[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor :

chr4:102,868,793-104,627,833

Best TWAS P=6.43e-12 · Best GWAS P=1.19e-10 conditioned to 0.925

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CISD2 0.02 0.00 blup 322 0.00 2.7e-01 -4.9 5.1 2.9e-07 0.80 0.05 0.78 FALSE
2 CommonMind Brain Pre-frontal Cortex SLC9B1 0.13 0.23 enet 24 0.24 4.4e-29 6.4 -6.0 2.4e-09 -0.93 0.04 0.96 FALSE
3 GTEx Adipose Subcutaneous CISD2 0.06 0.09 enet 12 0.06 7.3e-06 6.3 -6.0 1.5e-09 -0.97 0.05 0.95 FALSE
4 GTEx Adrenal Gland CISD2 0.08 0.03 lasso 2 0.03 4.1e-02 6.4 -6.3 2.8e-10 -0.94 0.05 0.87 FALSE
5 GTEx Artery Aorta UBE2D3 0.07 0.06 lasso 5 0.04 3.5e-03 6.3 -6.3 2.3e-10 -0.97 0.05 0.92 FALSE
6 GTEx Artery Aorta CISD2 0.10 0.08 lasso 4 0.06 1.8e-04 6.3 -6.4 1.9e-10 -0.99 0.05 0.95 FALSE
7 GTEx Artery Coronary CISD2 0.14 0.15 lasso 8 0.12 7.4e-05 -5.9 -5.9 3.1e-09 -0.94 0.05 0.91 FALSE
8 GTEx Artery Tibial CISD2 0.11 0.12 lasso 4 0.10 3.1e-08 6.4 -6.3 3.6e-10 -0.98 0.05 0.95 FALSE
9 GTEx Brain Cerebellum MANBA 0.18 0.03 enet 27 0.05 1.2e-02 4.0 -5.4 6.3e-08 -0.59 0.08 0.31 FALSE
10 GTEx Brain Cerebellum CISD2 0.13 0.18 lasso 3 0.17 1.1e-05 6.3 -6.4 1.8e-10 -0.98 0.04 0.95 FALSE
11 GTEx Breast Mammary Tissue (Male) CISD2 0.15 0.02 lasso 3 -0.01 6.5e-01 6.4 -6.1 1.4e-09 -0.97 0.04 0.42 FALSE
12 GTEx Cells Transformed fibroblasts MANBA 0.26 0.22 lasso 9 0.27 1.9e-20 4.0 5.6 2.8e-08 0.74 0.96 0.04 FALSE
13 GTEx Cells Transformed fibroblasts UBE2D3 0.11 0.09 enet 13 0.08 2.3e-06 6.3 -6.2 4.6e-10 -0.99 0.05 0.95 FALSE
14 GTEx Cells Transformed fibroblasts CISD2 0.16 0.17 enet 12 0.13 9.7e-10 6.3 -6.4 1.5e-10 -0.96 0.05 0.95 FALSE
15 GTEx Colon Sigmoid CISD2 0.20 0.24 enet 15 0.13 2.1e-05 6.3 -6.7 2.7e-11 -0.95 0.05 0.95 FALSE
16 GTEx Colon Transverse CISD2 0.12 0.09 enet 19 0.06 1.0e-03 6.3 -5.9 4.4e-09 -0.84 0.05 0.92 FALSE
17 GTEx Esophagus Gastroesophageal Junction CISD2 0.10 0.05 enet 6 0.04 1.6e-02 -5.9 -6.1 1.2e-09 -0.98 0.05 0.84 FALSE
18 GTEx Esophagus Mucosa CISD2 0.12 0.06 enet 13 0.05 2.1e-04 6.3 -6.1 1.2e-09 -0.98 0.05 0.95 FALSE
19 GTEx Esophagus Muscularis CISD2 0.19 0.22 enet 25 0.21 6.2e-13 6.3 -6.9 6.4e-12 -0.94 0.05 0.95 TRUE
20 GTEx Lung CISD2 0.06 0.05 enet 10 0.04 5.4e-04 6.3 -5.3 9.9e-08 -0.89 0.04 0.95 FALSE
21 GTEx Nerve Tibial UBE2D3 0.14 0.07 lasso 5 0.04 4.9e-04 5.8 -6.1 1.3e-09 -0.71 0.12 0.50 FALSE
22 GTEx Nerve Tibial CISD2 0.19 0.14 enet 43 0.14 7.5e-10 6.3 -5.3 9.4e-08 -0.78 0.05 0.95 FALSE
23 GTEx Ovary CISD2 0.12 0.12 lasso 4 0.07 6.9e-03 6.3 -6.3 2.4e-10 -0.96 0.05 0.78 FALSE
24 GTEx Pancreas UBE2D3 0.13 0.09 enet 12 0.12 6.7e-06 4.1 -5.9 3.3e-09 -0.88 0.05 0.95 FALSE
