	-0.92	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RBM6	0.09	0.11	blup	79	0.11	3.8e-12	-5.3	-5.3	1.0e-07	0.97	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RBM6	0.14	0.17	lasso	5	0.17	5.7e-10	5.1	-5.6	2.4e-08	0.96	0.04	0.96	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBM6	0.10	0.14	enet	17	0.14	7.7e-16	-5.3	-5.3	1.4e-07	0.97	0.04	0.96	FALSE
51	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RBM6	0.09	0.07	blup	79	0.08	1.3e-04	-5.3	-5.2	2.2e-07	0.94	0.05	0.94	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RBM6	0.05	0.06	lasso	10	0.04	9.1e-06	-5.3	-5.3	1.2e-07	0.97	0.04	0.96	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RBM6	0.06	0.05	enet	6	0.07	7.3e-04	4.0	-5.7	1.4e-08	0.79	0.03	0.70	TRUE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	RBM6	0.09	0.15	enet	16	0.15	1.1e-15	-5.3	-5.3	8.8e-08	0.96	0.04	0.96	FALSE
55	The Cancer Genome Atlas	Stomach Adenocarcinoma	RBM6	0.05	0.05	blup	79	0.06	3.7e-05	-5.3	-5.4	5.6e-08	0.93	0.04	0.92	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	MST1R	0.03	0.01	blup	32	0.03	3.1e-04	5.0	5.4	7.1e-08	-0.93	0.02	0.93	FALSE