[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr5:130,830,617-132,425,049

Best TWAS P=1.18e-09 · Best GWAS P=2.26e-09 conditioned to 0.00452

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	5.7	-5.5	2.9e-08	0.73	0.02	0.97	FALSE
2	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	5.2	5.2	1.8e-07	-0.69	0.06	0.93	FALSE
3	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	5.4	5.4	5.9e-08	-0.68	0.08	0.83	FALSE
4	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	5.5	5.4	8.1e-08	-0.67	0.04	0.96	FALSE
5	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	5.7	-5.6	1.9e-08	0.82	0.01	0.99	FALSE
6	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	5.3	5.6	1.8e-08	-0.74	0.05	0.95	FALSE
7	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-5.3	-5.8	7.9e-09	0.88	0.06	0.94	FALSE
8	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	5.8	-5.6	2.2e-08	0.80	0.02	0.96	FALSE
9	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	5.2	5.2	1.8e-07	-0.72	0.05	0.95	FALSE
10	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	5.8	-5.5	4.1e-08	0.74	0.02	0.98	FALSE
11	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	5.2	5.2	2.0e-07	-0.73	0.05	0.95	FALSE
12	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-4.3	5.2	1.6e-07	-0.64	0.49	0.51	FALSE
13	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	5.8	-5.4	7.0e-08	0.77	0.01	0.99	FALSE
14	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-4.5	5.3	9.9e-08	-0.77	0.10	0.60	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	5.8	-5.7	1.6e-08	0.75	0.02	0.96	FALSE
16	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	5.2	-5.9	3.0e-09	0.85	0.02	0.98	FALSE
17	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	5.7	-5.7	1.5e-08	0.74	0.01	0.99	FALSE
18	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	5.8	5.3	1.0e-07	-0.67	0.01	0.97	FALSE
19	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-6.0	-5.9	4.7e-09	0.96	0.03	0.83	FALSE
20	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	5.2	5.6	2.1e-08	-0.74	0.03	0.97	FALSE
21	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	5.5	5.7	1.0e-08	-0.67	0.05	0.94	FALSE
22	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	4.8	-5.7	1.5e-08	0.62	0.04	0.91	FALSE
23	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	5.5	6.1	1.2e-09	-0.61	0.05	0.94	TRUE
24	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-5.3	-5.4	5.2e-08	0.75	0.04	0.94	FALSE
25	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	5.8	-5.8	8.5e-09	0.76	0.01	0.99	FALSE
26	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	5.6	-6.0	2.7e-09	0.78	0.02	0.98	FALSE
27	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	5.8	-5.8	8.5e-09	0.76	0.01	0.99	FALSE
28	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-4.4	-5.4	5.2e-08	0.72	0.88	0.12	FALSE
29	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	5.8	-5.4	5.4e-08	0.72	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	5.8	-5.2	2.4e-07	0.74	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-5.3	-5.1	3.1e-07	0.81	0.03	0.91	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-4.3	-5.3	9.2e-08	0.80	0.08	0.92	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-4.5	-5.5	3.7e-08	0.84	0.04	0.96	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	5.7	5.7	1.5e-08	-0.86	0.01	0.86	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	5.3	5.1	2.8e-07	-0.66	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-5.3	-5.3	1.3e-07	0.89	0.02	0.70	FALSE