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chr4:102,868,793-104,627,833

Best TWAS P=2.27e-11 · Best GWAS P=3.73e-10 conditioned to 0.821

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Esophagus Muscularis	CISD2	0.19	0.22	enet	25	0.21	6.2e-13	-6.2	6.7	2.3e-11	-0.95	0.05	0.95	TRUE
14	GTEx	Colon Sigmoid	CISD2	0.20	0.24	enet	15	0.13	2.1e-05	-6.1	6.5	8.5e-11	-0.96	0.05	0.95	FALSE
13	GTEx	Cells Transformed fibroblasts	CISD2	0.16	0.17	enet	12	0.13	9.7e-10	-6.3	6.3	2.5e-10	-0.98	0.05	0.95	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CISD2	0.05	0.01	blup	18	0.06	1.9e-03	-6.1	6.3	2.7e-10	-0.99	0.01	0.70	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	CISD2	0.02	0.02	enet	7	0.02	1.3e-03	5.7	-6.3	3.3e-10	0.88	0.01	0.86	FALSE
3	GTEx	Adrenal Gland	CISD2	0.08	0.03	lasso	2	0.03	4.1e-02	-6.3	6.3	3.6e-10	-0.97	0.05	0.87	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	CISD2	0.15	0.34	lasso	9	0.34	1.2e-44	-6.3	6.3	3.9e-10	-1.00	0.04	0.96	FALSE
21	GTEx	Ovary	CISD2	0.12	0.12	lasso	4	0.07	6.9e-03	-6.3	6.2	4.5e-10	-0.98	0.05	0.78	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBE2D3	0.03	0.04	enet	11	0.03	1.4e-04	-6.1	6.2	5.0e-10	-0.99	0.02	0.97	FALSE
28	GTEx	Thyroid	CISD2	0.12	0.07	lasso	3	0.05	8.8e-05	-6.3	6.2	5.1e-10	-0.98	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	CISD2	0.05	0.08	enet	5	0.06	1.9e-06	-6.1	6.2	6.1e-10	-0.99	0.01	0.99	FALSE
9	GTEx	Brain Cerebellum	CISD2	0.13	0.18	lasso	3	0.17	1.1e-05	-6.2	6.2	6.8e-10	-0.99	0.04	0.94	FALSE
5	GTEx	Artery Aorta	CISD2	0.10	0.08	lasso	4	0.06	1.8e-04	-6.1	6.2	7.2e-10	-0.98	0.05	0.95	FALSE
4	GTEx	Artery Aorta	UBE2D3	0.07	0.06	lasso	5	0.04	3.5e-03	-6.2	6.2	7.7e-10	-0.99	0.05	0.92	FALSE
19	GTEx	Nerve Tibial	UBE2D3	0.14	0.07	lasso	5	0.04	4.9e-04	-5.8	6.1	1.2e-09	-0.73	0.11	0.57	FALSE
26	GTEx	Small Intestine Terminal Ileum	CISD2	0.29	0.19	enet	34	0.15	3.2e-04	-6.3	6.1	1.2e-09	-0.94	0.05	0.86	FALSE
7	GTEx	Artery Tibial	CISD2	0.11	0.12	lasso	4	0.10	3.1e-08	-6.2	6.0	1.6e-09	-0.99	0.05	0.95	FALSE
25	GTEx	Skin Sun Exposed Lower leg	CISD2	0.12	0.20	lasso	14	0.20	1.1e-16	-6.1	6.0	1.7e-09	-0.98	0.04	0.96	FALSE
12	GTEx	Cells Transformed fibroblasts	UBE2D3	0.11	0.09	enet	13	0.08	2.3e-06	-6.1	6.0	2.1e-09	-0.99	0.05	0.95	FALSE
17	GTEx	Esophagus Mucosa	CISD2	0.12	0.06	enet	13	0.05	2.1e-04	-6.1	6.0	2.7e-09	-0.96	0.05	0.95	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	CISD2	0.10	0.05	enet	6	0.04	1.6e-02	5.7	5.9	3.7e-09	-0.96	0.05	0.84	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CISD2	0.15	0.02	lasso	3	-0.01	6.5e-01	-6.2	5.9	4.6e-09	-0.95	0.04	0.41	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	RP11-10L12.4	0.08	0.10	lasso	7	0.09	5.1e-12	-6.1	5.9	4.8e-09	-0.97	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	CISD2	0.06	0.09	enet	12	0.06	7.3e-06	-6.1	5.8	5.3e-09	-0.96	0.05	0.95	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	CISD2	0.13	0.14	enet	18	0.10	6.0e-06	-6.1	5.8	6.7e-09	-0.96	0.05	0.95	FALSE
