TWAS hub - PRDM8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0310	0.00160	0.025	0.021	0.024	0.024	0.009	4.1e-04	1.1e-03	5.2e-04	6.2e-04	2.4e-02
2	GTEx	Adipose Visceral Omentum	0.2900	0.0890	0.00110	0.010	NA	-0.005	NA	0.008	9.4e-02	NA	9.5e-01	NA	1.2e-01
3	GTEx	Breast Mammary Tissue	0.2290	0.0830	0.00210	0.065	NA	0.052	NA	0.054	3.1e-04	NA	1.2e-03	NA	9.5e-04
4	GTEx	Breast Mammary Tissue (Male)	0.1805	0.1691	0.16000	0.062	NA	0.054	NA	0.026	1.5e-02	NA	2.2e-02	NA	8.3e-02
5	GTEx	Breast Mammary Tissue (Female)	0.1205	0.1285	0.13000	0.004	NA	0.058	NA	-0.003	2.4e-01	NA	8.0e-03	NA	4.1e-01
6	GTEx	Nerve Tibial	0.1358	0.0576	0.00500	0.138	NA	0.095	NA	0.134	5.4e-10	NA	3.0e-07	NA	1.0e-09
7	GTEx	Ovary	0.4950	0.0870	0.00012	0.008	NA	0.035	NA	0.161	1.9e-01	NA	4.8e-02	NA	9.4e-05
8	METSIM	Adipose	0.0599	0.0222	0.00008	0.009	0.033	0.018	0.033	0.011	1.4e-02	9.1e-06	9.7e-04	9.2e-06	7.0e-03
9	NTR	Blood	0.0249	0.0093	0.00027	0.000	0.013	0.005	0.012	0.002	3.9e-01	3.0e-05	6.2e-03	5.4e-05	7.5e-02
10	ROSMAP	Brain Pre-frontal Cortex	0.0517	0.0231	0.00460	0.000	0.006	0.005	0.009	0.001	3.8e-01	5.5e-02	6.5e-02	1.9e-02	2.5e-01
11	YFS	Blood	0.1310	0.0270	0.00000	0.065	0.075	0.072	0.078	0.071	2.8e-20	2.4e-23	1.9e-22	2.1e-24	3.0e-22
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0690	0.0310	0.00044	0.031	0.026	0.021	NA	0.028	3.4e-03	6.5e-03	1.4e-02	NA	5.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Hair/balding pattern: Pattern 2	8.5	10.9	21.0	0.9	-3.9	-4.6	-2.7	-2.6	-4.5	-3.4	-2.4	4.5	0.7	3.5	2.9
Hair/balding pattern: Pattern 3	8.5	12.7	34.7	0.5	4.1	5.9	3.7	2.2	4.8	4.7	2.9	-3.4	-1.7	-2.2	-2.9
Medication: Blood pressure	6.5	11.4	35.3	-1.3	-5.9	-4.3	-4.6	-0.4	-5.6	-2.5	1.3	2.7	-2.2	1.6	2.2
Hair/balding pattern: Pattern 4	6.4	15.6	32.3	0.0	4.4	5.0	2.2	2.1	5.6	5.7	3.4	-4.7	-0.1	-4.3	-4.2
Medication for cholesterol, blood pressure or diabetes	4.0	6.6	18.4	1.5	4.3	3.1	3.4	0.9	3.9	2.8	-1.2	-1.7	1.1	-1.9	-2.1
Medication: Aspirin	3.9	5.1	15.7	0.2	-4.0	-3.2	-2.4	-1.4	-3.7	-3.2	0.5	1.1	-0.2	-0.1	1.6
Medication for pain relief, constipation, heartburn	3.6	6.2	16.7	0.1	4.1	3.1	2.6	1.3	4.1	1.7	-0.2	-2.7	2.5	-1.0	-2.4
Medication: Aspirin	3.6	4.7	13.6	0.0	-3.7	-2.9	-2.6	-0.9	-3.5	-3.3	0.7	1.1	-0.1	-0.2	1.6
High blood pressure	3.5	9.7	26.6	-0.7	-4.7	-4.8	-4.0	-1.2	-5.2	-3.8	2.1	2.2	-0.8	-0.1	1.8
Hypertension (Self-reported)	3.4	9.5	28.1	-0.5	-4.7	-4.8	-4.0	-0.9	-5.3	-3.5	1.9	2.2	-0.3	-0.1	1.7
High blood pressure (siblings)	3.2	4.6	13.3	-0.7	-2.7	-2.9	-2.6	1.0	-3.2	-3.7	0.8	1.9	0.6	0.3	1.5
Vascular/heart problems diagnosed by doctor	3.2	8.7	22.5	1.0	4.4	4.6	3.6	1.3	4.7	3.7	-2.0	-1.5	1.2	0.3	-2.1
Number of operations (self-reported)	3.1	4.6	14.5	-1.0	-3.8	-3.1	-3.0	-1.8	-3.3	-1.5	-0.9	1.0	-1.9	0.2	0.2
Cardiovascular Disease	2.9	9.5	24.8	-0.9	-4.7	-4.5	-4.0	-0.8	-5.0	-3.8	3.2	1.6	-0.0	-0.4	1.6
Illnesses of siblings	2.9	4.1	10.8	1.7	3.0	2.2	2.6	-0.4	2.7	3.3	-1.2	-1.1	0.4	-1.2	-1.7
Had major operations	2.8	3.3	11.5	-1.5	-3.4	-3.0	-1.2	-0.8	-2.9	-1.4	-0.1	0.1	-1.1	0.8	1.5
Systolic Blood Pressure	2.7	13.5	41.3	0.1	-5.7	-5.2	-5.1	-0.6	-6.4	-4.4	0.5	3.5	0.6	-1.2	0.9
Illnesses of father: Heart disease	2.6	3.7	10.7	-1.6	-2.0	-2.5	-2.5	-0.2	-3.3	-2.9	0.1	1.9	-0.2	0.4	1.4
Financial difficulties in last 2 years	2.5	3.4	9.2	-1.9	-1.6	-2.2	-3.0	0.5	-2.4	0.5	0.5	1.8	-1.2	1.8	2.5
