TWAS hub - IRF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0323	0.0125	4.2e-06	0.022	0.012	0.010	0.012	0.011	1.2e-07	5.7e-05	0.00027	8.5e-05	0.0001
2	TCGA	Thyroid Carcinoma	0.0540	0.0350	6.7e-03	0.025	0.025	0.024	NA	0.023	1.6e-03	1.5e-03	0.00180	NA	0.0022

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	76.8	591.2	876.2	-17.5	-29.6
Crohns Disease (2017)	49.8	109.2	110.2	10.4	10.5
Crohns Disease (2012)	38.0	61.1	64.2	7.6	8.0
Irritable Bowel Disease (IBD)	36.2	86.2	91.0	9.5	9.0
Asthma	33.7	66.4	79.5	-7.3	-8.9
Asthma (self-reported)	33.7	67.1	79.2	-7.4	-8.9
Respiratory disease	29.2	65.1	83.4	-6.8	-9.1
Allergy	26.0	59.8	61.3	7.6	7.8
Blood White Count	19.4	143.8	204.5	-9.1	-14.3
Blood Platelet Count	18.5	214.8	228.0	-15.1	-14.2
Lung FEV1/FVC ratio	15.7	79.7	98.8	7.8	9.9
Hayfever, allergic rhinitis or eczema	15.7	34.0	40.1	-6.3	-5.3
Medication: Seretide 50 evohaler	15.3	17.7	20.7	-3.8	-4.6
Hand grip strength (left)	14.8	38.9	50.7	5.2	7.1
Hand grip strength (right)	14.2	38.6	49.7	5.2	7.1
Height	14.1	271.4	377.0	12.9	19.4
Standing height	14.0	138.9	201.2	8.7	14.2
Comparative height size at age 10	13.0	71.3	106.1	6.0	10.3
Father’s age at death	10.2	13.7	14.3	3.6	3.8
Allergy or Eczema	9.8	25.8	31.6	-5.6	-4.5
Ulcerative Colitis (UC)	9.3	17.4	21.3	4.6	3.7
Ulcerative Colitis	9.3	13.5	16.2	4.0	3.3
Vascular/heart problems diagnosed by doctor	8.0	21.9	32.1	3.4	5.7
Medication: Ventolin 100micrograms inhaler	7.9	10.1	12.2	-3.5	-2.8
Leg fat-free mass (left)	7.6	40.4	57.8	4.8	7.6
Leg predicted mass (left)	7.5	39.5	56.9	4.7	7.5
Number of self-reported non-cancer illnesses	7.4	12.8	18.3	-2.7	-4.3
High blood pressure	7.2	20.1	28.6	-3.4	-5.3
Whole body water mass	7.2	41.2	60.4	4.7	7.8
Leg predicted mass (right)	7.2	38.2	53.7	4.8	7.3
Whole body fat-free mass	7.1	40.4	59.4	4.6	7.7
Leg fat-free mass (right)	7.1	38.1	53.7	4.7	7.3
Breast Cancer	7.0	16.9	23.4	-3.2	-4.8
Sitting height	6.9	48.7	69.7	5.3	8.3
Trunk fat-free mass	6.9	39.6	60.0	4.4	7.7
Trunk predicted mass	6.8	39.1	59.6	4.3	7.7
Medication: Blood pressure	6.8	13.0	23.9	-1.5	-4.9
Medication: Bendroflumethiazide	6.6	10.0	15.6	-2.1	-4.0
Basal metabolic rate	6.5	35.9	52.9	4.3	7.3
Hypertension (Self-reported)	6.4	17.8	26.2	-3.1	-5.1
Cardiovascular Disease	6.1	20.3	23.3	-4.8	-4.2
Average weekly beer plus cider intake	6.0	8.6	9.4	2.8	3.1
Arm predicted mass (left)	5.9	30.1	44.5	4.0	6.7
Lung FVC	5.8	29.5	43.2	-4.0	-6.6
Arm fat-free mass (left)	5.6	28.3	40.3	4.0	6.3
Arm fat-free mass (right)	5.1	26.1	39.1	3.6	6.2
Arm predicted mass (right)	5.1	25.9	38.9	3.6	6.2
Illnesses of mother	5.0	6.2	6.4	2.5	2.4
High blood pressure (siblings)	4.9	7.1	8.0	-2.8	-2.5
Fractured/broken bones in last 5 years	4.9	6.3	8.9	3.0	1.9
Hayfever/allergic rhinitis (self-reported)	4.8	6.4	8.1	-2.8	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	4.7	9.7	18.4	1.0	4.3
Number of treatments/medications taken	4.6	8.2	9.7	-2.6	-3.1
