Best TWAS P=4.39e-13 · Best GWAS P=8.77e-16 conditioned to 2.13e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Thyroid | CA12 | 0.33 | 0.27 | enet | 19 | 0.32 | 9.7e-25 | -6.3 | -7.2 | 4.4e-13 | 0.32 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | CA12 | 0.14 | 0.24 | lasso | 4 | 0.23 | 1.4e-22 | -6.7 | -7.0 | 1.9e-12 | 0.34 | 0.98 | 0.02 | TRUE |
| 8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | APH1B | 0.05 | 0.02 | blup | 45 | 0.03 | 1.6e-03 | 6.2 | 5.6 | 2.3e-08 | -0.67 | 0.01 | 0.26 | TRUE |
| 1 | GTEx | Adipose Visceral Omentum | LACTB | 0.16 | 0.11 | lasso | 3 | 0.09 | 2.7e-05 | 4.8 | 5.3 | 1.5e-07 | -0.57 | 0.06 | 0.92 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | CA12 | 0.11 | 0.12 | lasso | 4 | 0.10 | 9.9e-08 | -6.3 | 6.3 | 2.2e-10 | -0.26 | 0.99 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RAB8B | 0.15 | 0.07 | blup | 63 | 0.06 | 1.0e-02 | 6.3 | -6.2 | 4.1e-10 | 0.66 | 0.02 | 0.76 | FALSE |
| 6 | GTEx | Thyroid | APH1B | 0.15 | 0.07 | lasso | 4 | 0.07 | 2.8e-06 | 4.9 | 5.6 | 2.1e-08 | -0.64 | 0.86 | 0.13 | FALSE |
| 2 | GTEx | Artery Tibial | LACTB | 0.14 | 0.14 | enet | 18 | 0.14 | 4.4e-11 | 4.7 | 5.6 | 2.7e-08 | -0.60 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Spleen | LACTB | 0.35 | 0.13 | lasso | 5 | 0.10 | 1.9e-03 | 6.3 | 5.5 | 3.3e-08 | -0.60 | 0.05 | 0.58 | FALSE |