Medication: Atenolol	2.4	3.0	10.4	-0.8	-2.0	-2.0	-2.7	-0.6	-2.1	-3.2	1.9	0.0	0.2	-0.5	0.8
Chronic bronchitis/emphysema (father)	2.4	2.8	12.8	1.6	-0.6	-1.9	-1.1	-1.3	-1.2	-1.9	1.5	3.6	0.0	-1.6	-1.2
Medication: Lansoprazole	2.4	2.7	9.1	-1.0	1.1	1.4	3.0	0.9	2.0	2.3	0.5	-1.6	-2.3	0.8	-0.0
Alzheimer’s Disease (in mother)	2.3	2.6	6.2	-0.8	-2.0	-2.5	-2.2	-1.2	-2.2	-1.1	-2.4	0.5	0.2	1.3	1.0
Medication: Ibuprofen	2.3	2.8	7.9	0.4	-1.8	-2.5	-1.0	-0.2	-2.8	-0.9	-0.7	2.2	-0.4	0.7	2.8
Back pain experienced in last month	2.3	3.3	8.6	-1.5	-1.7	-1.5	-1.0	-2.3	-2.3	-1.7	-0.5	0.4	-0.8	2.9	2.9
Lupus	2.2	3.3	11.7	3.4	0.5	0.2	0.0	0.5	1.0	-1.4	-0.8	1.4	1.8	-3.0	-3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	9.1	-2.5	-1.2	-1.0	-0.8	0.6	-0.8	1.3	-0.7	-0.6	-1.7	3.0	2.5
Ever had prostate specific antigen (PSA) test	2.2	2.5	7.0	2.2	-2.1	-1.4	-1.7	0.6	-2.1	-0.1	-1.5	2.6	0.1	-1.2	-0.7
Number of treatments/medications taken	2.0	3.6	10.6	-1.4	-3.3	-1.9	-1.8	-1.1	-2.8	-1.4	0.7	0.5	-2.3	1.1	2.1
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	7.0	0.9	-1.7	-1.9	-0.7	-0.3	-2.6	-0.5	-0.1	2.6	-1.3	0.6	2.6
Father’s age at death	1.9	2.5	7.4	1.8	1.3	1.7	0.8	0.0	1.4	1.0	-2.7	-1.0	-0.9	-2.3	-2.1
Number of children fathered	1.9	2.2	5.1	-1.5	-1.6	-1.7	-2.2	-2.1	-1.7	-0.7	0.1	1.0	-0.5	1.4	1.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	7.7	-1.1	-1.0	-2.3	-1.6	-1.2	-2.4	-2.8	1.3	0.7	-0.5	0.4	0.7
Medication: Ramipril	1.8	2.4	6.3	-0.6	-2.1	-2.1	-2.3	0.4	-2.5	-2.5	-0.5	1.0	-0.1	0.2	0.4
Medication: Amlodipine	1.8	2.5	5.8	-0.3	-1.6	-2.4	-2.2	-0.5	-2.3	-2.1	-0.7	2.2	0.1	0.7	0.8
Guilty feelings	1.8	2.7	8.5	0.9	-2.6	-2.6	-1.2	-0.6	-2.9	-1.4	1.3	2.1	-0.3	-0.1	0.7
Medication: Bendroflumethiazide	1.8	2.7	10.8	-0.6	-3.3	-2.2	-2.1	-0.7	-2.8	-0.4	-0.1	0.6	-1.4	-0.1	1.0
Risk taking	1.8	2.6	6.9	-0.1	-1.2	-1.8	-1.7	-0.1	-1.8	-2.3	1.3	2.6	1.0	1.8	1.3
Unable to work because of sickness or disability	1.8	2.3	5.0	-1.8	-1.5	-2.2	-1.5	-0.1	-2.2	-1.5	-0.1	0.0	-1.8	1.0	1.9
Diabetes (father)	1.7	2.1	4.3	0.5	-1.5	-1.9	-1.3	-1.8	-1.8	-0.7	-1.4	2.1	-0.4	1.7	1.2
Fed-up feelings	1.7	3.1	7.1	-0.5	-2.7	-1.9	-1.1	-1.2	-2.5	0.4	1.1	0.8	-2.3	2.2	2.3
Had other major operations	1.7	2.1	7.5	-1.6	-1.6	-1.3	-2.7	-2.4	-1.0	-1.3	0.1	-0.3	-1.4	0.1	-0.0
Ever had bowel cancer screening	1.7	2.0	7.7	-2.8	-1.3	-0.9	-1.4	-0.7	-1.0	-1.0	-1.5	-0.2	-0.1	1.8	2.1
Osteoarthritis (self-reported)	1.7	2.2	6.6	-2.5	-0.4	-1.3	-1.2	-1.1	-1.6	-1.3	1.1	-0.7	-1.6	0.3	2.6
Medication: Lisinopril	1.7	2.2	5.6	-1.2	-2.4	-2.1	-1.0	-1.0	-2.4	-1.2	-0.4	0.9	-0.8	1.0	1.9
Basal cell carcinoma (self-reported)	1.7	2.1	12.0	-0.1	-1.0	-1.7	-1.8	-1.4	-1.4	-0.2	-3.5	0.8	-0.6	0.6	0.7
Heart attack/myocardial infarction (self-reported)	1.7	2.2	6.9	-0.5	-2.6	-2.4	-1.7	-0.4	-1.9	-1.6	-0.7	0.3	-1.2	-0.4	1.4
Supplements: Glucosamine	1.6	2.1	7.4	-1.4	-2.7	-1.6	-1.0	-0.3	-2.7	-0.9	-0.2	-0.4	-1.1	1.4	1.0
Heart attack	1.6	2.0	6.5	-0.4	-2.5	-2.4	-1.5	-0.4	-1.9	-1.6	-0.8	0.4	-0.9	-0.5	1.3
Lung cancer (father)	1.6	1.8	8.1	0.6	-1.6	-1.8	-1.2	-0.7	-1.7	-2.9	0.5	0.8	1.2	0.1	0.5
Pulse wave reflection index	1.6	2.0	6.2	-1.5	-1.8	-2.1	-2.5	0.1	-2.1	-0.6	-0.5	-0.8	-0.4	0.2	1.1
Exposure to tobacco smoke outside home	1.6	2.2	4.5	-0.8	-1.6	-1.8	-2.1	-1.2	-1.8	-1.0	-1.2	1.6	-0.9	1.3	1.5
