TWAS
hub
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Models
Genes
Traits
[Hub]/) :
Traits
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Vascular/heart problems diagnosed by doctor
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chr20:56,858,751-58,262,841
Best TWAS P=8.12e-20 · Best GWAS P=1.35e-34 conditioned to 2.47e-10
56.8M
57M
57.2M
57.4M
57.6M
57.8M
58M
58.2M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Skin Cutaneous Melanoma
ZNF831
0.22
0.03
enet
6
0.15
9.0e-05
-12.0
9.1
8.1e-20
-0.65
0.02
0.63
TRUE
3
The Cancer Genome Atlas
Colon Adenocarcinoma
TH1L
0.08
0.05
lasso
3
0.07
8.1e-05
4.3
-5.2
2.1e-07
0.14
0.01
0.98
TRUE
1
GTEx
Esophagus Mucosa
NELFCD
0.32
0.20
enet
8
0.27
2.1e-18
4.3
-5.1
2.7e-07
0.22
1.00
0.00
TRUE
2
GTEx
Nerve Tibial
NELFCD
0.30
0.17
enet
25
0.23
2.8e-16
3.9
-5.5
4.2e-08
0.27
1.00
0.00
FALSE