Hub : Genes

TMEM26

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2660	0.0440	0.0e+00	0.148	0.199	0.266	0.210	0.261	1.5e-17	9.2e-24	2.8e-32	4.5e-25	1.3e-31
2	ROSMAP	Brain Pre-frontal Cortex	0.0906	0.0316	1.2e-04	0.047	0.028	0.076	0.068	0.081	1.0e-06	1.3e-04	5.2e-10	4.2e-09	1.2e-10
3	TCGA	Brain Lower Grade Glioma	0.0824	0.0465	1.2e-05	0.035	0.041	0.039	NA	0.036	7.5e-05	1.8e-05	2.6e-05	NA	5.1e-05
4	TCGA	Prostate Adenocarcinoma	0.1385	0.0510	3.4e-15	0.176	0.145	0.172	NA	0.175	5.0e-18	5.5e-15	1.1e-17	NA	6.1e-18
5	TCGA	Thyroid Carcinoma	0.0940	0.0370	1.0e-10	0.098	0.123	0.127	NA	0.129	8.9e-10	5.1e-12	2.3e-12	NA	1.7e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	3.3	0.7	0.4	1.2	-1.8	1.0
Bipolar Disorder or Schizophrenia	0.8	2.0	4.2	0.9	0.5	1.7	-2.0	1.3
Depressed Affect (Nagel 2018)	2.1	4.4	8.1	-1.7	-2.0	-1.5	2.2	-2.9
Depression (Nagel 2018)	0.1	0.1	0.6	0.0	-0.2	0.8	0.2	0.0
Intelligence (Savage-Jansen 2018)	1.0	3.0	4.1	-2.0	-1.6	-1.8	1.7	-1.5
Neuroticism (Nagel 2018)	0.1	0.2	0.8	-0.3	-0.9	0.5	0.2	-0.2
Schizophrenia (2018)	0.4	0.8	1.6	0.6	0.4	1.2	-1.2	0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	3.4	0.6	0.8	1.2	-0.6	1.9
Worry (Nagel 2018)	2.8	5.9	8.9	2.5	1.7	3.0	-2.5	2.4
Alzheimer’s Disease (in mother)	1.0	1.2	2.0	-0.8	-0.3	-1.3	1.4	-1.2
Alzheimer’s Disease (in father)	1.1	1.2	1.7	-1.2	-1.2	-1.3	0.9	-0.8
Alzheimer’s Disease (including proxy)	1.0	1.4	2.4	-1.3	-0.8	-1.3	1.5	-0.9
Crohns Disease (2017)	0.2	0.4	0.9	-0.3	-0.6	-0.9	0.0	-0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-0.4	-1.1	0.2	-1.0	0.1
Ulcerative Colitis (UC)	1.2	2.2	5.3	0.3	-0.6	1.7	-2.3	1.5
Major Depression (MDD)	0.3	0.4	0.8	0.6	0.9	0.8	-0.2	0.5
Reaction Time	0.0	0.1	0.2	0.1	-0.3	-0.1	-0.5	0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.3	-1.1	-0.3	-1.2	1.5	-0.5
Breast Cancer	0.8	1.9	4.4	1.8	2.1	0.8	-0.9	0.6
Ovarian Cancer	1.0	1.3	1.8	-1.2	-1.0	-1.1	1.4	-1.0
Prostate Cancer	0.1	0.2	0.4	-0.2	0.2	-0.3	0.6	-0.6
Age at First Birth	3.7	5.4	9.3	-3.0	-2.9	-1.8	2.2	-1.0
Bipolar Disorder (2011)	0.1	0.1	0.5	0.3	0.7	0.2	-0.1	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	1.1	1.0	0.0	-0.4	-0.7
Coronary Artery Disease (CAD)	0.7	0.9	2.2	1.2	1.5	0.7	-0.4	0.2
Crohns Disease (2012)	0.2	0.3	0.8	-0.5	-0.5	-0.9	0.2	-0.5
Mean Putamen Volume	0.2	0.3	1.0	-0.1	-0.2	-0.5	0.2	-1.0
Fasting Glucose	4.3	5.2	6.9	2.4	2.0	2.6	-2.4	1.9
HbA1C	0.3	0.3	0.9	-0.2	-0.0	0.0	0.8	-0.9
HDL Cholesterol	0.1	0.2	0.3	-0.0	0.4	-0.2	0.6	-0.5
LDL Cholesterol	1.0	1.6	2.8	-1.3	-1.7	-0.7	1.0	-1.4
Lupus	0.3	0.5	1.3	0.7	1.2	-0.2	0.4	-0.5
Neuroticism (2016)	0.4	0.5	1.4	-0.8	-1.2	-0.4	0.5	0.1
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.0	-0.5	0.0	-0.8	-0.2
Rheumatoid Arthritis	0.3	0.4	0.9	-0.7	-0.9	-0.7	0.0	0.2
Schizophrenia (2014)	1.0	2.2	3.9	0.8	0.5	1.7	-2.0	1.8
