Hub : Genes

TMEM26

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2660 0.0440 0.0e+00 0.148 0.199 0.266 0.210 0.261 1.5e-17 9.2e-24 2.8e-32 4.5e-25 1.3e-31
2 ROSMAP Brain Pre-frontal Cortex 0.0906 0.0316 1.2e-04 0.047 0.028 0.076 0.068 0.081 1.0e-06 1.3e-04 5.2e-10 4.2e-09 1.2e-10
3 TCGA Brain Lower Grade Glioma 0.0824 0.0465 1.2e-05 0.035 0.041 0.039 NA 0.036 7.5e-05 1.8e-05 2.6e-05 NA 5.1e-05
4 TCGA Prostate Adenocarcinoma 0.1385 0.0510 3.4e-15 0.176 0.145 0.172 NA 0.175 5.0e-18 5.5e-15 1.1e-17 NA 6.1e-18
5 TCGA Thyroid Carcinoma 0.0940 0.0370 1.0e-10 0.098 0.123 0.127 NA 0.129 8.9e-10 5.1e-12 2.3e-12 NA 1.7e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.8 1.3 3.3 0.7 0.4 1.2 -1.8 1.0
Bipolar Disorder or Schizophrenia 0.8 2.0 4.2 0.9 0.5 1.7 -2.0 1.3
Depressed Affect (Nagel 2018) 2.1 4.4 8.1 -1.7 -2.0 -1.5 2.2 -2.9
Depression (Nagel 2018) 0.1 0.1 0.6 0.0 -0.2 0.8 0.2 0.0
Intelligence (Savage-Jansen 2018) 1.0 3.0 4.1 -2.0 -1.6 -1.8 1.7 -1.5
Neuroticism (Nagel 2018) 0.1 0.2 0.8 -0.3 -0.9 0.5 0.2 -0.2
Schizophrenia (2018) 0.4 0.8 1.6 0.6 0.4 1.2 -1.2 0.8
Schizophrenia vs Biploar Disorder 0.9 1.2 3.4 0.6 0.8 1.2 -0.6 1.9
Worry (Nagel 2018) 2.8 5.9 8.9 2.5 1.7 3.0 -2.5 2.4
Alzheimer’s Disease (in mother) 1.0 1.2 2.0 -0.8 -0.3 -1.3 1.4 -1.2
Alzheimer’s Disease (in father) 1.1 1.2 1.7 -1.2 -1.2 -1.3 0.9 -0.8
Alzheimer’s Disease (including proxy) 1.0 1.4 2.4 -1.3 -0.8 -1.3 1.5 -0.9
Crohns Disease (2017) 0.2 0.4 0.9 -0.3 -0.6 -0.9 0.0 -0.7
Irritable Bowel Disease (IBD) 0.2 0.5 1.2 -0.4 -1.1 0.2 -1.0 0.1
Ulcerative Colitis (UC) 1.2 2.2 5.3 0.3 -0.6 1.7 -2.3 1.5
Major Depression (MDD) 0.3 0.4 0.8 0.6 0.9 0.8 -0.2 0.5
Reaction Time 0.0 0.1 0.2 0.1 -0.3 -0.1 -0.5 0.3
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.3 -1.1 -0.3 -1.2 1.5 -0.5
Breast Cancer 0.8 1.9 4.4 1.8 2.1 0.8 -0.9 0.6
Ovarian Cancer 1.0 1.3 1.8 -1.2 -1.0 -1.1 1.4 -1.0
Prostate Cancer 0.1 0.2 0.4 -0.2 0.2 -0.3 0.6 -0.6
Age at First Birth 3.7 5.4 9.3 -3.0 -2.9 -1.8 2.2 -1.0
Bipolar Disorder (2011) 0.1 0.1 0.5 0.3 0.7 0.2 -0.1 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.3 1.1 1.0 0.0 -0.4 -0.7
Coronary Artery Disease (CAD) 0.7 0.9 2.2 1.2 1.5 0.7 -0.4 0.2
Crohns Disease (2012) 0.2 0.3 0.8 -0.5 -0.5 -0.9 0.2 -0.5
Mean Putamen Volume 0.2 0.3 1.0 -0.1 -0.2 -0.5 0.2 -1.0
Fasting Glucose 4.3 5.2 6.9 2.4 2.0 2.6 -2.4 1.9
HbA1C 0.3 0.3 0.9 -0.2 -0.0 0.0 0.8 -0.9
HDL Cholesterol 0.1 0.2 0.3 -0.0 0.4 -0.2 0.6 -0.5
LDL Cholesterol 1.0 1.6 2.8 -1.3 -1.7 -0.7 1.0 -1.4
Lupus 0.3 0.5 1.3 0.7 1.2 -0.2 0.4 -0.5
Neuroticism (2016) 0.4 0.5 1.4 -0.8 -1.2 -0.4 0.5 0.1
Primary Biliary Cirrhosis 0.1 0.2 0.6 -0.0 -0.5 0.0 -0.8 -0.2
Rheumatoid Arthritis 0.3 0.4 0.9 -0.7 -0.9 -0.7 0.0 0.2
Schizophrenia (2014) 1.0 2.2 3.9 0.8 0.5 1.7 -2.0 1.8
Triglycerides 0.5 0.9 1.2 -0.9 -1.1 -0.9 0.6 -1.1
