TWAS
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Traits
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Traits
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Vascular/heart problems diagnosed by doctor
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chr14:103,349,176-104,866,687
Best TWAS P=1.07e-07 · Best GWAS P=2.05e-07 conditioned to 1
103.4M
103.6M
103.8M
104M
104.2M
104.4M
104.6M
104.8M
0
2
4
6
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Stomach Adenocarcinoma
C14orf153
0.20
0.05
lasso
2
0.04
0.00088
-5.2
5.3
1.1e-07
-0.97
0.00
0.95
TRUE
3
GTEx
Spleen
KLC1
0.15
0.05
lasso
3
0.03
0.06370
-5.2
-5.3
1.3e-07
0.92
0.03
0.66
FALSE
1
GTEx
Brain Frontal Cortex BA9
APOPT1
0.17
0.07
lasso
3
0.08
0.00465
-5.2
5.2
2.1e-07
-0.94
0.02
0.85
FALSE
2
GTEx
Nerve Tibial
KLC1
0.07
0.00
enet
22
0.01
0.08530
-3.9
-5.2
2.2e-07
0.63
0.07
0.71
FALSE
4
The Cancer Genome Atlas
Glioblastoma Multiforme
MARK3
0.12
0.05
blup
64
0.07
0.00329
4.0
5.2
2.6e-07
-0.63
0.02
0.20
FALSE