Chest pain or discomfort	1.6	2.3	6.4	-0.5	-2.0	-1.9	-0.6	-2.5	-1.9	-0.8	-0.6	1.1	-0.6	1.7	2.1
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.0	-1.3	-1.6	-1.6	-1.6	-1.2	-1.6	-0.2	1.6	0.6	-1.7	1.3	1.5
Smoking status: Previous	1.6	2.4	8.1	1.8	-2.2	-2.2	-1.2	-0.7	-2.2	-0.1	-0.1	2.8	-0.4	0.6	-0.1
Alzheimer’s Disease (in father)	1.5	1.6	6.8	1.0	0.9	0.9	0.3	0.4	1.2	0.3	-0.3	-1.1	0.9	-2.6	-2.6
Neuroticism	1.5	3.5	9.9	-0.8	-2.9	-2.6	-2.0	-2.3	-3.2	0.3	0.7	0.1	-1.2	1.2	2.0
Fluid intelligence score	1.5	3.2	9.7	0.4	-0.6	-2.5	-1.2	-0.4	-2.2	-1.7	-3.0	-0.0	3.1	0.1	1.6
Breastfed as a baby	1.5	1.9	6.9	-0.9	0.2	-1.4	-2.1	-0.8	-1.3	-2.6	-0.1	-0.4	1.3	-2.2	0.2
Medication: Omeprazole	1.5	1.8	9.6	-0.1	-0.7	-1.9	-1.0	-0.7	-2.1	-3.1	1.3	0.6	0.3	-0.1	0.2
Knee pain experienced in last month	1.5	2.3	5.9	-0.7	-1.7	-1.8	-0.1	-1.4	-1.6	-0.6	2.4	0.0	-2.0	1.6	2.0
Medication: Blood pressure	1.5	2.9	7.7	0.3	-1.8	-2.8	-2.1	-1.5	-2.5	-2.6	0.2	0.8	0.1	-1.9	-0.1
Commuting to job workplace: Cycle	1.5	1.8	7.0	0.3	-1.8	-1.2	-0.7	-0.4	-2.6	-2.5	0.7	0.5	1.4	-0.4	0.6
Systolic blood pressure, automated reading	1.4	4.1	13.2	0.6	-2.8	-2.7	-2.5	-0.0	-3.6	-2.8	0.7	1.3	-0.0	-2.0	-0.1
Maternal smoking around birth	1.4	2.1	8.2	1.1	0.5	-1.1	-0.6	-1.6	-0.3	-2.2	0.6	2.4	2.9	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.3	10.8	0.6	1.5	2.4	2.7	-0.4	3.3	2.9	-0.2	-1.6	-0.2	0.1	-1.1
Pulse wave Arterial Stiffness index	1.4	1.6	4.5	-1.8	-0.7	-1.5	-2.1	-0.0	-1.2	-0.9	1.7	-0.4	-1.0	0.7	1.3
Ever highly irritable/argumentative for 2 days	1.4	1.7	6.3	-0.0	2.5	0.5	1.5	0.8	1.7	-0.9	-0.4	0.2	2.4	-0.3	0.5
Illnesses of siblings: Diabetes	1.4	1.7	8.8	-0.4	-3.0	-0.9	-0.7	-0.7	-1.4	-0.8	-1.1	0.5	-0.7	2.0	1.1
Long-standing illness, disability or infirmity	1.4	2.1	5.3	-1.5	-1.5	-1.2	0.0	-1.2	-1.6	-1.8	0.9	0.5	-2.1	1.3	2.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	5.0	0.5	0.3	-2.1	-1.7	-0.3	-1.4	-2.2	1.4	1.4	-0.4	-0.3	0.3
Pain type(s) experienced in last month: Hip pain	1.4	1.7	4.2	-0.5	-1.9	-0.9	-0.2	-0.7	-2.0	-0.8	-1.7	0.5	0.2	1.9	1.9
Alcohol drinker status: Never	1.4	1.7	5.1	-2.3	-0.8	-0.1	-0.2	0.8	-0.5	1.9	-0.8	-1.6	-1.9	1.2	1.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.9	-0.9	-1.0	-1.9	-1.3	-0.8	-1.8	-1.7	-0.6	1.3	-0.9	0.4	2.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.3	-1.3	-0.3	-0.0	0.8	0.3	-0.1	-0.3	2.1	0.5	-1.6	1.8	1.9
Number of live births	1.3	1.8	7.6	-0.4	-0.6	-1.9	-2.8	-0.5	-1.8	-2.0	0.2	0.7	1.1	0.6	0.7
Medication: Cholesterol lowering	1.3	2.0	5.6	-1.4	-2.4	-0.8	-1.4	-0.3	-1.6	-1.8	0.5	0.4	-0.8	2.2	1.4
Exposure to tobacco smoke at home	1.3	1.4	9.0	1.6	0.5	-0.1	-0.4	0.7	0.1	-0.3	-0.4	1.8	3.0	-0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.6	-1.1	-1.0	-1.8	-0.6	-0.9	-1.3	-0.1	-0.1	-0.3	0.1	1.9	2.1
Illnesses of father: None of the above (group 1)	1.3	1.6	5.2	0.3	0.6	2.3	1.0	0.9	1.7	1.6	-0.9	-2.0	0.4	0.9	0.0
Average weekly champagne plus white wine intake	1.3	1.8	4.8	-1.6	-1.5	-1.2	-1.1	-1.0	-1.4	0.1	-0.8	-0.1	-1.2	2.1	2.2
Medication: Paracetamol	1.3	2.1	4.6	-1.3	-1.5	-0.9	-1.7	-1.4	-1.5	0.8	-1.5	1.0	-2.1	1.6	1.5
Pain experienced in last month	1.3	2.1	6.2	0.5	1.4	1.3	-0.0	1.6	1.2	-0.3	-1.8	-0.6	2.5	-2.4	-1.4
Depressed Affect (Nagel 2018)	1.2	2.4	4.6	-0.9	-1.9	-1.5	-0.2	-1.9	-2.1	0.5	2.2	0.1	-1.7	1.6	1.9
