[Hub]/) : Traits : Mouth/teeth dental problems: Dentures : →

chr1:154,238,383-155,910,830

Best TWAS P=9.5e-10 · Best GWAS P=1.93e-09 conditioned to 0.0216

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
28	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	5.6	-6.1	9.5e-10	0.72	0.07	0.61	TRUE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	5.6	-6.0	1.8e-09	0.70	0.01	0.96	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAG1AP1	0.07	0.05	blup	77	0.05	3.8e-06	5.2	6.0	2.5e-09	-0.83	0.10	0.89	FALSE
24	GTEx	Pancreas	GBA	0.12	0.05	enet	10	0.02	4.2e-02	-5.5	-5.9	3.0e-09	0.76	0.11	0.68	FALSE
6	GTEx	Brain Cerebellum	THBS3	0.17	0.15	enet	6	0.16	2.0e-05	-5.5	5.9	3.3e-09	-0.77	0.08	0.84	FALSE
14	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	-5.5	-5.9	3.3e-09	0.63	0.08	0.88	FALSE
2	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	-5.5	-5.9	3.8e-09	0.63	0.12	0.88	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	5.2	5.9	4.0e-09	-0.70	0.01	0.56	FALSE
9	GTEx	Brain Frontal Cortex BA9	MTX1P1	0.20	0.05	enet	21	0.01	1.5e-01	5.3	5.8	5.0e-09	-0.71	0.04	0.52	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THBS3	0.02	0.03	lasso	4	0.03	2.1e-04	-5.5	5.7	1.0e-08	-0.63	0.01	0.96	FALSE
7	GTEx	Brain Cerebellum	EFNA1	0.20	0.09	enet	13	0.06	9.2e-03	5.6	-5.7	1.1e-08	0.79	0.08	0.81	FALSE
13	GTEx	Cells Transformed fibroblasts	SLC50A1	0.08	0.07	lasso	6	0.07	3.9e-06	5.6	5.7	1.1e-08	-0.82	0.10	0.90	FALSE
30	GTEx	Spleen	GBAP1	0.33	0.23	enet	20	0.28	7.9e-08	-4.6	-5.7	1.4e-08	0.56	0.24	0.72	FALSE
3	GTEx	Artery Tibial	GBAP1	0.21	0.26	lasso	7	0.26	1.3e-20	-5.5	-5.7	1.5e-08	0.72	0.12	0.88	FALSE
15	GTEx	Colon Transverse	GBAP1	0.13	0.15	lasso	5	0.11	6.4e-06	-5.5	-5.6	2.2e-08	0.61	0.12	0.88	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	-4.5	-5.6	2.4e-08	0.79	0.02	0.98	FALSE
17	GTEx	Esophagus Mucosa	GBAP1	0.12	0.12	enet	22	0.09	1.7e-06	-5.5	-5.6	2.8e-08	0.64	0.14	0.86	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	5.1	-5.5	2.9e-08	0.51	0.12	0.79	FALSE
32	GTEx	Thyroid	GBAP1	0.23	0.28	lasso	10	0.27	4.6e-21	-5.5	-5.5	2.9e-08	0.63	0.11	0.89	FALSE
20	GTEx	Esophagus Mucosa	RP11-263K19.4	0.14	0.14	lasso	4	0.12	1.5e-08	-5.5	5.5	3.0e-08	-0.62	0.11	0.88	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	-5.5	-5.5	3.2e-08	0.59	0.01	0.61	FALSE
4	GTEx	Brain Cerebellar Hemisphere	THBS3	0.19	0.26	lasso	2	0.24	8.6e-07	-5.5	5.5	3.5e-08	-0.61	0.07	0.85	FALSE
33	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	5.4	-5.5	3.5e-08	0.78	0.06	0.76	FALSE