25 GTEx Skin Not Sun Exposed Suprapubic UBE2D3 0.11 0.00 enet 17 0.00 2.5e-01 2.6 -5.9 4.7e-09 -0.67 0.06 0.78 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic CISD2 0.13 0.14 enet 18 0.10 6.0e-06 6.3 -6.0 1.5e-09 -0.96 0.04 0.96 FALSE
27 GTEx Skin Sun Exposed Lower leg CISD2 0.12 0.20 lasso 14 0.20 1.1e-16 6.4 -6.2 5.1e-10 -0.99 0.04 0.96 FALSE
28 GTEx Small Intestine Terminal Ileum CISD2 0.29 0.19 enet 34 0.15 3.2e-04 6.4 -6.2 4.6e-10 -0.92 0.05 0.86 FALSE
29 GTEx Testis CISD2 0.10 0.04 lasso 5 0.03 1.3e-02 6.3 -5.7 1.1e-08 -0.93 0.05 0.88 FALSE
30 GTEx Thyroid CISD2 0.12 0.07 lasso 3 0.05 8.8e-05 6.3 -6.3 2.6e-10 -0.97 0.04 0.95 FALSE
31 GTEx Uterus CISD2 0.34 0.22 enet 25 0.19 8.9e-05 6.3 -5.9 3.4e-09 -0.92 0.05 0.91 FALSE
32 METSIM Adipose UBE2D3 0.04 0.02 bslmm 332 0.03 2.0e-05 6.4 -5.6 2.1e-08 -0.81 0.06 0.91 FALSE
33 ROSMAP Brain Pre-frontal Cortex MANBA 0.20 0.30 enet 26 0.31 2.3e-40 5.6 -5.1 3.0e-07 -0.70 0.79 0.21 FALSE
34 ROSMAP Brain Pre-frontal Cortex UBE2D3 0.05 0.06 blup 337 0.07 5.0e-09 6.3 -5.9 3.4e-09 -0.95 0.04 0.96 FALSE
35 ROSMAP Brain Pre-frontal Cortex CISD2 0.15 0.34 lasso 9 0.34 1.2e-44 6.4 -6.4 1.4e-10 -0.98 0.05 0.95 FALSE
36 ROSMAP Brain Pre-frontal Cortex RP11-10L12.4 0.08 0.10 lasso 7 0.09 5.1e-12 6.4 -6.1 1.2e-09 -0.98 0.04 0.96 FALSE
37 The Cancer Genome Atlas Bladder Urothelial Carcinoma MANBA 0.10 0.13 lasso 4 0.11 1.8e-09 5.8 5.8 8.0e-09 0.73 0.23 0.77 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma MANBA 0.11 0.16 lasso 4 0.16 3.4e-32 5.8 5.5 3.2e-08 0.72 0.25 0.75 FALSE
39 The Cancer Genome Atlas Colon Adenocarcinoma MANBA 0.33 0.11 enet 13 0.21 2.0e-12 3.9 5.7 1.1e-08 0.78 0.02 0.98 FALSE
40 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MANBA 0.03 0.03 blup 71 0.04 2.0e-05 4.5 5.8 4.9e-09 0.84 0.04 0.95 FALSE
41 The Cancer Genome Atlas Brain Lower Grade Glioma UBE2D3 0.02 0.02 enet 6 0.02 3.7e-03 6.4 -5.9 3.1e-09 -0.95 0.02 0.82 FALSE
42 The Cancer Genome Atlas Lung Adenocarcinoma CISD2 0.02 0.02 enet 7 0.02 1.3e-03 -5.9 6.5 1.0e-10 0.87 0.01 0.86 FALSE
43 The Cancer Genome Atlas Lung Adenocarcinoma MANBA 0.13 0.10 blup 69 0.10 4.5e-12 5.8 5.5 4.8e-08 0.79 0.21 0.79 FALSE
44 The Cancer Genome Atlas Pancreatic Adenocarcinoma CISD2 0.05 0.01 blup 18 0.06 1.9e-03 6.3 -6.5 6.4e-11 -0.98 0.01 0.69 FALSE
45 The Cancer Genome Atlas Prostate Adenocarcinoma MANBA 0.11 0.04 lasso 7 0.04 3.5e-05 5.8 5.3 1.2e-07 0.69 0.16 0.82 FALSE
46 The Cancer Genome Atlas Prostate Adenocarcinoma UBE2D3 0.03 0.04 enet 11 0.03 1.4e-04 6.3 -6.4 1.6e-10 -0.97 0.02 0.97 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma CISD2 0.05 0.08 enet 5 0.06 1.9e-06 6.3 -6.4 1.8e-10 -0.97 0.01 0.99 FALSE