Mean Putamen Volume	1.2	1.4	2.9	-0.3	1.7	1.4	1.3	1.3	1.5	-0.1	0.8	-1.0	0.8	-1.5	-1.2
Medication for hormone replacement therapy	1.2	1.3	5.7	-2.4	-0.2	-0.6	-1.3	-0.6	-0.8	-1.6	0.9	-0.2	-0.5	1.4	1.3
Past tobacco smoking	1.2	2.2	6.1	-1.5	2.3	2.2	0.9	1.2	2.2	0.1	0.4	-2.5	0.9	-0.6	-0.1
Loud music exposure frequency	1.2	1.3	4.5	1.4	-0.1	0.1	0.4	1.0	-0.2	-1.7	0.4	1.6	2.1	-1.1	-0.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	6.2	0.3	2.5	0.6	2.0	0.6	1.4	-0.8	1.6	0.5	0.6	-1.0	-1.0
Wheeze or whistling in the chest in last year	1.2	2.2	7.0	0.5	-1.6	-1.6	-1.5	-1.3	-1.8	-2.6	0.1	2.6	-0.4	-0.1	0.1
Neck or shoulder pain in last month	1.2	1.7	3.7	-0.6	-1.0	-1.4	0.3	-1.9	-1.6	0.3	1.7	0.6	-1.8	1.5	1.3
Medication for cholesterol	1.2	1.8	4.2	2.1	1.6	1.7	2.0	0.0	1.9	1.2	-0.2	0.4	0.9	0.2	-1.5
Myopia	1.2	1.7	7.8	-0.7	-1.4	-0.1	0.4	1.9	-0.2	1.3	-2.8	-1.7	0.5	0.7	1.1
Irritable Bowel Disease (IBD)	1.1	2.6	6.8	-2.6	0.7	1.1	1.0	-0.0	1.8	1.7	2.2	-1.7	-2.5	1.3	0.1
Major Depression (MDD)	1.1	1.3	5.5	-0.9	-0.8	-1.2	-0.0	-1.3	-0.8	-0.6	0.0	1.1	-0.9	2.4	1.7
Relative age of first facial hair	1.1	2.3	8.9	0.4	-1.6	-0.9	1.2	-1.2	-1.9	-3.0	0.9	2.2	0.9	1.0	0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.3	-2.1	0.2	-1.0	-2.0	-1.2	-1.2	-1.5	-0.8	-0.6	0.5	-0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	6.0	-0.6	-1.1	-1.1	-1.2	-2.4	-1.5	-0.6	0.8	1.3	-1.1	-0.1	1.3
Falls in the last year	1.1	1.5	5.5	-0.5	-1.2	-0.8	0.3	-0.0	-1.1	-1.4	0.5	-0.9	-1.7	1.7	2.3
Pulse wave peak to peak time	1.1	1.4	3.6	1.6	0.6	1.4	1.9	-0.5	1.1	0.9	-1.7	0.3	1.1	-0.3	-1.0
Number of self-reported non-cancer illnesses	1.1	2.0	8.5	-0.7	-1.4	-1.6	-0.9	-2.4	-1.3	-2.9	1.0	0.6	0.1	-0.0	0.9
Diastolic blood pressure, automated reading	1.1	3.5	13.5	-0.2	-1.9	-2.4	-1.6	0.7	-2.9	-3.7	1.7	1.3	0.9	-1.3	0.9
Alcohol drinker status: Previous	1.1	1.3	4.3	-1.0	-1.0	-0.9	0.0	-0.7	-1.0	0.0	-1.4	-0.4	-2.1	1.2	1.6
Schizophrenia (2018)	1.0	2.1	7.5	2.5	0.4	0.8	0.6	-0.9	0.5	-1.4	1.3	0.9	-0.3	-2.7	-2.0
Crohns Disease (2017)	1.0	2.1	4.0	-2.0	1.1	1.5	1.4	0.6	2.0	1.4	1.7	-1.0	-1.8	1.7	0.1
Breast Cancer	1.0	2.3	12.6	0.4	-1.7	-1.6	-0.3	-1.6	-1.8	-1.2	0.4	0.9	3.5	0.9	0.9
Prostate Cancer	1.0	1.3	4.7	2.2	-0.4	-0.1	1.2	0.0	0.8	1.0	0.9	1.7	-0.3	-0.2	-2.1
Smoking Status	1.0	2.4	7.2	0.3	-1.7	-2.5	-2.0	-2.7	-1.7	-1.0	-1.0	1.6	-0.7	0.5	0.7
Sensitivity / hurt feelings	1.0	1.7	4.3	-2.1	-1.0	-1.2	-1.4	0.2	-1.9	-1.1	1.1	-1.1	0.2	0.8	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	5.9	0.4	0.5	-0.1	0.0	-1.7	-0.4	-1.5	2.4	1.7	0.9	-1.0	-0.2
Multivitamins +/- minerals	1.0	1.3	7.4	-0.3	0.6	1.0	0.3	0.2	0.3	-2.0	1.5	0.3	2.7	0.4	0.1
Qualifications: College or University degree	1.0	3.1	14.3	1.9	-0.1	-0.3	-0.8	0.9	-0.6	-1.5	-3.8	-0.1	3.6	-1.4	-0.9
Medication: Allopurinol	1.0	1.3	4.7	2.2	-0.6	0.9	0.8	1.1	1.2	1.0	0.7	0.5	-0.5	-0.8	-2.0
Leg pain on walking	1.0	1.2	2.5	-0.3	-1.4	-1.2	-1.0	-1.4	-1.1	-1.6	1.1	0.6	-1.6	0.4	0.6
Diabetes diagnosed by doctor	1.0	1.6	7.3	-0.5	0.7	1.9	2.7	0.2	1.8	-0.6	1.3	-0.8	-1.1	0.5	0.1
Mineral and other dietary supplements	1.0	1.4	5.9	0.4	2.4	1.0	0.3	1.8	1.7	0.5	1.2	0.8	0.9	-0.1	-0.8
Hearing aid user	1.0	1.1	11.0	-0.1	-0.1	-0.1	-0.1	0.7	-1.0	-3.3	0.5	0.2	0.6	-0.7	-0.1
Ever smoked	1.0	1.7	5.0	1.3	-2.2	-2.0	-0.1	-1.4	-1.9	-0.1	-0.5	1.3	-1.0	1.1	0.6
