TWAS hub - CA12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2480	0.0530	2.1e-12	0.146	0.094	0.178	0.165	0.171	2.0e-17	1.5e-11	3.4e-21	1.5e-19	2.6e-20
2	GTEx	Adipose Subcutaneous	0.1660	0.0530	2.1e-04	0.006	NA	0.035	NA	0.007	9.4e-02	NA	6.7e-04	NA	8.6e-02
3	GTEx	Brain Cerebellar Hemisphere	0.2290	0.0890	9.2e-03	-0.003	NA	0.082	NA	0.050	3.8e-01	NA	4.0e-03	NA	2.1e-02
4	GTEx	Cells Transformed fibroblasts	0.1140	0.0440	4.4e-04	0.115	NA	0.043	NA	0.097	6.5e-09	NA	3.4e-04	NA	9.9e-08
5	GTEx	Thyroid	0.3260	0.0500	5.6e-17	0.274	NA	0.316	NA	0.309	4.1e-21	NA	9.8e-25	NA	4.3e-24
6	METSIM	Adipose	0.0455	0.0178	5.1e-04	0.014	0.020	0.025	0.018	0.017	3.2e-03	4.2e-04	1.1e-04	9.7e-04	1.1e-03
7	TCGA	Esophageal Carcinoma	0.3720	0.1170	4.1e-03	0.009	0.001	0.004	NA	-0.003	1.6e-01	3.0e-01	2.3e-01	NA	4.3e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0673	0.0310	6.4e-03	0.005	0.020	0.016	NA	0.004	7.9e-02	2.5e-03	5.2e-03	NA	9.4e-02
9	TCGA	Brain Lower Grade Glioma	0.0754	0.0282	1.1e-04	0.000	0.028	0.017	NA	0.005	3.0e-01	3.2e-04	4.8e-03	NA	8.5e-02
10	TCGA	Thyroid Carcinoma	0.1360	0.0350	0.0e+00	0.239	0.224	0.232	NA	0.234	4.4e-23	1.6e-21	2.4e-22	NA	1.4e-22

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Mouth/teeth dental problems: Dentures	12.4	21.0	52.5	4.7	0.4	4.2	6.3	-7.2	4.2	0.2	-1.5	2.9	-7.0
Severe depression (siblings)	4.5	5.0	11.7	2.7	-1.7	1.9	3.3	-3.4	1.2	0.2	0.5	1.7	-3.0
Bipolar Disorder (2011)	4.3	4.2	10.7	-2.7	-1.0	-2.0	-1.8	1.9	-2.4	-1.5	1.4	-3.3	1.6
Bipolar Disorder or Schizophrenia	3.4	8.3	15.5	-3.9	-2.0	-3.3	-3.1	3.1	-3.1	-1.3	1.4	-3.3	2.9
Glaucoma (self-reported)	3.3	3.9	10.6	2.1	0.8	1.3	3.3	-2.5	1.8	0.1	-1.7	0.8	-2.8
Bipolar Disorder (2018)	3.2	5.0	10.3	-3.2	-2.2	-2.2	-2.6	2.5	-1.9	-1.1	0.9	-2.8	1.9
Commuting to job workplace: Public transport	2.8	3.4	7.8	-0.9	-1.5	-2.5	-2.3	2.4	-2.1	0.6	-0.9	0.7	2.8
Eye problems/disorders: Glaucoma	2.8	3.3	9.3	2.0	0.6	1.2	3.0	-2.3	1.8	1.1	-1.1	0.5	-2.6
Hypothyroidism (self reported)	2.6	6.0	12.8	-2.8	-1.7	-1.5	-3.6	3.4	-1.8	-0.0	2.5	-1.2	3.6
Medication: Levothyroxine sodium	2.6	4.3	9.7	-2.5	-0.6	0.4	-2.7	2.6	-1.0	-0.6	2.7	-2.0	3.1
Number of children fathered	2.5	2.8	6.1	1.6	1.0	2.5	1.4	-2.2	1.8	-1.7	-1.2	0.3	-2.0
Mouth/teeth dental problems	2.4	3.7	8.6	-1.6	-0.4	-2.4	-2.9	2.9	-1.5	-0.4	0.7	-1.0	2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	5.5	2.1	-0.9	1.8	2.0	-2.3	1.7	-0.1	-0.9	1.6	-2.2
Hypothyroidism/myxoedema (self-reported)	2.3	4.5	9.1	-2.3	-0.6	-0.7	-3.0	2.9	-1.4	-0.3	2.4	-2.0	3.0
Schizophrenia (2014)	2.1	4.6	10.3	-2.6	-1.2	-3.2	-2.4	2.3	-2.4	-1.2	1.0	-1.9	2.1
Supplements: Zinc	2.0	2.2	8.0	-1.3	-2.2	0.2	-1.6	1.0	-2.8	0.2	-1.1	-1.1	1.0
Frequency of depressed mood in last 2 weeks	1.9	2.7	6.7	-2.5	-1.1	-0.7	-2.0	2.1	-1.1	0.8	0.9	-1.1	2.6
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.8	-1.9	-1.0	-0.9	-1.6	1.8	-1.7	0.9	0.1	-1.4	1.9
Pulse rate, automated reading	1.9	6.1	15.8	3.2	1.1	2.2	4.0	-3.5	1.6	-0.1	-1.1	1.1	-3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	5.6	0.8	0.3	2.0	2.4	-1.8	0.1	-1.2	2.2	-0.2	-1.7
Financial situation satisfaction	1.9	2.3	5.2	-2.1	-0.9	-0.5	-1.8	2.3	-1.5	-0.8	0.9	-1.2	2.2
Schizophrenia (2018)	1.8	3.8	6.5	-2.5	-0.8	-2.5	-1.8	1.9	-2.5	-0.9	1.1	-1.9	2.2
Lupus	1.8	2.7	6.4	1.5	2.1	2.3	0.4	-0.9	2.5	1.4	-1.8	0.6	-1.3
Hayfever, allergic rhinitis or eczema	1.8	3.9	10.2	-2.7	-1.5	-0.9	-2.2	2.1	-1.6	-1.3	0.8	-3.2	2.0
Crohns Disease (2017)	1.7	3.8	9.1	2.0	1.8	1.6	3.0	-2.6	1.4	-1.4	-0.8	0.5	-2.7
Coronary Artery Disease (CAD)	1.7	2.1	5.3	-1.5	-1.2	-0.0	-0.7	1.2	-2.1	-2.3	0.7	-1.8	1.3
Type 2 Diabetes (T2D) (2012)	1.7	2.0	3.7	1.6	-1.1	0.2	1.9	-1.7	1.2	1.7	1.5	1.1	-1.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.9	-1.6	-0.4	-0.8	-1.5	1.9	-0.4	-0.3	1.6	-1.8	2.0
Serious illness, injury or assault to yourself	1.7	2.0	9.8	-0.6	-1.8	-0.8	-0.3	0.2	-1.0	-0.0	3.1	-2.2	0.1