Age when periods started (menarche)	4.4	10.6	14.5	3.8	2.6
Medication for cholesterol, blood pressure or diabetes	4.3	7.2	7.5	2.7	2.6
Exposure to tobacco smoke outside home	4.3	5.8	8.0	1.9	2.8
Wheeze or whistling in the chest in last year	4.1	7.3	10.8	-1.9	-3.3
Medication: Blood pressure	4.1	7.3	8.7	-2.4	-3.0
Medication: Omeprazole (e.g. Zanprol)	4.1	5.0	9.5	-0.6	-3.1
Noisy workplace	4.0	4.9	6.4	-2.5	-1.9
Basal cell carcinoma (self-reported)	4.0	4.8	5.8	1.9	2.4
Frequency of tenseness / restlessness in last 2 weeks	3.9	6.0	11.3	0.9	3.4
Peak expiratory flow (PEF)	3.8	8.8	10.2	2.7	3.2
Birth weight	3.7	8.1	8.9	2.7	3.0
Breast cancer (self-reported)	3.7	4.5	6.6	1.5	2.6
Exposure to tobacco smoke at home	3.6	4.0	6.4	2.5	1.3
Triglycerides	3.5	5.7	9.8	-1.2	-3.1
Mouth/teeth dental problems: Dentures	3.5	6.0	11.0	3.3	1.0
Pack years of smoking	3.5	5.1	5.9	2.4	2.1
Pack years adult smoking proportion	3.4	5.2	5.8	2.4	2.1
Weight	3.4	16.7	25.9	2.7	5.1
Medication: Aspirin	3.4	4.5	8.9	-0.4	-3.0
Forced expiratory volume in 1-second (FEV1)	3.3	11.0	16.7	2.3	4.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.6	14.1	2.7	3.8
Stomach or abdominal pain in last month	3.2	4.0	4.3	1.9	2.1
Illness, injury, bereavement, stress in last 2 years	3.2	3.9	7.7	-0.2	-2.8
Illnesses of father: Heart disease	3.1	4.3	4.5	-2.1	-2.0
Taking other prescription medications	3.0	4.7	7.1	-1.5	-2.7
Medication: Amlodipine	3.0	4.2	7.5	-0.9	-2.7
Chronic bronchitis/emphysema (mother)	3.0	3.5	3.8	-1.8	-2.0
Diastolic blood pressure, automated reading	3.0	9.4	10.2	-2.9	-3.2
Number of full brothers	2.9	3.7	4.5	1.7	2.1
Illnesses of siblings	2.8	3.9	5.1	1.6	2.3
Lung cancer (father)	2.6	3.0	5.6	0.6	2.4
LDL Cholesterol	2.4	3.8	4.8	-2.2	1.7
Medication: Atenolol	2.4	3.0	5.5	-0.7	-2.4
Medication: Cholesterol lowering	2.4	3.7	4.4	-2.1	-1.7
Back pain experienced in last month	2.4	3.5	3.7	1.8	1.9
Medication: Aspirin	2.4	3.1	6.0	-0.5	-2.4
Frequency of depressed mood in last 2 weeks	2.3	3.3	6.6	0.0	2.6
High blood pressure (mother)	2.2	3.1	5.3	-0.9	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	3.1	1.8	1.6
Smoking status: Previous	2.2	3.2	4.4	-2.1	-1.4
Osteoarthritis (self-reported)	2.2	2.9	5.4	-0.5	-2.3
Leg fat percentage (left)	2.2	8.0	8.4	-2.8	-2.9
Lupus	2.1	3.2	4.9	1.2	2.2
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	6.8	0.3	2.6
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	3.9	-1.0	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.6	4.9	0.5	2.2
Medication for cholesterol	2.1	3.2	5.9	0.7	2.4
Pain type(s) experienced in last month: Hip pain	2.1	2.6	3.9	2.0	1.2
Hair/balding pattern: Pattern 3	2.0	2.9	5.9	-0.1	-2.4
Supplements: Calcium	2.0	2.2	3.3	1.8	1.0
Birth weight of first child	1.9	3.4	5.6	1.1	2.4
Loud music exposure frequency	1.9	2.1	3.0	-1.1	-1.7
Migraine (self-reported)	1.9	2.3	4.4	-2.1	-0.5
Alcohol drinker status: Previous	1.9	2.1	3.0	1.1	1.7
Chronotype (morning person)	1.8	4.2	7.8	-2.8	-0.8