Neuroticism (Nagel 2018)	0.9	2.2	7.0	-0.6	-2.2	-2.0	-0.9	-1.8	-2.6	-0.6	1.9	-0.4	-0.0	0.0	1.4
Body Mass Index (BMI) (2010)	0.9	1.2	3.4	-1.9	1.5	1.2	0.0	1.3	0.9	0.8	1.2	-0.6	-1.3	0.7	0.8
Trunk fat percentage	0.9	3.7	19.3	-1.6	1.1	0.6	1.2	2.8	0.4	-2.4	4.4	-0.6	-1.0	1.7	1.2
Serious illness, injury or assault to yourself	0.9	1.1	2.7	0.3	-1.1	-1.0	-0.6	0.3	-1.4	-1.6	-0.8	1.6	0.9	0.4	1.2
Stomach or abdominal pain in last month	0.9	1.1	3.5	0.6	-0.9	-1.5	-0.4	-1.7	-1.4	-0.2	0.8	-0.1	1.9	0.7	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	5.1	-0.2	-0.4	-1.7	-1.3	-2.2	-0.9	-1.6	-0.4	1.4	0.0	-0.7	1.3
Depression (self-reported)	0.9	1.1	3.1	0.0	1.4	1.1	1.8	-0.5	1.5	0.7	1.0	0.3	0.7	1.6	0.3
Illnesses of mother	0.9	1.1	3.0	-0.0	1.7	1.4	1.4	0.0	1.5	1.1	1.1	-0.9	0.4	-0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	6.1	1.3	1.6	0.3	-0.1	1.0	0.5	-0.5	0.7	0.7	2.5	-1.8	-1.0
Blood clot in the leg (DVT)	0.9	1.1	4.4	-0.2	1.2	0.5	0.8	-0.4	1.0	-1.7	2.1	-0.2	1.1	1.1	0.1
Body fat percentage	0.9	3.6	20.4	-1.4	1.1	0.2	1.4	2.5	0.3	-2.5	4.5	-0.3	-0.9	1.7	1.2
Eye problems/disorders: None of the above	0.9	1.0	3.5	0.2	1.9	1.4	0.1	0.6	1.2	1.1	-1.0	0.9	1.4	0.2	0.0
Leg fat percentage (left)	0.9	3.3	19.0	-1.6	1.3	-0.4	1.4	1.8	0.3	-2.2	4.4	-0.2	-1.0	1.6	1.6
Bipolar Disorder or Schizophrenia	0.8	2.1	9.1	3.0	0.8	1.3	1.4	0.2	0.9	-1.0	0.4	1.3	0.5	-2.2	-1.6
Worry (Nagel 2018)	0.8	1.6	4.0	0.0	-1.6	-1.9	-1.5	-1.0	-2.0	-1.1	0.5	-0.9	1.2	-1.3	0.5
Verbal and Numeric Reasoning (VNR)	0.8	1.9	8.7	-0.5	-0.8	-1.5	-0.7	0.5	-1.7	-1.6	-1.4	-0.5	3.0	1.2	1.3
Age at First Birth	0.8	1.2	7.5	1.0	0.3	-0.4	-0.7	0.5	-0.9	-0.3	-1.1	1.1	2.7	-0.9	-0.6
Primary Biliary Cirrhosis	0.8	1.1	5.9	0.4	-0.7	0.4	-0.1	1.2	-0.2	1.4	-0.1	-0.7	-2.4	-1.1	-1.0
Ulcerative Colitis	0.8	1.1	4.1	-0.9	0.5	0.2	0.3	-1.4	1.2	1.3	1.2	-1.0	-2.0	-0.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	6.3	-0.8	-0.1	1.2	2.5	-0.0	0.9	-0.3	1.1	-0.8	-2.1	1.3	0.8
Average weekly spirits intake	0.8	1.0	5.6	0.4	0.8	0.0	-0.0	1.1	-1.0	-1.2	2.4	0.4	0.6	-0.8	-0.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.1	0.2	-0.7	-0.7	-0.4	-1.3	-1.0	0.6	0.6	0.9	-2.0	1.3	1.6
Diabetes (mother)	0.8	1.0	4.0	0.7	-1.1	0.4	1.1	-0.1	-0.0	1.8	0.2	-0.9	-2.0	0.9	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.9	-1.3	0.9	0.3	-0.1	0.2	0.4	0.9	1.7	-1.7	-0.4	-0.6	-0.4
Trunk fat mass	0.8	3.4	18.0	-1.6	0.9	0.1	0.8	1.9	-0.0	-2.7	4.2	-0.2	-0.7	2.0	1.8
Nervous feelings	0.8	1.4	5.4	1.7	1.2	-0.0	0.3	-1.2	0.8	-0.1	0.0	-0.8	1.7	-2.3	-1.1
Had menopause	0.8	1.0	2.3	-1.5	-0.8	-1.4	-1.2	-0.6	-0.7	-0.2	-0.8	-1.5	-0.3	0.4	1.0
Pain all over the body in last month	0.8	0.9	3.3	-1.4	-0.6	-0.4	-0.5	0.5	-1.5	-0.7	1.8	1.0	-0.3	-0.4	0.7
Neuroticism score	0.8	1.8	5.5	-0.3	-2.1	-1.6	-1.4	-1.0	-2.3	-0.6	1.8	0.4	-0.1	0.4	1.2
Arm fat percentage (right)	0.8	3.3	17.0	-1.4	0.2	-0.5	0.9	2.1	-0.4	-2.6	4.1	-0.1	-1.8	1.6	1.4
Time employed in main current job	0.8	0.9	3.4	1.3	0.1	0.0	0.5	0.5	-0.1	-0.6	-0.5	-0.6	1.7	-1.9	-0.9
Worrier / anxious feelings	0.8	1.5	5.6	0.2	-1.9	-1.5	-1.5	0.4	-2.4	-0.4	0.9	-0.3	0.7	-1.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.0	1.7	2.0	1.2	0.9	1.0	1.2	0.4	-0.7	-0.1	2.0	-1.6	-1.4
Gout (self-reported)	0.8	1.1	3.4	0.5	0.4	1.8	0.9	1.4	1.7	0.9	0.6	-0.4	-0.4	0.8	-1.1
