TWAS hub - APH1B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.1520	0.0460	7.3e-05	0.069	NA	0.066	NA	0.073	5.3e-06	NA	8.7e-06	NA	2.8e-06
2	YFS	Blood	0.2992	0.0433	0.0e+00	0.043	0.118	0.116	0.118	0.068	6.1e-14	1.7e-36	5.6e-36	1.8e-36	3.4e-21
3	TCGA	Breast Invasive Carcinoma	0.0257	0.0118	3.4e-04	0.008	0.018	0.011	NA	0.011	6.0e-03	1.2e-04	1.6e-03	NA	1.7e-03
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0600	0.0340	7.8e-03	0.021	0.029	0.009	NA	0.026	1.3e-02	4.6e-03	7.9e-02	NA	7.2e-03
5	TCGA	Prostate Adenocarcinoma	0.0541	0.0239	1.9e-04	0.025	0.038	0.030	NA	0.016	1.1e-03	7.3e-05	4.1e-04	NA	7.9e-03
6	TCGA	Stomach Adenocarcinoma	0.0460	0.0260	8.2e-03	0.017	0.034	-0.001	NA	0.009	2.1e-02	1.6e-03	4.1e-01	NA	6.5e-02
7	TCGA	Thyroid Carcinoma	0.1490	0.0510	8.6e-09	0.027	0.097	0.096	NA	0.103	9.9e-04	1.0e-09	1.3e-09	NA	3.1e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Mouth/teeth dental problems: Dentures	7.8	13.1	31.4	5.6	-0.6	0.6	0.6	3.1	5.6	4.3
Cholesterol lowering medication	4.7	6.9	15.0	-3.3	-1.3	-0.9	-2.0	-2.6	-3.0	-3.9
Diabetes diagnosed by doctor	3.9	6.4	14.6	-1.4	-1.4	-3.2	-2.4	-3.8	-1.3	-2.9
Medication: Gliclazide	3.9	4.4	10.4	-0.2	-0.3	-3.2	-2.7	-3.2	-0.6	-1.4
Supplements: Glucosamine	3.4	4.4	9.0	2.6	0.1	0.7	1.6	2.3	3.0	2.6
HDL Cholesterol	3.3	5.6	14.8	3.5	-0.2	1.2	1.5	1.6	3.9	2.3
Hypothyroidism (self reported)	3.3	7.6	17.3	-4.2	-1.1	-1.9	-1.5	-2.4	-2.7	-4.0
Chronic bronchitis/emphysema (father)	3.2	3.8	7.7	1.3	0.1	1.5	2.8	2.3	2.2	2.2
Medication: Seretide 50 evohaler	3.2	3.7	9.1	2.7	1.0	0.9	1.2	1.4	2.0	3.0
Age started oral contraceptive pill	3.1	3.8	8.7	0.5	-0.5	2.9	2.4	3.0	0.5	1.8
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	9.7	0.8	-0.3	3.1	3.0	2.2	0.9	1.4
Number of children fathered	2.7	3.0	5.6	2.3	-0.3	1.1	1.8	1.7	1.7	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.2	10.0	3.2	-0.0	0.5	1.1	1.0	2.4	2.1
Multivitamins +/- minerals	2.6	3.4	9.7	2.5	-0.9	0.4	1.3	1.2	3.1	1.8
Mineral and other dietary supplements	2.6	3.5	9.4	-3.1	-0.3	-0.9	-1.0	-1.4	-2.7	-2.1
Eye problems/disorders: Glaucoma	2.6	3.1	7.6	2.7	-0.3	1.1	1.0	1.2	1.8	2.8
Schizophrenia (2018)	2.5	5.1	17.3	-4.2	-0.2	0.2	-0.6	-0.7	-3.2	-2.7
Happiness	2.5	3.1	5.4	-2.3	-1.9	-0.3	-0.3	-1.6	-2.2	-2.3
Medication: Ventolin 100micrograms inhaler	2.5	3.2	5.7	2.4	0.4	1.5	2.1	1.6	2.1	1.7
Lupus	2.4	3.7	7.5	2.5	0.9	1.3	1.4	2.1	1.8	2.7
Vitamin and mineral supplements	2.4	3.2	6.3	-2.2	1.2	-1.1	-1.3	-1.8	-2.5	-2.0
Diabetes (self-reported)	2.4	3.7	10.6	-0.3	-0.6	-2.7	-2.0	-3.3	-0.5	-1.9
Loud music exposure frequency	2.4	2.6	3.9	-1.1	-0.5	-1.9	-2.0	-1.8	-1.6	-1.8
Pulse rate, automated reading	2.4	7.7	20.8	4.6	0.6	1.2	1.9	1.5	3.4	3.7
Medication for cholesterol	2.4	3.6	5.4	1.7	1.9	1.0	1.8	2.2	2.1	2.3
Hearing difficulty/problems: Yes	2.2	3.4	7.8	2.3	-0.4	-1.1	1.2	1.3	2.8	2.5
Glaucoma (self-reported)	2.2	2.6	6.2	2.4	-0.1	1.7	0.7	1.3	1.2	2.5
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	12.1	-3.5	-1.6	-0.9	-0.5	-1.2	-1.8	-3.0
Eye problems/disorders: Cataract	2.2	2.5	4.9	-2.2	-1.7	1.5	1.4	1.2	-2.0	0.3
Medication: Atorvastatin	2.2	2.7	6.5	-2.6	-0.4	0.1	-0.6	-1.0	-2.5	-2.1
Lung FEV1/FVC ratio	2.1	10.7	20.7	-2.9	-4.5	-3.2	-2.4	-3.1	-2.1	-4.0
Maternal smoking around birth	2.1	3.0	8.0	2.4	1.1	0.2	1.4	1.3	2.8	1.5