Allergy	1.7	3.8	8.7	2.2	1.5	1.6	2.6	-2.3	1.8	0.1	-0.4	2.9	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	5.2	-2.0	-0.6	-1.3	-2.3	2.1	-1.4	1.3	-0.4	-0.8	2.2
Medication: Cholesterol lowering	1.6	2.5	4.0	2.0	0.9	1.1	2.0	-1.7	1.8	-0.1	-0.9	1.9	-2.0
Health satisfaction	1.6	2.0	7.2	-0.6	-2.4	-0.7	0.0	0.2	-1.5	-1.3	2.7	-1.6	0.5
Medication: Allopurinol	1.6	2.2	4.7	-1.9	-1.2	-0.6	-1.3	1.2	-1.2	-1.0	2.0	-2.2	1.4
Leg pain on walking	1.6	2.0	4.5	-1.9	-0.3	-1.5	-1.4	1.0	-0.4	-1.0	2.1	-2.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	7.4	-2.3	-1.8	1.4	-2.7	2.4	-1.0	-0.5	-0.4	-1.5	2.5
Exposure to tobacco smoke outside home	1.5	2.1	5.2	-1.9	-1.4	-0.5	-2.3	1.6	-1.8	0.6	-0.3	-1.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	5.5	-0.7	2.3	-0.1	-1.3	0.7	-0.4	-2.0	-2.0	-0.2	0.4
Wears glasses or contact lenses	1.5	1.8	5.0	1.2	0.9	0.6	2.2	-1.7	1.8	-1.0	0.4	1.1	-1.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	7.7	0.0	-1.5	1.1	1.4	-0.6	2.0	0.2	2.8	-1.1	-0.2
Ever depressed for a whole week	1.5	1.8	3.2	-1.3	-1.5	-1.8	-1.3	1.5	-1.2	-1.2	0.5	-0.9	1.8
Medication: Co-codamol	1.4	1.6	4.9	1.0	0.6	1.1	2.2	-1.8	1.3	-0.2	1.4	0.9	-1.0
Townsend deprivation index at recruitment	1.4	1.9	4.7	2.2	-1.6	1.6	1.6	-1.5	0.3	1.4	0.5	1.0	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.0	-1.2	-2.0	-1.1	-1.3	1.6	-1.2	1.2	-0.6	-0.3	2.0
Number of live births	1.4	1.9	4.7	2.1	0.2	1.6	1.2	-1.7	0.0	1.4	0.6	2.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.3	-1.0	-0.6	-1.8	-1.4	1.5	-1.6	-0.6	0.7	-0.8	1.6
Commuting to job workplace: Cycle	1.4	1.7	4.6	-1.0	-2.1	1.8	-0.3	-0.3	-1.3	-2.0	1.1	-1.1	0.3
Depression (Nagel 2018)	1.3	1.9	5.3	-1.9	-2.3	-0.8	-1.1	1.7	-0.9	0.8	0.2	-0.5	1.9
Irritable Bowel Disease (IBD)	1.3	3.0	5.7	2.4	1.4	1.4	2.4	-2.3	0.8	-0.1	-1.1	1.3	-2.4
Ovarian Cancer	1.3	1.8	4.0	1.4	0.2	2.0	2.0	-1.3	0.1	0.2	-1.4	0.6	-1.9
Fasting Glucose	1.3	1.5	5.7	-0.3	-1.5	-1.1	-0.3	0.6	-1.3	0.9	2.4	-1.5	0.8
Systolic blood pressure, automated reading	1.3	3.7	7.3	1.7	-0.7	-2.5	2.7	-2.5	-0.1	-1.6	2.3	0.7	-2.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.9	-0.8	-0.5	-1.7	-1.0	0.6	-1.6	-1.5	1.4	-1.7	0.4
Number of incorrect matches in round	1.3	2.1	6.7	1.7	1.4	0.3	1.6	-2.2	0.8	-0.8	-0.9	0.4	-2.6
Qualifications: None of the above	1.3	2.8	6.3	2.0	-0.0	1.2	2.3	-2.5	1.3	0.4	1.2	1.9	-2.0
Pain all over the body in last month	1.3	1.4	5.9	-1.5	-0.8	0.6	-1.0	0.6	-0.8	-0.4	1.5	-2.4	0.6
Hair/balding pattern: Pattern 4	1.3	3.1	13.0	-2.1	-0.6	-3.6	-1.8	2.0	-1.2	-0.1	-0.3	-1.5	1.6
Loud music exposure frequency	1.3	1.5	3.1	-1.8	-0.0	0.7	-1.0	1.4	-1.2	-0.8	1.0	-1.6	1.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.2	-1.9	-0.6	-0.5	-2.2	2.0	-1.2	-0.1	0.1	-1.5	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	7.5	-1.8	-2.7	1.9	-1.4	1.6	-2.0	-1.0	0.2	-0.9	1.5
Medication: Lansoprazole	1.2	1.4	6.3	0.8	0.9	2.5	0.9	-0.6	0.0	1.7	1.1	1.0	-0.5
Gout (self-reported)	1.2	1.7	3.5	-1.9	-0.5	-1.5	-1.3	1.2	-0.8	-0.0	1.7	-1.4	1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	8.0	0.9	2.8	0.1	0.5	-0.9	1.7	-0.1	-1.0	0.7	-0.7
Eye problems/disorders: Cataract	1.2	1.4	3.2	-1.1	0.9	-1.3	-1.4	1.8	-1.6	0.3	0.7	-0.7	1.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.7	-1.2	-1.4	-0.1	-0.9	1.6	-1.7	1.4	1.3	-1.2	1.9
Alzheimer’s Disease (in father)	1.1	1.2	2.1	1.2	-0.5	1.2	1.3	-1.4	1.0	0.4	1.1	0.5	-1.4
Age at First Birth	1.1	1.6	3.1	0.2	0.5	-1.6	-1.7	1.6	-1.1	1.7	-1.4	0.6	1.1
HbA1C	1.1	1.2	2.5	-0.8	-1.1	0.7	-0.9	1.4	-0.9	-0.8	0.8	-1.6	1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.3	1.1	1.0	-0.8	1.3	-1.6	1.3	0.7	1.0	-0.5	-1.8
Hearing difficulty/problems with background noise	1.1	1.8	4.5	-2.1	0.2	-0.6	-1.6	1.4	-1.1	-1.4	1.6	-1.5	0.9
Noisy workplace	1.1	1.4	5.4	0.8	-0.9	1.2	0.7	-1.6	2.3	0.3	-0.1	-0.1	-1.6
Pulse wave reflection index	1.1	1.4	4.7	-0.8	-2.2	-0.7	-1.9	1.2	-1.4	-0.1	-0.1	-0.7	1.0