Leg fat percentage (right)	0.8	3.0	19.8	-1.3	1.1	-0.1	1.2	1.8	0.4	-1.9	4.5	0.1	-1.0	1.7	1.2
Age at first live birth	0.8	1.3	4.7	2.0	0.8	0.1	-0.1	0.5	-0.1	-0.4	-2.2	1.3	2.0	-0.6	-0.6
Shortness of breath walking on level ground	0.8	0.9	3.5	-1.0	-0.3	-0.2	0.9	-1.9	-0.2	0.3	1.1	-0.3	-1.0	1.3	1.2
Migraine (self-reported)	0.8	1.0	4.4	-0.1	0.8	-0.1	-1.4	-0.6	0.1	-0.9	0.5	0.6	-0.1	-1.8	-2.1
Medication: Seretide 50 evohaler	0.8	0.9	6.4	0.3	-0.5	-1.3	-0.5	-2.5	0.0	-0.4	-1.2	0.3	-0.3	0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.6	1.3	0.3	0.4	0.7	0.9	0.9	0.5	-1.0	-0.6	0.6	-1.2	-1.9
Commuting to job workplace: Car/motor vehicle	0.8	1.0	5.2	-0.4	0.0	0.7	-0.3	0.7	1.1	1.4	0.5	-0.6	-2.3	0.7	-0.8
Arm fat percentage (left)	0.8	3.0	15.2	-1.2	0.3	-0.4	0.9	2.2	-0.4	-2.4	3.9	-0.1	-1.8	1.4	1.5
Mood swings	0.8	1.4	4.0	-0.3	-1.9	-0.9	-0.8	-0.8	-1.7	-0.1	0.4	0.6	-0.7	2.0	1.7
Mother’s age at death	0.8	1.1	2.6	0.3	1.6	0.3	0.8	1.5	1.5	0.5	-1.3	-0.9	1.2	-0.7	-0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.4	-0.3	-1.9	-0.5	-0.2	-1.7	-0.9	-0.9	-1.3	-1.0	-0.9	-0.2	0.5
Supplements: Calcium	0.8	0.8	3.6	0.1	-0.1	-1.1	-1.2	-0.5	-0.9	-1.9	-0.3	1.2	0.9	-0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	4.5	-0.1	1.2	0.4	0.5	-0.7	1.1	-1.8	2.1	0.0	1.1	0.9	-0.1
Depression (Nagel 2018)	0.7	1.0	2.3	-0.2	-0.8	-1.0	-0.1	-1.5	-1.4	-1.1	1.4	0.8	-0.8	0.3	1.3
Intelligence (Savage-Jansen 2018)	0.7	2.0	7.9	0.2	-1.8	-1.5	-0.6	0.4	-2.1	-1.3	-1.6	0.1	2.8	0.8	1.1
Crohns Disease (2012)	0.7	1.2	3.5	-1.4	1.5	0.9	0.7	-0.2	1.9	1.0	0.4	-0.8	-1.6	0.9	0.2
LDL Cholesterol	0.7	1.0	4.4	-1.0	-0.2	-0.3	0.6	0.0	-0.4	-1.3	-1.7	-0.9	0.8	0.7	2.1
Rheumatoid Arthritis	0.7	1.0	5.3	0.0	0.1	-0.5	1.1	-1.3	0.6	0.2	0.7	1.0	-2.3	1.0	1.0
Schizophrenia (2014)	0.7	1.6	5.6	2.3	1.2	0.7	0.4	-0.0	1.2	-1.2	0.9	0.7	0.3	-2.4	-1.5
BMI	0.7	4.1	8.6	-2.0	-1.2	-1.9	-0.8	0.4	-2.0	-2.9	2.8	0.8	-2.8	2.2	2.5
Hearing difficulty/problems: Yes	0.7	1.1	5.9	1.2	-0.0	-0.4	-0.8	-0.4	-0.1	-1.3	0.7	2.4	0.1	-0.7	-1.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.5	-1.6	-1.1	-0.7	-1.4	-0.4	-0.7	-0.0	-0.2	0.2	-0.7	1.2	0.7
Supplements: Zinc	0.7	0.8	3.7	0.3	-0.5	-0.8	1.0	0.3	-0.7	-1.9	0.6	0.8	-0.4	0.2	1.4
Pack years adult smoking proportion	0.7	1.1	6.1	-2.5	0.7	-0.7	-0.7	0.2	0.0	-1.3	0.5	-0.4	-0.9	0.9	1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.2	-1.8	0.2	-0.6	-0.7	-0.5	0.5	-0.6	-1.3	-1.1	0.1	1.1	0.9
Qualifications: CSEs or equivalent	0.7	0.9	4.0	-0.8	0.6	0.5	0.5	0.0	1.2	2.0	0.4	0.7	-1.9	0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.1	-0.7	-0.8	-1.8	-0.6	-0.7	-0.4	-0.3	-0.8	-1.1	0.4	-0.2	1.4
Sitting height	0.7	4.8	9.5	-0.8	-1.7	-2.3	-2.2	-3.0	-2.1	-2.2	-2.9	1.4	3.1	1.6	2.1
Body mass index (BMI)	0.7	3.1	12.6	-1.9	0.2	-0.9	0.2	1.2	-0.8	-2.5	3.5	-0.1	-2.0	1.5	2.2
Waist circumference	0.7	2.4	7.8	-1.5	-0.5	-1.2	-0.0	-0.1	-1.0	-1.4	2.8	0.1	-1.8	2.3	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	5.9	-0.6	1.1	1.3	1.5	0.4	2.1	2.4	0.1	-1.4	0.1	1.0	-0.1
Qualifications: None of the above	0.7	1.4	9.1	-0.3	-0.3	0.2	0.9	-1.5	0.8	1.8	0.2	-0.5	-3.0	0.7	0.4
Mouth/teeth dental problems	0.7	1.1	2.9	0.9	-1.5	-0.3	-1.7	-0.2	-1.2	0.5	-1.1	1.6	0.3	1.3	0.0
Hip circumference	0.7	3.1	8.7	-2.1	-0.6	-1.3	-0.3	0.6	-1.3	-2.2	2.6	0.2	-0.6	2.9	3.0
Pulse rate	0.7	1.1	6.4	-1.0	0.8	0.4	0.7	0.6	1.1	1.2	0.8	-1.1	-2.5	0.3	0.4