Triglycerides	0.5	0.9	1.2	-0.9	-1.1	-0.9	0.6	-1.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.3	-0.6
Ulcerative Colitis	1.9	2.8	5.1	0.8	0.1	2.1	-2.2	1.9
Blood Eosinophil Count	0.1	1.1	2.3	1.2	1.5	0.4	-1.1	0.7
Blood Platelet Count	1.5	17.0	19.9	4.4	3.9	3.9	-4.5	4.0
Blood Red Count	0.7	6.7	9.2	2.6	2.5	2.4	-2.3	3.0
Blood White Count	1.5	10.9	12.7	3.6	3.1	3.1	-3.5	3.2
Heel T-Score	0.4	3.4	4.8	-1.9	-1.8	-1.4	1.8	-2.2
BMI	0.4	2.2	4.6	0.1	0.8	-2.0	1.4	-2.1
Height	0.6	11.3	18.3	-2.9	-2.0	-2.9	4.3	-4.2
Waist Hip Ratio (WHR)	1.6	7.4	12.9	2.1	1.7	3.1	-2.6	3.6
Systolic Blood Pressure	5.0	25.1	37.3	6.1	5.6	4.3	-5.1	3.4
Smoking Status	0.9	2.3	4.9	-1.6	-1.2	-1.0	2.2	-1.2
Allergy or Eczema	0.2	0.5	1.0	0.5	0.3	1.0	-0.7	0.7
Cardiovascular Disease	5.0	16.5	23.5	4.8	4.3	3.9	-4.1	2.9
Hypothyroidism (self reported)	0.4	0.8	1.3	1.1	1.1	0.4	-1.2	0.6
Respiratory disease	0.8	1.7	2.7	-1.5	-1.6	-0.5	0.9	-1.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.4	1.1	1.1	0.2	-1.2	0.8
Lung FEV1/FVC ratio	0.5	2.5	4.8	2.2	2.1	0.4	-1.7	0.5
Lung FVC	0.6	3.2	5.7	-2.4	-2.3	0.1	2.0	-1.1
Neuroticism	0.1	0.3	1.3	-0.4	-1.2	0.2	-0.0	-0.3
Chronotype (morning person)	0.7	1.7	5.7	1.5	0.7	0.3	-2.4	0.3
Hair Pigment	0.0	1.0	1.8	1.0	0.7	0.6	-1.3	1.2
Tanning	0.2	2.4	3.5	-1.9	-1.6	-1.4	1.6	-1.2
Hand grip strength (left)	0.2	0.5	1.3	-0.2	-0.7	1.1	-0.5	-0.6
Number of treatments/medications taken	3.0	5.4	8.8	3.0	2.4	2.3	-2.5	0.8
Average weekly spirits intake	0.9	1.1	1.5	-1.1	-0.9	-0.7	1.2	-1.2
Sensitivity / hurt feelings	2.1	3.5	8.7	1.0	0.2	1.9	-2.1	2.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.2	-0.5	0.3	0.1	0.0
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.1	0.1
Relative age of first facial hair	0.6	1.2	2.1	-1.1	-0.8	-1.0	1.4	-1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.8	0.5	0.5	-0.4	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	-0.5	0.2	-0.4	1.2	-1.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.3	-0.4	0.5	0.3	0.1
Systolic blood pressure, automated reading	2.9	8.6	12.5	3.5	3.2	3.0	-2.9	1.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.3	0.1	-0.8	0.6	-0.8
Angina	1.5	1.9	2.4	1.2	1.2	1.6	-1.4	1.4
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.3	0.0	0.1	0.4	-0.0
Vitamin and mineral supplements	0.2	0.2	0.5	-0.4	-0.3	0.3	0.7	0.6
Supplements: Zinc	0.5	0.6	1.3	0.8	0.5	0.7	-1.1	0.4
Medication: Co-codamol	1.3	1.5	3.1	1.0	0.9	1.3	-0.8	1.8
Medication: Metformin	0.8	1.2	1.9	1.3	1.0	1.0	-1.4	0.5
Diabetes (father)	1.2	1.4	2.9	1.5	1.7	1.1	-0.7	0.8
Diabetes (mother)	0.1	0.1	0.3	0.2	-0.1	-0.1	-0.2	-0.5
Severe depression (siblings)	0.3	0.4	0.5	0.7	0.6	0.6	-0.5	0.7
Pack years adult smoking proportion	0.1	0.1	0.3	0.2	0.2	0.6	-0.3	0.2
Impedance of leg (right)	0.1	0.5	1.6	-0.9	-1.3	0.3	0.4	0.1
Leg fat-free mass (left)	0.5	2.7	5.7	-0.3	0.6	-2.1	1.8	-2.4