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.0	-1.7	1.7	-1.0	-1.3	1.6	-0.4	-0.2	-0.2	-1.0	1.3
Emphysema/chronic bronchitis	1.1	1.3	2.8	0.7	1.7	0.8	1.1	-1.0	0.8	1.3	1.6	-1.1	-0.9
Neck or shoulder pain in last month	1.1	1.5	7.2	0.3	-2.7	-1.9	0.1	0.8	-0.9	1.2	0.7	0.7	0.3
Osteoarthritis (self-reported)	1.1	1.5	2.9	1.5	1.1	1.1	1.6	-1.7	1.3	0.6	-0.6	-0.3	-1.4
Guilty feelings	1.1	1.6	6.8	-2.6	0.7	0.3	0.0	0.2	-0.3	-1.2	1.7	-2.0	0.4
Prostate Cancer	1.0	1.4	3.6	-1.9	-0.5	-0.9	-0.8	1.1	0.9	-0.2	1.6	-1.1	1.9
LDL Cholesterol	1.0	1.6	8.0	0.6	2.8	-0.0	1.7	-1.1	1.6	0.5	-0.4	0.4	-0.9
Smoking Status	1.0	2.4	10.8	-1.6	0.4	3.3	-0.0	0.0	0.0	0.1	2.6	-1.6	0.9
Relative age of first facial hair	1.0	2.0	5.8	0.5	2.4	2.4	0.5	-0.6	1.5	1.0	0.0	2.1	-0.4
Maternal smoking around birth	1.0	1.5	4.2	-0.9	0.2	1.2	0.6	-0.7	1.9	0.3	1.6	-2.0	-1.4
Had menopause	1.0	1.2	5.0	0.9	0.4	-0.5	1.0	-1.6	1.5	-0.2	0.5	-0.0	-2.2
Happiness	1.0	1.2	5.3	-0.5	-1.1	-0.7	-0.3	0.6	-1.7	-0.7	2.3	-0.0	1.1
Lung cancer (father)	1.0	1.2	2.9	-1.7	0.5	1.3	-1.0	0.9	-0.6	-1.6	-0.1	-1.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.0	6.7	-2.0	-1.1	1.3	-2.3	2.6	-1.7	0.6	-1.4	-0.2	2.5
Pulse wave Arterial Stiffness index	1.0	1.2	4.1	-0.6	-1.9	-0.0	0.7	-0.8	0.1	-0.7	2.0	-1.5	-0.5
Length of working week for main job	1.0	1.1	3.6	-0.1	-1.7	0.0	-1.1	0.8	-0.8	0.1	-1.9	1.4	0.6
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.0	1.2	1.3	1.2	1.1	-1.1	-0.3	-1.0	-0.2	0.6	-1.7
Pulse wave peak to peak time	1.0	1.2	4.2	0.4	2.0	-0.1	-0.8	0.9	0.0	0.7	-1.9	1.3	0.6
Had major operations	1.0	1.2	2.6	1.4	1.6	-0.1	1.4	-1.3	0.7	0.1	-0.1	0.6	-1.6
Mineral and other dietary supplements	1.0	1.3	2.9	-0.6	-1.3	-1.3	-0.8	1.3	-1.3	-1.0	1.1	0.7	1.7
Medication: Gliclazide	1.0	1.2	5.7	1.1	-0.3	1.3	0.7	-0.6	0.5	1.3	-0.2	2.4	-0.1
Diastolic blood pressure, automated reading	1.0	3.1	6.8	1.5	-0.4	-2.0	2.4	-2.5	0.7	-1.8	0.9	1.0	-2.6
Allergy or Eczema	0.9	2.5	6.1	-2.5	-1.8	-0.9	-1.7	1.6	-0.1	-1.2	0.4	-2.3	1.4
Average weekly spirits intake	0.9	1.1	4.9	-0.8	0.3	0.7	-1.5	1.0	-0.4	0.3	-2.2	-0.7	1.0
Vitamin and mineral supplements	0.9	1.2	5.7	-0.4	0.8	-1.7	0.4	0.2	-0.3	-1.4	2.4	0.3	0.4
Multivitamins +/- minerals	0.9	1.1	3.4	-0.8	-0.1	1.8	-0.7	0.0	1.5	0.4	-1.4	-1.5	-0.3
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.5	1.4	0.7	0.2	1.3	-1.2	0.3	1.6	0.7	1.0	-0.8
Age at first live birth	0.9	1.5	9.5	-0.6	1.0	-1.1	-0.3	0.3	0.2	-1.7	-3.1	-0.3	0.2
Qualifications: College or University degree	0.9	2.7	7.3	-2.7	-0.0	-1.3	-1.9	1.8	-0.2	-0.4	0.8	-2.7	1.8
Medication: Seretide 50 evohaler	0.9	1.0	2.3	1.4	0.5	0.8	1.3	-1.4	0.4	1.0	-0.8	0.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.7	1.6	-0.8	1.5	0.8	-1.0	0.8	-0.1	-0.8	1.2	-1.0
Illnesses of father: Heart disease	0.9	1.2	5.0	1.2	2.2	-0.4	0.8	-0.4	-0.3	0.6	-0.6	2.0	-0.5
Average weekly red wine intake	0.9	1.3	6.7	-0.3	1.0	-0.6	1.1	-1.1	2.6	-1.4	-0.2	0.0	-0.9
Mood swings	0.9	1.6	3.2	-1.8	-1.7	-1.5	-1.8	1.2	-1.0	-0.1	0.2	-0.6	1.1
Diabetes diagnosed by doctor	0.9	1.5	3.7	-0.7	-0.6	0.7	-1.3	1.9	-0.1	1.6	0.2	1.3	1.9
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.9	0.8	0.7	1.7	0.8	-1.0	1.3	1.5	-0.7	0.1	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.2	1.3	-0.5	0.6	0.7	-0.3	-1.1	1.0	1.4	2.0	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.3	-0.9	-1.3	-0.4	-1.5	1.3	-0.8	1.1	0.3	-1.1	1.5
Schizophrenia vs Biploar Disorder	0.8	1.0	4.0	0.1	2.0	0.4	1.1	-0.9	0.2	-1.4	0.6	-0.4	-1.2
Reaction Time	0.8	1.6	4.9	-1.1	0.1	-0.7	-1.8	1.3	-2.2	-1.4	0.8	-0.7	1.1
Body Mass Index (BMI) (2010)	0.8	1.1	3.8	0.6	0.6	-0.2	2.0	-1.2	-0.4	-1.0	1.7	0.2	-1.2
Crohns Disease (2012)	0.8	1.3	3.8	1.0	0.3	0.9	1.9	-1.5	0.8	-1.4	0.7	-0.1	-1.3
Mean Putamen Volume	0.8	0.9	3.4	1.4	-1.7	0.3	0.1	-0.4	-0.4	1.8	-0.3	0.7	-0.3
Triglycerides	0.8	1.3	3.1	0.5	-1.3	-1.7	1.2	-1.4	0.0	-0.9	1.1	1.5	-0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.0	0.2	0.3	1.6	-0.8	1.1	0.8	1.7	-1.2	2.0	1.0