Prospective memory result	0.7	0.9	3.6	-1.6	-0.5	0.0	-0.6	-0.7	0.1	-0.7	1.9	1.0	-1.1	0.5	0.5
Tense / ‘highly strung’	0.7	1.2	3.8	0.8	-1.8	-1.3	-1.7	0.5	-1.9	-0.8	-0.1	0.6	0.3	-0.6	0.4
Glaucoma (self-reported)	0.7	0.8	5.1	-0.4	-0.7	-0.8	0.4	-1.1	0.0	0.3	-2.3	-0.3	-0.6	1.0	0.6
Number of full brothers	0.7	0.9	2.3	-1.5	0.5	1.2	-0.2	-1.0	1.5	0.5	1.1	0.9	-0.6	1.1	-0.4
Whole body fat mass	0.7	3.0	16.4	-1.5	1.2	-0.0	0.9	1.5	0.2	-2.5	4.0	-0.3	-0.6	1.8	1.7
Leg fat mass (right)	0.7	2.5	15.0	-1.3	0.7	-0.5	0.6	0.9	-0.2	-2.1	3.9	0.2	-0.8	2.0	1.7
Alcohol intake frequency.	0.7	1.5	4.3	-1.9	0.9	0.5	1.1	0.7	1.2	1.4	0.6	-2.1	-1.0	0.8	1.4
Number of full sisters	0.7	0.9	2.4	0.5	-1.0	0.7	0.9	-0.7	0.6	1.4	-1.5	0.6	-1.1	1.3	0.3
Overall health rating	0.7	1.4	8.2	-0.9	-0.3	-0.5	-0.5	-2.4	0.1	0.7	0.7	0.3	-2.9	1.0	0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.0	0.0	0.3	-0.9	-0.0	-2.0	0.0	-1.0	1.0	-0.7	0.2	-1.5	-1.0
Asthma (self-reported)	0.7	1.3	6.5	0.4	-0.1	-0.1	0.1	-2.5	-0.3	0.7	1.6	0.1	0.3	-1.8	-1.6
Arm fat mass (left)	0.7	2.7	15.2	-1.6	0.6	-0.3	0.5	1.4	-0.4	-2.4	3.9	-0.2	-1.2	1.5	1.7
Wears glasses or contact lenses	0.7	0.8	2.4	0.1	-1.1	-1.6	-0.6	-1.2	-1.0	0.1	-0.9	-0.7	0.7	0.9	0.6
Commuting to job workplace: Public transport	0.7	0.8	4.7	0.1	0.4	0.4	0.9	-0.7	0.2	-0.8	-1.3	-0.7	2.2	-0.2	0.5
Medication: Atorvastatin	0.7	0.9	3.4	-0.8	-0.9	-0.5	0.2	0.2	-0.7	-1.8	1.4	0.9	-0.9	0.8	0.9
Illnesses of father: High blood pressure	0.7	0.9	2.8	-1.1	-0.9	-1.2	-0.9	-0.0	-1.7	-0.9	0.4	0.6	-0.2	-0.0	1.6
Average weekly beer plus cider intake	0.7	1.0	4.5	0.7	1.2	-0.1	0.5	-0.3	0.4	-1.4	2.1	0.8	0.9	-0.9	-0.8
Fractured/broken bones in last 5 years	0.7	0.8	3.2	-0.8	0.6	-0.2	-0.9	-0.7	0.5	0.3	1.5	0.9	-1.8	1.0	0.2
Pack years of smoking	0.7	1.1	5.4	-2.3	0.4	-1.0	-1.0	-0.1	-0.3	-1.9	0.2	-0.2	-0.5	0.6	1.0
Leg fat mass (left)	0.7	2.7	15.0	-1.4	1.1	-0.5	0.8	0.9	-0.1	-2.2	3.9	-0.0	-0.8	1.8	1.9
Bipolar Disorder (2018)	0.6	1.0	2.8	1.7	0.7	1.1	1.4	1.4	0.8	0.1	-1.0	1.0	1.2	-0.1	-0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	4.0	-0.7	-0.7	-1.0	-0.8	-0.4	-0.6	-1.2	-2.0	-1.3	0.6	-0.1	-0.4
Ulcerative Colitis (UC)	0.6	1.1	3.8	-2.0	0.1	0.2	0.1	-0.4	1.0	0.4	1.8	-1.4	-1.7	0.5	-0.0
Bipolar Disorder (2011)	0.6	0.5	2.2	0.4	1.3	0.4	0.1	-0.1	0.3	0.0	1.5	0.2	0.4	-1.4	0.0
Lung FVC	0.6	3.2	9.5	3.1	0.8	0.5	-0.8	-0.6	-0.5	-2.1	1.0	3.1	2.1	-2.1	-2.0
Vitamin and mineral supplements	0.6	0.8	3.4	0.3	-0.8	-1.2	-0.3	0.5	-0.6	0.9	-0.9	-0.1	-1.8	-0.8	-0.7
Medication: Co-codamol	0.6	0.7	1.6	-1.2	-0.6	-0.9	-1.1	-1.3	-0.6	0.9	-0.3	-0.9	-0.8	0.5	0.5
Medication: Metformin	0.6	0.9	3.1	-0.9	0.2	0.6	1.8	-0.0	1.0	-0.4	1.3	-1.4	-1.3	-0.1	-0.4
Current tobacco smoking	0.6	1.0	5.6	-1.0	0.3	0.1	-0.2	-2.4	0.8	0.4	-0.5	-0.9	-1.7	-0.4	0.1
Average weekly fortified wine intake	0.6	0.7	4.5	-1.1	0.1	-1.2	-0.7	0.5	0.4	-2.1	-0.3	-0.5	0.5	-0.4	0.1
Taking other prescription medications	0.6	0.9	2.4	-0.2	-0.8	-0.8	-0.4	-1.2	-0.5	-1.0	1.5	1.4	-1.6	-0.1	-0.2
High blood pressure (mother)	0.6	0.8	2.7	0.3	-1.6	-1.6	-0.9	-0.5	-0.9	-1.0	-0.1	0.7	-0.5	-0.7	0.4
Weight	0.6	2.8	9.1	-1.9	0.1	-0.9	-0.1	-0.1	-0.9	-2.4	3.0	0.0	-0.6	2.5	2.8
Mouth/teeth dental problems: Dentures	0.6	1.0	3.8	-1.4	-1.1	-0.5	0.4	-0.2	-0.4	0.9	-0.1	-2.0	-1.8	-0.4	0.5