Trunk fat percentage	0.4	1.6	3.6	0.1	0.9	-1.3	1.4	-1.9
Hand grip strength (right)	0.1	0.3	0.7	-0.3	-0.3	0.7	0.4	-0.8
Townsend deprivation index at recruitment	1.5	2.1	2.7	1.6	1.2	1.6	-1.6	1.1
Current tobacco smoking	0.1	0.2	0.3	-0.4	-0.6	0.4	0.5	-0.4
Average weekly fortified wine intake	1.5	1.8	3.0	-0.7	-0.4	-1.5	1.7	-1.7
Maternal smoking around birth	1.8	2.6	3.2	1.8	1.5	1.7	-1.5	1.6
Fed-up feelings	0.4	0.8	1.2	-0.8	-1.1	-0.7	0.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.7	0.1	-0.5	1.6	-1.3	1.3
Relative age voice broke	1.9	3.0	5.1	-1.6	-1.5	-1.3	2.3	-1.9
Taking other prescription medications	2.9	4.5	6.4	2.5	1.9	2.3	-2.3	1.5
Age when periods started (menarche)	0.1	0.3	0.6	-0.4	-0.3	0.7	0.4	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	0.9	-0.9	-1.0	0.3	0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.2	-0.5	-0.2	-1.5	0.7	-1.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.5	0.2	0.4	-0.7	0.4
Qualifications: CSEs or equivalent	3.0	3.9	6.6	-1.2	-0.9	-2.5	2.1	-2.6
Serious illness, injury or assault to yourself	0.0	0.1	0.2	0.0	0.1	-0.3	-0.1	0.4
High blood pressure	5.3	14.8	19.8	4.5	4.4	3.7	-3.5	3.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.1	-0.6	0.7	-0.7	0.8
Multivitamins +/- minerals	0.8	1.0	1.9	1.4	1.4	0.5	-1.0	-0.0
Stomach or abdominal pain in last month	1.3	1.7	2.5	1.2	0.8	1.6	-1.2	1.5
Supplements: Glucosamine	4.4	5.7	12.7	-1.8	-1.5	-2.3	2.2	-3.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.3	-0.5	-0.0	-0.5	1.8	-1.0
Medication: Atenolol	3.9	4.9	6.0	2.4	2.0	2.4	-2.5	1.6
Medication: Levothyroxine sodium	2.1	3.5	6.6	2.3	2.6	1.2	-1.5	1.2
Sitting height	0.3	1.9	4.7	-0.4	0.2	-1.3	1.6	-2.2
Chronic bronchitis/emphysema (father)	1.3	1.5	3.3	-1.2	-1.0	-0.7	1.8	-1.2
High blood pressure (mother)	1.1	1.5	3.0	0.9	0.1	1.3	-1.7	1.3
Body mass index (BMI)	0.2	1.0	1.8	0.6	1.2	-0.9	0.7	-1.4
Impedance of leg (left)	0.1	0.6	1.7	-0.8	-1.3	0.7	0.1	0.4
Leg predicted mass (left)	0.5	2.9	6.0	-0.4	0.6	-2.2	1.8	-2.4
Trunk fat mass	0.5	2.2	5.0	0.2	1.0	-1.6	1.6	-2.2
Waist circumference	0.2	0.6	1.8	0.9	1.4	-0.0	0.0	-0.5
Number of incorrect matches in round	0.6	1.0	2.4	0.9	0.2	1.5	-1.2	0.5
Past tobacco smoking	0.2	0.4	0.9	0.7	0.3	0.8	-1.0	0.2
Alcohol usually taken with meals	0.2	0.4	0.7	-0.5	-0.3	-0.6	0.7	-0.8
Nervous feelings	1.1	2.0	2.5	1.4	0.7	1.6	-1.6	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.4	-0.6	0.1	0.4	-0.0
Hearing difficulty/problems with background noise	1.5	2.3	4.1	1.0	0.2	2.0	-1.9	1.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	0.5	0.9	-0.2	-0.2	0.7
Had menopause	1.0	1.3	1.8	-1.3	-1.1	-0.7	1.4	-1.1
Had other major operations	2.5	3.0	4.5	-2.1	-2.1	-1.5	1.3	-1.5
Forced vital capacity (FVC)	2.8	10.7	14.0	-3.7	-3.1	-2.8	3.7	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.5	-0.8	-0.5	-1.7	1.1	-1.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	0.7	0.5	0.7	-0.5	-0.0