Commuting to job workplace: Car/motor vehicle	2.1	2.5	6.9	-1.4	-0.9	-1.3	-1.3	-1.6	-1.2	-2.6
Medication: Levothyroxine sodium	2.0	3.4	7.5	-2.5	-1.6	-1.9	-0.8	-1.5	-0.9	-2.7
Had menopause	2.0	2.5	5.8	0.3	-0.4	2.4	2.1	2.2	0.5	1.3
Supplements: Vitamin C	2.0	2.3	3.9	1.6	-0.6	0.9	1.4	1.8	2.0	1.9
Alzheimer’s Disease (including proxy)	1.9	2.8	7.7	2.8	0.4	-1.9	-0.9	-0.6	2.3	1.2
Pulse rate	1.9	3.2	7.3	2.0	0.1	1.3	2.1	1.6	2.7	1.4
Prostate Cancer	1.8	2.5	6.6	-2.6	-1.6	1.1	0.7	-0.2	-2.0	-1.7
Overall health rating	1.8	3.8	11.4	-3.4	-1.6	0.3	0.6	-0.7	-1.5	-3.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	5.5	-1.7	-0.3	-1.3	-0.9	-1.6	-1.4	-2.3
Medication: Metformin	1.7	2.4	5.7	1.0	-1.5	-2.4	-1.3	-2.3	0.7	-0.7
Diabetes (father)	1.6	2.0	5.7	0.2	0.0	-2.4	-2.0	-2.0	-0.4	-0.3
Medication: Simvastatin	1.6	2.3	5.5	-0.5	-1.6	-1.6	-1.6	-2.3	-0.7	-1.7
Mean time to correctly identify matches	1.6	3.1	7.1	-2.7	-0.8	0.1	-0.3	-1.5	-2.6	-2.2
Leg pain on walking	1.6	2.0	4.9	-2.2	-1.6	0.5	0.7	0.1	-1.0	-2.1
Osteoarthritis (self-reported)	1.6	2.1	3.7	1.9	1.0	1.5	1.0	1.2	1.5	1.6
Ever had prostate specific antigen (PSA) test	1.6	1.8	4.2	1.3	-0.1	1.8	1.1	1.6	0.1	2.0
Schizophrenia (2014)	1.5	3.4	12.9	-3.6	0.3	1.0	0.6	0.4	-2.2	-2.2
Type 2 Diabetes (T2D) (2018)	1.5	2.8	7.2	0.2	-0.4	-2.5	-1.9	-2.7	-0.2	-1.7
Number of incorrect matches in round	1.5	2.5	8.2	2.3	-0.6	0.5	0.7	1.3	1.2	2.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	4.6	-2.0	-1.0	-0.4	-1.0	-1.6	-2.2	-2.0
Age at first live birth	1.5	2.6	8.7	1.2	0.6	1.2	0.7	2.5	-0.1	3.0
Eye problems/disorders: None of the above	1.5	1.7	4.0	0.3	1.5	-2.0	-1.8	-1.4	-0.2	-0.8
Illnesses of father: Heart disease	1.5	2.1	8.2	-1.6	-0.6	-0.1	-1.2	-1.2	-2.9	-1.0
Illnesses of siblings: Diabetes	1.5	1.8	3.5	-1.0	-0.2	-1.7	-1.2	-1.8	-0.7	-1.9
Hearing aid user	1.5	1.7	5.8	1.7	0.1	0.5	1.3	0.7	2.4	0.8
Reaction Time	1.4	2.6	4.9	-2.1	-0.9	-1.0	-0.8	-1.8	-2.2	-1.9
Triglycerides	1.4	2.3	5.6	-2.2	0.7	-0.4	-1.0	-1.0	-2.4	-1.7
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.4	-1.0	-0.7	1.7	2.1	1.8	-0.2	0.0
Medication: Ramipril	1.4	1.7	7.5	-0.4	-2.7	0.9	-0.2	-0.9	-1.3	-1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	4.0	-1.8	-0.9	0.9	-0.1	-0.6	-2.0	-1.9
Medication: Omeprazole	1.4	1.7	5.6	-1.5	-0.2	-0.8	-0.6	-1.3	-1.1	-2.4
Bipolar Disorder or Schizophrenia	1.3	3.1	12.4	-3.5	-0.1	1.0	0.5	0.4	-2.1	-1.9
Alzheimer’s Disease (in father)	1.3	1.4	3.2	1.6	-0.9	-1.4	-0.5	-0.1	1.8	1.0
Blood Red Count	1.3	12.8	26.4	-1.5	2.6	-4.6	-5.1	-4.5	-2.6	-2.4
Blood White Count	1.3	9.5	14.6	-3.0	-0.1	-3.5	-3.3	-3.8	-2.5	-3.6
Mouth/teeth dental problems	1.3	2.0	5.3	-2.3	1.2	-0.8	-0.4	-1.1	-1.9	-1.5
Ovarian Cancer	1.2	1.6	3.9	1.9	-0.6	0.6	0.9	0.8	1.3	2.0
Primary Biliary Cirrhosis	1.2	1.7	3.5	-1.5	-0.0	-0.6	-1.2	-1.5	-1.9	-1.5
Noisy workplace	1.2	1.5	2.8	1.7	1.7	0.4	0.7	0.6	1.5	1.4
Length of working week for main job	1.2	1.4	4.2	0.3	1.2	-1.4	-2.1	-1.2	-0.4	-0.0
Worry too long after embarrassment	1.2	1.9	9.4	-1.2	-3.1	0.7	0.2	0.4	-1.4	-0.3
Handedness (chirality/laterality): Left-handed	1.2	1.5	4.2	-1.1	-1.5	-0.1	-0.5	-1.4	-0.8	-2.0
Financial situation satisfaction	1.2	1.4	4.0	-1.9	-0.6	-0.3	0.1	-0.9	-1.0	-2.0
Breast Cancer	1.1	2.7	4.7	-0.8	-1.7	-1.9	-2.2	-1.8	-1.3	-1.4
