Hub : Genes

CA12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2480	0.0530	2.1e-12	0.146	0.094	0.178	0.165	0.171	2.0e-17	1.5e-11	3.4e-21	1.5e-19	2.6e-20
2	GTEx	Adipose Subcutaneous	0.1660	0.0530	2.1e-04	0.006	NA	0.035	NA	0.007	9.4e-02	NA	6.7e-04	NA	8.6e-02
3	GTEx	Brain Cerebellar Hemisphere	0.2290	0.0890	9.2e-03	-0.003	NA	0.082	NA	0.050	3.8e-01	NA	4.0e-03	NA	2.1e-02
4	GTEx	Cells Transformed fibroblasts	0.1140	0.0440	4.4e-04	0.115	NA	0.043	NA	0.097	6.5e-09	NA	3.4e-04	NA	9.9e-08
5	GTEx	Thyroid	0.3260	0.0500	5.6e-17	0.274	NA	0.316	NA	0.309	4.1e-21	NA	9.8e-25	NA	4.3e-24
6	METSIM	Adipose	0.0455	0.0178	5.1e-04	0.014	0.020	0.025	0.018	0.017	3.2e-03	4.2e-04	1.1e-04	9.7e-04	1.1e-03
7	TCGA	Esophageal Carcinoma	0.3720	0.1170	4.1e-03	0.009	0.001	0.004	NA	-0.003	1.6e-01	3.0e-01	2.3e-01	NA	4.3e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0673	0.0310	6.4e-03	0.005	0.020	0.016	NA	0.004	7.9e-02	2.5e-03	5.2e-03	NA	9.4e-02
9	TCGA	Brain Lower Grade Glioma	0.0754	0.0282	1.1e-04	0.000	0.028	0.017	NA	0.005	3.0e-01	3.2e-04	4.8e-03	NA	8.5e-02
10	TCGA	Thyroid Carcinoma	0.1360	0.0350	0.0e+00	0.239	0.224	0.232	NA	0.234	4.4e-23	1.6e-21	2.4e-22	NA	1.4e-22

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	3.2	5.0	10.3	-3.2	-2.2	-2.2	-2.6	2.5	-1.9	-1.1	0.9	-2.8	1.9
Bipolar Disorder or Schizophrenia	3.4	8.3	15.5	-3.9	-2.0	-3.3	-3.1	3.1	-3.1	-1.3	1.4	-3.3	2.9
Depressed Affect (Nagel 2018)	0.3	0.5	3.4	-0.9	-1.8	-0.6	-0.4	0.3	-0.1	0.7	0.6	0.1	0.0
Depression (Nagel 2018)	1.3	1.9	5.3	-1.9	-2.3	-0.8	-1.1	1.7	-0.9	0.8	0.2	-0.5	1.9
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.9	0.2	-0.2	0.3	1.7	-1.5	1.3	-1.0	1.3	-0.4	-0.5
Neuroticism (Nagel 2018)	0.3	0.8	1.9	-0.8	-0.5	-0.4	0.8	-1.3	-0.1	0.3	1.3	-1.1	-1.4
Schizophrenia (2018)	1.8	3.8	6.5	-2.5	-0.8	-2.5	-1.8	1.9	-2.5	-0.9	1.1	-1.9	2.2
Schizophrenia vs Biploar Disorder	0.8	1.0	4.0	0.1	2.0	0.4	1.1	-0.9	0.2	-1.4	0.6	-0.4	-1.2
Worry (Nagel 2018)	0.4	0.8	1.7	-0.4	0.6	-1.1	0.5	-1.0	-1.1	-0.1	1.3	-0.9	-0.9
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	-1.1	-0.5	0.5	-0.6	0.6	-0.4	0.7	0.5	-1.1	0.4
Alzheimer’s Disease (in father)	1.1	1.2	2.1	1.2	-0.5	1.2	1.3	-1.4	1.0	0.4	1.1	0.5	-1.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.9	-0.3	-0.5	1.4	0.5	-0.4	1.0	0.6	0.9	-0.6	-0.9
Crohns Disease (2017)	1.7	3.8	9.1	2.0	1.8	1.6	3.0	-2.6	1.4	-1.4	-0.8	0.5	-2.7
Irritable Bowel Disease (IBD)	1.3	3.0	5.7	2.4	1.4	1.4	2.4	-2.3	0.8	-0.1	-1.1	1.3	-2.4
Ulcerative Colitis (UC)	0.5	0.9	1.7	1.3	0.6	0.9	0.6	-0.8	0.6	0.8	-1.3	1.2	-1.0
Major Depression (MDD)	0.6	0.8	5.0	-1.4	-0.2	0.4	-0.4	0.3	-0.3	-2.2	-0.2	0.1	0.0
Reaction Time	0.8	1.6	4.9	-1.1	0.1	-0.7	-1.8	1.3	-2.2	-1.4	0.8	-0.7	1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.6	-0.2	-1.1	-0.7	0.5	-0.6	-0.4	-1.3	0.5	-0.2	-0.2
Breast Cancer	0.4	1.0	5.3	-0.1	1.7	-2.3	-0.6	0.5	0.1	0.9	0.1	0.4	0.8
Ovarian Cancer	1.3	1.8	4.0	1.4	0.2	2.0	2.0	-1.3	0.1	0.2	-1.4	0.6	-1.9
Prostate Cancer	1.0	1.4	3.6	-1.9	-0.5	-0.9	-0.8	1.1	0.9	-0.2	1.6	-1.1	1.9
Age at First Birth	1.1	1.6	3.1	0.2	0.5	-1.6	-1.7	1.6	-1.1	1.7	-1.4	0.6	1.1
Bipolar Disorder (2011)	4.3	4.2	10.7	-2.7	-1.0	-2.0	-1.8	1.9	-2.4	-1.5	1.4	-3.3	1.6
Body Mass Index (BMI) (2010)	0.8	1.1	3.8	0.6	0.6	-0.2	2.0	-1.2	-0.4	-1.0	1.7	0.2	-1.2
Coronary Artery Disease (CAD)	1.7	2.1	5.3	-1.5	-1.2	-0.0	-0.7	1.2	-2.1	-2.3	0.7	-1.8	1.3
Crohns Disease (2012)	0.8	1.3	3.8	1.0	0.3	0.9	1.9	-1.5	0.8	-1.4	0.7	-0.1	-1.3
Mean Putamen Volume	0.8	0.9	3.4	1.4	-1.7	0.3	0.1	-0.4	-0.4	1.8	-0.3	0.7	-0.3
Fasting Glucose	1.3	1.5	5.7	-0.3	-1.5	-1.1	-0.3	0.6	-1.3	0.9	2.4	-1.5	0.8
HbA1C	1.1	1.2	2.5	-0.8	-1.1	0.7	-0.9	1.4	-0.9	-0.8	0.8	-1.6	1.5
HDL Cholesterol	0.5	0.8	2.5	0.1	0.8	1.5	-0.2	0.8	0.5	0.8	-1.6	-1.0	-0.2
LDL Cholesterol	1.0	1.6	8.0	0.6	2.8	-0.0	1.7	-1.1	1.6	0.5	-0.4	0.4	-0.9
Lupus	1.8	2.7	6.4	1.5	2.1	2.3	0.4	-0.9	2.5	1.4	-1.8	0.6	-1.3