Lung FEV1/FVC ratio	0.8	3.9	17.1	-1.0	-2.3	4.1	-0.1	-0.3	-1.9	-2.3	2.6	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	10.8	0.9	-1.3	-3.3	-0.8	0.5	-0.7	1.4	0.2	1.4	0.1
Medication: Simvastatin	0.8	1.1	3.3	0.3	-0.1	1.3	1.2	-1.3	-0.1	-1.8	1.2	-0.6	-1.2
Depression (self-reported)	0.8	1.0	2.6	-1.5	0.1	0.6	-1.6	1.1	-1.0	-0.7	-0.5	-0.3	1.3
Peak expiratory flow (PEF)	0.8	1.9	5.1	-1.8	-0.2	0.4	-2.1	2.2	-0.9	-0.4	0.2	-1.1	2.0
Blood clot in the leg (DVT)	0.8	1.1	1.9	-0.9	-0.8	-0.6	-1.3	1.3	-0.5	1.1	0.7	-1.3	1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.9	1.7	-0.1	-0.2	1.2	-0.9	0.8	1.3	-0.4	1.1	-0.9
Forced vital capacity (FVC), Best measure	0.8	2.8	7.3	-1.9	-1.0	0.2	-2.2	2.7	-1.1	0.8	-1.7	-0.3	2.6
Medication for pain relief, constipation, heartburn	0.8	1.4	2.8	-0.8	1.1	-0.2	-1.6	1.3	-0.9	-1.1	-1.7	-0.4	1.7
Family relationship satisfaction	0.8	1.0	2.5	-0.8	-1.3	-1.1	-0.6	0.2	-1.0	-1.3	1.6	-0.9	0.4
Handedness (chirality/laterality): Left-handed	0.8	0.9	5.6	0.4	-2.4	0.1	0.3	0.4	-0.6	1.1	0.6	0.6	1.0
Loneliness, isolation	0.8	1.2	3.2	-1.1	-1.8	-0.8	-0.8	0.7	-1.5	0.4	1.0	-0.7	1.2
Ever had bowel cancer screening	0.8	0.9	2.1	1.4	-0.7	-1.0	0.9	-1.0	0.6	0.7	0.7	0.9	-1.3
Breast cancer (self-reported)	0.8	0.9	3.8	0.2	-1.1	-0.6	-0.7	0.9	-2.0	1.0	-0.4	0.7	0.8
Average weekly champagne plus white wine intake	0.8	1.1	3.0	-0.6	0.3	-0.8	-1.3	1.2	0.7	1.5	-1.7	0.1	0.9
Hearing aid user	0.8	0.9	4.5	0.5	-1.9	-0.3	-0.5	-0.0	0.2	2.1	-0.1	-0.2	-0.6
Risk taking	0.8	1.2	5.7	0.4	0.4	2.4	0.6	-0.9	1.9	0.2	-0.1	0.2	-1.0
Cholesterol lowering medication	0.8	1.2	6.9	-0.3	-0.5	0.7	0.7	-1.1	-0.3	-1.3	2.6	-0.7	-0.2
Heart disease (siblings)	0.8	1.0	2.5	-1.1	-0.9	-0.9	-0.4	1.6	1.0	0.0	1.1	-0.4	1.5
Alcohol drinker status: Previous	0.8	0.9	4.8	0.1	-1.6	2.2	0.1	-0.5	-1.1	-0.3	0.3	-0.1	-0.6
Relative age voice broke	0.7	1.1	4.3	0.1	1.7	2.1	0.0	-0.1	1.1	0.5	0.2	1.4	-0.0
Qualifications: CSEs or equivalent	0.7	0.9	4.2	-0.4	0.5	-0.2	-1.4	1.0	-2.0	0.6	-0.5	-0.2	0.9
Supplements: Glucosamine	0.7	0.9	3.6	-1.1	-0.4	0.9	-1.0	0.1	0.2	-1.0	-1.2	-1.9	0.0
Diabetes (self-reported)	0.7	1.1	2.2	-0.3	-0.8	1.5	-0.8	1.5	-0.3	1.4	-0.1	1.1	1.3
Medication: Ramipril	0.7	0.9	4.9	0.3	2.2	0.0	0.3	-0.1	-0.5	-0.2	-1.6	0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.5	-0.5	-1.0	-0.9	-0.8	1.3	-1.6	1.4	-0.4	0.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.5	-1.8	-0.8	2.0	-2.0	2.3	-0.5	0.8	-0.9	-0.5	2.1
Pulse rate	0.7	1.2	3.6	1.3	-0.8	0.6	1.9	-1.8	0.2	0.1	-0.1	-0.3	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-0.9	0.7	-0.9	0.3	0.0	0.2	-1.7	1.4	-0.9	0.3
Medication: Blood pressure	0.7	1.3	4.4	0.9	-0.4	0.1	1.7	-1.7	1.1	-0.3	0.8	0.2	-2.1
Angina (self-reported)	0.7	1.0	3.1	1.3	0.7	1.8	1.2	-0.7	0.3	-0.4	-0.3	0.6	-1.2
Heart disease (mother)	0.7	0.9	2.5	0.6	0.0	0.6	1.6	-1.2	1.1	-0.2	0.3	1.1	-1.4
Alcohol intake frequency.	0.7	1.7	5.3	1.1	-2.1	1.2	-0.3	0.4	-2.3	1.2	1.0	1.2	0.7
Overall health rating	0.7	1.6	5.7	-0.8	-1.1	-1.1	-0.5	0.8	-1.8	-0.3	2.4	-1.4	0.8
Chest pain or discomfort	0.7	1.0	4.5	0.2	-2.1	-1.3	-0.9	0.7	-1.5	0.6	-0.1	0.1	-0.1
Friendships satisfaction	0.7	0.8	2.7	0.0	-0.2	-1.1	1.0	-0.9	0.1	-1.0	1.7	-1.1	-0.5
Osteoporosis (self-reported)	0.7	0.9	3.5	1.4	-0.4	0.5	0.9	-0.9	0.7	1.9	-0.2	0.7	-0.7
Medication: Aspirin	0.7	0.9	3.1	0.2	0.4	0.3	1.1	-1.4	1.3	-0.8	0.7	-0.5	-1.8
Ever taken oral contraceptive pill	0.7	0.8	1.9	1.0	0.7	0.4	0.3	-0.4	1.4	1.1	-1.0	1.3	-0.7
Illnesses of father: High blood pressure	0.7	0.8	4.4	0.7	-0.1	0.2	0.5	-0.8	0.8	1.1	-0.7	2.1	0.1
Ever smoked	0.7	1.3	3.7	-1.9	0.6	1.3	-0.9	1.0	0.2	-1.0	0.5	-0.9	1.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.4	0.5	1.0	-0.3	0.6	-0.1	1.0	-0.6	-2.1	-0.0	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	3.6	-0.8	1.9	0.2	0.5	-0.6	0.6	-0.3	0.2	-1.5	-1.0
Age started oral contraceptive pill	0.7	0.9	3.6	0.9	1.2	-0.6	0.8	-1.3	-0.0	-0.6	-0.5	-0.2	-1.9