Body Mass Index (BMI) (2010)	1.1	1.5	3.7	-1.6	-0.5	-0.3	-0.9	-1.0	-1.5	-1.9
HbA1C	1.1	1.2	3.5	0.0	0.3	-1.9	-1.1	-1.7	0.1	-0.8
Blood Platelet Count	1.1	12.8	49.3	7.0	2.1	-0.5	0.8	-0.9	5.3	2.4
Systolic blood pressure, automated reading	1.1	3.3	9.4	-3.1	-0.4	1.7	1.0	0.2	-1.6	-2.7
Breastfed as a baby	1.1	1.3	2.6	-1.6	-0.1	1.1	-0.1	-0.9	-1.6	-1.5
Blood clot in the leg (DVT)	1.1	1.5	4.7	0.3	-0.3	1.2	2.2	1.1	1.7	0.1
Emphysema/chronic bronchitis	1.1	1.3	2.3	0.6	-0.7	0.8	1.5	1.3	1.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	6.3	1.2	1.0	-2.5	-1.5	-1.6	1.5	-0.3
Ever had bowel cancer screening	1.1	1.2	3.5	-0.9	0.8	1.9	1.6	0.9	-0.6	-0.1
Guilty feelings	1.1	1.7	6.9	-1.2	-2.6	-1.1	-1.0	0.1	-1.0	-0.6
High cholesterol (Self-reported)	1.1	2.0	4.9	-2.2	0.2	0.1	-0.9	-1.1	-1.9	-1.9
Myopia	1.1	1.7	4.2	1.0	0.9	0.9	1.2	1.6	1.0	2.1
Mean Putamen Volume	1.0	1.1	2.2	0.9	-0.0	0.5	1.1	1.3	1.3	1.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.3	-0.8	0.3	-1.1	-0.4	-1.8	-0.6	-1.5
Supplements: Zinc	1.0	1.1	3.5	1.4	-0.0	0.3	0.8	0.8	1.1	1.9
Trunk fat percentage	1.0	4.0	10.4	-2.0	-2.5	0.7	-0.5	-1.4	-2.1	-3.2
Nervous feelings	1.0	1.9	6.8	-1.7	-2.6	0.1	-0.2	0.1	-1.9	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	4.7	-0.7	-2.2	-2.0	-2.1	-2.0	-1.1	-1.6
Exposure to tobacco smoke at home	1.0	1.1	2.3	1.1	0.8	0.3	0.9	0.7	1.5	1.4
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.6	0.8	1.4	-1.9	-1.7	-1.4	0.3	0.2
Body fat percentage	1.0	3.9	11.5	-2.0	-2.3	0.5	-0.6	-1.5	-2.0	-3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	4.2	0.8	-0.4	0.2	1.0	1.6	0.9	2.0
Arm fat percentage (left)	1.0	4.2	11.3	-2.3	-2.5	0.8	-0.3	-1.3	-2.1	-3.4
Arm fat mass (left)	1.0	3.9	11.4	-2.0	-2.0	-0.1	-1.1	-1.9	-1.8	-3.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.0	2.0	0.5	0.0	0.3	0.7	1.7	1.2
Smoking Status	0.9	2.1	8.2	0.2	-1.0	-2.9	-1.4	-1.5	0.5	-0.7
Respiratory disease	0.9	2.0	3.6	0.9	-0.9	1.1	1.9	1.6	1.7	1.4
Hand grip strength (left)	0.9	2.3	5.0	-0.6	0.4	-2.2	-2.2	-1.7	-0.3	-1.7
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.0	-1.3	-0.8	-0.9	-0.4	-1.1	-0.9	-2.0
Medication for hormone replacement therapy	0.9	1.0	2.8	-0.2	-0.4	-1.0	-1.1	-1.7	-0.7	-1.0
Serious illness, injury or assault to yourself	0.9	1.1	3.8	-2.0	-0.9	-0.2	0.5	0.1	-0.0	-1.6
Arm fat percentage (right)	0.9	3.6	9.7	-1.9	-2.5	0.8	-0.3	-1.2	-1.9	-3.1
Depression (self-reported)	0.9	1.1	4.0	0.2	0.4	-2.0	-1.6	-0.4	-0.4	0.7
Medication: Lansoprazole	0.9	1.1	3.1	0.0	-0.4	-1.8	-1.0	-1.4	0.1	-1.0
Pulse wave reflection index	0.9	1.1	2.3	-1.5	0.7	0.2	-0.5	-0.7	-1.3	-1.5
Number of full brothers	0.9	1.1	5.8	-0.4	-2.4	-0.3	0.0	-1.2	-0.6	0.1
Whole body fat mass	0.9	3.7	10.8	-1.8	-1.8	-0.0	-1.1	-1.9	-1.8	-3.3
Family relationship satisfaction	0.9	1.1	2.6	-1.6	-0.5	1.2	1.0	0.5	-1.0	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.1	1.4	1.2	-0.9	-1.0	-1.4	0.7	-0.2
Long-standing illness, disability or infirmity	0.9	1.4	4.0	0.2	-0.8	1.4	2.0	1.3	1.1	0.7
Wears glasses or contact lenses	0.9	1.0	3.2	0.5	-1.8	1.2	1.1	0.5	-0.2	0.9
Medication: Paracetamol	0.9	1.4	3.0	-1.1	-1.5	1.0	1.7	0.9	0.5	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.5	0.3	-0.2	0.9	1.9	1.1	1.6	0.1
