[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr20:61,522,825-62,912,463

Best TWAS P=5.71e-14 · Best GWAS P=2.2e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	6.7	7.5	5.7e-14	0.35	0.01	0.99	TRUE
2	CommonMind	Brain Pre-frontal Cortex	ZBTB46	0.11	0.08	lasso	3	0.07	1.2e-08	7.0	7.1	9.1e-13	1.00	0.00	1.00	TRUE
7	GTEx	Artery Aorta	TCEA2	0.09	0.04	lasso	3	0.03	1.3e-02	6.7	-7.0	2.0e-12	-0.23	0.02	0.96	TRUE
4	GTEx	Adrenal Gland	RGS19	0.32	0.20	lasso	8	0.21	5.8e-08	6.7	6.9	6.1e-12	0.26	0.01	0.98	TRUE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RGS19	0.12	0.05	blup	47	0.08	1.8e-05	5.4	5.6	1.8e-08	0.21	0.04	0.78	TRUE
13	GTEx	Breast Mammary Tissue	GMEB2	0.18	0.02	lasso	5	0.06	3.0e-04	3.4	5.3	1.0e-07	0.11	0.16	0.04	TRUE
26	GTEx	Stomach	OPRL1	0.36	0.23	enet	16	0.19	1.3e-09	6.7	7.3	2.4e-13	0.28	0.01	0.99	FALSE
29	GTEx	Vagina	RGS19	0.39	0.08	lasso	8	0.03	7.5e-02	-6.2	7.2	5.7e-13	0.27	0.03	0.60	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS19	0.07	0.05	blup	48	0.07	1.1e-07	5.4	7.1	1.3e-12	0.28	0.07	0.93	FALSE
17	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	6.7	7.1	1.4e-12	0.30	0.01	0.99	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	ZBTB46	0.11	0.07	lasso	1	0.06	5.2e-08	7.0	7.0	2.2e-12	1.00	0.00	1.00	FALSE
21	GTEx	Nerve Tibial	OPRL1	0.20	0.15	lasso	3	0.14	3.3e-10	6.7	7.0	2.9e-12	0.24	0.01	0.99	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	6.7	6.8	8.9e-12	0.28	0.02	0.98	FALSE
8	GTEx	Artery Tibial	OPRL1	0.10	0.10	lasso	2	0.06	1.1e-05	6.7	6.8	9.3e-12	0.26	0.01	0.99	FALSE
27	GTEx	Stomach	RGS19	0.18	0.25	lasso	2	0.25	2.2e-12	6.7	6.8	1.1e-11	0.25	0.01	0.99	FALSE
18	GTEx	Esophagus Muscularis	OPRL1	0.17	0.14	lasso	1	0.13	4.7e-08	6.7	6.7	1.6e-11	0.25	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	OPRL1	0.03	0.02	lasso	1	0.01	3.5e-02	6.7	6.7	1.6e-11	0.25	0.00	0.98	FALSE
24	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	-6.2	6.7	1.7e-11	0.27	0.02	0.98	FALSE
22	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	6.7	6.7	2.5e-11	0.27	0.01	0.99	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	RGS19	0.51	0.28	enet	28	0.32	4.3e-18	6.7	6.6	3.1e-11	0.23	0.01	0.99	FALSE
15	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	-6.2	6.6	4.5e-11	0.26	0.11	0.89	FALSE
28	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	-6.2	6.5	7.5e-11	0.35	0.04	0.96	FALSE
19	GTEx	Esophagus Muscularis	RGS19	0.22	0.10	lasso	4	0.10	1.6e-06	6.7	6.5	9.0e-11	0.26	0.01	0.99	FALSE
16	GTEx	Colon Sigmoid	RGS19	0.27	0.07	enet	33	0.09	3.8e-04	5.2	6.4	1.1e-10	0.38	0.04	0.92	FALSE
30	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	-6.3	-6.4	1.1e-10	-0.26	0.04	0.96	FALSE
12	GTEx	Brain Cerebellum	RGS19	0.28	0.22	lasso	4	0.18	7.2e-06	6.7	6.4	1.7e-10	0.27	0.01	0.95	FALSE
3	GTEx	Adrenal Gland	OPRL1	0.48	0.29	enet	21	0.22	1.5e-08	6.7	6.3	2.4e-10	0.31	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RGS19	0.11	0.00	blup	48	0.03	1.7e-02	-5.1	6.3	2.6e-10	0.19	0.03	0.48	FALSE
10	GTEx	Brain Cerebellar Hemisphere	OPRL1	0.27	0.14	lasso	7	0.17	4.4e-05	6.7	6.3	3.2e-10	0.27	0.02	0.78	FALSE
33	YFS	Blood	OPRL1	0.07	0.07	lasso	5	0.09	5.0e-27	6.7	-6.3	3.5e-10	-0.26	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS19	0.05	0.02	blup	48	0.02	1.1e-03	-4.3	6.2	5.6e-10	0.29	0.01	0.98	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS19	0.06	0.06	blup	47	0.05	1.4e-06	6.7	6.1	8.7e-10	0.22	0.00	1.00	FALSE
9	GTEx	Artery Tibial	RGS19	0.12	0.07	lasso	2	0.07	2.8e-06	-6.2	6.1	1.1e-09	0.25	0.06	0.94	FALSE
20	GTEx	Muscle Skeletal	RGS19	0.26	0.16	lasso	4	0.16	5.1e-15	-6.2	6.1	1.3e-09	0.27	0.21	0.79	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	C20orf201	0.10	0.09	enet	9	0.10	9.9e-13	5.4	-6.0	2.0e-09	-0.21	0.90	0.10	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	RGS19	0.07	0.04	blup	48	0.06	8.4e-07	-4.5	6.0	2.3e-09	0.23	0.00	1.00	FALSE
14	GTEx	Cells Transformed fibroblasts	OPRL1	0.25	0.07	enet	13	0.12	5.5e-09	-4.6	6.0	2.6e-09	0.25	0.22	0.78	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	OPRL1	0.07	0.08	lasso	4	0.08	7.8e-09	5.4	5.9	3.5e-09	0.24	0.05	0.95	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RGS19	0.18	0.08	enet	10	0.07	2.2e-03	-4.3	5.8	7.8e-09	0.25	0.12	0.29	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	RGS19	0.03	0.02	blup	48	0.02	6.9e-06	-5.1	5.8	8.3e-09	0.14	0.03	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TPD52L2	0.13	0.07	bslmm	418	0.08	4.5e-10	4.4	-5.6	1.8e-08	-0.36	0.76	0.24	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS19	0.09	0.04	enet	4	0.04	2.8e-03	5.1	5.3	1.1e-07	0.22	0.03	0.87	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RGS19	0.36	0.10	lasso	5	0.07	8.2e-03	5.4	5.3	1.2e-07	0.27	0.04	0.27	FALSE
5	GTEx	Artery Aorta	TPD52L2	0.16	0.07	enet	15	0.16	4.4e-09	-1.5	5.2	2.3e-07	0.20	0.70	0.04	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	C20orf201	0.03	0.01	lasso	4	0.01	2.3e-03	5.4	-5.1	2.7e-07	-0.25	0.30	0.18	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	UCKL1AS	0.05	0.02	blup	41	0.03	4.6e-04	-3.9	5.1	3.0e-07	0.16	0.03	0.30	FALSE