Qualifications: None of the above	6.5	13.9	17.0	3.5	2.6	4.1	-4.1	4.0
Financial difficulties in last 2 years	0.4	0.5	0.9	1.0	0.7	0.6	-0.9	0.3
Mouth/teeth dental problems	0.2	0.2	0.4	-0.6	-0.6	0.2	-0.2	0.6
Heart attack	2.9	3.7	4.8	1.6	1.3	2.2	-2.1	2.2
Allergy	0.2	0.4	1.3	0.7	1.2	-0.1	-0.1	0.3
Pain all over the body in last month	0.3	0.4	1.0	-0.4	-1.0	0.8	-0.2	0.2
Diabetes (self-reported)	0.4	0.6	1.4	1.0	1.2	-0.1	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	-0.9	-1.4	0.7	-0.3	0.8
Medication: Ramipril	0.2	0.3	0.5	0.1	0.6	-0.6	0.7	-0.6
Medication: Simvastatin	0.7	1.1	1.9	1.4	0.8	1.1	-1.3	-0.1
Fluid intelligence score	1.2	2.4	4.0	-2.0	-1.7	-1.8	1.3	-0.3
Illnesses of siblings	4.6	6.5	10.4	-2.2	-1.2	-2.9	3.2	-2.7
Neuroticism score	0.1	0.3	0.9	-0.2	-1.0	0.6	-0.3	0.1
Weight	0.6	2.9	6.7	-0.3	0.6	-1.9	1.9	-2.6
Impedance of arm (right)	0.3	1.6	2.6	-1.6	-1.5	-1.1	1.1	-0.8
Arm fat percentage (right)	0.6	2.3	5.2	-0.3	0.5	-1.7	1.7	-2.3
Trunk fat-free mass	0.4	2.0	4.7	-0.2	0.6	-1.6	1.6	-2.2
Hip circumference	0.7	3.0	6.2	-0.2	0.9	-2.1	1.9	-2.5
Time employed in main current job	4.1	4.7	8.0	2.2	1.6	1.9	-2.8	2.0
Alcohol intake versus 10 years previously	1.5	2.3	4.8	1.1	0.1	1.6	-2.2	1.7
Father’s age at death	0.1	0.2	0.3	-0.5	-0.2	-0.5	0.6	-0.4
Worrier / anxious feelings	4.2	8.0	11.2	2.9	2.0	3.1	-3.4	2.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.3	-0.4	-1.1	0.7	-0.5	0.0
Falls in the last year	0.1	0.2	0.5	0.0	-0.1	0.7	0.5	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.3	-0.3	0.4	0.0	0.4
Number of live births	1.2	1.7	3.8	-1.8	-1.9	-1.0	0.5	-0.6
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	8.3	-2.9	-2.5	-2.3	2.6	-2.4
Pulse rate	3.7	6.2	10.3	2.3	1.3	2.6	-3.2	2.7
Happiness	0.1	0.1	0.3	0.4	-0.1	0.2	-0.5	-0.1
Noisy workplace	0.6	0.8	2.2	-0.2	0.0	-0.3	1.2	-1.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	-0.7	-0.1	-0.4	0.9	0.1
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	3.9	-1.6	-1.4	-2.0	1.6	-1.6
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.6	1.0	-0.5	0.5	-0.4
Asthma	1.3	2.6	4.9	-1.9	-2.2	-0.3	1.2	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	2.9	-1.3	-0.9	-1.3	1.7	-0.8
Medication: Cholesterol lowering	0.7	1.1	1.8	1.3	1.3	0.8	-1.0	0.3
Depression (self-reported)	0.5	0.6	1.0	1.0	1.0	0.7	-0.2	-0.5
Medication: Lansoprazole	1.4	1.6	2.1	1.4	1.1	1.3	-1.4	1.2
Prospective memory result	0.3	0.4	1.5	0.4	0.2	0.0	0.4	-1.2
Lung cancer (father)	2.0	2.4	3.6	-1.8	-1.9	-1.7	1.0	-1.0
Illnesses of mother	0.0	0.1	0.1	-0.3	0.0	-0.2	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	9.4	-3.1	-2.7	-2.4	2.7	-2.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.4	0.2	0.6	-0.2	0.4