Major Depression (MDD)	0.6	0.8	5.0	-1.4	-0.2	0.4	-0.4	0.3	-0.3	-2.2	-0.2	0.1	0.0
Ulcerative Colitis	0.6	0.9	2.0	1.2	0.8	1.2	0.8	-0.9	-0.2	0.6	-1.4	1.1	-0.8
Hearing difficulty/problems: Yes	0.6	0.9	3.0	-1.0	0.2	0.7	0.1	-0.5	1.1	-0.7	1.7	-1.4	-1.1
Angina	0.6	0.8	2.6	1.1	0.4	1.6	1.1	-0.7	0.5	-0.6	-0.4	0.6	-1.1
Pack years adult smoking proportion	0.6	0.9	3.6	0.1	0.8	-0.7	-0.1	0.3	-1.5	-0.9	0.9	-1.9	0.5
Impedance of leg (right)	0.6	3.1	9.5	1.3	-0.1	0.9	1.0	-1.6	3.1	2.5	-0.8	2.6	-1.3
Medication: Atenolol	0.6	0.8	3.5	0.2	-0.4	-0.4	0.8	-0.6	1.0	-1.9	-0.5	0.8	-1.0
High blood pressure (mother)	0.6	0.8	2.5	0.2	-1.6	0.1	0.5	-0.0	-1.3	-1.1	-0.9	1.1	0.3
Impedance of leg (left)	0.6	2.9	8.0	1.4	0.1	0.5	0.9	-1.3	2.8	2.5	-1.1	2.8	-1.2
Forced vital capacity (FVC)	0.6	2.5	5.6	-1.6	-0.5	1.8	-1.8	2.4	0.1	1.4	-1.6	-0.3	2.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	4.1	-1.1	-0.0	-0.1	-0.7	1.0	0.1	0.1	0.6	-2.0	1.1
Father’s age at death	0.6	0.8	4.2	-0.0	-2.0	-0.8	-0.1	0.3	1.1	0.3	0.3	-1.1	-0.5
Worrier / anxious feelings	0.6	1.2	5.8	-0.3	2.0	-0.6	-0.2	-0.1	-2.4	0.7	0.1	-0.8	0.0
Falls in the last year	0.6	0.9	1.5	-0.6	1.1	-1.0	-0.9	1.1	-0.8	1.2	-0.4	-0.7	1.1
Prospective memory result	0.6	0.8	4.4	-0.0	-2.1	-1.1	-0.9	0.7	-0.2	0.5	0.2	0.3	0.8
Illnesses of mother	0.6	0.8	3.1	-0.6	-0.1	-0.9	-1.1	0.9	0.4	1.8	-0.2	-0.5	1.0
Exposure to tobacco smoke at home	0.6	0.6	1.7	0.7	-1.3	0.3	0.7	-1.1	0.3	0.2	-0.5	0.8	-1.2
Birth weight of first child	0.6	1.0	4.0	-0.9	-1.7	0.2	0.3	-0.4	-0.7	-0.7	1.1	-2.0	-0.2
Headache pain in last month	0.6	1.1	3.1	-1.0	-0.5	-1.0	-1.7	1.8	-0.6	0.3	-0.5	0.6	1.4
High blood pressure (siblings)	0.6	0.9	2.0	1.1	0.1	0.2	1.3	-1.2	-0.1	-0.4	-0.8	1.4	-1.3
Eye problems/disorders: None of the above	0.6	0.7	2.1	-0.8	-0.1	0.5	-1.5	0.5	0.3	-1.4	-0.3	0.5	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	4.6	0.3	2.1	-0.2	0.4	-0.3	0.5	-0.5	-1.1	0.4	-0.5
Migraine (self-reported)	0.6	0.8	3.5	0.7	1.9	0.7	-0.0	-0.1	0.2	0.1	-1.0	1.5	-0.3
Suffer from ‘nerves’	0.6	1.0	6.3	-0.4	0.2	-0.5	0.8	-0.9	-0.8	0.0	2.5	-1.2	-0.0
Knee pain experienced in last month	0.6	1.0	3.6	0.7	-1.2	-0.1	1.2	-1.1	0.5	0.2	1.9	-0.2	-1.3
Hypertension (Self-reported)	0.6	1.6	4.3	1.1	-0.7	0.0	2.1	-2.0	-0.3	-1.7	0.9	0.4	-1.4
Medication: Bendroflumethiazide	0.6	1.0	2.5	1.0	1.6	0.5	1.3	-0.7	1.3	0.2	-1.0	0.9	-0.2
Medication: Paracetamol	0.6	1.0	3.0	-0.7	-1.7	-0.6	-0.9	1.2	-0.5	1.2	0.9	-0.5	1.0
Average weekly beer plus cider intake	0.6	0.9	1.8	1.1	-0.6	-0.3	0.4	-1.2	-0.8	-1.3	-1.2	1.1	-1.0
Ulcerative Colitis (UC)	0.5	0.9	1.7	1.3	0.6	0.9	0.6	-0.8	0.6	0.8	-1.3	1.2	-1.0
HDL Cholesterol	0.5	0.8	2.5	0.1	0.8	1.5	-0.2	0.8	0.5	0.8	-1.6	-1.0	-0.2
Heel T-Score	0.5	4.3	18.1	1.6	-1.5	-4.2	-1.2	0.9	-0.6	2.7	-1.1	2.9	0.4
Systolic Blood Pressure	0.5	2.4	5.1	1.6	1.0	-2.1	2.2	-2.0	0.2	-0.7	1.3	1.4	-1.7
Cardiovascular Disease	0.5	1.5	3.9	1.1	0.4	-1.0	1.7	-1.9	-0.2	-2.0	0.1	1.2	-1.0
Lung FVC	0.5	2.3	5.8	-1.7	-0.6	-0.4	-1.9	2.4	-2.2	0.3	-0.6	-0.0	2.2
Chronotype (morning person)	0.5	1.2	3.5	0.4	-0.3	0.8	1.7	-1.7	0.9	0.2	1.9	-0.5	-1.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.8	0.1	-0.2	1.1	-1.0	0.6	0.2	0.3	1.1	-1.1
Stomach or abdominal pain in last month	0.5	0.6	1.6	-0.7	0.2	-1.3	-0.7	0.9	-0.4	-0.5	0.1	-1.1	1.0
Past tobacco smoking	0.5	1.0	4.0	1.4	0.0	-2.0	0.8	-0.7	-0.5	0.3	-0.4	0.3	-1.4
Nervous feelings	0.5	1.0	3.2	-0.8	1.8	-1.7	-0.3	0.0	-0.8	0.7	1.3	-0.1	0.4
Hair/balding pattern: Pattern 2	0.5	0.7	1.9	-0.8	-1.4	0.6	-1.4	0.5	0.2	-0.7	0.6	-0.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.9	-1.4	-0.8	-0.3	-0.4	0.4	-0.6	-1.0	1.2	-0.5	0.9
Time employed in main current job	0.5	0.5	1.9	0.8	1.4	-0.3	-0.4	0.4	-0.7	0.7	-0.5	1.1	0.4
Hair/balding pattern: Pattern 3	0.5	0.7	2.4	1.2	-0.0	0.3	1.6	-0.9	0.3	0.1	-0.4	1.2	-1.1
Medication: Paracetamol	0.5	0.9	3.3	-0.5	-1.8	-0.5	-0.4	0.5	-0.6	0.9	1.6	-0.6	0.5