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 -0.3 -0.2 -0.3 0.3 -0.6
Ulcerative Colitis 1.9 2.8 5.1 0.8 0.1 2.1 -2.2 1.9
Blood Eosinophil Count 0.1 1.1 2.3 1.2 1.5 0.4 -1.1 0.7
Blood Platelet Count 1.5 17.0 19.9 4.4 3.9 3.9 -4.5 4.0
Blood Red Count 0.7 6.7 9.2 2.6 2.5 2.4 -2.3 3.0
Blood White Count 1.5 10.9 12.7 3.6 3.1 3.1 -3.5 3.2
Heel T-Score 0.4 3.4 4.8 -1.9 -1.8 -1.4 1.8 -2.2
BMI 0.4 2.2 4.6 0.1 0.8 -2.0 1.4 -2.1
Height 0.6 11.3 18.3 -2.9 -2.0 -2.9 4.3 -4.2
Waist Hip Ratio (WHR) 1.6 7.4 12.9 2.1 1.7 3.1 -2.6 3.6
Systolic Blood Pressure 5.0 25.1 37.3 6.1 5.6 4.3 -5.1 3.4
Smoking Status 0.9 2.3 4.9 -1.6 -1.2 -1.0 2.2 -1.2
Allergy or Eczema 0.2 0.5 1.0 0.5 0.3 1.0 -0.7 0.7
Cardiovascular Disease 5.0 16.5 23.5 4.8 4.3 3.9 -4.1 2.9
Hypothyroidism (self reported) 0.4 0.8 1.3 1.1 1.1 0.4 -1.2 0.6
Respiratory disease 0.8 1.7 2.7 -1.5 -1.6 -0.5 0.9 -1.6
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.4 1.1 1.1 0.2 -1.2 0.8
Lung FEV1/FVC ratio 0.5 2.5 4.8 2.2 2.1 0.4 -1.7 0.5
Lung FVC 0.6 3.2 5.7 -2.4 -2.3 0.1 2.0 -1.1
Neuroticism 0.1 0.3 1.3 -0.4 -1.2 0.2 -0.0 -0.3
Chronotype (morning person) 0.7 1.7 5.7 1.5 0.7 0.3 -2.4 0.3
Hair Pigment 0.0 1.0 1.8 1.0 0.7 0.6 -1.3 1.2
Tanning 0.2 2.4 3.5 -1.9 -1.6 -1.4 1.6 -1.2
Hand grip strength (left) 0.2 0.5 1.3 -0.2 -0.7 1.1 -0.5 -0.6
Number of treatments/medications taken 3.0 5.4 8.8 3.0 2.4 2.3 -2.5 0.8
Average weekly spirits intake 0.9 1.1 1.5 -1.1 -0.9 -0.7 1.2 -1.2
Sensitivity / hurt feelings 2.1 3.5 8.7 1.0 0.2 1.9 -2.1 2.9
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.2 -0.5 0.3 0.1 0.0
Hearing difficulty/problems: Yes 0.0 0.0 0.1 -0.1 -0.2 0.1 -0.1 0.1
Relative age of first facial hair 0.6 1.2 2.1 -1.1 -0.8 -1.0 1.4 -1.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.6 0.8 0.5 0.5 -0.4 -0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.5 -0.5 0.2 -0.4 1.2 -1.1
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.3 -0.4 0.5 0.3 0.1
Systolic blood pressure, automated reading 2.9 8.6 12.5 3.5 3.2 3.0 -2.9 1.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 -0.3 0.1 -0.8 0.6 -0.8
Angina 1.5 1.9 2.4 1.2 1.2 1.6 -1.4 1.4
Medication for hormone replacement therapy 0.1 0.1 0.1 -0.3 0.0 0.1 0.4 -0.0
Vitamin and mineral supplements 0.2 0.2 0.5 -0.4 -0.3 0.3 0.7 0.6
Supplements: Zinc 0.5 0.6 1.3 0.8 0.5 0.7 -1.1 0.4
Medication: Co-codamol 1.3 1.5 3.1 1.0 0.9 1.3 -0.8 1.8
Medication: Metformin 0.8 1.2 1.9 1.3 1.0 1.0 -1.4 0.5
Diabetes (father) 1.2 1.4 2.9 1.5 1.7 1.1 -0.7 0.8
Diabetes (mother) 0.1 0.1 0.3 0.2 -0.1 -0.1 -0.2 -0.5
Severe depression (siblings) 0.3 0.4 0.5 0.7 0.6 0.6 -0.5 0.7
Pack years adult smoking proportion 0.1 0.1 0.3 0.2 0.2 0.6 -0.3 0.2
Impedance of leg (right) 0.1 0.5 1.6 -0.9 -1.3 0.3 0.4 0.1
Leg fat-free mass (left) 0.5 2.7 5.7 -0.3 0.6 -2.1 1.8 -2.4
