Best TWAS P=1.56e-09 · Best GWAS P=2.45e-10 conditioned to 0.0209
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RRP1B | 0.11 | 0.09 | lasso | 11 | 0.11 | 3.7e-13 | 4.8 | 5.6 | 1.8e-08 | 0.94 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | PDXK | 0.14 | 0.11 | lasso | 3 | 0.12 | 6.2e-07 | 6.0 | 6.0 | 2.3e-09 | 0.97 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Esophagus Mucosa | RRP1B | 0.14 | 0.10 | enet | 13 | 0.11 | 8.0e-08 | 5.4 | 5.3 | 9.7e-08 | 0.91 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Esophagus Mucosa | PDXK | 0.29 | 0.18 | enet | 12 | 0.24 | 4.1e-16 | 6.0 | 6.0 | 1.6e-09 | 0.84 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Muscle Skeletal | HSF2BP | 0.10 | 0.04 | lasso | 7 | 0.04 | 1.5e-04 | 4.8 | 5.4 | 7.7e-08 | 0.86 | 0.06 | 0.94 | FALSE |
| 6 | GTEx | Vagina | PDXK | 0.23 | 0.19 | lasso | 1 | 0.23 | 5.2e-06 | 5.5 | 5.5 | 3.9e-08 | 0.90 | 0.08 | 0.88 | FALSE |
| 7 | GTEx | Whole Blood | RRP1B | 0.06 | 0.02 | lasso | 3 | 0.00 | 1.3e-01 | 5.8 | 5.4 | 6.9e-08 | 0.94 | 0.03 | 0.86 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RRP1B | 0.04 | 0.01 | lasso | 4 | 0.03 | 7.1e-03 | 5.2 | -5.5 | 3.7e-08 | -0.94 | 0.02 | 0.74 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HSF2BP | 0.16 | -0.01 | blup | 62 | 0.02 | 4.7e-02 | -2.0 | -5.6 | 2.3e-08 | -0.87 | 0.01 | 0.18 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RRP1B | 0.05 | 0.06 | lasso | 2 | 0.05 | 2.4e-04 | 5.2 | -5.2 | 2.4e-07 | -0.90 | 0.04 | 0.94 | FALSE |