Impedance of arm (left)	0.2	0.9	1.6	-1.3	-1.2	-0.7	0.8	-0.4
Arm fat mass (right)	0.5	2.2	5.3	0.1	1.0	-1.6	1.6	-2.3
Trunk predicted mass	0.4	2.0	4.7	-0.1	0.6	-1.6	1.6	-2.2
Standing height	0.4	4.4	7.4	-1.5	-0.8	-2.2	2.6	-2.7
Length of working week for main job	0.8	0.8	1.7	1.3	1.3	0.4	-0.4	0.7
Exposure to tobacco smoke at home	0.3	0.4	0.9	0.6	0.7	-0.4	0.1	-0.9
Breastfed as a baby	2.2	2.7	5.0	-1.4	-0.9	-1.3	2.0	-2.2
Tense / ‘highly strung’	1.0	1.7	3.9	1.1	0.6	2.0	-1.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	0.4	0.8	-0.2	0.8	-1.3
Hair/balding pattern: Pattern 4	0.3	0.7	2.4	-0.9	-1.6	-0.4	-0.3	-0.1
Birth weight of first child	0.3	0.5	1.6	-0.7	-1.3	0.2	-0.2	-0.3
Peak expiratory flow (PEF)	3.0	6.9	10.1	-3.2	-2.9	-2.5	2.3	-2.2
Pulse wave reflection index	0.5	0.6	1.0	-0.7	-0.4	-1.0	0.9	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.1	0.4	0.4	-0.1	0.1	-1.0
Loud music exposure frequency	0.1	0.1	0.2	0.2	-0.3	0.5	-0.3	-0.4
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	6.2	-1.7	-0.8	-2.5	2.2	-2.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.3	1.1	1.1	0.5	-0.2	-0.2
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.9	0.7	0.4	-0.8	0.7
Medication: Paracetamol	0.0	0.0	0.1	0.0	-0.1	0.3	-0.2	-0.0
Headache pain in last month	1.8	3.2	5.6	1.1	0.4	2.0	-2.2	2.4
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	6.5	-2.5	-2.5	-1.6	1.8	-1.5
Glaucoma (self-reported)	0.1	0.1	0.2	0.1	-0.2	0.3	-0.5	0.1
Gout (self-reported)	1.0	1.3	3.8	0.7	0.1	0.5	-2.0	1.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.3	1.3	1.5	0.5	-0.7	0.3
Medication: Amlodipine	11.3	15.8	19.9	4.3	4.5	3.4	-3.6	3.9
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.5	-0.8	-0.4	0.1	-0.4
Birth weight	0.4	0.9	1.6	-0.9	-0.8	-0.6	1.0	-1.3
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.1	-1.1	-1.8	-0.3	-0.2	-0.3
High blood pressure (siblings)	3.8	5.4	9.2	2.3	1.3	2.6	-3.0	2.0
Forced vital capacity (FVC), Best measure	3.4	12.3	15.6	-4.0	-3.6	-2.8	3.8	-3.2
Body fat percentage	0.4	1.5	3.7	0.0	0.7	-1.3	1.4	-1.9
Leg fat percentage (right)	0.2	0.8	1.7	0.5	0.9	-0.6	0.9	-1.3
Arm fat-free mass (right)	0.4	1.9	4.8	-0.3	0.4	-1.5	1.5	-2.2
Exposure to tobacco smoke outside home	2.8	3.7	7.4	-1.4	-1.4	-2.2	1.6	-2.7
Comparative body size at age 10	0.9	2.5	3.8	-1.5	-1.3	-1.8	1.2	-2.0
Number of full brothers	2.9	3.6	7.8	-1.5	-1.2	-1.8	1.8	-2.8
Worry too long after embarrassment	0.6	1.0	2.9	-1.3	-1.7	-0.2	0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.9	1.0	0.2	0.3	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	-0.4	-1.1	0.9	-0.5	0.1
Number of children fathered	1.3	1.4	1.9	1.3	1.4	1.3	-0.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	0.1	-0.3	0.2	-0.7	-0.0
Age at first live birth	0.8	1.5	2.8	-1.2	-0.6	-1.6	1.7	-0.5
Pulse wave peak to peak time	0.2	0.2	0.5	-0.4	-0.2	-0.7	0.3	-0.5