Trunk fat percentage 0.4 1.6 3.6 0.1 0.9 -1.3 1.4 -1.9
Hand grip strength (right) 0.1 0.3 0.7 -0.3 -0.3 0.7 0.4 -0.8
Townsend deprivation index at recruitment 1.5 2.1 2.7 1.6 1.2 1.6 -1.6 1.1
Current tobacco smoking 0.1 0.2 0.3 -0.4 -0.6 0.4 0.5 -0.4
Average weekly fortified wine intake 1.5 1.8 3.0 -0.7 -0.4 -1.5 1.7 -1.7
Maternal smoking around birth 1.8 2.6 3.2 1.8 1.5 1.7 -1.5 1.6
Fed-up feelings 0.4 0.8 1.2 -0.8 -1.1 -0.7 0.7 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.7 0.1 -0.5 1.6 -1.3 1.3
Relative age voice broke 1.9 3.0 5.1 -1.6 -1.5 -1.3 2.3 -1.9
Taking other prescription medications 2.9 4.5 6.4 2.5 1.9 2.3 -2.3 1.5
Age when periods started (menarche) 0.1 0.3 0.6 -0.4 -0.3 0.7 0.4 0.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 0.9 -0.9 -1.0 0.3 0.7 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.2 -0.5 -0.2 -1.5 0.7 -1.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 0.5 0.2 0.4 -0.7 0.4
Qualifications: CSEs or equivalent 3.0 3.9 6.6 -1.2 -0.9 -2.5 2.1 -2.6
Serious illness, injury or assault to yourself 0.0 0.1 0.2 0.0 0.1 -0.3 -0.1 0.4
High blood pressure 5.3 14.8 19.8 4.5 4.4 3.7 -3.5 3.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.7 -0.1 -0.6 0.7 -0.7 0.8
Multivitamins +/- minerals 0.8 1.0 1.9 1.4 1.4 0.5 -1.0 -0.0
Stomach or abdominal pain in last month 1.3 1.7 2.5 1.2 0.8 1.6 -1.2 1.5
Supplements: Glucosamine 4.4 5.7 12.7 -1.8 -1.5 -2.3 2.2 -3.6
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.3 -0.5 -0.0 -0.5 1.8 -1.0
Medication: Atenolol 3.9 4.9 6.0 2.4 2.0 2.4 -2.5 1.6
Medication: Levothyroxine sodium 2.1 3.5 6.6 2.3 2.6 1.2 -1.5 1.2
Sitting height 0.3 1.9 4.7 -0.4 0.2 -1.3 1.6 -2.2
Chronic bronchitis/emphysema (father) 1.3 1.5 3.3 -1.2 -1.0 -0.7 1.8 -1.2
High blood pressure (mother) 1.1 1.5 3.0 0.9 0.1 1.3 -1.7 1.3
Body mass index (BMI) 0.2 1.0 1.8 0.6 1.2 -0.9 0.7 -1.4
Impedance of leg (left) 0.1 0.6 1.7 -0.8 -1.3 0.7 0.1 0.4
Leg predicted mass (left) 0.5 2.9 6.0 -0.4 0.6 -2.2 1.8 -2.4
Trunk fat mass 0.5 2.2 5.0 0.2 1.0 -1.6 1.6 -2.2
Waist circumference 0.2 0.6 1.8 0.9 1.4 -0.0 0.0 -0.5
Number of incorrect matches in round 0.6 1.0 2.4 0.9 0.2 1.5 -1.2 0.5
Past tobacco smoking 0.2 0.4 0.9 0.7 0.3 0.8 -1.0 0.2
Alcohol usually taken with meals 0.2 0.4 0.7 -0.5 -0.3 -0.6 0.7 -0.8
Nervous feelings 1.1 2.0 2.5 1.4 0.7 1.6 -1.6 1.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.4 -0.4 -0.6 0.1 0.4 -0.0
Hearing difficulty/problems with background noise 1.5 2.3 4.1 1.0 0.2 2.0 -1.9 1.7
Hair/balding pattern: Pattern 2 0.3 0.3 0.8 0.5 0.9 -0.2 -0.2 0.7
Had menopause 1.0 1.3 1.8 -1.3 -1.1 -0.7 1.4 -1.1
Had other major operations 2.5 3.0 4.5 -2.1 -2.1 -1.5 1.3 -1.5
Forced vital capacity (FVC) 2.8 10.7 14.0 -3.7 -3.1 -2.8 3.7 -3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 3.5 -0.8 -0.5 -1.7 1.1 -1.9