Neuroticism (2016)	0.3	0.4	2.1	-0.1	-0.0	0.2	0.4	-0.6	-0.1	-1.2	0.5	-1.4	-0.4
Primary Biliary Cirrhosis	0.3	0.4	2.9	0.5	1.7	0.1	0.6	0.0	-0.1	-0.1	0.4	0.8	-0.4
Rheumatoid Arthritis	0.2	0.3	0.8	-0.6	-0.4	0.9	-0.7	0.4	0.3	0.6	-0.3	-0.2	-0.0
Schizophrenia (2014)	2.1	4.6	10.3	-2.6	-1.2	-3.2	-2.4	2.3	-2.4	-1.2	1.0	-1.9	2.1
Triglycerides	0.8	1.3	3.1	0.5	-1.3	-1.7	1.2	-1.4	0.0	-0.9	1.1	1.5	-0.7
Type 2 Diabetes (T2D) (2012)	1.7	2.0	3.7	1.6	-1.1	0.2	1.9	-1.7	1.2	1.7	1.5	1.1	-1.2
Ulcerative Colitis	0.6	0.9	2.0	1.2	0.8	1.2	0.8	-0.9	-0.2	0.6	-1.4	1.1	-0.8
Blood Eosinophil Count	0.3	2.0	4.9	-1.4	-0.3	-0.9	-1.2	1.5	-1.8	-2.2	0.2	-1.1	1.8
Blood Platelet Count	0.2	2.6	10.4	0.7	-1.1	3.2	1.6	0.1	1.4	2.9	-0.1	-0.5	-0.6
Blood Red Count	0.1	1.3	4.0	-0.9	-2.0	-1.6	-0.9	0.7	-0.4	-0.6	-0.3	2.0	0.5
Blood White Count	0.1	1.1	3.3	-0.9	-1.2	0.9	1.3	0.1	-0.5	-0.8	1.8	0.6	1.1
Heel T-Score	0.5	4.3	18.1	1.6	-1.5	-4.2	-1.2	0.9	-0.6	2.7	-1.1	2.9	0.4
BMI	0.2	1.3	4.0	-0.5	-1.8	-0.6	-0.2	0.4	-2.0	-1.9	0.5	-0.8	-0.0
Height	0.1	1.3	9.3	-0.5	0.0	-0.6	-0.2	0.2	3.0	1.7	-0.3	0.5	-0.0
Waist Hip Ratio (WHR)	0.3	1.2	3.3	0.5	-0.3	1.7	1.4	-1.8	0.2	-0.4	-1.0	0.4	-1.5
Systolic Blood Pressure	0.5	2.4	5.1	1.6	1.0	-2.1	2.2	-2.0	0.2	-0.7	1.3	1.4	-1.7
Smoking Status	1.0	2.4	10.8	-1.6	0.4	3.3	-0.0	0.0	0.0	0.1	2.6	-1.6	0.9
Allergy or Eczema	0.9	2.5	6.1	-2.5	-1.8	-0.9	-1.7	1.6	-0.1	-1.2	0.4	-2.3	1.4
Cardiovascular Disease	0.5	1.5	3.9	1.1	0.4	-1.0	1.7	-1.9	-0.2	-2.0	0.1	1.2	-1.0
Hypothyroidism (self reported)	2.6	6.0	12.8	-2.8	-1.7	-1.5	-3.6	3.4	-1.8	-0.0	2.5	-1.2	3.6
Respiratory disease	0.3	0.7	3.0	0.9	-1.0	-0.8	-0.1	-0.0	-0.9	1.7	-0.6	0.3	-0.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.0	0.2	0.3	1.6	-0.8	1.1	0.8	1.7	-1.2	2.0	1.0
Lung FEV1/FVC ratio	0.8	3.9	17.1	-1.0	-2.3	4.1	-0.1	-0.3	-1.9	-2.3	2.6	-0.1	0.1
Lung FVC	0.5	2.3	5.8	-1.7	-0.6	-0.4	-1.9	2.4	-2.2	0.3	-0.6	-0.0	2.2
Neuroticism	0.2	0.4	1.1	-0.4	-0.0	-0.7	0.7	-1.1	-0.2	0.1	0.5	-0.4	-0.9
Chronotype (morning person)	0.5	1.2	3.5	0.4	-0.3	0.8	1.7	-1.7	0.9	0.2	1.9	-0.5	-1.0
Hair Pigment	0.0	0.3	1.2	-0.6	0.6	1.1	-0.6	0.3	-0.4	0.5	-0.1	0.2	0.4
Tanning	0.0	0.2	0.5	-0.1	0.4	0.3	0.6	-0.6	0.5	0.3	-0.4	-0.7	-0.6
Hand grip strength (left)	0.4	1.2	3.7	-1.1	-0.1	0.6	-1.8	1.0	-0.2	-1.9	-1.1	0.1	1.1
Number of treatments/medications taken	0.3	0.6	1.6	0.3	0.0	0.1	1.2	-1.3	0.4	-0.5	0.9	-0.7	-1.1
Average weekly spirits intake	0.9	1.1	4.9	-0.8	0.3	0.7	-1.5	1.0	-0.4	0.3	-2.2	-0.7	1.0
Sensitivity / hurt feelings	0.2	0.4	1.2	-0.5	-0.6	0.7	0.1	-0.5	-0.1	0.2	1.0	-1.1	-0.4
Frequency of depressed mood in last 2 weeks	1.9	2.7	6.7	-2.5	-1.1	-0.7	-2.0	2.1	-1.1	0.8	0.9	-1.1	2.6
Hearing difficulty/problems: Yes	0.6	0.9	3.0	-1.0	0.2	0.7	0.1	-0.5	1.1	-0.7	1.7	-1.4	-1.1
Relative age of first facial hair	1.0	2.0	5.8	0.5	2.4	2.4	0.5	-0.6	1.5	1.0	0.0	2.1	-0.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.3	1.1	1.0	-0.8	1.3	-1.6	1.3	0.7	1.0	-0.5	-1.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	-0.9	0.9	-0.2	-0.9	0.2	0.2	-0.4	0.7	-0.3	0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.5	-0.7	0.4	0.2	-0.4	0.1	0.2	0.4	0.5	-0.7
Systolic blood pressure, automated reading	1.3	3.7	7.3	1.7	-0.7	-2.5	2.7	-2.5	-0.1	-1.6	2.3	0.7	-2.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.9	-1.6	-0.4	-0.8	-1.5	1.9	-0.4	-0.3	1.6	-1.8	2.0
Angina	0.6	0.8	2.6	1.1	0.4	1.6	1.1	-0.7	0.5	-0.6	-0.4	0.6	-1.1
Medication for hormone replacement therapy	0.4	0.4	3.3	0.1	0.0	0.5	0.4	-0.0	0.2	1.8	0.6	0.4	0.4
Vitamin and mineral supplements	0.9	1.2	5.7	-0.4	0.8	-1.7	0.4	0.2	-0.3	-1.4	2.4	0.3	0.4
Supplements: Zinc	2.0	2.2	8.0	-1.3	-2.2	0.2	-1.6	1.0	-2.8	0.2	-1.1	-1.1	1.0
Medication: Co-codamol	1.4	1.6	4.9	1.0	0.6	1.1	2.2	-1.8	1.3	-0.2	1.4	0.9	-1.0
Medication: Metformin	0.3	0.5	3.0	-0.0	-0.7	1.7	-0.2	0.3	0.5	0.3	-0.1	0.8	0.5
Diabetes (father)	0.3	0.4	1.2	0.5	-1.1	0.2	-0.1	0.2	-0.7	0.7	-0.1	1.0	0.6