Medication: Amlodipine	0.5	0.7	2.7	0.3	1.1	-0.1	1.0	-0.7	-0.5	-0.8	1.6	-0.6	-0.7
Comparative body size at age 10	0.5	1.4	3.2	-0.9	0.9	-0.2	-1.8	1.8	-1.3	0.3	-1.4	-0.8	1.0
Number of full brothers	0.5	0.6	1.5	1.2	-0.7	1.1	0.5	-0.3	0.3	0.2	0.4	1.2	-0.6
Worry too long after embarrassment	0.5	0.9	2.0	-0.3	1.2	0.8	0.8	-1.3	-0.1	-0.8	1.4	-1.1	-0.6
Shortness of breath walking on level ground	0.5	0.6	2.1	-0.0	-0.1	-1.5	0.7	-0.7	-0.6	-0.7	1.0	-0.8	-0.7
Medication: Omeprazole	0.5	0.6	2.4	0.2	-0.8	1.0	0.1	0.3	-1.5	0.0	1.2	0.6	0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.6	-0.8	-0.5	-0.1	-0.5	1.1	0.1	0.7	1.2	-0.6	1.1
Back pain experienced in last month	0.5	0.8	2.6	0.4	0.6	-0.0	0.1	0.2	1.0	1.4	-1.3	1.6	-0.2
High cholesterol (Self-reported)	0.5	0.8	1.9	0.7	0.8	-0.7	1.2	-1.4	0.8	-1.1	0.4	0.5	-1.0
Pack years of smoking	0.5	0.8	2.8	0.5	1.2	-0.9	0.4	-0.3	-0.7	-1.0	0.8	-1.7	-0.3
Worry (Nagel 2018)	0.4	0.8	1.7	-0.4	0.6	-1.1	0.5	-1.0	-1.1	-0.1	1.3	-0.9	-0.9
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	-1.1	-0.5	0.5	-0.6	0.6	-0.4	0.7	0.5	-1.1	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.9	-0.3	-0.5	1.4	0.5	-0.4	1.0	0.6	0.9	-0.6	-0.9
Breast Cancer	0.4	1.0	5.3	-0.1	1.7	-2.3	-0.6	0.5	0.1	0.9	0.1	0.4	0.8
Hand grip strength (left)	0.4	1.2	3.7	-1.1	-0.1	0.6	-1.8	1.0	-0.2	-1.9	-1.1	0.1	1.1
Medication for hormone replacement therapy	0.4	0.4	3.3	0.1	0.0	0.5	0.4	-0.0	0.2	1.8	0.6	0.4	0.4
Diabetes (mother)	0.4	0.5	2.3	0.5	0.9	-0.1	0.2	0.7	-0.1	0.5	-1.5	0.9	0.2
Average weekly fortified wine intake	0.4	0.4	2.7	-0.5	-0.3	-0.7	-0.3	0.6	0.3	-1.7	0.0	-0.5	0.3
Fed-up feelings	0.4	0.7	2.0	-1.2	-1.4	0.2	-0.6	0.7	1.1	1.2	0.1	-0.0	0.8
Age when periods started (menarche)	0.4	0.9	2.6	0.6	0.3	1.0	1.3	-1.6	0.2	0.4	0.7	0.6	-1.4
High blood pressure	0.4	1.1	3.1	0.7	-0.4	0.3	1.8	-1.6	-0.4	-1.7	0.6	0.2	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.5	1.1	-1.2	-1.9	0.1	-0.5	-0.7	-0.0	0.3	1.3	-0.8
Heart attack	0.4	0.6	2.1	0.4	-0.5	0.4	1.0	-0.3	1.1	-1.4	-0.3	0.3	-0.8
Fluid intelligence score	0.4	0.8	2.9	-1.1	-0.5	-0.5	0.4	-0.0	-0.0	-1.7	0.9	-1.5	0.3
Tense / ‘highly strung’	0.4	0.7	5.2	-0.5	-0.5	-2.3	-0.4	0.1	-0.7	0.1	-0.5	-0.0	0.3
Birth weight	0.4	0.8	2.8	0.6	1.7	0.8	1.1	-0.9	1.4	-0.5	-0.2	0.5	-0.5
Medication: Ibuprofen	0.4	0.5	1.4	-1.2	-1.2	-0.2	0.1	0.6	-0.0	-0.9	0.0	-0.8	0.5
Age at last live birth	0.4	0.5	3.5	0.2	0.7	-0.5	0.1	-0.1	0.2	-0.0	-1.9	1.0	0.1
Supplements: Vitamin C	0.4	0.5	1.2	0.9	-1.0	0.2	-0.2	-0.1	-1.1	0.7	-0.9	0.2	-0.6
Smoking status: Previous	0.4	0.6	3.2	-0.8	-0.5	1.8	-0.4	-0.1	0.5	-0.6	1.1	-0.4	0.4
Long-standing illness, disability or infirmity	0.4	0.5	1.7	1.1	-0.7	0.1	1.3	-0.8	-0.6	0.2	0.8	0.1	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	-0.6	-1.4	0.8	-0.7	0.4	-0.2	-0.2	-0.1	-1.0	0.2
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	0.6	-0.0	-0.1	1.4	-1.0	-0.1	-1.0	1.2	-0.7	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	3.4	0.2	1.9	0.1	0.4	-0.4	0.6	0.2	0.5	-0.5	-0.6
Medication: Lisinopril	0.4	0.5	2.2	-0.3	-1.5	1.2	0.2	-0.1	-0.1	-0.5	0.8	-0.4	-0.2
Irritability	0.4	0.7	3.5	-0.5	-1.3	-0.6	0.4	-0.5	-0.2	-1.9	-0.1	-0.8	-0.7
Supplements: Calcium	0.4	0.4	0.9	-0.1	-0.9	-0.1	-1.0	0.6	-0.4	1.0	-0.4	-0.4	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.9	0.3	-1.0	0.4	0.7	0.0	0.7	-1.4	-0.5	0.2	-0.4
Impedance of whole body	0.4	1.8	4.9	0.9	0.4	1.1	0.7	-0.4	2.0	2.2	-1.4	2.2	-0.3
Depressed Affect (Nagel 2018)	0.3	0.5	3.4	-0.9	-1.8	-0.6	-0.4	0.3	-0.1	0.7	0.6	0.1	0.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.9	0.2	-0.2	0.3	1.7	-1.5	1.3	-1.0	1.3	-0.4	-0.5
Neuroticism (Nagel 2018)	0.3	0.8	1.9	-0.8	-0.5	-0.4	0.8	-1.3	-0.1	0.3	1.3	-1.1	-1.4
Neuroticism (2016)	0.3	0.4	2.1	-0.1	-0.0	0.2	0.4	-0.6	-0.1	-1.2	0.5	-1.4	-0.4
Primary Biliary Cirrhosis	0.3	0.4	2.9	0.5	1.7	0.1	0.6	0.0	-0.1	-0.1	0.4	0.8	-0.4