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.4 0.7 0.5 0.7 -0.5 -0.0
Qualifications: None of the above 6.5 13.9 17.0 3.5 2.6 4.1 -4.1 4.0
Financial difficulties in last 2 years 0.4 0.5 0.9 1.0 0.7 0.6 -0.9 0.3
Mouth/teeth dental problems 0.2 0.2 0.4 -0.6 -0.6 0.2 -0.2 0.6
Heart attack 2.9 3.7 4.8 1.6 1.3 2.2 -2.1 2.2
Allergy 0.2 0.4 1.3 0.7 1.2 -0.1 -0.1 0.3
Pain all over the body in last month 0.3 0.4 1.0 -0.4 -1.0 0.8 -0.2 0.2
Diabetes (self-reported) 0.4 0.6 1.4 1.0 1.2 -0.1 -0.7 -0.2
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.1 -0.9 -1.4 0.7 -0.3 0.8
Medication: Ramipril 0.2 0.3 0.5 0.1 0.6 -0.6 0.7 -0.6
Medication: Simvastatin 0.7 1.1 1.9 1.4 0.8 1.1 -1.3 -0.1
Fluid intelligence score 1.2 2.4 4.0 -2.0 -1.7 -1.8 1.3 -0.3
Illnesses of siblings 4.6 6.5 10.4 -2.2 -1.2 -2.9 3.2 -2.7
Neuroticism score 0.1 0.3 0.9 -0.2 -1.0 0.6 -0.3 0.1
Weight 0.6 2.9 6.7 -0.3 0.6 -1.9 1.9 -2.6
Impedance of arm (right) 0.3 1.6 2.6 -1.6 -1.5 -1.1 1.1 -0.8
Arm fat percentage (right) 0.6 2.3 5.2 -0.3 0.5 -1.7 1.7 -2.3
Trunk fat-free mass 0.4 2.0 4.7 -0.2 0.6 -1.6 1.6 -2.2
Hip circumference 0.7 3.0 6.2 -0.2 0.9 -2.1 1.9 -2.5
Time employed in main current job 4.1 4.7 8.0 2.2 1.6 1.9 -2.8 2.0
Alcohol intake versus 10 years previously 1.5 2.3 4.8 1.1 0.1 1.6 -2.2 1.7
Father’s age at death 0.1 0.2 0.3 -0.5 -0.2 -0.5 0.6 -0.4
Worrier / anxious feelings 4.2 8.0 11.2 2.9 2.0 3.1 -3.4 2.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.3 -0.4 -1.1 0.7 -0.5 0.0
Falls in the last year 0.1 0.2 0.5 0.0 -0.1 0.7 0.5 -0.5
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.3 -0.3 0.4 0.0 0.4
Number of live births 1.2 1.7 3.8 -1.8 -1.9 -1.0 0.5 -0.6
Forced expiratory volume in 1-second (FEV1) 1.9 6.4 8.3 -2.9 -2.5 -2.3 2.6 -2.4
Pulse rate 3.7 6.2 10.3 2.3 1.3 2.6 -3.2 2.7
Happiness 0.1 0.1 0.3 0.4 -0.1 0.2 -0.5 -0.1
Noisy workplace 0.6 0.8 2.2 -0.2 0.0 -0.3 1.2 -1.5
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.8 -0.7 -0.1 -0.4 0.9 0.1
Serious illness, injury or assault of a close relative in last 2 years 2.3 2.7 3.9 -1.6 -1.4 -2.0 1.6 -1.6
Mouth/teeth dental problems: Dentures 0.2 0.4 1.0 0.6 1.0 -0.5 0.5 -0.4
Asthma 1.3 2.6 4.9 -1.9 -2.2 -0.3 1.2 -1.7
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.6 2.9 -1.3 -0.9 -1.3 1.7 -0.8
Medication: Cholesterol lowering 0.7 1.1 1.8 1.3 1.3 0.8 -1.0 0.3
Depression (self-reported) 0.5 0.6 1.0 1.0 1.0 0.7 -0.2 -0.5
Medication: Lansoprazole 1.4 1.6 2.1 1.4 1.1 1.3 -1.4 1.2
Prospective memory result 0.3 0.4 1.5 0.4 0.2 0.0 0.4 -1.2
Lung cancer (father) 2.0 2.4 3.6 -1.8 -1.9 -1.7 1.0 -1.0
Illnesses of mother 0.0 0.1 0.1 -0.3 0.0 -0.2 0.4 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.1 9.4 -3.1 -2.7 -2.4 2.7 -2.4
Pulse wave Arterial Stiffness index 0.1 0.2 0.4 0.4 0.2 0.6 -0.2 0.4