Diabetes (mother)	0.4	0.5	2.3	0.5	0.9	-0.1	0.2	0.7	-0.1	0.5	-1.5	0.9	0.2
Severe depression (siblings)	4.5	5.0	11.7	2.7	-1.7	1.9	3.3	-3.4	1.2	0.2	0.5	1.7	-3.0
Pack years adult smoking proportion	0.6	0.9	3.6	0.1	0.8	-0.7	-0.1	0.3	-1.5	-0.9	0.9	-1.9	0.5
Impedance of leg (right)	0.6	3.1	9.5	1.3	-0.1	0.9	1.0	-1.6	3.1	2.5	-0.8	2.6	-1.3
Leg fat-free mass (left)	0.3	1.6	5.4	-1.6	-0.2	-0.6	-1.0	1.0	-1.3	-1.8	0.6	-2.3	0.7
Trunk fat percentage	0.1	0.5	2.2	-0.2	-0.3	-0.1	1.0	-0.5	-0.1	-1.5	0.5	-0.5	-0.8
Hand grip strength (right)	0.3	0.9	3.6	-1.0	0.4	0.9	-1.3	0.6	0.2	-1.9	-0.6	-0.3	1.2
Townsend deprivation index at recruitment	1.4	1.9	4.7	2.2	-1.6	1.6	1.6	-1.5	0.3	1.4	0.5	1.0	-1.1
Current tobacco smoking	0.3	0.6	2.6	0.0	1.6	1.2	0.8	-0.6	0.4	-0.1	0.3	-0.3	-0.1
Average weekly fortified wine intake	0.4	0.4	2.7	-0.5	-0.3	-0.7	-0.3	0.6	0.3	-1.7	0.0	-0.5	0.3
Maternal smoking around birth	1.0	1.5	4.2	-0.9	0.2	1.2	0.6	-0.7	1.9	0.3	1.6	-2.0	-1.4
Fed-up feelings	0.4	0.7	2.0	-1.2	-1.4	0.2	-0.6	0.7	1.1	1.2	0.1	-0.0	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.0	-1.2	-2.0	-1.1	-1.3	1.6	-1.2	1.2	-0.6	-0.3	2.0
Relative age voice broke	0.7	1.1	4.3	0.1	1.7	2.1	0.0	-0.1	1.1	0.5	0.2	1.4	-0.0
Taking other prescription medications	0.2	0.4	1.2	0.2	-0.6	-0.6	0.5	-0.4	-0.6	-0.4	1.1	-0.7	-0.2
Age when periods started (menarche)	0.4	0.9	2.6	0.6	0.3	1.0	1.3	-1.6	0.2	0.4	0.7	0.6	-1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.8	0.1	-0.2	1.1	-1.0	0.6	0.2	0.3	1.1	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	10.8	0.9	-1.3	-3.3	-0.8	0.5	-0.7	1.4	0.2	1.4	0.1
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.8	-1.9	-1.0	-0.9	-1.6	1.8	-1.7	0.9	0.1	-1.4	1.9
Qualifications: CSEs or equivalent	0.7	0.9	4.2	-0.4	0.5	-0.2	-1.4	1.0	-2.0	0.6	-0.5	-0.2	0.9
Serious illness, injury or assault to yourself	1.7	2.0	9.8	-0.6	-1.8	-0.8	-0.3	0.2	-1.0	-0.0	3.1	-2.2	0.1
High blood pressure	0.4	1.1	3.1	0.7	-0.4	0.3	1.8	-1.6	-0.4	-1.7	0.6	0.2	-1.2
Hayfever, allergic rhinitis or eczema	1.8	3.9	10.2	-2.7	-1.5	-0.9	-2.2	2.1	-1.6	-1.3	0.8	-3.2	2.0
Multivitamins +/- minerals	0.9	1.1	3.4	-0.8	-0.1	1.8	-0.7	0.0	1.5	0.4	-1.4	-1.5	-0.3
Stomach or abdominal pain in last month	0.5	0.6	1.6	-0.7	0.2	-1.3	-0.7	0.9	-0.4	-0.5	0.1	-1.1	1.0
Supplements: Glucosamine	0.7	0.9	3.6	-1.1	-0.4	0.9	-1.0	0.1	0.2	-1.0	-1.2	-1.9	0.0
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.9	-0.8	-0.5	-1.7	-1.0	0.6	-1.6	-1.5	1.4	-1.7	0.4
Medication: Atenolol	0.6	0.8	3.5	0.2	-0.4	-0.4	0.8	-0.6	1.0	-1.9	-0.5	0.8	-1.0
Medication: Levothyroxine sodium	2.6	4.3	9.7	-2.5	-0.6	0.4	-2.7	2.6	-1.0	-0.6	2.7	-2.0	3.1
Sitting height	0.2	1.7	8.2	-0.1	1.6	-0.2	0.0	-0.2	2.9	0.1	-2.2	0.8	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	1.5	-0.3	0.6	-0.1	0.2	-0.2	-0.1	-1.0	0.4	-1.2	-0.4
High blood pressure (mother)	0.6	0.8	2.5	0.2	-1.6	0.1	0.5	-0.0	-1.3	-1.1	-0.9	1.1	0.3
Body mass index (BMI)	0.2	1.1	3.3	-0.6	-0.9	-0.6	0.0	0.1	-1.7	-1.8	1.0	-1.3	-0.1
Impedance of leg (left)	0.6	2.9	8.0	1.4	0.1	0.5	0.9	-1.3	2.8	2.5	-1.1	2.8	-1.2
Leg predicted mass (left)	0.3	1.7	5.6	-1.7	-0.2	-0.6	-1.0	1.0	-1.3	-1.8	0.6	-2.4	0.8
Trunk fat mass	0.2	0.7	4.0	-0.7	-0.3	-0.1	0.5	-0.3	-0.3	-2.0	0.5	-1.1	-0.6
Waist circumference	0.3	1.3	3.8	-1.0	-1.9	-0.6	0.2	-0.0	-1.0	-1.7	1.2	-1.4	0.1
Number of incorrect matches in round	1.3	2.1	6.7	1.7	1.4	0.3	1.6	-2.2	0.8	-0.8	-0.9	0.4	-2.6
Past tobacco smoking	0.5	1.0	4.0	1.4	0.0	-2.0	0.8	-0.7	-0.5	0.3	-0.4	0.3	-1.4
Alcohol usually taken with meals	0.3	0.5	1.1	0.5	-0.7	-1.0	0.8	-0.4	0.8	1.1	0.4	0.5	-0.4
Nervous feelings	0.5	1.0	3.2	-0.8	1.8	-1.7	-0.3	0.0	-0.8	0.7	1.3	-0.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	5.2	-2.0	-0.6	-1.3	-2.3	2.1	-1.4	1.3	-0.4	-0.8	2.2
Hearing difficulty/problems with background noise	1.1	1.8	4.5	-2.1	0.2	-0.6	-1.6	1.4	-1.1	-1.4	1.6	-1.5	0.9
Hair/balding pattern: Pattern 2	0.5	0.7	1.9	-0.8	-1.4	0.6	-1.4	0.5	0.2	-0.7	0.6	-0.2	0.8