Bipolar Disorder (2011)	0.8	0.8	2.8	-1.7	-0.8	0.1	0.8	1.0	0.2	-0.4
Average weekly spirits intake	0.8	1.0	3.3	1.8	0.3	-0.6	-0.5	-0.2	1.4	0.8
Relative age of first facial hair	0.8	1.6	3.7	1.2	-0.9	-1.9	-1.6	-1.6	-0.6	0.3
Medication: Co-codamol	0.8	0.9	3.2	-1.0	-1.8	0.3	0.2	-0.7	-0.7	-1.2
Hand grip strength (right)	0.8	2.2	4.2	-1.1	0.7	-1.5	-2.0	-1.6	-0.8	-1.9
Townsend deprivation index at recruitment	0.8	1.1	1.7	1.3	1.1	1.0	1.2	0.2	1.3	0.8
Body mass index (BMI)	0.8	3.3	10.4	-2.1	-1.9	0.3	-0.5	-1.5	-1.4	-3.2
Waist circumference	0.8	3.0	9.9	-1.7	-1.5	-0.1	-0.8	-1.8	-1.2	-3.1
Had other major operations	0.8	0.9	3.1	0.7	-0.3	1.8	1.3	0.9	0.5	0.2
Financial difficulties in last 2 years	0.8	1.1	3.6	0.1	-0.9	-1.9	-0.7	-1.5	0.4	-0.4
Hip circumference	0.8	3.4	11.4	-2.6	-1.1	1.3	0.2	-0.9	-1.5	-3.4
Alcohol intake versus 10 years previously	0.8	1.2	3.6	1.3	0.7	0.3	1.4	0.1	1.9	0.6
Number of live births	0.8	1.2	2.2	-0.7	0.2	-1.4	-1.3	-1.5	-0.8	-1.1
Asthma	0.8	1.6	4.2	0.3	-0.1	1.3	2.1	1.5	1.4	1.0
Arm fat mass (right)	0.8	3.3	9.5	-1.7	-2.2	0.1	-0.9	-1.6	-1.6	-3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.4	0.9	-0.2	0.1	1.1	1.3	1.2	1.9
Birth weight of first child	0.8	1.4	3.1	0.6	-0.2	0.9	1.7	1.4	1.8	0.8
Peak expiratory flow (PEF)	0.8	1.8	8.0	-0.4	-2.8	-1.4	-0.6	-1.2	-0.0	-0.9
Medication: Amlodipine	0.8	1.2	3.7	-1.9	-0.3	-0.3	-0.3	-0.6	-1.9	-0.8
Comparative body size at age 10	0.8	2.3	6.1	0.4	-0.7	2.5	2.2	1.7	0.5	1.1
Had major operations	0.8	0.9	3.3	0.6	-1.8	1.1	1.0	0.3	0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.9	-0.6	0.7	-0.7	-0.5	-1.2	-0.0	-2.0
Breast cancer (self-reported)	0.8	1.0	2.8	-1.4	0.1	0.7	-0.0	-0.5	-1.7	-1.1
Asthma (self-reported)	0.8	1.5	4.4	0.1	0.0	1.2	2.1	1.5	1.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.6	-0.6	-1.6	-1.6	-1.1	-1.6	-0.2	-1.6
Risk taking	0.8	1.2	3.4	1.3	-0.1	-1.8	-1.1	-0.5	1.1	0.9
Depression (Nagel 2018)	0.7	1.1	4.2	-0.9	-1.0	-0.4	-0.3	-1.2	-0.2	-2.0
Worry (Nagel 2018)	0.7	1.4	2.8	0.2	-1.7	0.9	1.1	1.6	0.7	1.3
Neuroticism (2016)	0.7	1.1	1.9	1.0	-0.9	1.4	1.2	1.0	0.7	0.9
Systolic Blood Pressure	0.7	3.4	9.6	-3.1	-0.5	0.8	-0.2	-0.6	-2.2	-2.9
Ever had hysterectomy (womb removed)	0.7	0.8	3.7	0.3	1.9	-0.6	-0.7	-0.8	-0.1	-0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.9	-1.7	-0.9	0.2	0.3	0.6	-0.9	-0.7
Trunk fat mass	0.7	3.2	9.3	-1.6	-2.0	0.2	-0.9	-1.6	-1.7	-3.0
Illnesses of siblings	0.7	1.0	1.9	0.9	0.8	0.7	0.8	1.2	1.4	1.0
Time employed in main current job	0.7	0.9	2.0	-1.1	1.3	0.6	-0.6	-0.3	-1.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.8	1.7	0.8	-0.3	0.4	0.8	1.4	2.2
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	0.4	1.2	1.3	1.1	1.0	0.3	0.6
Exposure to tobacco smoke outside home	0.7	0.9	3.1	0.4	-0.7	-1.8	-0.8	-0.5	1.1	-0.5
Angina (self-reported)	0.7	0.9	1.9	0.8	-1.4	0.5	1.0	0.7	0.7	1.3
Commuting to job workplace: Public transport	0.7	0.9	2.2	-1.5	-0.6	0.8	0.4	-0.4	-1.3	-0.9
Leg fat percentage (left)	0.7	2.6	8.8	-1.3	-1.8	0.1	-0.9	-1.5	-1.2	-3.0
Pain experienced in last month	0.7	1.2	4.1	2.0	0.5	0.5	-0.2	0.4	0.4	1.8
Heart disease (siblings)	0.7	0.8	1.6	-1.3	-0.7	0.4	0.5	-0.7	-1.1	-1.2
Pack years of smoking	0.7	1.0	2.8	-0.7	-0.9	1.7	1.6	0.5	-0.3	-0.1
Bipolar Disorder (2018)	0.6	0.9	2.4	-0.4	0.1	1.2	1.6	1.5	0.6	0.4