Health satisfaction	5.7	7.4	10.9	2.9	2.3	2.6	-3.3	2.4
Shortness of breath walking on level ground	1.8	2.1	2.9	-1.6	-1.7	-1.3	1.1	-1.4
Qualifications: College or University degree	0.9	2.8	4.4	-2.0	-1.4	-1.2	2.1	-1.5
Eye problems/disorders: None of the above	1.7	1.9	2.9	-1.4	-1.1	-1.7	1.6	-1.1
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.8	0.5	-0.1	1.2	-1.4	1.3
Emphysema/chronic bronchitis	0.9	1.0	1.5	-1.1	-1.0	-1.2	1.0	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.8	-0.5	-0.2	-0.4	1.4	-0.6
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.0	0.0
Medication: Blood pressure	4.0	7.0	11.5	3.3	3.4	2.1	-2.2	1.8
Angina (self-reported)	1.7	2.2	2.7	1.3	1.3	1.7	-1.6	1.6
Migraine (self-reported)	0.3	0.3	0.5	-0.0	-0.7	0.7	-0.7	0.5
Medication: Ibuprofen	1.4	1.6	3.2	-1.3	-0.9	-1.3	1.8	-1.0
Medication: Allopurinol	0.6	0.8	2.0	0.7	0.5	0.2	-1.4	1.1
Medication: Omeprazole	0.1	0.2	0.6	0.4	0.0	0.1	-0.8	0.2
Medication: Seretide 50 evohaler	1.4	1.6	2.1	-1.3	-1.4	-1.2	1.1	-1.3
Mean time to correctly identify matches	0.1	0.3	0.6	-0.4	-0.5	-0.8	0.3	-0.5
Heart disease (mother)	0.3	0.4	0.7	0.8	0.8	0.8	-0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.2	1.6	1.8	1.1	-0.9	0.7
Whole body fat mass	0.5	2.1	4.8	0.1	0.9	-1.6	1.5	-2.2
Leg fat mass (right)	0.3	1.3	2.7	0.5	1.2	-1.1	1.0	-1.6
Arm predicted mass (right)	0.3	1.3	3.4	-0.0	0.6	-1.2	1.2	-1.9
Pulse rate, automated reading	7.8	25.2	32.4	4.7	3.5	5.3	-5.6	5.7
Alcohol intake frequency.	0.9	2.0	3.4	1.6	1.0	1.0	-1.9	1.5
Comparative height size at age 10	0.5	3.0	5.6	-1.1	-0.2	-2.3	1.7	-2.4
Number of full sisters	1.4	1.7	2.0	1.3	1.2	1.3	-1.2	1.4
Suffer from ‘nerves’	0.6	1.0	1.6	0.5	-0.2	1.2	-1.3	1.2
Overall health rating	4.2	9.0	12.3	3.1	2.2	2.9	-3.5	3.2
Chest pain or discomfort	0.6	0.9	2.9	-0.8	-1.7	0.1	-0.6	-0.6
Had major operations	0.5	0.6	1.5	0.0	0.2	-0.9	0.7	-1.2
Age at last live birth	1.7	2.5	3.8	-1.5	-1.1	-1.8	1.9	-1.4
Family relationship satisfaction	0.1	0.2	0.4	0.3	0.4	-0.6	0.1	-0.6
Leg pain on walking	0.6	0.7	2.8	-0.1	0.1	-0.5	0.8	-1.7
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.5	-1.1	-1.0	-0.5	1.2	-1.0
Commuting to job workplace: Car/motor vehicle	2.6	3.0	5.0	2.2	2.1	1.5	-1.2	1.3
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	3.1	1.2	1.0	1.7	-1.3	1.5
Medication: Aspirin	3.7	4.8	8.9	1.9	1.5	2.0	-3.0	2.3
Supplements: Vitamin C	1.9	2.2	3.0	1.6	1.5	1.2	-1.7	1.4
Knee pain experienced in last month	0.3	0.5	1.5	-0.0	-0.4	-1.0	-0.1	-1.2
Hypertension (Self-reported)	6.3	17.6	24.0	4.9	4.8	4.0	-3.8	3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.7	-0.8	-0.9	-1.2	0.7	-1.9
Illnesses of father: Heart disease	0.5	0.7	1.4	0.5	0.1	1.2	-1.2	0.6
Illnesses of siblings: Diabetes	1.2	1.4	3.4	0.6	0.3	1.1	-1.5	1.8