Had menopause	1.0	1.2	5.0	0.9	0.4	-0.5	1.0	-1.6	1.5	-0.2	0.5	-0.0	-2.2
Had other major operations	0.3	0.3	1.2	0.6	0.3	1.1	0.7	-0.4	0.2	-0.1	-0.8	0.0	-0.7
Forced vital capacity (FVC)	0.6	2.5	5.6	-1.6	-0.5	1.8	-1.8	2.4	0.1	1.4	-1.6	-0.3	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.5	1.1	-1.2	-1.9	0.1	-0.5	-0.7	-0.0	0.3	1.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.9	-1.4	-0.8	-0.3	-0.4	0.4	-0.6	-1.0	1.2	-0.5	0.9
Qualifications: None of the above	1.3	2.8	6.3	2.0	-0.0	1.2	2.3	-2.5	1.3	0.4	1.2	1.9	-2.0
Financial difficulties in last 2 years	0.3	0.4	1.5	-0.1	-0.3	1.2	-0.1	0.5	-0.4	0.8	0.4	1.0	0.8
Mouth/teeth dental problems	2.4	3.7	8.6	-1.6	-0.4	-2.4	-2.9	2.9	-1.5	-0.4	0.7	-1.0	2.8
Heart attack	0.4	0.6	2.1	0.4	-0.5	0.4	1.0	-0.3	1.1	-1.4	-0.3	0.3	-0.8
Allergy	1.7	3.8	8.7	2.2	1.5	1.6	2.6	-2.3	1.8	0.1	-0.4	2.9	-2.1
Pain all over the body in last month	1.3	1.4	5.9	-1.5	-0.8	0.6	-1.0	0.6	-0.8	-0.4	1.5	-2.4	0.6
Diabetes (self-reported)	0.7	1.1	2.2	-0.3	-0.8	1.5	-0.8	1.5	-0.3	1.4	-0.1	1.1	1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	4.1	-1.1	-0.0	-0.1	-0.7	1.0	0.1	0.1	0.6	-2.0	1.1
Medication: Ramipril	0.7	0.9	4.9	0.3	2.2	0.0	0.3	-0.1	-0.5	-0.2	-1.6	0.6	-0.4
Medication: Simvastatin	0.8	1.1	3.3	0.3	-0.1	1.3	1.2	-1.3	-0.1	-1.8	1.2	-0.6	-1.2
Fluid intelligence score	0.4	0.8	2.9	-1.1	-0.5	-0.5	0.4	-0.0	-0.0	-1.7	0.9	-1.5	0.3
Illnesses of siblings	0.2	0.3	0.8	-0.3	-0.2	0.3	-0.9	0.2	-0.6	0.7	-0.3	-0.6	0.4
Neuroticism score	0.2	0.4	1.5	-1.2	0.3	-0.3	0.0	-0.2	-0.7	-0.2	0.9	-1.1	0.1
Weight	0.2	0.8	2.6	-1.2	-0.5	-0.3	-0.5	0.4	-0.9	-1.6	0.6	-1.5	0.2
Impedance of arm (right)	0.3	1.4	5.2	0.7	1.1	1.4	0.8	-0.4	2.3	1.4	-0.9	1.1	-0.3
Arm fat percentage (right)	0.2	0.9	5.0	-0.8	0.1	0.1	0.2	0.0	-0.9	-2.2	0.7	-1.5	-0.1
Trunk fat-free mass	0.2	1.3	4.9	-1.8	-0.1	-0.1	-1.3	0.7	-0.3	-1.6	0.5	-2.2	0.5
Hip circumference	0.3	1.1	3.3	-0.7	-1.8	-0.9	-0.2	0.3	-1.2	-0.7	1.5	-1.4	0.3
Time employed in main current job	0.5	0.5	1.9	0.8	1.4	-0.3	-0.4	0.4	-0.7	0.7	-0.5	1.1	0.4
Alcohol intake versus 10 years previously	0.2	0.3	1.3	0.4	-0.8	-0.6	0.1	0.0	1.2	0.1	0.6	-0.3	0.2
Father’s age at death	0.6	0.8	4.2	-0.0	-2.0	-0.8	-0.1	0.3	1.1	0.3	0.3	-1.1	-0.5
Worrier / anxious feelings	0.6	1.2	5.8	-0.3	2.0	-0.6	-0.2	-0.1	-2.4	0.7	0.1	-0.8	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.5	-0.5	-1.0	-0.9	-0.8	1.3	-1.6	1.4	-0.4	0.7	1.4
Falls in the last year	0.6	0.9	1.5	-0.6	1.1	-1.0	-0.9	1.1	-0.8	1.2	-0.4	-0.7	1.1
Hair/balding pattern: Pattern 3	0.5	0.7	2.4	1.2	-0.0	0.3	1.6	-0.9	0.3	0.1	-0.4	1.2	-1.1
Number of live births	1.4	1.9	4.7	2.1	0.2	1.6	1.2	-1.7	0.0	1.4	0.6	2.2	-1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.5	-1.8	-0.8	2.0	-2.0	2.3	-0.5	0.8	-0.9	-0.5	2.1
Pulse rate	0.7	1.2	3.6	1.3	-0.8	0.6	1.9	-1.8	0.2	0.1	-0.1	-0.3	-1.6
Happiness	1.0	1.2	5.3	-0.5	-1.1	-0.7	-0.3	0.6	-1.7	-0.7	2.3	-0.0	1.1
Noisy workplace	1.1	1.4	5.4	0.8	-0.9	1.2	0.7	-1.6	2.3	0.3	-0.1	-0.1	-1.6
Qualifications: A levels/AS levels or equivalent	0.2	0.3	1.0	0.3	-0.4	0.2	0.7	-1.0	0.7	-0.8	0.2	-0.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.3	-1.0	-0.6	-1.8	-1.4	1.5	-1.6	-0.6	0.7	-0.8	1.6
Mouth/teeth dental problems: Dentures	12.4	21.0	52.5	4.7	0.4	4.2	6.3	-7.2	4.2	0.2	-1.5	2.9	-7.0
Asthma	0.3	0.5	1.1	-0.1	-0.8	-1.0	-0.7	0.6	-0.8	0.6	-0.3	-0.9	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.9	-0.8	0.1	0.6	0.2	0.0	-0.6	0.4	-0.7	0.2
Medication: Cholesterol lowering	1.6	2.5	4.0	2.0	0.9	1.1	2.0	-1.7	1.8	-0.1	-0.9	1.9	-2.0
Depression (self-reported)	0.8	1.0	2.6	-1.5	0.1	0.6	-1.6	1.1	-1.0	-0.7	-0.5	-0.3	1.3
Medication: Lansoprazole	1.2	1.4	6.3	0.8	0.9	2.5	0.9	-0.6	0.0	1.7	1.1	1.0	-0.5
Prospective memory result	0.6	0.8	4.4	-0.0	-2.1	-1.1	-0.9	0.7	-0.2	0.5	0.2	0.3	0.8
Lung cancer (father)	1.0	1.2	2.9	-1.7	0.5	1.3	-1.0	0.9	-0.6	-1.6	-0.1	-1.3	0.7