Eye problems/disorders: Diabetes related eye disease	1.8	1.9	3.0	0.9	1.7
Past tobacco smoking	1.8	3.3	5.7	2.4	0.9
Hearing difficulty/problems with background noise	1.8	2.9	3.3	-1.8	-1.5
Leg fat percentage (right)	1.8	6.6	6.9	-2.6	-2.5
Family relationship satisfaction	1.8	2.2	4.1	0.6	2.0
Mouth/teeth dental problems	1.7	2.6	2.7	-1.6	-1.6
Blood clot in the leg (DVT)	1.7	2.2	3.1	1.1	1.8
Medication: Paracetamol	1.7	2.8	5.6	0.0	2.4
Depression (Nagel 2018)	1.6	2.4	4.1	0.8	2.0
Major Depression (MDD)	1.6	2.0	2.0	1.4	1.4
Maternal smoking around birth	1.6	2.4	3.8	1.9	1.0
Impedance of leg (left)	1.6	7.8	9.4	-2.5	-3.1
Pain all over the body in last month	1.6	1.7	3.0	0.7	1.7
Alcohol intake versus 10 years previously	1.6	2.3	3.1	-1.3	-1.8
Medication: Omeprazole	1.6	2.0	3.9	-0.0	-2.0
Number of full sisters	1.6	1.9	2.6	1.1	1.6
Long-standing illness, disability or infirmity	1.6	2.5	4.4	-0.7	-2.1
Relative age of first facial hair	1.5	3.1	5.5	-0.8	-2.4
Prospective memory result	1.5	1.9	3.7	-1.9	-0.0
Pulse wave reflection index	1.5	1.8	2.0	-1.3	-1.4
Comparative body size at age 10	1.5	4.1	7.1	-1.1	-2.7
Commuting to job workplace: Walk	1.5	1.6	1.9	-1.4	-1.1
Tinnitus: Yes, now most or all of the time	1.5	1.8	2.2	-1.5	-1.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.7	-0.5	-1.9
Fed-up feelings	1.4	2.5	3.9	1.1	2.0
Number of children fathered	1.4	1.6	1.7	1.2	1.3
Cholesterol lowering medication	1.4	2.0	2.5	1.6	1.3
Sensitivity / hurt feelings	1.3	2.2	4.3	-0.4	2.1
Medication for hormone replacement therapy	1.3	1.4	2.1	-1.4	-0.9
Heart attack	1.3	1.7	3.1	-0.4	-1.8
Number of live births	1.3	1.8	2.5	1.6	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.8	-0.3	-1.7
Illnesses of siblings: Diabetes	1.3	1.6	3.1	-0.3	-1.7
Qualifications: nursing, teaching	1.3	2.0	3.8	-2.0	-0.3
Bipolar Disorder (2018)	1.2	1.8	2.5	-1.1	-1.6
Hypothyroidism (self reported)	1.2	2.8	2.9	1.6	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.3	1.0	1.5
Had major operations	1.2	1.4	1.8	-1.4	-1.0
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.8	-1.7	0.4
Ever had bowel cancer screening	1.2	1.4	1.6	1.1	1.3
Illnesses of father: None of the above (group 1)	1.2	1.5	2.6	0.6	1.6
Waist Hip Ratio (WHR)	1.1	5.0	9.5	0.7	3.1
Current tobacco smoking	1.1	1.9	1.9	1.4	1.4
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	-0.3	1.6
Breastfed as a baby	1.1	1.3	1.9	1.4	0.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.6	0.9	1.9
Age at first live birth	1.1	1.9	3.4	-0.7	-1.8
Shortness of breath walking on level ground	1.1	1.3	1.6	-1.0	-1.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.3	0.5	1.5
Ever smoked	1.1	2.0	3.9	-2.0	-0.2
Number of operations (self-reported)	1.1	1.6	2.2	1.0	1.5
Commuting to job workplace: Cycle	1.1	1.3	1.7	0.9	1.3
Bipolar Disorder or Schizophrenia	1.0	2.4	3.8	-1.0	-2.0
Alzheimer’s Disease (in father)	1.0	1.1	2.2	-1.5	0.1
Rheumatoid Arthritis	1.0	1.4	2.1	-0.8	-1.5