Blood Eosinophil Count	0.3	2.0	4.9	-1.4	-0.3	-0.9	-1.2	1.5	-1.8	-2.2	0.2	-1.1	1.8
Waist Hip Ratio (WHR)	0.3	1.2	3.3	0.5	-0.3	1.7	1.4	-1.8	0.2	-0.4	-1.0	0.4	-1.5
Respiratory disease	0.3	0.7	3.0	0.9	-1.0	-0.8	-0.1	-0.0	-0.9	1.7	-0.6	0.3	-0.0
Number of treatments/medications taken	0.3	0.6	1.6	0.3	0.0	0.1	1.2	-1.3	0.4	-0.5	0.9	-0.7	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	-0.9	0.9	-0.2	-0.9	0.2	0.2	-0.4	0.7	-0.3	0.2
Medication: Metformin	0.3	0.5	3.0	-0.0	-0.7	1.7	-0.2	0.3	0.5	0.3	-0.1	0.8	0.5
Diabetes (father)	0.3	0.4	1.2	0.5	-1.1	0.2	-0.1	0.2	-0.7	0.7	-0.1	1.0	0.6
Leg fat-free mass (left)	0.3	1.6	5.4	-1.6	-0.2	-0.6	-1.0	1.0	-1.3	-1.8	0.6	-2.3	0.7
Hand grip strength (right)	0.3	0.9	3.6	-1.0	0.4	0.9	-1.3	0.6	0.2	-1.9	-0.6	-0.3	1.2
Current tobacco smoking	0.3	0.6	2.6	0.0	1.6	1.2	0.8	-0.6	0.4	-0.1	0.3	-0.3	-0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.5	-0.3	0.6	-0.1	0.2	-0.2	-0.1	-1.0	0.4	-1.2	-0.4
Leg predicted mass (left)	0.3	1.7	5.6	-1.7	-0.2	-0.6	-1.0	1.0	-1.3	-1.8	0.6	-2.4	0.8
Waist circumference	0.3	1.3	3.8	-1.0	-1.9	-0.6	0.2	-0.0	-1.0	-1.7	1.2	-1.4	0.1
Alcohol usually taken with meals	0.3	0.5	1.1	0.5	-0.7	-1.0	0.8	-0.4	0.8	1.1	0.4	0.5	-0.4
Had other major operations	0.3	0.3	1.2	0.6	0.3	1.1	0.7	-0.4	0.2	-0.1	-0.8	0.0	-0.7
Financial difficulties in last 2 years	0.3	0.4	1.5	-0.1	-0.3	1.2	-0.1	0.5	-0.4	0.8	0.4	1.0	0.8
Impedance of arm (right)	0.3	1.4	5.2	0.7	1.1	1.4	0.8	-0.4	2.3	1.4	-0.9	1.1	-0.3
Hip circumference	0.3	1.1	3.3	-0.7	-1.8	-0.9	-0.2	0.3	-1.2	-0.7	1.5	-1.4	0.3
Asthma	0.3	0.5	1.1	-0.1	-0.8	-1.0	-0.7	0.6	-0.8	0.6	-0.3	-0.9	0.7
Arm fat mass (right)	0.3	1.1	4.7	-1.2	-0.2	-0.3	-0.3	0.4	-1.1	-2.2	0.6	-1.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-1.0	0.5	-0.3	-1.2	0.5	-0.7	0.1	0.8	-0.7	0.7
Arm fat-free mass (right)	0.3	1.7	3.7	-1.8	-1.2	-0.9	-1.4	1.0	-1.4	-1.5	0.8	-1.9	0.6
Wheeze or whistling in the chest in last year	0.3	0.6	3.8	-0.1	1.9	0.1	0.1	0.3	0.8	-0.4	-0.3	-0.9	-0.5
Mean time to correctly identify matches	0.3	0.5	2.0	-0.4	0.4	-1.4	-0.5	0.5	-0.7	-0.7	1.0	-0.2	0.5
Arm predicted mass (right)	0.3	1.7	4.5	-1.9	-0.8	-0.7	-1.3	0.8	-1.4	-1.5	0.7	-2.1	0.5
Medication: Aspirin	0.3	0.4	1.4	-0.1	0.9	-0.1	0.4	-0.7	0.8	-0.2	0.4	-0.6	-1.2
Whole body fat-free mass	0.3	1.5	5.4	-1.7	-0.1	-0.6	-1.2	0.8	-0.9	-1.7	0.6	-2.3	0.5
Leg fat-free mass (right)	0.3	1.8	5.3	-1.6	0.1	-0.8	-1.1	1.3	-1.7	-1.8	0.4	-2.3	0.9
Arm fat percentage (left)	0.3	1.1	4.8	-1.1	-0.4	-0.2	0.1	0.3	-1.3	-2.2	0.8	-1.6	0.3
Commuting to job workplace: Walk	0.3	0.3	0.9	0.2	0.9	0.4	0.7	-0.5	0.3	0.6	0.4	0.0	-0.9
Medication for cholesterol	0.3	0.5	1.2	0.7	-0.2	-1.0	-0.8	0.5	0.7	0.9	-1.1	0.4	-0.3
Asthma (self-reported)	0.3	0.7	1.5	-0.1	-1.2	-1.0	-0.7	0.6	-0.9	0.8	0.1	-1.1	0.8
Smoking status: Current	0.3	0.6	3.1	-0.1	1.8	1.2	0.6	-0.3	0.5	0.2	-0.4	-0.1	0.1
Whole body water mass	0.3	1.7	5.3	-1.8	-0.3	-0.7	-1.4	1.0	-1.2	-1.8	0.5	-2.3	0.7
Leg predicted mass (right)	0.3	1.8	5.6	-1.7	0.0	-0.8	-1.0	1.3	-1.6	-1.7	0.5	-2.4	0.9
Arm fat mass (left)	0.3	1.4	5.0	-1.5	-0.5	-0.4	-0.7	0.9	-1.4	-2.2	0.4	-1.5	0.7
Medication: Blood pressure	0.3	0.6	1.6	0.3	0.7	0.5	1.2	-0.8	-1.0	-1.3	-0.2	0.1	-0.4
Medication: Atorvastatin	0.3	0.3	0.9	0.1	0.8	-0.6	0.1	0.1	1.0	0.4	0.4	1.0	0.4
Basal metabolic rate	0.3	1.6	4.9	-1.7	-0.4	-0.6	-1.2	0.9	-1.1	-1.8	0.5	-2.2	0.6
Unable to work because of sickness or disability	0.3	0.4	0.6	-0.7	0.6	-0.3	-0.8	0.8	-0.7	-0.7	-0.6	-0.4	0.8
Myopia	0.3	0.4	1.9	0.5	-0.6	-1.4	0.7	-0.4	0.8	-0.3	-0.1	0.6	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.2	-0.8	0.4	-0.4	-1.5	1.4	-0.0	1.4	-0.2	-0.5	1.2
Pain experienced in last month	0.3	0.6	2.0	0.2	1.4	1.2	0.2	-0.4	-0.3	-0.5	-1.2	-0.5	0.0
Basal cell carcinoma (self-reported)	0.3	0.4	2.4	-0.1	0.3	-1.6	-0.7	0.7	-0.1	0.1	0.1	0.2	0.1
Arm predicted mass (left)	0.3	1.6	3.7	-1.9	-0.7	-0.7	-1.6	1.1	-1.2	-1.4	0.2	-1.9	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.6	-0.2	-1.1	-0.7	0.5	-0.6	-0.4	-1.3	0.5	-0.2	-0.2