Illnesses of mother	0.6	0.8	3.1	-0.6	-0.1	-0.9	-1.1	0.9	0.4	1.8	-0.2	-0.5	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.0	6.7	-2.0	-1.1	1.3	-2.3	2.6	-1.7	0.6	-1.4	-0.2	2.5
Pulse wave Arterial Stiffness index	1.0	1.2	4.1	-0.6	-1.9	-0.0	0.7	-0.8	0.1	-0.7	2.0	-1.5	-0.5
Impedance of arm (left)	0.1	0.7	1.9	0.2	0.3	1.1	0.4	0.2	1.4	1.4	-0.8	0.9	0.4
Arm fat mass (right)	0.3	1.1	4.7	-1.2	-0.2	-0.3	-0.3	0.4	-1.1	-2.2	0.6	-1.6	0.1
Trunk predicted mass	0.2	1.4	4.8	-1.8	-0.2	-0.2	-1.4	0.8	-0.4	-1.5	0.6	-2.2	0.5
Standing height	0.1	0.6	1.9	-1.2	0.5	0.6	-0.9	0.6	1.4	0.3	-0.6	-0.5	0.5
Length of working week for main job	1.0	1.1	3.6	-0.1	-1.7	0.0	-1.1	0.8	-0.8	0.1	-1.9	1.4	0.6
Exposure to tobacco smoke at home	0.6	0.6	1.7	0.7	-1.3	0.3	0.7	-1.1	0.3	0.2	-0.5	0.8	-1.2
Breastfed as a baby	0.2	0.2	1.5	0.1	-0.5	0.3	-0.2	0.2	-0.1	-1.2	-0.1	0.0	0.1
Tense / ‘highly strung’	0.4	0.7	5.2	-0.5	-0.5	-2.3	-0.4	0.1	-0.7	0.1	-0.5	-0.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-1.0	0.5	-0.3	-1.2	0.5	-0.7	0.1	0.8	-0.7	0.7
Hair/balding pattern: Pattern 4	1.3	3.1	13.0	-2.1	-0.6	-3.6	-1.8	2.0	-1.2	-0.1	-0.3	-1.5	1.6
Birth weight of first child	0.6	1.0	4.0	-0.9	-1.7	0.2	0.3	-0.4	-0.7	-0.7	1.1	-2.0	-0.2
Peak expiratory flow (PEF)	0.8	1.9	5.1	-1.8	-0.2	0.4	-2.1	2.2	-0.9	-0.4	0.2	-1.1	2.0
Pulse wave reflection index	1.1	1.4	4.7	-0.8	-2.2	-0.7	-1.9	1.2	-1.4	-0.1	-0.1	-0.7	1.0
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.5	1.4	0.7	0.2	1.3	-1.2	0.3	1.6	0.7	1.0	-0.8
Loud music exposure frequency	1.3	1.5	3.1	-1.8	-0.0	0.7	-1.0	1.4	-1.2	-0.8	1.0	-1.6	1.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.3	-0.2	-0.2	1.1	0.3	-0.5	0.2	-0.7	0.2	0.2	-0.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.0	-1.7	1.7	-1.0	-1.3	1.6	-0.4	-0.2	-0.2	-1.0	1.3
Blood clot in the leg (DVT)	0.8	1.1	1.9	-0.9	-0.8	-0.6	-1.3	1.3	-0.5	1.1	0.7	-1.3	1.4
Medication: Paracetamol	0.5	0.9	3.3	-0.5	-1.8	-0.5	-0.4	0.5	-0.6	0.9	1.6	-0.6	0.5
Headache pain in last month	0.6	1.1	3.1	-1.0	-0.5	-1.0	-1.7	1.8	-0.6	0.3	-0.5	0.6	1.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.2	-1.9	-0.6	-0.5	-2.2	2.0	-1.2	-0.1	0.1	-1.5	2.3
Glaucoma (self-reported)	3.3	3.9	10.6	2.1	0.8	1.3	3.3	-2.5	1.8	0.1	-1.7	0.8	-2.8
Gout (self-reported)	1.2	1.7	3.5	-1.9	-0.5	-1.5	-1.3	1.2	-0.8	-0.0	1.7	-1.4	1.3
Hypothyroidism/myxoedema (self-reported)	2.3	4.5	9.1	-2.3	-0.6	-0.7	-3.0	2.9	-1.4	-0.3	2.4	-2.0	3.0
Medication: Amlodipine	0.5	0.7	2.7	0.3	1.1	-0.1	1.0	-0.7	-0.5	-0.8	1.6	-0.6	-0.7
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.9	1.7	-0.1	-0.2	1.2	-0.9	0.8	1.3	-0.4	1.1	-0.9
Birth weight	0.4	0.8	2.8	0.6	1.7	0.8	1.1	-0.9	1.4	-0.5	-0.2	0.5	-0.5
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.0	1.2	1.3	1.2	1.1	-1.1	-0.3	-1.0	-0.2	0.6	-1.7
High blood pressure (siblings)	0.6	0.9	2.0	1.1	0.1	0.2	1.3	-1.2	-0.1	-0.4	-0.8	1.4	-1.3
Forced vital capacity (FVC), Best measure	0.8	2.8	7.3	-1.9	-1.0	0.2	-2.2	2.7	-1.1	0.8	-1.7	-0.3	2.6
Body fat percentage	0.1	0.5	1.9	-0.3	-0.5	-0.1	0.8	-0.5	-0.3	-1.4	0.7	-0.7	-0.6
Leg fat percentage (right)	0.2	0.7	1.9	0.2	-0.5	0.0	1.2	-1.3	0.4	-0.8	0.9	-0.3	-1.4
Arm fat-free mass (right)	0.3	1.7	3.7	-1.8	-1.2	-0.9	-1.4	1.0	-1.4	-1.5	0.8	-1.9	0.6
Exposure to tobacco smoke outside home	1.5	2.1	5.2	-1.9	-1.4	-0.5	-2.3	1.6	-1.8	0.6	-0.3	-1.2	1.4
Comparative body size at age 10	0.5	1.4	3.2	-0.9	0.9	-0.2	-1.8	1.8	-1.3	0.3	-1.4	-0.8	1.0
Number of full brothers	0.5	0.6	1.5	1.2	-0.7	1.1	0.5	-0.3	0.3	0.2	0.4	1.2	-0.6
Worry too long after embarrassment	0.5	0.9	2.0	-0.3	1.2	0.8	0.8	-1.3	-0.1	-0.8	1.4	-1.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.4	0.7	-0.3	-0.5	0.2	-0.9	-0.6	0.3	-0.7	0.3
Wheeze or whistling in the chest in last year	0.3	0.6	3.8	-0.1	1.9	0.1	0.1	0.3	0.8	-0.4	-0.3	-0.9	-0.5
Number of children fathered	2.5	2.8	6.1	1.6	1.0	2.5	1.4	-2.2	1.8	-1.7	-1.2	0.3	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-0.9	0.7	-0.9	0.3	0.0	0.2	-1.7	1.4	-0.9	0.3
