[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr21:44,251,223-45,879,403

Best TWAS P=1.56e-09 · Best GWAS P=2.45e-10 conditioned to 0.0209

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Esophagus Mucosa	PDXK	0.29	0.18	enet	12	0.24	4.1e-16	6.0	6.0	1.6e-09	0.84	0.01	0.99	TRUE
2	GTEx	Artery Aorta	PDXK	0.14	0.11	lasso	3	0.12	6.2e-07	6.0	6.0	2.3e-09	0.97	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RRP1B	0.11	0.09	lasso	11	0.11	3.7e-13	4.8	5.6	1.8e-08	0.94	0.02	0.98	FALSE
9	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSF2BP	0.16	-0.01	blup	62	0.02	4.7e-02	-2.0	-5.6	2.3e-08	-0.87	0.01	0.18	FALSE
8	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RRP1B	0.04	0.01	lasso	4	0.03	7.1e-03	5.2	-5.5	3.7e-08	-0.94	0.02	0.74	FALSE
6	GTEx	Vagina	PDXK	0.23	0.19	lasso	1	0.23	5.2e-06	5.5	5.5	3.9e-08	0.90	0.08	0.88	FALSE
7	GTEx	Whole Blood	RRP1B	0.06	0.02	lasso	3	0.00	1.3e-01	5.8	5.4	6.9e-08	0.94	0.03	0.86	FALSE
5	GTEx	Muscle Skeletal	HSF2BP	0.10	0.04	lasso	7	0.04	1.5e-04	4.8	5.4	7.7e-08	0.86	0.06	0.94	FALSE
3	GTEx	Esophagus Mucosa	RRP1B	0.14	0.10	enet	13	0.11	8.0e-08	5.4	5.3	9.7e-08	0.91	0.03	0.97	FALSE
10	The Cancer Genome Atlas	Stomach Adenocarcinoma	RRP1B	0.05	0.06	lasso	2	0.05	2.4e-04	5.2	-5.2	2.4e-07	-0.90	0.04	0.94	FALSE