29	GTEx	Uterus	CISD2	0.34	0.22	enet	25	0.19	8.9e-05	-6.3	5.8	6.9e-09	-0.93	0.05	0.91	FALSE
6	GTEx	Artery Coronary	CISD2	0.14	0.15	lasso	8	0.12	7.4e-05	5.7	5.8	7.6e-09	-0.93	0.05	0.91	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MANBA	0.10	0.13	lasso	4	0.11	1.8e-09	-5.8	-5.8	7.6e-09	0.75	0.10	0.90	FALSE
22	GTEx	Pancreas	UBE2D3	0.13	0.09	enet	12	0.12	6.7e-06	-4.2	5.8	8.4e-09	-0.89	0.05	0.95	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MANBA	0.03	0.03	blup	71	0.04	2.0e-05	-4.6	-5.7	9.9e-09	0.87	0.04	0.95	FALSE
15	GTEx	Colon Transverse	CISD2	0.12	0.09	enet	19	0.06	1.0e-03	-6.3	5.7	1.1e-08	-0.85	0.05	0.92	FALSE
30	METSIM	Adipose	UBE2D3	0.04	0.02	bslmm	332	0.03	2.0e-05	-6.2	5.7	1.1e-08	-0.81	0.06	0.91	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	UBE2D3	0.05	0.06	blup	337	0.07	5.0e-09	-6.3	5.7	1.2e-08	-0.95	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBE2D3	0.02	0.02	enet	6	0.02	3.7e-03	-6.2	5.7	1.5e-08	-0.96	0.02	0.82	FALSE
11	GTEx	Cells Transformed fibroblasts	MANBA	0.26	0.22	lasso	9	0.27	1.9e-20	-4.1	-5.6	1.7e-08	0.76	0.90	0.10	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	MANBA	0.33	0.11	enet	13	0.21	2.0e-12	-3.8	-5.6	1.7e-08	0.79	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SLC9B1	0.13	0.23	enet	24	0.24	4.4e-29	-6.2	5.6	2.2e-08	-0.91	0.04	0.96	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	MANBA	0.11	0.16	lasso	4	0.16	3.4e-32	-5.8	-5.5	2.9e-08	0.74	0.10	0.90	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	MANBA	0.13	0.10	blup	69	0.10	4.5e-12	-5.8	-5.5	3.1e-08	0.81	0.11	0.89	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	UBE2D3	0.11	0.00	enet	17	0.00	2.5e-01	-2.2	5.5	3.7e-08	-0.68	0.06	0.78	FALSE
27	GTEx	Testis	CISD2	0.10	0.04	lasso	5	0.03	1.3e-02	-6.1	5.4	5.9e-08	-0.92	0.05	0.88	FALSE
8	GTEx	Brain Cerebellum	MANBA	0.18	0.03	enet	27	0.05	1.2e-02	-4.1	5.4	6.3e-08	-0.60	0.07	0.31	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	MANBA	0.11	0.04	lasso	7	0.04	3.5e-05	-5.8	-5.3	1.1e-07	0.72	0.10	0.88	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	MANBA	0.20	0.30	enet	26	0.31	2.3e-40	-5.7	5.2	1.9e-07	-0.71	0.44	0.56	FALSE
20	GTEx	Nerve Tibial	CISD2	0.19	0.14	enet	43	0.14	7.5e-10	-6.1	5.2	2.1e-07	-0.79	0.05	0.95	FALSE