Age at first live birth	0.9	1.5	9.5	-0.6	1.0	-1.1	-0.3	0.3	0.2	-1.7	-3.1	-0.3	0.2
Pulse wave peak to peak time	1.0	1.2	4.2	0.4	2.0	-0.1	-0.8	0.9	0.0	0.7	-1.9	1.3	0.6
Health satisfaction	1.6	2.0	7.2	-0.6	-2.4	-0.7	0.0	0.2	-1.5	-1.3	2.7	-1.6	0.5
Shortness of breath walking on level ground	0.5	0.6	2.1	-0.0	-0.1	-1.5	0.7	-0.7	-0.6	-0.7	1.0	-0.8	-0.7
Qualifications: College or University degree	0.9	2.7	7.3	-2.7	-0.0	-1.3	-1.9	1.8	-0.2	-0.4	0.8	-2.7	1.8
Eye problems/disorders: None of the above	0.6	0.7	2.1	-0.8	-0.1	0.5	-1.5	0.5	0.3	-1.4	-0.3	0.5	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	4.6	0.3	2.1	-0.2	0.4	-0.3	0.5	-0.5	-1.1	0.4	-0.5
Emphysema/chronic bronchitis	1.1	1.3	2.8	0.7	1.7	0.8	1.1	-1.0	0.8	1.3	1.6	-1.1	-0.9
Medication for pain relief, constipation, heartburn	0.8	1.4	2.8	-0.8	1.1	-0.2	-1.6	1.3	-0.9	-1.1	-1.7	-0.4	1.7
Neck or shoulder pain in last month	1.1	1.5	7.2	0.3	-2.7	-1.9	0.1	0.8	-0.9	1.2	0.7	0.7	0.3
Medication: Blood pressure	0.7	1.3	4.4	0.9	-0.4	0.1	1.7	-1.7	1.1	-0.3	0.8	0.2	-2.1
Angina (self-reported)	0.7	1.0	3.1	1.3	0.7	1.8	1.2	-0.7	0.3	-0.4	-0.3	0.6	-1.2
Migraine (self-reported)	0.6	0.8	3.5	0.7	1.9	0.7	-0.0	-0.1	0.2	0.1	-1.0	1.5	-0.3
Medication: Ibuprofen	0.4	0.5	1.4	-1.2	-1.2	-0.2	0.1	0.6	-0.0	-0.9	0.0	-0.8	0.5
Medication: Allopurinol	1.6	2.2	4.7	-1.9	-1.2	-0.6	-1.3	1.2	-1.2	-1.0	2.0	-2.2	1.4
Medication: Omeprazole	0.5	0.6	2.4	0.2	-0.8	1.0	0.1	0.3	-1.5	0.0	1.2	0.6	0.1
Medication: Seretide 50 evohaler	0.9	1.0	2.3	1.4	0.5	0.8	1.3	-1.4	0.4	1.0	-0.8	0.2	-1.5
Mean time to correctly identify matches	0.3	0.5	2.0	-0.4	0.4	-1.4	-0.5	0.5	-0.7	-0.7	1.0	-0.2	0.5
Heart disease (mother)	0.7	0.9	2.5	0.6	0.0	0.6	1.6	-1.2	1.1	-0.2	0.3	1.1	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	0.3	-0.0	0.9	-0.6	0.3	0.0	0.1	-0.5	0.5	0.0
Whole body fat mass	0.2	0.7	3.8	-0.8	-0.6	-0.3	0.3	-0.1	-0.6	-1.9	0.6	-1.1	-0.3
Leg fat mass (right)	0.2	0.7	2.7	-0.4	-0.4	-0.2	0.8	-0.8	0.2	-1.7	0.8	-1.1	-1.0
Arm predicted mass (right)	0.3	1.7	4.5	-1.9	-0.8	-0.7	-1.3	0.8	-1.4	-1.5	0.7	-2.1	0.5
Pulse rate, automated reading	1.9	6.1	15.8	3.2	1.1	2.2	4.0	-3.5	1.6	-0.1	-1.1	1.1	-3.4
Alcohol intake frequency.	0.7	1.7	5.3	1.1	-2.1	1.2	-0.3	0.4	-2.3	1.2	1.0	1.2	0.7
Comparative height size at age 10	0.1	0.6	2.2	-0.4	-0.2	1.1	0.1	-0.3	0.8	-1.0	-0.0	-1.5	-1.0
Number of full sisters	0.1	0.2	0.8	0.2	-0.9	-0.0	-0.5	0.3	-0.5	0.2	0.1	0.3	-0.0
Suffer from ‘nerves’	0.6	1.0	6.3	-0.4	0.2	-0.5	0.8	-0.9	-0.8	0.0	2.5	-1.2	-0.0
Overall health rating	0.7	1.6	5.7	-0.8	-1.1	-1.1	-0.5	0.8	-1.8	-0.3	2.4	-1.4	0.8
Chest pain or discomfort	0.7	1.0	4.5	0.2	-2.1	-1.3	-0.9	0.7	-1.5	0.6	-0.1	0.1	-0.1
Had major operations	1.0	1.2	2.6	1.4	1.6	-0.1	1.4	-1.3	0.7	0.1	-0.1	0.6	-1.6
Age at last live birth	0.4	0.5	3.5	0.2	0.7	-0.5	0.1	-0.1	0.2	-0.0	-1.9	1.0	0.1
Family relationship satisfaction	0.8	1.0	2.5	-0.8	-1.3	-1.1	-0.6	0.2	-1.0	-1.3	1.6	-0.9	0.4
Leg pain on walking	1.6	2.0	4.5	-1.9	-0.3	-1.5	-1.4	1.0	-0.4	-1.0	2.1	-2.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.7	1.6	-0.8	1.5	0.8	-1.0	0.8	-0.1	-0.8	1.2	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.0	-0.3	-0.7	0.1	0.3	0.7	1.0	0.3	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	8.0	0.9	2.8	0.1	0.5	-0.9	1.7	-0.1	-1.0	0.7	-0.7
Medication: Aspirin	0.3	0.4	1.4	-0.1	0.9	-0.1	0.4	-0.7	0.8	-0.2	0.4	-0.6	-1.2
Supplements: Vitamin C	0.4	0.5	1.2	0.9	-1.0	0.2	-0.2	-0.1	-1.1	0.7	-0.9	0.2	-0.6
Knee pain experienced in last month	0.6	1.0	3.6	0.7	-1.2	-0.1	1.2	-1.1	0.5	0.2	1.9	-0.2	-1.3
Hypertension (Self-reported)	0.6	1.6	4.3	1.1	-0.7	0.0	2.1	-2.0	-0.3	-1.7	0.9	0.4	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	5.6	0.8	0.3	2.0	2.4	-1.8	0.1	-1.2	2.2	-0.2	-1.7