Financial difficulties in last 2 years	1.0	1.3	2.3	-0.5	1.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.8	-0.6	1.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	-1.5	-0.7
Hearing aid user	1.0	1.1	1.7	-1.3	-0.7
Illnesses of father: High blood pressure	1.0	1.3	1.5	-1.0	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.1	0.6	1.4
Systolic Blood Pressure	0.9	4.4	5.5	-2.3	-1.8
Trunk fat mass	0.9	4.1	6.4	1.3	2.5
Number of incorrect matches in round	0.9	1.5	2.3	1.5	0.8
Nervous feelings	0.9	1.7	2.8	-1.7	-0.8
Medication: Ramipril	0.9	1.1	2.2	-0.2	-1.5
Qualifications: College or University degree	0.9	3.0	3.0	-1.7	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.8	-0.5	-1.3
Average weekly red wine intake	0.9	1.4	2.2	-0.7	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.9	0.3	1.4
Eye problems/disorders: Glaucoma	0.9	1.1	2.0	0.3	-1.4
Medication: Lisinopril	0.9	1.1	2.1	-0.3	-1.5
Alzheimer’s Disease (including proxy)	0.8	1.1	1.7	-1.3	-0.7
Prostate Cancer	0.8	1.1	2.2	-1.5	-0.1
Mean Putamen Volume	0.8	0.9	1.4	0.6	1.2
Heel T-Score	0.8	6.4	8.7	-3.0	-2.0
BMI	0.8	4.4	4.5	-2.1	-2.1
Average weekly spirits intake	0.8	1.0	1.6	-1.3	0.6
Angina	0.8	1.1	2.1	-0.1	-1.4
Medication: Metformin	0.8	1.2	2.4	-0.1	-1.5
Impedance of leg (right)	0.8	4.0	4.0	-2.0	-2.0
Medication: Levothyroxine sodium	0.8	1.4	2.2	0.8	1.5
Chronic bronchitis/emphysema (father)	0.8	1.0	1.9	0.2	-1.4
Happiness	0.8	1.0	2.0	-0.1	1.4
Angina (self-reported)	0.8	1.0	2.0	-0.3	-1.4
Osteoporosis (self-reported)	0.8	1.0	1.3	0.8	1.1
Smoking status: Current	0.8	1.3	1.4	1.2	1.1
Myopia	0.8	1.2	1.9	-1.4	-0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.3	-1.8	-0.3
Schizophrenia (2014)	0.7	1.6	3.0	-0.5	-1.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	1.3	-0.4
Vitamin and mineral supplements	0.7	0.9	1.6	-1.3	-0.5
Diabetes (mother)	0.7	0.9	1.3	-0.7	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	0.8	0.9	0.9
Had other major operations	0.7	0.9	0.9	0.9	0.9
Diabetes (self-reported)	0.7	1.1	1.2	1.0	-1.1
Emphysema/chronic bronchitis	0.7	0.8	1.5	1.2	0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	-1.1	-0.7
Neuroticism (Nagel 2018)	0.6	1.3	2.1	-0.8	1.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	1.2	-0.0
Forced vital capacity (FVC)	0.6	2.2	3.7	0.8	1.9
Falls in the last year	0.6	0.8	1.3	1.1	0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.3	-1.5	-0.6
Pulse wave Arterial Stiffness index	0.6	0.6	1.0	-0.5	1.0
Hair/balding pattern: Pattern 4	0.6	1.4	2.3	1.5	-0.7
Pulse wave peak to peak time	0.6	0.7	1.3	1.1	-0.1
Supplements: Vitamin C	0.6	0.8	1.3	-1.2	0.4
Loneliness, isolation	0.6	0.8	1.1	-1.1	0.6
Average weekly champagne plus white wine intake	0.6	0.9	1.0	0.9	1.0
Ever taken oral contraceptive pill	0.6	0.7	1.0	-0.7	-1.0
Medication: Paracetamol	0.6	0.9	1.4	-0.5	1.2
Medication: Atorvastatin	0.6	0.7	1.3	-1.2	-0.4
Depressed Affect (Nagel 2018)	0.5	1.1	2.1	-0.4	1.5
Fasting Glucose	0.5	0.6	1.1	0.3	1.0
Relative age voice broke	0.5	0.8	1.0	-0.8	-1.0