Rheumatoid Arthritis	0.2	0.3	0.8	-0.6	-0.4	0.9	-0.7	0.4	0.3	0.6	-0.3	-0.2	-0.0
Blood Platelet Count	0.2	2.6	10.4	0.7	-1.1	3.2	1.6	0.1	1.4	2.9	-0.1	-0.5	-0.6
BMI	0.2	1.3	4.0	-0.5	-1.8	-0.6	-0.2	0.4	-2.0	-1.9	0.5	-0.8	-0.0
Neuroticism	0.2	0.4	1.1	-0.4	-0.0	-0.7	0.7	-1.1	-0.2	0.1	0.5	-0.4	-0.9
Sensitivity / hurt feelings	0.2	0.4	1.2	-0.5	-0.6	0.7	0.1	-0.5	-0.1	0.2	1.0	-1.1	-0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.5	-0.7	0.4	0.2	-0.4	0.1	0.2	0.4	0.5	-0.7
Taking other prescription medications	0.2	0.4	1.2	0.2	-0.6	-0.6	0.5	-0.4	-0.6	-0.4	1.1	-0.7	-0.2
Sitting height	0.2	1.7	8.2	-0.1	1.6	-0.2	0.0	-0.2	2.9	0.1	-2.2	0.8	-0.5
Body mass index (BMI)	0.2	1.1	3.3	-0.6	-0.9	-0.6	0.0	0.1	-1.7	-1.8	1.0	-1.3	-0.1
Trunk fat mass	0.2	0.7	4.0	-0.7	-0.3	-0.1	0.5	-0.3	-0.3	-2.0	0.5	-1.1	-0.6
Illnesses of siblings	0.2	0.3	0.8	-0.3	-0.2	0.3	-0.9	0.2	-0.6	0.7	-0.3	-0.6	0.4
Neuroticism score	0.2	0.4	1.5	-1.2	0.3	-0.3	0.0	-0.2	-0.7	-0.2	0.9	-1.1	0.1
Weight	0.2	0.8	2.6	-1.2	-0.5	-0.3	-0.5	0.4	-0.9	-1.6	0.6	-1.5	0.2
Arm fat percentage (right)	0.2	0.9	5.0	-0.8	0.1	0.1	0.2	0.0	-0.9	-2.2	0.7	-1.5	-0.1
Trunk fat-free mass	0.2	1.3	4.9	-1.8	-0.1	-0.1	-1.3	0.7	-0.3	-1.6	0.5	-2.2	0.5
Alcohol intake versus 10 years previously	0.2	0.3	1.3	0.4	-0.8	-0.6	0.1	0.0	1.2	0.1	0.6	-0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.3	1.0	0.3	-0.4	0.2	0.7	-1.0	0.7	-0.8	0.2	-0.4	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.9	-0.8	0.1	0.6	0.2	0.0	-0.6	0.4	-0.7	0.2
Trunk predicted mass	0.2	1.4	4.8	-1.8	-0.2	-0.2	-1.4	0.8	-0.4	-1.5	0.6	-2.2	0.5
Breastfed as a baby	0.2	0.2	1.5	0.1	-0.5	0.3	-0.2	0.2	-0.1	-1.2	-0.1	0.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.3	-0.2	-0.2	1.1	0.3	-0.5	0.2	-0.7	0.2	0.2	-0.6
Leg fat percentage (right)	0.2	0.7	1.9	0.2	-0.5	0.0	1.2	-1.3	0.4	-0.8	0.9	-0.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.4	0.7	-0.3	-0.5	0.2	-0.9	-0.6	0.3	-0.7	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	0.3	-0.0	0.9	-0.6	0.3	0.0	0.1	-0.5	0.5	0.0
Whole body fat mass	0.2	0.7	3.8	-0.8	-0.6	-0.3	0.3	-0.1	-0.6	-1.9	0.6	-1.1	-0.3
Leg fat mass (right)	0.2	0.7	2.7	-0.4	-0.4	-0.2	0.8	-0.8	0.2	-1.7	0.8	-1.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.0	-0.3	-0.7	0.1	0.3	0.7	1.0	0.3	0.5	0.3
Miserableness	0.2	0.4	1.4	-0.5	-0.6	0.7	-0.6	0.2	0.3	1.2	0.5	0.6	-0.0
Mother’s age at death	0.2	0.3	1.3	-0.5	0.7	0.0	-0.4	-0.1	-0.4	-0.7	-1.1	0.2	-0.2
Leg fat percentage (left)	0.2	0.6	1.8	0.3	-0.2	-0.1	1.1	-1.1	0.1	-0.8	0.8	-0.2	-1.4
Arm fat-free mass (left)	0.2	1.3	2.7	-1.7	-0.4	-0.7	-1.4	0.9	-1.2	-1.4	0.1	-1.6	0.5
Number of operations (self-reported)	0.2	0.3	1.5	0.2	1.2	0.6	0.5	-0.5	0.4	-0.4	-0.0	-0.3	-0.8
Leg fat mass (left)	0.2	0.7	2.4	-0.4	-0.4	-0.3	0.7	-0.7	-0.1	-1.6	0.8	-1.0	-1.0
Blood Red Count	0.1	1.3	4.0	-0.9	-2.0	-1.6	-0.9	0.7	-0.4	-0.6	-0.3	2.0	0.5
Blood White Count	0.1	1.1	3.3	-0.9	-1.2	0.9	1.3	0.1	-0.5	-0.8	1.8	0.6	1.1
Height	0.1	1.3	9.3	-0.5	0.0	-0.6	-0.2	0.2	3.0	1.7	-0.3	0.5	-0.0
Trunk fat percentage	0.1	0.5	2.2	-0.2	-0.3	-0.1	1.0	-0.5	-0.1	-1.5	0.5	-0.5	-0.8
Impedance of arm (left)	0.1	0.7	1.9	0.2	0.3	1.1	0.4	0.2	1.4	1.4	-0.8	0.9	0.4
Standing height	0.1	0.6	1.9	-1.2	0.5	0.6	-0.9	0.6	1.4	0.3	-0.6	-0.5	0.5
Body fat percentage	0.1	0.5	1.9	-0.3	-0.5	-0.1	0.8	-0.5	-0.3	-1.4	0.7	-0.7	-0.6
Comparative height size at age 10	0.1	0.6	2.2	-0.4	-0.2	1.1	0.1	-0.3	0.8	-1.0	-0.0	-1.5	-1.0
Number of full sisters	0.1	0.2	0.8	0.2	-0.9	-0.0	-0.5	0.3	-0.5	0.2	0.1	0.3	-0.0
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	0.4	0.1	0.0	-0.4	0.3	0.3
Alcohol drinker status: Never	0.1	0.1	0.4	0.1	-0.3	-0.4	-0.4	0.7	-0.3	0.4	-0.1	-0.2	0.6
Hair Pigment	0.0	0.3	1.2	-0.6	0.6	1.1	-0.6	0.3	-0.4	0.5	-0.1	0.2	0.4
Tanning	0.0	0.2	0.5	-0.1	0.4	0.3	0.6	-0.6	0.5	0.3	-0.4	-0.7	-0.6

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