Illnesses of father: Heart disease	0.9	1.2	5.0	1.2	2.2	-0.4	0.8	-0.4	-0.3	0.6	-0.6	2.0	-0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.6	-0.8	-0.5	-0.1	-0.5	1.1	0.1	0.7	1.2	-0.6	1.1
Smoking status: Previous	0.4	0.6	3.2	-0.8	-0.5	1.8	-0.4	-0.1	0.5	-0.6	1.1	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	7.4	-2.3	-1.8	1.4	-2.7	2.4	-1.0	-0.5	-0.4	-1.5	2.5
Whole body fat-free mass	0.3	1.5	5.4	-1.7	-0.1	-0.6	-1.2	0.8	-0.9	-1.7	0.6	-2.3	0.5
Leg fat-free mass (right)	0.3	1.8	5.3	-1.6	0.1	-0.8	-1.1	1.3	-1.7	-1.8	0.4	-2.3	0.9
Arm fat percentage (left)	0.3	1.1	4.8	-1.1	-0.4	-0.2	0.1	0.3	-1.3	-2.2	0.8	-1.6	0.3
Average weekly red wine intake	0.9	1.3	6.7	-0.3	1.0	-0.6	1.1	-1.1	2.6	-1.4	-0.2	0.0	-0.9
Handedness (chirality/laterality): Left-handed	0.8	0.9	5.6	0.4	-2.4	0.1	0.3	0.4	-0.6	1.1	0.6	0.6	1.0
Mood swings	0.9	1.6	3.2	-1.8	-1.7	-1.5	-1.8	1.2	-1.0	-0.1	0.2	-0.6	1.1
Loneliness, isolation	0.8	1.2	3.2	-1.1	-1.8	-0.8	-0.8	0.7	-1.5	0.4	1.0	-0.7	1.2
Long-standing illness, disability or infirmity	0.4	0.5	1.7	1.1	-0.7	0.1	1.3	-0.8	-0.6	0.2	0.8	0.1	-0.6
Ever had bowel cancer screening	0.8	0.9	2.1	1.4	-0.7	-1.0	0.9	-1.0	0.6	0.7	0.7	0.9	-1.3
Diabetes diagnosed by doctor	0.9	1.5	3.7	-0.7	-0.6	0.7	-1.3	1.9	-0.1	1.6	0.2	1.3	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	5.5	-0.7	2.3	-0.1	-1.3	0.7	-0.4	-2.0	-2.0	-0.2	0.4
Friendships satisfaction	0.7	0.8	2.7	0.0	-0.2	-1.1	1.0	-0.9	0.1	-1.0	1.7	-1.1	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	0.4	0.1	0.0	-0.4	0.3	0.3
Commuting to job workplace: Walk	0.3	0.3	0.9	0.2	0.9	0.4	0.7	-0.5	0.3	0.6	0.4	0.0	-0.9
Eye problems/disorders: Cataract	1.2	1.4	3.2	-1.1	0.9	-1.3	-1.4	1.8	-1.6	0.3	0.7	-0.7	1.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.7	-1.2	-1.4	-0.1	-0.9	1.6	-1.7	1.4	1.3	-1.2	1.9
Medication for cholesterol	0.3	0.5	1.2	0.7	-0.2	-1.0	-0.8	0.5	0.7	0.9	-1.1	0.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	5.5	2.1	-0.9	1.8	2.0	-2.3	1.7	-0.1	-0.9	1.6	-2.2
Back pain experienced in last month	0.5	0.8	2.6	0.4	0.6	-0.0	0.1	0.2	1.0	1.4	-1.3	1.6	-0.2
Mineral and other dietary supplements	1.0	1.3	2.9	-0.6	-1.3	-1.3	-0.8	1.3	-1.3	-1.0	1.1	0.7	1.7
Breast cancer (self-reported)	0.8	0.9	3.8	0.2	-1.1	-0.6	-0.7	0.9	-2.0	1.0	-0.4	0.7	0.8
Asthma (self-reported)	0.3	0.7	1.5	-0.1	-1.2	-1.0	-0.7	0.6	-0.9	0.8	0.1	-1.1	0.8
Osteoporosis (self-reported)	0.7	0.9	3.5	1.4	-0.4	0.5	0.9	-0.9	0.7	1.9	-0.2	0.7	-0.7
Osteoarthritis (self-reported)	1.1	1.5	2.9	1.5	1.1	1.1	1.6	-1.7	1.3	0.6	-0.6	-0.3	-1.4
Medication: Aspirin	0.7	0.9	3.1	0.2	0.4	0.3	1.1	-1.4	1.3	-0.8	0.7	-0.5	-1.8
Medication: Gliclazide	1.0	1.2	5.7	1.1	-0.3	1.3	0.7	-0.6	0.5	1.3	-0.2	2.4	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	-0.6	-1.4	0.8	-0.7	0.4	-0.2	-0.2	-0.1	-1.0	0.2
Smoking status: Current	0.3	0.6	3.1	-0.1	1.8	1.2	0.6	-0.3	0.5	0.2	-0.4	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	7.5	-1.8	-2.7	1.9	-1.4	1.6	-2.0	-1.0	0.2	-0.9	1.5
Whole body water mass	0.3	1.7	5.3	-1.8	-0.3	-0.7	-1.4	1.0	-1.2	-1.8	0.5	-2.3	0.7
Leg predicted mass (right)	0.3	1.8	5.6	-1.7	0.0	-0.8	-1.0	1.3	-1.6	-1.7	0.5	-2.4	0.9
Arm fat mass (left)	0.3	1.4	5.0	-1.5	-0.5	-0.4	-0.7	0.9	-1.4	-2.2	0.4	-1.5	0.7
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	0.6	-0.0	-0.1	1.4	-1.0	-0.1	-1.0	1.2	-0.7	-0.8
Average weekly champagne plus white wine intake	0.8	1.1	3.0	-0.6	0.3	-0.8	-1.3	1.2	0.7	1.5	-1.7	0.1	0.9
Miserableness	0.2	0.4	1.4	-0.5	-0.6	0.7	-0.6	0.2	0.3	1.2	0.5	0.6	-0.0
Guilty feelings	1.1	1.6	6.8	-2.6	0.7	0.3	0.0	0.2	-0.3	-1.2	1.7	-2.0	0.4
Wears glasses or contact lenses	1.5	1.8	5.0	1.2	0.9	0.6	2.2	-1.7	1.8	-1.0	0.4	1.1	-1.4
Ever taken oral contraceptive pill	0.7	0.8	1.9	1.0	0.7	0.4	0.3	-0.4	1.4	1.1	-1.0	1.3	-0.7
Hearing aid user	0.8	0.9	4.5	0.5	-1.9	-0.3	-0.5	-0.0	0.2	2.1	-0.1	-0.2	-0.6
Mother’s age at death	0.2	0.3	1.3	-0.5	0.7	0.0	-0.4	-0.1	-0.4	-0.7	-1.1	0.2	-0.2
