Best TWAS P=5.37e-12 · Best GWAS P=6.36e-28 conditioned to 7.5e-26
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM26 | 0.27 | 0.15 | enet | 14 | 0.27 | 2.8e-32 | -3.7 | -5.4 | 8.1e-08 | -0.17 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | -5.1 | -5.4 | 7.5e-08 | -0.01 | 0.73 | 0.27 | FALSE |
| 3 | GTEx | Muscle Skeletal | RP11-436D10.3 | 0.08 | 0.04 | enet | 13 | 0.06 | 3.2e-06 | 6.5 | -6.4 | 1.6e-10 | 0.02 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | NRBF2 | 0.06 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | 5.8 | -6.9 | 5.4e-12 | 0.05 | 0.08 | 0.17 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ADO | 0.06 | 0.04 | lasso | 2 | 0.06 | 3.1e-08 | 6.5 | -5.2 | 1.6e-07 | 0.06 | 0.00 | 1.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | TMEM26 | 0.09 | 0.05 | lasso | 5 | 0.08 | 1.2e-10 | -4.3 | -5.1 | 2.9e-07 | -0.10 | 0.99 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADO | 0.10 | 0.03 | enet | 6 | 0.06 | 4.6e-07 | -4.9 | -5.5 | 4.1e-08 | 0.03 | 0.00 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADO | 0.14 | 0.05 | blup | 53 | 0.05 | 3.8e-06 | 5.8 | -6.8 | 1.4e-11 | 0.00 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADO | 0.06 | 0.04 | blup | 55 | 0.01 | 1.4e-01 | 6.5 | -5.6 | 1.6e-08 | 0.08 | 0.00 | 0.86 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ADO | 0.12 | 0.10 | lasso | 5 | 0.09 | 5.2e-09 | 6.5 | -6.3 | 2.4e-10 | 0.02 | 0.00 | 1.00 | FALSE |