Neuroticism (Nagel 2018)	0.6	1.5	4.6	0.3	-2.1	1.0	1.2	1.4	1.0	0.7
Schizophrenia vs Biploar Disorder	0.6	0.7	2.0	-1.2	0.4	-0.2	-0.8	-0.4	-1.4	-0.8
Coronary Artery Disease (CAD)	0.6	0.7	1.3	-1.0	0.6	-0.6	-0.4	-1.0	-1.1	-0.7
Crohns Disease (2012)	0.6	1.0	3.0	-1.7	0.6	0.9	0.2	0.2	-1.2	-1.1
Fasting Glucose	0.6	0.7	1.5	-1.1	-1.2	-1.2	0.0	-0.5	-0.0	-0.8
Waist Hip Ratio (WHR)	0.6	2.8	8.8	3.0	-1.3	-1.0	-0.5	-0.3	2.1	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.4	-1.1	0.4	0.4	0.1	-0.8	-0.4	-1.8
Taking other prescription medications	0.6	0.9	2.3	-0.2	-1.5	0.9	1.5	0.7	0.4	-0.5
Sitting height	0.6	4.3	14.5	1.3	0.5	-2.8	-3.8	-2.2	-0.7	0.2
Past tobacco smoking	0.6	1.1	4.5	-0.2	-0.2	2.1	1.2	1.1	-0.3	0.1
Weight	0.6	2.8	7.9	-1.5	-1.5	-0.4	-1.3	-1.9	-1.4	-2.8
Worrier / anxious feelings	0.6	1.2	3.0	0.1	-1.7	1.1	0.5	1.5	-0.1	1.2
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.0	0.3	-1.7	-2.0	-1.6	-1.8	-0.0	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	-1.4	0.9	0.5	0.6	-0.2	-0.4	-1.2
Tense / ‘highly strung’	0.6	1.0	3.0	-0.6	-0.8	1.1	1.1	1.7	-0.2	0.5
Hair/balding pattern: Pattern 4	0.6	1.5	3.0	-1.7	1.1	1.2	1.1	1.7	-1.1	-0.0
Gout (self-reported)	0.6	0.8	2.3	-1.5	0.3	0.6	0.9	0.8	-0.5	-1.1
Leg fat percentage (right)	0.6	2.0	7.5	-0.9	-1.5	-0.2	-0.9	-1.5	-0.8	-2.7
Wheeze or whistling in the chest in last year	0.6	1.1	2.3	0.8	-0.3	1.2	1.5	1.1	1.0	1.0
Health satisfaction	0.6	0.8	1.8	-1.1	-1.0	0.4	1.3	0.3	-0.0	-1.0
Neck or shoulder pain in last month	0.6	0.9	2.9	-0.5	0.1	1.2	1.7	0.5	0.8	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	0.6	0.9	-0.8	-1.2	-0.7	-0.5	0.5
Osteoporosis (self-reported)	0.6	0.7	3.2	-0.3	0.7	1.8	1.1	0.4	-0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.6	3.2	0.5	-1.8	0.1	0.6	0.5	0.4	0.5
Illnesses of father: High blood pressure	0.6	0.7	2.0	-0.2	0.3	-1.0	-1.4	-0.6	-1.1	-0.3
Alcohol drinker status: Never	0.6	0.8	2.2	0.4	-1.5	1.2	1.1	0.2	0.1	0.6
Ever smoked	0.6	1.0	5.2	0.1	-0.0	-2.3	-1.2	-0.7	0.2	0.3
Commuting to job workplace: Cycle	0.6	0.8	2.3	0.9	0.1	-1.5	-0.6	-0.8	1.1	0.1
Alcohol drinker status: Previous	0.6	0.7	1.7	1.1	-1.3	0.1	0.3	-0.4	1.2	-0.4
Leg fat mass (left)	0.6	2.2	7.3	-1.2	-1.5	0.1	-0.9	-1.6	-1.1	-2.7
Age at First Birth	0.5	0.8	1.9	-0.9	0.5	1.4	1.0	1.0	-0.7	0.3
Rheumatoid Arthritis	0.5	0.7	2.2	1.4	-0.0	-0.7	-0.2	-0.3	1.5	0.5
Lung FVC	0.5	2.3	5.0	-2.2	-1.9	-0.2	-0.2	-0.7	-1.9	-1.9
Angina	0.5	0.6	1.3	0.7	-1.1	0.4	0.8	0.6	0.6	1.1
Severe depression (siblings)	0.5	0.6	1.3	1.0	0.2	0.7	0.4	0.8	1.2	0.5
Pack years adult smoking proportion	0.5	0.8	1.9	-0.8	-0.9	1.4	1.3	0.2	-0.3	-0.4
Medication: Atenolol	0.5	0.6	1.9	0.6	-1.4	0.5	0.7	0.5	0.7	0.5
Hair/balding pattern: Pattern 2	0.5	0.6	0.9	0.9	-0.5	-0.9	-0.4	-0.9	0.8	-0.8
Prospective memory result	0.5	0.6	1.4	0.3	1.0	-0.0	1.2	0.5	0.9	0.8
Lung cancer (father)	0.5	0.6	1.5	0.5	0.2	-1.2	-0.8	-1.0	0.5	-0.6
Medication: Paracetamol	0.5	0.9	2.1	-0.9	-1.4	0.7	1.4	0.6	0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	3.3	-0.1	-1.8	-0.7	0.1	-0.2	-0.1	-0.1
Shortness of breath walking on level ground	0.5	0.6	2.1	-1.5	-1.1	0.1	0.2	0.3	-0.8	-0.4
Leg fat mass (right)	0.5	1.9	6.7	-1.0	-1.3	0.1	-0.9	-1.5	-0.9	-2.6
Loneliness, isolation	0.5	0.8	1.8	-0.8	-1.3	0.8	1.0	-0.1	-0.0	-1.1