Financial situation satisfaction	1.9	2.3	5.2	-2.1	-0.9	-0.5	-1.8	2.3	-1.5	-0.8	0.9	-1.2	2.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	3.4	0.2	1.9	0.1	0.4	-0.4	0.6	0.2	0.5	-0.5	-0.6
Commuting to job workplace: Public transport	2.8	3.4	7.8	-0.9	-1.5	-2.5	-2.3	2.4	-2.1	0.6	-0.9	0.7	2.8
Eye problems/disorders: Glaucoma	2.8	3.3	9.3	2.0	0.6	1.2	3.0	-2.3	1.8	1.1	-1.1	0.5	-2.6
Medication: Blood pressure	0.3	0.6	1.6	0.3	0.7	0.5	1.2	-0.8	-1.0	-1.3	-0.2	0.1	-0.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	7.7	0.0	-1.5	1.1	1.4	-0.6	2.0	0.2	2.8	-1.1	-0.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.9	0.8	0.7	1.7	0.8	-1.0	1.3	1.5	-0.7	0.1	-1.1
High cholesterol (Self-reported)	0.5	0.8	1.9	0.7	0.8	-0.7	1.2	-1.4	0.8	-1.1	0.4	0.5	-1.0
Medication: Bendroflumethiazide	0.6	1.0	2.5	1.0	1.6	0.5	1.3	-0.7	1.3	0.2	-1.0	0.9	-0.2
Medication: Paracetamol	0.6	1.0	3.0	-0.7	-1.7	-0.6	-0.9	1.2	-0.5	1.2	0.9	-0.5	1.0
Medication: Lisinopril	0.4	0.5	2.2	-0.3	-1.5	1.2	0.2	-0.1	-0.1	-0.5	0.8	-0.4	-0.2
Medication: Atorvastatin	0.3	0.3	0.9	0.1	0.8	-0.6	0.1	0.1	1.0	0.4	0.4	1.0	0.4
Illnesses of father: High blood pressure	0.7	0.8	4.4	0.7	-0.1	0.2	0.5	-0.8	0.8	1.1	-0.7	2.1	0.1
Alcohol drinker status: Never	0.1	0.1	0.4	0.1	-0.3	-0.4	-0.4	0.7	-0.3	0.4	-0.1	-0.2	0.6
Ever smoked	0.7	1.3	3.7	-1.9	0.6	1.3	-0.9	1.0	0.2	-1.0	0.5	-0.9	1.9
Basal metabolic rate	0.3	1.6	4.9	-1.7	-0.4	-0.6	-1.2	0.9	-1.1	-1.8	0.5	-2.2	0.6
Leg fat percentage (left)	0.2	0.6	1.8	0.3	-0.2	-0.1	1.1	-1.1	0.1	-0.8	0.8	-0.2	-1.4
Arm fat-free mass (left)	0.2	1.3	2.7	-1.7	-0.4	-0.7	-1.4	0.9	-1.2	-1.4	0.1	-1.6	0.5
Number of operations (self-reported)	0.2	0.3	1.5	0.2	1.2	0.6	0.5	-0.5	0.4	-0.4	-0.0	-0.3	-0.8
Average weekly beer plus cider intake	0.6	0.9	1.8	1.1	-0.6	-0.3	0.4	-1.2	-0.8	-1.3	-1.2	1.1	-1.0
Irritability	0.4	0.7	3.5	-0.5	-1.3	-0.6	0.4	-0.5	-0.2	-1.9	-0.1	-0.8	-0.7
Risk taking	0.8	1.2	5.7	0.4	0.4	2.4	0.6	-0.9	1.9	0.2	-0.1	0.2	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.4	0.5	1.0	-0.3	0.6	-0.1	1.0	-0.6	-2.1	-0.0	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	3.6	-0.8	1.9	0.2	0.5	-0.6	0.6	-0.3	0.2	-1.5	-1.0
Age started oral contraceptive pill	0.7	0.9	3.6	0.9	1.2	-0.6	0.8	-1.3	-0.0	-0.6	-0.5	-0.2	-1.9
Diastolic blood pressure, automated reading	1.0	3.1	6.8	1.5	-0.4	-2.0	2.4	-2.5	0.7	-1.8	0.9	1.0	-2.6
Ever depressed for a whole week	1.5	1.8	3.2	-1.3	-1.5	-1.8	-1.3	1.5	-1.2	-1.2	0.5	-0.9	1.8
Unable to work because of sickness or disability	0.3	0.4	0.6	-0.7	0.6	-0.3	-0.8	0.8	-0.7	-0.7	-0.6	-0.4	0.8
Commuting to job workplace: Cycle	1.4	1.7	4.6	-1.0	-2.1	1.8	-0.3	-0.3	-1.3	-2.0	1.1	-1.1	0.3
Myopia	0.3	0.4	1.9	0.5	-0.6	-1.4	0.7	-0.4	0.8	-0.3	-0.1	0.6	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.2	-0.8	0.4	-0.4	-1.5	1.4	-0.0	1.4	-0.2	-0.5	1.2
Cholesterol lowering medication	0.8	1.2	6.9	-0.3	-0.5	0.7	0.7	-1.1	-0.3	-1.3	2.6	-0.7	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.2	1.3	-0.5	0.6	0.7	-0.3	-1.1	1.0	1.4	2.0	-0.3
Pain experienced in last month	0.3	0.6	2.0	0.2	1.4	1.2	0.2	-0.4	-0.3	-0.5	-1.2	-0.5	0.0
Supplements: Calcium	0.4	0.4	0.9	-0.1	-0.9	-0.1	-1.0	0.6	-0.4	1.0	-0.4	-0.4	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	2.4	-0.1	0.3	-1.6	-0.7	0.7	-0.1	0.1	0.1	0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.9	0.3	-1.0	0.4	0.7	0.0	0.7	-1.4	-0.5	0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.3	-0.9	-1.3	-0.4	-1.5	1.3	-0.8	1.1	0.3	-1.1	1.5
Heart disease (siblings)	0.8	1.0	2.5	-1.1	-0.9	-0.9	-0.4	1.6	1.0	0.0	1.1	-0.4	1.5
Alcohol drinker status: Previous	0.8	0.9	4.8	0.1	-1.6	2.2	0.1	-0.5	-1.1	-0.3	0.3	-0.1	-0.6
Pack years of smoking	0.5	0.8	2.8	0.5	1.2	-0.9	0.4	-0.3	-0.7	-1.0	0.8	-1.7	-0.3
Impedance of whole body	0.4	1.8	4.9	0.9	0.4	1.1	0.7	-0.4	2.0	2.2	-1.4	2.2	-0.3
Leg fat mass (left)	0.2	0.7	2.4	-0.4	-0.4	-0.3	0.7	-0.7	-0.1	-1.6	0.8	-1.0	-1.0
Arm predicted mass (left)	0.3	1.6	3.7	-1.9	-0.7	-0.7	-1.6	1.1	-1.2	-1.4	0.2	-1.9	0.6