Impedance of arm (left) 0.2 0.9 1.6 -1.3 -1.2 -0.7 0.8 -0.4
Arm fat mass (right) 0.5 2.2 5.3 0.1 1.0 -1.6 1.6 -2.3
Trunk predicted mass 0.4 2.0 4.7 -0.1 0.6 -1.6 1.6 -2.2
Standing height 0.4 4.4 7.4 -1.5 -0.8 -2.2 2.6 -2.7
Length of working week for main job 0.8 0.8 1.7 1.3 1.3 0.4 -0.4 0.7
Exposure to tobacco smoke at home 0.3 0.4 0.9 0.6 0.7 -0.4 0.1 -0.9
Breastfed as a baby 2.2 2.7 5.0 -1.4 -0.9 -1.3 2.0 -2.2
Tense / ‘highly strung’ 1.0 1.7 3.9 1.1 0.6 2.0 -1.3 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.7 0.4 0.8 -0.2 0.8 -1.3
Hair/balding pattern: Pattern 4 0.3 0.7 2.4 -0.9 -1.6 -0.4 -0.3 -0.1
Birth weight of first child 0.3 0.5 1.6 -0.7 -1.3 0.2 -0.2 -0.3
Peak expiratory flow (PEF) 3.0 6.9 10.1 -3.2 -2.9 -2.5 2.3 -2.2
Pulse wave reflection index 0.5 0.6 1.0 -0.7 -0.4 -1.0 0.9 -0.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.1 0.4 0.4 -0.1 0.1 -1.0
Loud music exposure frequency 0.1 0.1 0.2 0.2 -0.3 0.5 -0.3 -0.4
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 6.2 -1.7 -0.8 -2.5 2.2 -2.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.3 1.1 1.1 0.5 -0.2 -0.2
Blood clot in the leg (DVT) 0.4 0.5 0.9 0.9 0.7 0.4 -0.8 0.7
Medication: Paracetamol 0.0 0.0 0.1 0.0 -0.1 0.3 -0.2 -0.0
Headache pain in last month 1.8 3.2 5.6 1.1 0.4 2.0 -2.2 2.4
Medication for cholesterol, blood pressure or diabetes 2.5 4.1 6.5 -2.5 -2.5 -1.6 1.8 -1.5
Glaucoma (self-reported) 0.1 0.1 0.2 0.1 -0.2 0.3 -0.5 0.1
Gout (self-reported) 1.0 1.3 3.8 0.7 0.1 0.5 -2.0 1.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.3 1.3 1.5 0.5 -0.7 0.3
Medication: Amlodipine 11.3 15.8 19.9 4.3 4.5 3.4 -3.6 3.9
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.6 -0.5 -0.8 -0.4 0.1 -0.4
Birth weight 0.4 0.9 1.6 -0.9 -0.8 -0.6 1.0 -1.3
Chronic bronchitis/emphysema (mother) 0.8 0.9 3.1 -1.1 -1.8 -0.3 -0.2 -0.3
High blood pressure (siblings) 3.8 5.4 9.2 2.3 1.3 2.6 -3.0 2.0
Forced vital capacity (FVC), Best measure 3.4 12.3 15.6 -4.0 -3.6 -2.8 3.8 -3.2
Body fat percentage 0.4 1.5 3.7 0.0 0.7 -1.3 1.4 -1.9
Leg fat percentage (right) 0.2 0.8 1.7 0.5 0.9 -0.6 0.9 -1.3
Arm fat-free mass (right) 0.4 1.9 4.8 -0.3 0.4 -1.5 1.5 -2.2
Exposure to tobacco smoke outside home 2.8 3.7 7.4 -1.4 -1.4 -2.2 1.6 -2.7
Comparative body size at age 10 0.9 2.5 3.8 -1.5 -1.3 -1.8 1.2 -2.0
Number of full brothers 2.9 3.6 7.8 -1.5 -1.2 -1.8 1.8 -2.8
Worry too long after embarrassment 0.6 1.0 2.9 -1.3 -1.7 -0.2 0.3 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.5 0.9 0.9 1.0 0.2 0.3 -0.7
Wheeze or whistling in the chest in last year 0.3 0.5 1.2 -0.4 -1.1 0.9 -0.5 0.1
Number of children fathered 1.3 1.4 1.9 1.3 1.4 1.3 -0.8 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 0.1 -0.3 0.2 -0.7 -0.0
Age at first live birth 0.8 1.5 2.8 -1.2 -0.6 -1.6 1.7 -0.5
Pulse wave peak to peak time 0.2 0.2 0.5 -0.4 -0.2 -0.7 0.3 -0.5