Smoking status: Previous	0.2	0.3	0.8	-0.4	0.0	-0.7	0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	-0.3	-0.1	-0.7	1.0	-1.0
Whole body fat-free mass	0.4	2.2	5.0	-0.2	0.7	-1.7	1.7	-2.2
Leg fat-free mass (right)	0.5	2.4	5.2	-0.3	0.5	-1.9	1.6	-2.3
Arm fat percentage (left)	0.5	2.1	4.9	-0.1	0.7	-1.7	1.6	-2.2
Average weekly red wine intake	1.4	2.1	3.0	-1.3	-0.7	-1.6	1.6	-1.7
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.6	1.3	1.3	1.9	-1.1	0.5
Mood swings	2.9	5.3	6.6	-2.4	-2.5	-1.6	2.3	-2.6
Loneliness, isolation	0.7	1.0	2.9	-1.0	-1.7	-0.6	0.4	-0.8
Long-standing illness, disability or infirmity	0.8	1.2	2.6	1.2	0.6	1.0	-1.6	0.6
Ever had bowel cancer screening	0.3	0.4	1.0	0.1	0.4	0.1	1.0	-0.9
Diabetes diagnosed by doctor	1.1	1.8	3.8	1.7	1.9	0.4	-1.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	0.8	0.9	0.8	-0.4	0.5
Friendships satisfaction	0.9	1.1	1.6	-1.0	-1.0	-0.9	1.1	-1.3
Qualifications: nursing, teaching	1.7	2.7	3.3	-1.8	-1.6	-1.5	1.7	-1.5
Commuting to job workplace: Walk	0.6	0.6	1.4	-0.4	0.0	-0.5	1.2	-1.2
Eye problems/disorders: Cataract	0.4	0.5	1.7	-0.4	-0.4	0.3	0.6	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.1	-0.4	-0.1	0.1	-0.5
Medication for cholesterol	2.7	4.0	4.5	-2.0	-2.0	-2.1	2.1	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.6	-0.9	-0.7	0.1	-0.0
Back pain experienced in last month	0.6	0.8	1.4	-0.9	-1.2	-0.7	0.5	-1.0
Mineral and other dietary supplements	1.4	1.9	6.6	0.6	0.7	1.3	-0.6	2.6
Breast cancer (self-reported)	0.8	1.0	2.5	-1.4	-1.6	-0.1	0.5	-0.5
Asthma (self-reported)	1.7	3.3	6.5	-2.2	-2.6	-0.7	1.3	-1.8
Osteoporosis (self-reported)	0.5	0.6	1.2	-1.1	-1.1	-0.4	0.7	0.1
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.6	0.4	0.2	-0.1	-0.8
Medication: Aspirin	2.5	3.2	5.9	1.6	1.3	1.5	-2.4	1.9
Medication: Gliclazide	0.4	0.5	1.1	0.7	1.1	-0.7	-0.2	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	-0.4	-0.4	-0.6	0.4	-0.6
Smoking status: Current	0.1	0.1	0.2	-0.3	-0.5	0.4	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.3	-1.8	-1.6	-1.3	1.3	-0.7
Whole body water mass	0.4	2.5	5.7	-0.2	0.6	-1.8	1.7	-2.4
Leg predicted mass (right)	0.5	2.5	5.3	-0.3	0.6	-2.0	1.7	-2.3
Arm fat mass (left)	0.5	2.1	4.8	0.2	1.1	-1.5	1.5	-2.2
Number of self-reported non-cancer illnesses	4.6	7.9	12.4	3.5	3.3	2.7	-2.5	1.8
Average weekly champagne plus white wine intake	4.0	5.5	10.1	-2.1	-1.3	-2.2	3.2	-2.5
Miserableness	4.3	7.5	12.7	-2.4	-2.4	-2.1	3.0	-3.6
Guilty feelings	0.7	1.0	2.4	-1.4	-1.6	-0.6	0.6	-0.5
Wears glasses or contact lenses	0.7	0.8	2.1	1.0	1.5	0.7	0.3	-0.5
Ever taken oral contraceptive pill	0.8	0.9	2.2	0.3	1.3	-0.6	1.5	-0.3
Hearing aid user	1.0	1.1	2.6	0.6	0.1	1.0	-1.6	1.4
Mother’s age at death	2.0	2.6	4.5	-1.2	-0.7	-1.4	2.1	-2.1
Financial situation satisfaction	0.4	0.5	1.1	1.0	1.1	0.4	0.2	-0.2
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.0	1.4	1.3	1.3	-0.9	0.9