Serious illness, injury or assault to yourself	0.5	0.6	1.0	-0.3	1.0
Waist circumference	0.5	1.9	3.8	0.0	2.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	-1.1	0.1
Neuroticism score	0.5	0.9	1.7	-0.4	1.3
Whole body fat mass	0.5	1.9	3.0	0.9	1.7
Diabetes diagnosed by doctor	0.5	0.8	1.4	0.5	-1.2
Medication: Gliclazide	0.5	0.6	0.7	0.8	0.7
Miserableness	0.5	0.9	1.7	-0.2	1.3
Guilty feelings	0.5	0.8	1.4	-0.4	1.2
High cholesterol (Self-reported)	0.5	0.9	1.1	-0.8	1.1
Schizophrenia (2018)	0.4	0.9	1.6	-0.4	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	-0.4	-1.0
Age at First Birth	0.4	0.6	0.6	0.7	-0.8
Body Mass Index (BMI) (2010)	0.4	0.6	1.1	-0.3	-1.1
Smoking Status	0.4	0.9	1.7	0.4	1.3
Hearing difficulty/problems: Yes	0.4	0.6	1.0	-1.0	-0.5
Townsend deprivation index at recruitment	0.4	0.5	1.0	0.1	-1.0
Multivitamins +/- minerals	0.4	0.6	1.1	1.1	0.0
Body mass index (BMI)	0.4	1.9	2.0	-1.3	-1.4
Arm fat mass (right)	0.4	1.5	2.5	0.8	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.5	1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	-0.3	0.9
Glaucoma (self-reported)	0.4	0.4	0.7	0.3	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.5	1.9	1.0	1.4
Worry too long after embarrassment	0.4	0.7	1.0	-0.6	1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	0.9	0.9	0.8
Pulse rate, automated reading	0.4	1.4	2.6	-0.5	-1.6
Alcohol intake frequency.	0.4	1.0	1.4	-1.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.1	0.7	1.0
Age started oral contraceptive pill	0.4	0.5	0.9	1.0	-0.0
Heart disease (siblings)	0.4	0.5	0.9	0.1	0.9
Worry (Nagel 2018)	0.3	0.6	1.1	-1.1	0.3
HbA1C	0.3	0.3	0.6	0.7	-0.3
Blood Red Count	0.3	3.0	3.5	-1.6	-1.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.0	0.2	-1.0
Neuroticism	0.3	0.7	1.3	-0.2	1.2
Medication: Co-codamol	0.3	0.4	0.6	0.8	0.4
Severe depression (siblings)	0.3	0.3	0.4	-0.3	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.3	0.8
Qualifications: CSEs or equivalent	0.3	0.3	0.6	-0.3	0.8
Qualifications: None of the above	0.3	0.7	1.3	1.2	0.2
Impedance of arm (right)	0.3	1.4	1.6	1.1	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.2	0.9
Impedance of arm (left)	0.3	1.6	1.6	1.3	1.2
Tense / ‘highly strung’	0.3	0.5	0.9	-0.1	1.0
Headache pain in last month	0.3	0.5	0.8	-0.9	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	0.4	0.7
Age at last live birth	0.3	0.5	0.7	0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	-0.4	-0.6
Friendships satisfaction	0.3	0.4	0.7	0.1	0.9
Mineral and other dietary supplements	0.3	0.4	0.8	0.2	0.9
Arm fat mass (left)	0.3	1.2	1.7	0.9	1.3
Alcohol drinker status: Never	0.3	0.3	0.4	0.5	-0.6
Unable to work because of sickness or disability	0.3	0.3	0.6	0.8	0.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.3	-0.5	-0.6
Bipolar Disorder (2011)	0.2	0.2	0.3	0.3	-0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.4	-0.6
HDL Cholesterol	0.2	0.3	0.5	0.1	0.7