Health satisfaction 5.7 7.4 10.9 2.9 2.3 2.6 -3.3 2.4
Shortness of breath walking on level ground 1.8 2.1 2.9 -1.6 -1.7 -1.3 1.1 -1.4
Qualifications: College or University degree 0.9 2.8 4.4 -2.0 -1.4 -1.2 2.1 -1.5
Eye problems/disorders: None of the above 1.7 1.9 2.9 -1.4 -1.1 -1.7 1.6 -1.1
Mouth/teeth dental problems: Loose teeth 0.9 1.0 1.8 0.5 -0.1 1.2 -1.4 1.3
Emphysema/chronic bronchitis 0.9 1.0 1.5 -1.1 -1.0 -1.2 1.0 -0.5
Medication for pain relief, constipation, heartburn 0.3 0.5 1.8 -0.5 -0.2 -0.4 1.4 -0.6
Neck or shoulder pain in last month 0.0 0.0 0.0 -0.1 -0.1 0.2 -0.0 0.0
Medication: Blood pressure 4.0 7.0 11.5 3.3 3.4 2.1 -2.2 1.8
Angina (self-reported) 1.7 2.2 2.7 1.3 1.3 1.7 -1.6 1.6
Migraine (self-reported) 0.3 0.3 0.5 -0.0 -0.7 0.7 -0.7 0.5
Medication: Ibuprofen 1.4 1.6 3.2 -1.3 -0.9 -1.3 1.8 -1.0
Medication: Allopurinol 0.6 0.8 2.0 0.7 0.5 0.2 -1.4 1.1
Medication: Omeprazole 0.1 0.2 0.6 0.4 0.0 0.1 -0.8 0.2
Medication: Seretide 50 evohaler 1.4 1.6 2.1 -1.3 -1.4 -1.2 1.1 -1.3
Mean time to correctly identify matches 0.1 0.3 0.6 -0.4 -0.5 -0.8 0.3 -0.5
Heart disease (mother) 0.3 0.4 0.7 0.8 0.8 0.8 -0.3 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 3.2 1.6 1.8 1.1 -0.9 0.7
Whole body fat mass 0.5 2.1 4.8 0.1 0.9 -1.6 1.5 -2.2
Leg fat mass (right) 0.3 1.3 2.7 0.5 1.2 -1.1 1.0 -1.6
Arm predicted mass (right) 0.3 1.3 3.4 -0.0 0.6 -1.2 1.2 -1.9
Pulse rate, automated reading 7.8 25.2 32.4 4.7 3.5 5.3 -5.6 5.7
Alcohol intake frequency. 0.9 2.0 3.4 1.6 1.0 1.0 -1.9 1.5
Comparative height size at age 10 0.5 3.0 5.6 -1.1 -0.2 -2.3 1.7 -2.4
Number of full sisters 1.4 1.7 2.0 1.3 1.2 1.3 -1.2 1.4
Suffer from ‘nerves’ 0.6 1.0 1.6 0.5 -0.2 1.2 -1.3 1.2
Overall health rating 4.2 9.0 12.3 3.1 2.2 2.9 -3.5 3.2
Chest pain or discomfort 0.6 0.9 2.9 -0.8 -1.7 0.1 -0.6 -0.6
Had major operations 0.5 0.6 1.5 0.0 0.2 -0.9 0.7 -1.2
Age at last live birth 1.7 2.5 3.8 -1.5 -1.1 -1.8 1.9 -1.4
Family relationship satisfaction 0.1 0.2 0.4 0.3 0.4 -0.6 0.1 -0.6
Leg pain on walking 0.6 0.7 2.8 -0.1 0.1 -0.5 0.8 -1.7
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.5 -1.1 -1.0 -0.5 1.2 -1.0
Commuting to job workplace: Car/motor vehicle 2.6 3.0 5.0 2.2 2.1 1.5 -1.2 1.3
Illness, injury, bereavement, stress in last 2 years 1.6 2.0 3.1 1.2 1.0 1.7 -1.3 1.5
Medication: Aspirin 3.7 4.8 8.9 1.9 1.5 2.0 -3.0 2.3
Supplements: Vitamin C 1.9 2.2 3.0 1.6 1.5 1.2 -1.7 1.4
Knee pain experienced in last month 0.3 0.5 1.5 -0.0 -0.4 -1.0 -0.1 -1.2
Hypertension (Self-reported) 6.3 17.6 24.0 4.9 4.8 4.0 -3.8 3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.7 -0.8 -0.9 -1.2 0.7 -1.9
Illnesses of father: Heart disease 0.5 0.7 1.4 0.5 0.1 1.2 -1.2 0.6
Illnesses of siblings: Diabetes 1.2 1.4 3.4 0.6 0.3 1.1 -1.5 1.8