18	GTEx	Esophagus Mucosa	THBS3	0.15	0.15	lasso	2	0.13	6.8e-09	-5.5	5.5	4.0e-08	-0.61	0.12	0.88	FALSE
22	GTEx	Nerve Tibial	GBAP1	0.12	0.14	lasso	1	0.14	8.9e-10	-5.5	-5.5	4.0e-08	0.61	0.13	0.87	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM46	0.08	0.08	lasso	2	0.07	2.1e-05	-5.5	5.5	4.0e-08	-0.61	0.01	0.96	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	GBAP1	0.02	0.03	enet	2	0.02	2.3e-03	-5.5	-5.5	4.3e-08	0.61	0.01	0.83	FALSE
10	GTEx	Breast Mammary Tissue	GBAP1	0.15	0.17	lasso	2	0.15	5.2e-08	-5.5	-5.5	4.4e-08	0.60	0.12	0.88	FALSE
38	The Cancer Genome Atlas	Esophageal Carcinoma	FAM189B	0.36	0.05	lasso	3	0.02	6.1e-02	-5.5	-5.5	4.9e-08	0.61	0.00	0.62	FALSE
5	GTEx	Brain Cerebellar Hemisphere	EFNA1	0.33	0.04	enet	7	0.08	4.5e-03	-4.2	-5.4	5.6e-08	0.70	0.03	0.54	FALSE
27	GTEx	Skin Sun Exposed Lower leg	RP11-263K19.4	0.04	0.01	enet	9	0.01	3.3e-02	-5.5	5.4	5.8e-08	-0.65	0.06	0.82	FALSE
12	GTEx	Cells Transformed fibroblasts	GBAP1	0.18	0.16	lasso	6	0.15	1.6e-11	-5.5	-5.4	6.7e-08	0.63	0.11	0.89	FALSE
21	GTEx	Lung	THBS3	0.11	0.07	lasso	4	0.04	1.0e-03	-5.5	5.3	9.4e-08	-0.60	0.13	0.85	FALSE
19	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	5.2	5.3	1.1e-07	-0.45	0.44	0.56	FALSE
31	GTEx	Spleen	THBS3	0.23	0.10	enet	17	0.08	4.6e-03	5.4	5.3	1.1e-07	-0.84	0.07	0.70	FALSE
23	GTEx	Nerve Tibial	GBA	0.14	0.02	lasso	5	0.01	3.3e-02	-5.5	-5.3	1.2e-07	0.61	0.18	0.60	FALSE
29	GTEx	Spleen	SHC1	0.22	0.14	lasso	2	0.08	4.0e-03	5.4	5.3	1.3e-07	-0.76	0.07	0.55	FALSE
25	GTEx	Prostate	GBAP1	0.47	0.30	lasso	7	0.32	1.1e-08	-5.5	-5.2	1.5e-07	0.66	0.13	0.86	FALSE
8	GTEx	Brain Cortex	GBAP1	0.25	0.14	enet	25	0.23	4.7e-07	-4.6	5.2	1.9e-07	-0.68	0.13	0.82	FALSE
11	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	5.2	-5.2	1.9e-07	0.55	0.04	0.21	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAP1	0.02	0.03	lasso	4	0.03	1.3e-07	-5.5	-5.2	1.9e-07	0.54	0.02	0.98	FALSE
34	GTEx	Whole Blood	THBS3	0.17	0.20	enet	5	0.21	1.0e-18	-5.5	5.2	2.0e-07	-0.61	0.12	0.88	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAP1	0.05	0.04	blup	26	0.04	1.6e-03	-5.5	-5.2	2.1e-07	0.44	0.01	0.79	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	THBS3	0.02	0.02	blup	26	0.02	4.0e-05	-5.5	5.2	2.2e-07	-0.58	0.01	0.98	FALSE
16	GTEx	Colon Transverse	THBS3	0.11	0.09	lasso	4	0.09	5.9e-05	-5.5	5.1	2.7e-07	-0.59	0.11	0.80	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBAP1	0.04	0.04	blup	26	0.04	2.5e-05	5.6	-5.1	2.8e-07	0.76	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	THBS3	0.10	0.12	enet	11	0.10	4.4e-11	-5.5	5.1	2.8e-07	-0.55	0.01	0.99	FALSE