Friendships satisfaction	0.5	0.6	1.8	-0.9	-1.3	0.5	0.7	0.8	-0.1	0.2
Medication: Aspirin	0.5	0.7	1.5	0.9	-0.9	0.7	1.0	0.3	1.2	0.2
Miserableness	0.5	0.9	2.7	1.0	-0.1	-1.4	-0.2	-0.7	1.6	-0.3
Number of operations (self-reported)	0.5	0.8	1.6	0.8	-1.3	1.2	1.0	0.6	0.3	0.4
Ever depressed for a whole week	0.5	0.6	1.9	0.7	-0.3	0.7	1.4	0.6	0.6	0.7
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	0.5	0.5	-1.1	-0.9	-0.5	0.5	-0.2
Crohns Disease (2017)	0.4	0.9	2.9	-0.8	0.1	1.7	0.4	1.0	-1.4	0.1
Major Depression (MDD)	0.4	0.4	0.9	0.5	-0.3	-0.9	-0.9	-0.9	-0.4	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	-0.7	-0.5	-1.1	-0.3	-0.7	0.3	-0.9
Blood Eosinophil Count	0.4	3.3	8.3	-2.6	-0.8	1.6	0.6	-0.5	-2.9	-2.0
Heel T-Score	0.4	3.4	7.6	-2.8	0.5	-0.6	-1.7	-1.4	-2.6	-1.9
Neuroticism	0.4	1.0	2.3	0.4	-0.7	1.5	1.1	1.5	0.5	0.8
Number of treatments/medications taken	0.4	0.8	1.7	0.3	-1.3	0.6	1.3	0.7	1.0	0.2
Impedance of leg (right)	0.4	1.8	3.6	1.9	1.2	-1.7	-1.2	-0.6	1.0	1.1
Average weekly fortified wine intake	0.4	0.5	1.6	-0.3	-0.1	0.5	0.6	1.3	-0.1	1.1
Stomach or abdominal pain in last month	0.4	0.5	1.7	-1.3	1.3	-0.0	0.1	0.6	-0.4	0.1
Neuroticism score	0.4	0.7	2.3	0.1	-1.5	1.0	0.9	0.9	0.2	0.3
Father’s age at death	0.4	0.5	1.5	0.5	-0.4	0.9	1.2	0.6	0.6	0.6
Medication: Cholesterol lowering	0.4	0.6	1.5	1.2	-0.0	-0.7	-0.5	-1.2	0.5	0.5
Heart disease (mother)	0.4	0.4	1.0	-0.1	-0.7	0.7	0.8	1.0	0.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.6	-0.0	-1.6	0.4	0.6	0.1	0.2	-0.1
Alcohol intake frequency.	0.4	0.9	3.0	-1.0	-0.9	0.1	0.2	-1.2	-0.4	-1.7
Chest pain or discomfort	0.4	0.6	3.1	-0.4	1.8	-0.2	0.3	0.0	0.7	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	-0.8	-0.9	-0.9	-0.6	-1.0	-1.1	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	0.5	1.3	-0.1	-0.2	-0.1	1.0	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.6	-0.8	-0.5	0.4	1.3	-0.2	0.5	-1.0
Medication: Lisinopril	0.4	0.6	1.8	-0.4	0.2	-0.5	-0.5	-1.2	-0.2	-1.4
Arm fat-free mass (left)	0.4	1.9	4.5	-0.5	-0.2	-1.5	-2.1	-1.8	-0.6	-1.6
Irritability	0.4	0.7	1.2	0.9	0.9	1.1	1.0	0.5	0.5	0.6
Depressed Affect (Nagel 2018)	0.3	0.5	1.1	0.1	-1.0	0.6	0.9	0.1	1.0	-0.8
Irritable Bowel Disease (IBD)	0.3	0.8	2.8	-0.4	0.5	1.7	0.5	0.9	-1.1	0.2
LDL Cholesterol	0.3	0.5	1.8	-0.2	0.1	1.3	0.4	1.1	-0.5	0.4
BMI	0.3	1.7	6.4	-1.0	-1.2	-0.4	-0.6	-1.5	-0.7	-2.5
Sensitivity / hurt feelings	0.3	0.5	2.4	0.6	-0.5	-0.1	0.4	0.8	1.5	-0.0
Fed-up feelings	0.3	0.5	1.9	0.1	0.4	-0.2	-0.5	-1.1	0.3	-1.4
Relative age voice broke	0.3	0.5	1.0	1.0	0.4	-1.0	-0.8	-0.8	-0.5	0.2
Age when periods started (menarche)	0.3	0.6	1.3	1.1	-0.5	-0.6	0.1	0.2	1.1	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.6	-1.6	0.4	0.3	0.1	-0.0	-1.0	-1.0
Hearing difficulty/problems with background noise	0.3	0.5	2.8	-0.4	0.6	-1.7	-0.6	-0.3	-0.3	0.1
Forced vital capacity (FVC)	0.3	1.3	3.1	1.0	-0.5	-1.8	-1.5	-1.4	0.2	0.1
Heart attack	0.3	0.4	1.2	-0.3	-0.5	-0.0	-0.1	-1.1	-0.1	-1.1
Allergy	0.3	0.6	1.5	-0.1	-0.2	-0.3	-1.2	-1.2	-1.0	-0.3
Pain all over the body in last month	0.3	0.4	1.6	-0.6	-1.3	-0.1	0.6	0.5	0.3	-0.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	0.3	0.1	0.4	0.8	0.9	0.5	0.7
Forced vital capacity (FVC), Best measure	0.3	1.2	2.5	-0.4	-0.8	-1.4	-1.6	-1.4	-1.0	-0.8
