[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr3:137,189,600-139,050,702

Best TWAS P=1.71e-11 · Best GWAS P=1.24e-11 conditioned to 0.149

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Brain Frontal Cortex BA9	DBR1	0.18	0.10	lasso	5	0.11	9.7e-04	-6.5	-6.7	1.7e-11	0.93	0.03	0.88	TRUE
3	GTEx	Artery Aorta	MRAS	0.52	0.53	lasso	5	0.54	2.5e-34	-6.6	-6.6	5.1e-11	0.95	0.01	0.99	FALSE
5	GTEx	Artery Tibial	MRAS	0.24	0.20	enet	7	0.20	2.3e-15	-6.6	-6.5	9.4e-11	0.93	0.01	0.99	FALSE
4	GTEx	Artery Coronary	MRAS	0.32	0.10	lasso	4	0.12	7.4e-05	-6.5	-6.4	1.2e-10	0.91	0.02	0.96	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRAS	0.03	0.01	blup	49	0.01	9.6e-03	-5.3	6.3	3.0e-10	-0.69	0.04	0.63	FALSE
22	The Cancer Genome Atlas	Soft Tissue Sarcoma	MRAS	0.04	0.03	blup	49	0.04	1.8e-03	-5.4	-6.2	4.3e-10	0.63	0.07	0.42	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ESYT3	0.04	0.01	blup	314	0.04	2.4e-05	-5.7	-6.2	5.1e-10	0.53	0.27	0.65	FALSE
14	GTEx	Testis	MRAS	0.20	0.14	lasso	4	0.11	1.2e-05	-5.3	6.0	2.1e-09	-0.64	0.09	0.86	FALSE
10	GTEx	Muscle Skeletal	FAIM	0.13	0.12	lasso	7	0.13	2.1e-12	-5.6	6.0	2.5e-09	-0.37	0.68	0.32	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAIM	0.04	0.04	lasso	2	0.03	1.1e-04	-5.8	5.9	4.7e-09	-0.34	0.01	0.98	FALSE
9	GTEx	Muscle Skeletal	CEP70	0.08	0.06	lasso	5	0.06	2.1e-06	-5.8	-5.8	5.9e-09	0.32	0.66	0.30	FALSE
13	GTEx	Skin Sun Exposed Lower leg	FAIM	0.04	0.03	lasso	3	0.03	3.2e-03	-5.8	5.8	6.4e-09	-0.33	0.39	0.33	FALSE
8	GTEx	Esophagus Mucosa	FAIM	0.09	0.07	enet	9	0.06	1.1e-04	-5.8	5.8	7.6e-09	-0.33	0.72	0.23	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAIM	0.02	0.03	enet	6	0.02	1.3e-03	-5.8	5.8	8.8e-09	-0.36	0.01	0.90	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAIM	0.14	0.20	lasso	12	0.21	3.2e-25	-5.7	5.7	9.4e-09	-0.31	0.79	0.21	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	CEP70	0.03	0.03	enet	15	0.02	9.0e-04	-5.7	-5.6	2.3e-08	0.32	0.02	0.96	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	FAIM	0.06	0.02	lasso	6	0.01	7.5e-02	-4.4	5.6	2.6e-08	-0.32	0.59	0.22	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FAIM	0.03	0.02	blup	41	0.03	3.9e-03	4.2	5.5	4.2e-08	-0.33	0.02	0.72	FALSE
11	GTEx	Pancreas	FAIM	0.13	0.13	enet	15	0.10	4.3e-05	-5.4	5.5	4.3e-08	-0.29	0.85	0.10	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	FAIM	0.03	0.01	blup	41	0.03	7.1e-04	-4.4	5.5	4.8e-08	-0.34	0.03	0.81	FALSE
7	GTEx	Brain Frontal Cortex BA9	FAIM	0.10	0.10	enet	11	0.07	7.4e-03	-5.4	5.5	5.0e-08	-0.30	0.20	0.07	FALSE
15	GTEx	Thyroid	CEP70	0.17	0.01	enet	13	0.04	6.8e-04	-5.8	-5.2	2.5e-07	0.32	0.44	0.20	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAIM	0.03	0.02	blup	42	0.03	4.0e-04	-5.3	5.1	2.7e-07	-0.27	0.02	0.80	FALSE