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.8	-0.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.6	-0.1
Supplements: Zinc	0.2	0.3	0.5	0.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.5	-0.7	0.4
Alcohol usually taken with meals	0.2	0.3	0.5	0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.9	-1.0	0.3
Fluid intelligence score	0.2	0.5	1.0	-1.0	0.2
Arm fat percentage (right)	0.2	0.9	1.3	-0.7	-1.1
Time employed in main current job	0.2	0.3	0.5	0.7	0.2
Body fat percentage	0.2	0.6	0.7	-0.7	-0.8
Health satisfaction	0.2	0.2	0.4	-0.7	-0.2
Medication: Ibuprofen	0.2	0.2	0.3	-0.4	0.6
Medication: Allopurinol	0.2	0.2	0.5	-0.0	-0.7
Mean time to correctly identify matches	0.2	0.4	0.7	0.5	-0.8
Heart disease (mother)	0.2	0.2	0.4	-0.7	-0.2
Suffer from ‘nerves’	0.2	0.3	0.6	-0.2	0.7
Overall health rating	0.2	0.3	0.6	-0.8	-0.3
Arm fat percentage (left)	0.2	0.9	1.5	-0.6	-1.2
Eye problems/disorders: Cataract	0.2	0.3	0.3	-0.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.8	-0.1	0.9
Financial situation satisfaction	0.2	0.2	0.2	-0.5	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.5	0.4
Reaction Time	0.1	0.2	0.3	0.1	-0.6
Ovarian Cancer	0.1	0.1	0.2	0.2	-0.5
Neuroticism (2016)	0.1	0.1	0.1	-0.2	0.4
Tanning	0.1	0.8	1.0	1.0	-0.7
Systolic blood pressure, automated reading	0.1	0.4	0.7	-0.8	-0.2
Had menopause	0.1	0.1	0.2	-0.2	-0.4
Medication: Simvastatin	0.1	0.2	0.2	0.4	0.3
Hip circumference	0.1	0.3	0.6	-0.1	0.8
Worrier / anxious feelings	0.1	0.1	0.1	-0.3	0.3
Pulse rate	0.1	0.2	0.3	0.0	0.5
Depression (self-reported)	0.1	0.1	0.2	-0.4	0.1
Medication: Lansoprazole	0.1	0.1	0.1	-0.3	0.4
Gout (self-reported)	0.1	0.1	0.2	0.4	-0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.2	0.5
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.3	-0.5
Chest pain or discomfort	0.1	0.2	0.3	0.1	-0.6
Leg pain on walking	0.1	0.2	0.2	-0.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.1	0.4
Wears glasses or contact lenses	0.1	0.1	0.1	-0.3	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.1
Irritability	0.1	0.2	0.2	-0.5	-0.4
Risk taking	0.1	0.1	0.2	-0.1	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	0.6	-0.1
Ever depressed for a whole week	0.1	0.2	0.3	-0.6	0.1
Pain experienced in last month	0.1	0.2	0.5	-0.7	-0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	-0.1	-0.1
Hair Pigment	0.0	0.8	1.4	-0.5	-1.2
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	0.1	-0.0
Diabetes (father)	0.0	0.1	0.1	-0.2	-0.3
Trunk fat percentage	0.0	0.1	0.1	0.3	0.3
Average weekly fortified wine intake	0.0	0.0	0.0	-0.2	0.2
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	0.1
Length of working week for main job	0.0	0.0	0.1	0.0	-0.3
Leg fat mass (right)	0.0	0.2	0.2	-0.4	0.5
Knee pain experienced in last month	0.0	0.0	0.0	-0.1	-0.2
Mood swings	0.0	0.0	0.1	-0.1	0.3
Mother’s age at death	0.0	0.0	0.1	-0.0	-0.3
Impedance of whole body	0.0	0.0	0.1	0.0	-0.3
Leg fat mass (left)	0.0	0.1	0.2	-0.5	0.3

Hub : Genes

IRF1

Models

Trait associations