Arm fat-free mass (right)	0.3	1.8	3.4	-0.9	0.2	-1.3	-1.7	-1.8	-0.5	-1.8
Qualifications: College or University degree	0.3	1.0	4.4	0.1	-0.5	-0.1	0.6	1.4	-0.2	2.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.7	-0.5	0.6	-0.7	-1.3	-0.1	-1.0	0.6
Medication: Allopurinol	0.3	0.4	1.2	-0.3	0.6	0.2	1.1	0.6	0.7	-0.5
Arm predicted mass (right)	0.3	1.4	2.9	-0.5	0.1	-1.4	-1.7	-1.6	-0.2	-1.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	0.7	-0.3	0.6	-0.1	0.5	-0.7	1.1
Smoking status: Previous	0.3	0.4	1.4	0.3	0.3	-1.2	-0.4	-0.8	0.6	-0.3
Average weekly champagne plus white wine intake	0.3	0.4	1.2	0.2	-0.2	0.0	-1.0	-0.7	-1.1	-0.0
Supplements: Calcium	0.3	0.3	0.9	0.9	0.1	0.3	0.3	-0.1	0.8	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	0.4	0.5	0.6	0.8	0.9	0.0	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.3	-0.5	-0.0	0.1	-1.1	0.1	-1.1
Arm predicted mass (left)	0.3	1.6	3.6	-0.4	-0.0	-1.4	-1.9	-1.8	-0.3	-1.5
Ulcerative Colitis (UC)	0.2	0.3	0.6	0.7	0.8	0.6	0.2	0.5	0.2	0.4
Ulcerative Colitis	0.2	0.2	0.9	-0.2	0.1	1.0	0.2	0.6	-0.3	-0.0
Allergy or Eczema	0.2	0.5	1.8	1.3	0.5	-0.7	0.0	0.2	0.8	0.8
Cardiovascular Disease	0.2	0.6	1.1	-1.0	-0.0	-0.5	-1.0	-0.7	-0.8	-1.0
Chronotype (morning person)	0.2	0.4	0.9	0.7	0.8	0.1	0.3	0.2	0.8	0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	-0.6	-0.9	-0.1	-0.2	0.1	-0.4	-0.4
Diabetes (mother)	0.2	0.3	0.7	-0.3	-0.5	0.4	-0.4	-0.5	-0.9	-0.4
Current tobacco smoking	0.2	0.4	0.8	0.8	-0.9	-0.5	0.1	0.1	0.8	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	-0.2	0.9	-0.1	-0.6	-0.5	-0.6	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.9	0.3	0.1	-1.0	-0.6	-0.3	0.3	0.5
High blood pressure (mother)	0.2	0.3	0.8	0.0	0.4	-0.8	-0.9	-0.1	0.3	-0.5
Impedance of leg (left)	0.2	0.9	1.9	1.2	0.9	-1.4	-1.2	-0.6	0.2	0.6
Alcohol usually taken with meals	0.2	0.4	1.7	0.6	1.3	0.3	0.3	0.2	0.4	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	-0.9	0.9	-0.0	-0.2	-0.1	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.6	0.1	-0.8	-0.1	-0.4	0.8	-0.0
Impedance of arm (right)	0.2	1.1	2.3	1.0	-0.4	1.0	1.3	1.3	0.1	1.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.5	0.3	0.4	0.5	-0.2	0.0	-0.8
Headache pain in last month	0.2	0.4	0.8	-0.7	0.6	-0.9	-0.5	-0.6	-0.3	-0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.8	0.2	0.2	-0.1	0.1	-0.6	-0.8
Pulse wave peak to peak time	0.2	0.3	0.8	0.6	-0.4	-0.4	-0.5	0.2	0.0	0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.2	-0.4	-0.3	-0.7	-0.4	-0.7	0.3
Migraine (self-reported)	0.2	0.3	0.7	0.8	0.6	-0.3	-0.7	-0.2	-0.1	0.4
Medication: Ibuprofen	0.2	0.3	1.0	0.3	-0.5	1.0	0.7	-0.0	-0.1	-0.5
Suffer from ‘nerves’	0.2	0.2	1.1	-0.7	-1.0	-0.1	0.0	0.1	-0.4	0.0
Age at last live birth	0.2	0.4	1.7	-0.0	0.1	-0.0	-0.3	0.4	-0.7	1.3
Medication: Aspirin	0.2	0.2	0.6	0.5	-0.7	0.2	0.5	0.1	0.8	0.0
Knee pain experienced in last month	0.2	0.4	1.6	-0.5	-1.3	-0.3	0.0	0.0	-0.1	-0.8
Leg fat-free mass (right)	0.2	0.9	1.9	-1.2	-1.0	0.2	-0.4	-0.6	-1.1	-1.4
Mood swings	0.2	0.4	0.9	0.1	0.0	0.5	1.0	0.8	0.9	0.2
Back pain experienced in last month	0.2	0.4	0.8	0.5	-0.4	-0.8	-0.5	-0.9	0.4	-0.4
Smoking status: Current	0.2	0.3	0.9	0.7	-0.9	-0.5	-0.2	-0.0	0.6	0.5
Leg predicted mass (right)	0.2	0.8	1.9	-1.2	-0.9	0.2	-0.4	-0.6	-1.0	-1.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	0.3	-0.7	0.2	0.8	0.5	0.5	0.9