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.0	-0.2	0.4	-0.3	-0.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.6	0.2	0.4	-0.9	0.3
Medication: Blood pressure	5.1	9.7	11.3	3.4	3.2	3.1	-3.1	2.8
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.3	-0.6	-0.6	-0.9	0.8	-1.8
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.8	0.4	0.3	-0.2	-0.4	-0.9
High cholesterol (Self-reported)	1.6	2.9	4.7	2.2	2.1	1.8	-1.3	0.6
Medication: Bendroflumethiazide	3.5	5.3	7.4	2.7	2.7	2.2	-2.1	1.6
Medication: Paracetamol	0.1	0.2	0.4	-0.3	-0.4	-0.3	0.3	-0.6
Medication: Lisinopril	4.9	6.3	7.6	2.6	2.5	2.8	-2.0	2.6
Medication: Atorvastatin	2.1	2.5	3.6	1.6	1.9	1.6	-1.1	1.6
Illnesses of father: High blood pressure	2.2	2.7	3.8	1.9	1.7	1.8	-1.3	1.2
Alcohol drinker status: Never	5.1	6.1	7.4	2.4	2.0	2.6	-2.6	2.7
Ever smoked	1.0	1.7	2.4	-1.6	-1.3	-1.3	1.4	-1.0
Basal metabolic rate	0.5	2.6	6.1	-0.2	0.6	-1.9	1.8	-2.5
Leg fat percentage (left)	0.2	0.7	1.5	0.5	0.9	-0.4	0.8	-1.2
Arm fat-free mass (left)	0.4	2.2	5.5	-0.3	0.3	-1.6	1.6	-2.3
Number of operations (self-reported)	0.2	0.2	0.7	-0.1	0.1	-0.4	0.5	-0.9
Average weekly beer plus cider intake	0.3	0.4	0.6	0.6	0.6	0.8	-0.3	0.6
Irritability	0.3	0.5	1.0	-0.6	-0.5	-0.4	1.0	-0.9
Risk taking	1.3	1.8	3.3	-1.1	-0.3	-1.5	1.8	-1.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.1	-0.3	0.3	-0.6	0.2
Fractured/broken bones in last 5 years	1.1	1.5	2.6	-1.6	-1.3	-1.0	1.4	-0.4
Age started oral contraceptive pill	0.5	0.6	1.5	0.1	0.5	1.1	0.2	1.2
Diastolic blood pressure, automated reading	6.5	20.0	25.8	4.7	3.9	4.4	-5.1	4.2
Ever depressed for a whole week	0.4	0.5	1.8	-0.3	-0.2	0.1	0.9	-1.4
Unable to work because of sickness or disability	0.1	0.2	0.4	0.6	0.5	0.1	-0.1	-0.4
Commuting to job workplace: Cycle	1.0	1.2	2.2	-1.0	-1.3	-0.8	0.5	-1.5
Myopia	0.0	0.0	0.1	0.2	0.2	0.1	-0.4	-0.1
Vascular/heart problems diagnosed by doctor	8.1	22.0	28.8	-5.4	-5.1	-4.7	4.4	-3.7
Cholesterol lowering medication	0.6	0.9	1.9	1.0	0.7	1.4	-0.9	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.1	-0.4	-0.1	-0.4	-0.5
Pain experienced in last month	0.3	0.6	1.4	-0.8	-0.2	-0.8	1.2	-0.3
Supplements: Calcium	3.1	3.4	4.8	1.7	1.2	1.8	-2.2	2.2
Basal cell carcinoma (self-reported)	0.5	0.7	1.3	-0.8	-0.3	-1.1	1.0	-0.6
Heart attack/myocardial infarction (self-reported)	2.4	3.0	4.1	1.6	1.4	2.0	-1.8	1.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	1.0	1.0	0.2	-0.5	0.6
Heart disease (siblings)	0.3	0.4	0.9	0.5	-0.0	1.0	-0.9	0.1
Alcohol drinker status: Previous	0.1	0.2	0.4	0.4	0.5	-0.7	0.0	0.0
Pack years of smoking	0.5	0.7	1.4	0.8	0.7	1.2	-0.7	0.8
Impedance of whole body	0.2	0.8	2.0	-1.3	-1.4	-0.2	0.7	-0.1
Leg fat mass (left)	0.4	1.5	3.4	0.3	1.0	-1.2	1.2	-1.9
Arm predicted mass (left)	0.4	2.1	5.4	-0.3	0.3	-1.5	1.7	-2.3