Smoking status: Previous 0.2 0.3 0.8 -0.4 0.0 -0.7 0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.0 -0.3 -0.1 -0.7 1.0 -1.0
Whole body fat-free mass 0.4 2.2 5.0 -0.2 0.7 -1.7 1.7 -2.2
Leg fat-free mass (right) 0.5 2.4 5.2 -0.3 0.5 -1.9 1.6 -2.3
Arm fat percentage (left) 0.5 2.1 4.9 -0.1 0.7 -1.7 1.6 -2.2
Average weekly red wine intake 1.4 2.1 3.0 -1.3 -0.7 -1.6 1.6 -1.7
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.6 1.3 1.3 1.9 -1.1 0.5
Mood swings 2.9 5.3 6.6 -2.4 -2.5 -1.6 2.3 -2.6
Loneliness, isolation 0.7 1.0 2.9 -1.0 -1.7 -0.6 0.4 -0.8
Long-standing illness, disability or infirmity 0.8 1.2 2.6 1.2 0.6 1.0 -1.6 0.6
Ever had bowel cancer screening 0.3 0.4 1.0 0.1 0.4 0.1 1.0 -0.9
Diabetes diagnosed by doctor 1.1 1.8 3.8 1.7 1.9 0.4 -1.4 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.9 0.8 0.9 0.8 -0.4 0.5
Friendships satisfaction 0.9 1.1 1.6 -1.0 -1.0 -0.9 1.1 -1.3
Qualifications: nursing, teaching 1.7 2.7 3.3 -1.8 -1.6 -1.5 1.7 -1.5
Commuting to job workplace: Walk 0.6 0.6 1.4 -0.4 0.0 -0.5 1.2 -1.2
Eye problems/disorders: Cataract 0.4 0.5 1.7 -0.4 -0.4 0.3 0.6 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.1 -0.4 -0.1 0.1 -0.5
Medication for cholesterol 2.7 4.0 4.5 -2.0 -2.0 -2.1 2.1 -1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.8 -0.6 -0.9 -0.7 0.1 -0.0
Back pain experienced in last month 0.6 0.8 1.4 -0.9 -1.2 -0.7 0.5 -1.0
Mineral and other dietary supplements 1.4 1.9 6.6 0.6 0.7 1.3 -0.6 2.6
Breast cancer (self-reported) 0.8 1.0 2.5 -1.4 -1.6 -0.1 0.5 -0.5
Asthma (self-reported) 1.7 3.3 6.5 -2.2 -2.6 -0.7 1.3 -1.8
Osteoporosis (self-reported) 0.5 0.6 1.2 -1.1 -1.1 -0.4 0.7 0.1
Osteoarthritis (self-reported) 0.2 0.2 0.6 0.6 0.4 0.2 -0.1 -0.8
Medication: Aspirin 2.5 3.2 5.9 1.6 1.3 1.5 -2.4 1.9
Medication: Gliclazide 0.4 0.5 1.1 0.7 1.1 -0.7 -0.2 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.3 0.4 -0.4 -0.4 -0.6 0.4 -0.6
Smoking status: Current 0.1 0.1 0.2 -0.3 -0.5 0.4 0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 3.3 -1.8 -1.6 -1.3 1.3 -0.7
Whole body water mass 0.4 2.5 5.7 -0.2 0.6 -1.8 1.7 -2.4
Leg predicted mass (right) 0.5 2.5 5.3 -0.3 0.6 -2.0 1.7 -2.3
Arm fat mass (left) 0.5 2.1 4.8 0.2 1.1 -1.5 1.5 -2.2
Number of self-reported non-cancer illnesses 4.6 7.9 12.4 3.5 3.3 2.7 -2.5 1.8
Average weekly champagne plus white wine intake 4.0 5.5 10.1 -2.1 -1.3 -2.2 3.2 -2.5
Miserableness 4.3 7.5 12.7 -2.4 -2.4 -2.1 3.0 -3.6
Guilty feelings 0.7 1.0 2.4 -1.4 -1.6 -0.6 0.6 -0.5
Wears glasses or contact lenses 0.7 0.8 2.1 1.0 1.5 0.7 0.3 -0.5
Ever taken oral contraceptive pill 0.8 0.9 2.2 0.3 1.3 -0.6 1.5 -0.3
Hearing aid user 1.0 1.1 2.6 0.6 0.1 1.0 -1.6 1.4
Mother’s age at death 2.0 2.6 4.5 -1.2 -0.7 -1.4 2.1 -2.1
Financial situation satisfaction 0.4 0.5 1.1 1.0 1.1 0.4 0.2 -0.2