Medication: Blood pressure	0.2	0.4	0.7	-0.6	-0.7	0.7	-0.2	-0.6	-0.8	-0.8
Basal metabolic rate	0.2	1.0	2.2	-0.6	-0.4	-0.7	-1.2	-1.3	-0.5	-1.5
Average weekly beer plus cider intake	0.2	0.3	1.4	0.3	1.2	-0.1	-0.7	-0.0	0.1	0.4
Fractured/broken bones in last 5 years	0.2	0.3	1.0	0.2	0.0	-0.4	-0.6	1.0	0.4	0.3
Diastolic blood pressure, automated reading	0.2	0.6	1.2	-0.5	1.1	1.0	1.0	0.7	0.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	-0.7	0.1	0.6	0.1	-0.2	-0.7	0.2
Height	0.1	1.9	4.5	1.0	1.2	-2.1	-2.0	-1.5	0.2	0.5
Hair Pigment	0.1	2.1	5.6	-0.2	0.6	-2.3	-2.4	-1.5	-0.9	-0.7
Tanning	0.1	1.8	3.8	1.9	0.1	0.3	0.8	1.4	1.6	1.9
Leg fat-free mass (left)	0.1	0.6	1.7	-0.9	-0.7	-0.0	-0.5	-0.8	-0.7	-1.3
High blood pressure	0.1	0.3	1.3	-0.3	-0.2	-0.2	-0.6	-0.8	-0.1	-1.1
Leg predicted mass (left)	0.1	0.6	1.7	-1.0	-0.7	-0.0	-0.5	-0.7	-0.7	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.0	-0.6	-0.6	0.1	-0.3	0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.3	0.1	0.5	0.5	-0.0	-0.0	-0.1
Fluid intelligence score	0.1	0.2	0.8	0.0	0.8	0.3	0.2	0.3	0.2	0.9
Trunk fat-free mass	0.1	0.9	2.0	0.4	0.6	-1.3	-1.4	-1.1	0.4	-0.6
Falls in the last year	0.1	0.2	0.6	-0.6	-0.5	0.2	-0.1	0.1	-0.8	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.2	-0.3	-0.2	-0.4	-0.2	-0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.5	0.7	0.1	0.7	0.4	-0.4	-0.1	-0.1
Illnesses of mother	0.1	0.1	0.3	0.0	0.2	0.4	0.2	-0.5	-0.4	0.5
Impedance of arm (left)	0.1	0.5	1.0	0.5	-0.4	0.7	1.0	0.8	-0.3	1.0
Trunk predicted mass	0.1	0.8	1.9	0.4	0.5	-1.3	-1.4	-1.2	0.4	-0.7
Standing height	0.1	1.2	3.1	1.0	0.5	-1.6	-1.8	-1.1	-0.1	0.4
Birth weight	0.1	0.3	0.7	-0.3	-0.5	0.7	-0.2	-0.5	-0.9	-0.4
High blood pressure (siblings)	0.1	0.1	0.7	0.2	-0.8	0.1	-0.2	0.1	-0.3	0.4
Medication: Blood pressure	0.1	0.3	0.5	0.1	-0.6	0.5	0.7	0.6	0.6	0.0
Comparative height size at age 10	0.1	0.5	1.3	1.1	-0.2	0.3	0.4	0.2	1.1	0.7
Number of full sisters	0.1	0.2	0.4	0.4	0.3	-0.4	0.1	-0.5	0.6	0.5
Hypertension (Self-reported)	0.1	0.3	1.4	-0.6	-0.1	0.2	-0.2	-0.6	-0.1	-1.2
Whole body fat-free mass	0.1	0.5	1.0	-0.4	-0.0	-0.6	-1.0	-0.9	-0.2	-1.0
Average weekly red wine intake	0.1	0.2	0.5	0.0	0.0	-0.3	-0.7	-0.5	-0.2	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.6	0.8	-0.6	0.3	-0.0	-0.4	-0.2	0.3
Commuting to job workplace: Walk	0.1	0.1	0.5	0.1	0.0	-0.4	-0.3	0.3	0.2	0.7
Whole body water mass	0.1	0.7	1.3	-0.6	-0.1	-0.7	-1.1	-1.1	-0.3	-1.2
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.1	0.2	-0.2	-0.5	-0.2	-0.5	-0.0
Mother’s age at death	0.1	0.2	0.6	0.6	0.4	-0.0	-0.8	-0.0	-0.1	0.2
Unable to work because of sickness or disability	0.1	0.1	0.5	0.1	-0.1	-0.7	-0.2	-0.6	-0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.8	0.0	0.3	0.3	0.5	0.7	-0.1	0.9
Impedance of whole body	0.1	0.3	1.0	0.9	-0.0	-0.4	-0.2	0.1	-0.1	1.0
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	0.1	-0.2	-0.1	-0.2	0.2	0.0	0.7
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.1	-0.2	-0.1	0.5	0.4	0.1	-0.1
Qualifications: None of the above	0.0	0.1	0.3	-0.0	0.3	0.2	0.4	-0.0	0.2	-0.6
Medication: Bendroflumethiazide	0.0	0.1	0.2	0.1	-0.4	0.3	-0.4	0.0	0.0	-0.1

Hub : Genes

APH1B

Models

Trait associations