Tinnitus: Yes, now most or all of the time 1.2 1.4 2.0 1.4 1.3 1.3 -0.9 0.9
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.0 -0.2 0.4 -0.3 -0.0
Eye problems/disorders: Glaucoma 0.2 0.3 0.7 0.6 0.2 0.4 -0.9 0.3
Medication: Blood pressure 5.1 9.7 11.3 3.4 3.2 3.1 -3.1 2.8
Pain type(s) experienced in last month: Hip pain 0.9 1.1 3.3 -0.6 -0.6 -0.9 0.8 -1.8
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.8 0.4 0.3 -0.2 -0.4 -0.9
High cholesterol (Self-reported) 1.6 2.9 4.7 2.2 2.1 1.8 -1.3 0.6
Medication: Bendroflumethiazide 3.5 5.3 7.4 2.7 2.7 2.2 -2.1 1.6
Medication: Paracetamol 0.1 0.2 0.4 -0.3 -0.4 -0.3 0.3 -0.6
Medication: Lisinopril 4.9 6.3 7.6 2.6 2.5 2.8 -2.0 2.6
Medication: Atorvastatin 2.1 2.5 3.6 1.6 1.9 1.6 -1.1 1.6
Illnesses of father: High blood pressure 2.2 2.7 3.8 1.9 1.7 1.8 -1.3 1.2
Alcohol drinker status: Never 5.1 6.1 7.4 2.4 2.0 2.6 -2.6 2.7
Ever smoked 1.0 1.7 2.4 -1.6 -1.3 -1.3 1.4 -1.0
Basal metabolic rate 0.5 2.6 6.1 -0.2 0.6 -1.9 1.8 -2.5
Leg fat percentage (left) 0.2 0.7 1.5 0.5 0.9 -0.4 0.8 -1.2
Arm fat-free mass (left) 0.4 2.2 5.5 -0.3 0.3 -1.6 1.6 -2.3
Number of operations (self-reported) 0.2 0.2 0.7 -0.1 0.1 -0.4 0.5 -0.9
Average weekly beer plus cider intake 0.3 0.4 0.6 0.6 0.6 0.8 -0.3 0.6
Irritability 0.3 0.5 1.0 -0.6 -0.5 -0.4 1.0 -0.9
Risk taking 1.3 1.8 3.3 -1.1 -0.3 -1.5 1.8 -1.5
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 0.1 -0.3 0.3 -0.6 0.2
Fractured/broken bones in last 5 years 1.1 1.5 2.6 -1.6 -1.3 -1.0 1.4 -0.4
Age started oral contraceptive pill 0.5 0.6 1.5 0.1 0.5 1.1 0.2 1.2
Diastolic blood pressure, automated reading 6.5 20.0 25.8 4.7 3.9 4.4 -5.1 4.2
Ever depressed for a whole week 0.4 0.5 1.8 -0.3 -0.2 0.1 0.9 -1.4
Unable to work because of sickness or disability 0.1 0.2 0.4 0.6 0.5 0.1 -0.1 -0.4
Commuting to job workplace: Cycle 1.0 1.2 2.2 -1.0 -1.3 -0.8 0.5 -1.5
Myopia 0.0 0.0 0.1 0.2 0.2 0.1 -0.4 -0.1
Vascular/heart problems diagnosed by doctor 8.1 22.0 28.8 -5.4 -5.1 -4.7 4.4 -3.7
Cholesterol lowering medication 0.6 0.9 1.9 1.0 0.7 1.4 -0.9 0.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.1 -0.4 -0.1 -0.4 -0.5
Pain experienced in last month 0.3 0.6 1.4 -0.8 -0.2 -0.8 1.2 -0.3
Supplements: Calcium 3.1 3.4 4.8 1.7 1.2 1.8 -2.2 2.2
Basal cell carcinoma (self-reported) 0.5 0.7 1.3 -0.8 -0.3 -1.1 1.0 -0.6
Heart attack/myocardial infarction (self-reported) 2.4 3.0 4.1 1.6 1.4 2.0 -1.8 1.9
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.0 1.0 1.0 0.2 -0.5 0.6
Heart disease (siblings) 0.3 0.4 0.9 0.5 -0.0 1.0 -0.9 0.1
Alcohol drinker status: Previous 0.1 0.2 0.4 0.4 0.5 -0.7 0.0 0.0
Pack years of smoking 0.5 0.7 1.4 0.8 0.7 1.2 -0.7 0.8
Impedance of whole body 0.2 0.8 2.0 -1.3 -1.4 -0.2 0.7 -0.1
Leg fat mass (left) 0.4 1.5 3.4 0.3 1.0 -1.2 1.2 -1.9
Arm predicted mass (left) 0.4 2.1 5.4 -0.3 0.3 -1.5 1.7 -2.3