Asthma	0.6	1.2	6.2	0.3	-0.1	0.1	0.3	-2.5	-0.2	0.9	1.6	0.2	0.4	-1.4	-1.6
Arm fat mass (right)	0.6	2.7	12.5	-1.6	0.3	-0.6	0.3	1.1	-0.5	-2.5	3.5	-0.0	-1.4	1.8	1.9
Peak expiratory flow (PEF)	0.6	1.4	5.8	0.0	2.4	1.6	-0.0	-0.1	1.3	-0.9	0.7	0.8	1.9	0.8	0.3
Medication: Paracetamol	0.6	1.0	5.1	-0.3	-1.0	-0.4	-0.8	-1.1	-1.0	1.1	-0.7	0.6	-2.3	0.4	0.7
Birth weight	0.6	1.3	7.2	0.1	-0.9	0.2	-0.7	0.3	-1.2	-1.8	1.0	1.1	2.7	-0.1	0.1
Worry too long after embarrassment	0.6	1.0	2.7	-0.7	-1.0	-0.6	-0.4	-1.0	-1.6	-1.1	1.7	0.0	1.3	-0.3	0.4
Emphysema/chronic bronchitis	0.6	0.7	1.5	-0.8	-1.0	-0.4	-1.2	0.1	-0.6	-0.8	1.1	0.0	-1.0	1.2	0.8
Angina (self-reported)	0.6	0.7	3.9	0.1	-0.5	-0.9	0.1	-0.4	-0.7	-0.7	-0.4	0.4	-2.0	0.1	1.6
Pulse rate, automated reading	0.6	1.9	8.9	-3.0	0.4	0.4	0.5	1.0	0.4	0.4	-0.5	-1.9	-2.5	0.5	1.3
Age at last live birth	0.6	0.8	3.7	1.0	0.8	-0.5	-0.1	0.5	-0.3	-0.6	-1.9	0.8	1.6	-0.3	0.4
Supplements: Vitamin C	0.6	0.7	2.7	-0.5	-0.4	-0.3	-0.3	-0.4	-0.4	0.3	-1.2	0.4	-0.6	1.6	1.6
Handedness (chirality/laterality): Left-handed	0.6	0.8	4.4	0.5	-2.1	-0.4	-0.2	0.0	-0.5	1.1	-0.2	-0.3	-0.5	-0.3	-1.5
Loneliness, isolation	0.6	0.9	2.5	1.6	0.1	1.0	1.4	0.1	0.2	0.6	1.5	1.0	0.6	-0.6	-1.0
Osteoporosis (self-reported)	0.6	0.8	1.9	-0.4	-1.1	-0.9	-1.2	0.6	-1.4	-1.2	-0.8	-0.9	0.3	-0.4	0.5
Medication: Gliclazide	0.6	0.6	2.2	0.3	0.3	0.3	1.2	-1.0	0.8	0.5	-0.9	0.2	-1.5	0.8	0.5
Ever taken oral contraceptive pill	0.6	0.7	4.4	0.9	0.1	0.4	0.2	-0.1	-0.2	-1.5	0.2	0.7	2.1	-0.5	-0.4
High cholesterol (Self-reported)	0.6	1.1	3.3	-1.4	-1.4	-0.5	-0.1	-0.3	-1.4	-1.1	-0.2	-1.1	-0.7	0.7	1.8
Ever depressed for a whole week	0.6	0.7	3.4	0.1	-0.9	-1.0	-0.6	-0.5	-0.9	0.8	-0.3	0.2	-1.9	0.3	0.8
Heart disease (siblings)	0.6	0.8	3.0	-0.4	-1.1	-0.5	-0.2	-0.5	-0.7	-0.5	1.7	0.7	-1.7	0.1	-0.2
Reaction Time	0.5	0.9	2.5	1.4	0.7	0.8	-0.3	-0.1	-0.1	-0.5	-0.2	1.6	-0.9	-1.5	-1.2
HbA1C	0.5	0.6	2.2	-1.4	0.2	0.6	-0.6	0.5	0.2	0.2	0.1	-1.3	-1.5	0.0	0.2
Blood White Count	0.5	3.4	19.4	-2.1	-1.6	-0.1	-0.2	-0.0	-1.3	-0.9	4.4	-1.1	-3.0	1.0	0.2
Waist Hip Ratio (WHR)	0.5	2.1	7.2	-0.4	-1.4	-1.2	-0.6	-2.5	-0.8	2.3	-0.0	-0.5	-2.7	0.9	0.3
Chronotype (morning person)	0.5	1.1	3.9	-0.3	-1.4	-1.1	0.1	0.3	-0.9	1.1	-0.8	-0.5	-2.0	0.9	1.4
Hand grip strength (left)	0.5	1.4	3.3	0.7	0.9	1.8	0.6	-0.4	1.5	1.2	-1.7	-1.2	1.0	-1.4	-1.2
Angina	0.5	0.7	3.5	-0.0	-0.3	-1.0	0.0	-0.5	-0.7	-0.9	-0.4	0.3	-1.9	-0.2	1.4
Severe depression (siblings)	0.5	0.6	2.1	0.3	0.8	0.7	0.6	0.1	0.9	0.6	-0.7	1.5	-0.2	1.1	0.6
Impedance of leg (right)	0.5	2.3	7.3	0.8	1.2	2.2	1.0	1.2	2.0	1.7	1.4	0.1	1.5	-0.0	-2.7
Allergy	0.5	1.1	4.2	0.0	-1.4	-1.3	-0.2	0.8	-0.8	0.3	-2.0	0.5	-1.1	1.4	0.8
Medication: Simvastatin	0.5	0.7	2.0	-1.2	-1.4	0.1	-0.6	1.0	-0.7	-1.1	0.3	-1.1	0.1	-0.0	0.7
Alcohol intake versus 10 years previously	0.5	0.7	1.7	1.3	0.5	0.5	-0.5	-0.8	1.2	0.7	0.7	0.5	-0.3	-0.8	-1.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.7	-0.6	-0.3	-0.0	1.4	-0.3	-0.1	0.8	0.4	-1.3	-1.9	1.0	1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.2	-0.3	-0.1	-0.0	-0.0	-1.3	0.4	-0.8	0.7	1.8	-1.1	0.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	3.2	1.0	0.4	-0.3	1.0	-0.9	0.9	-0.6	1.8	0.0	0.1	0.4	-0.8
Suffer from ‘nerves’	0.5	0.7	3.3	-0.6	-0.9	-0.6	-0.5	-0.7	-0.6	0.2	0.6	-1.8	0.0	0.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.3	0.2	-0.6	-0.5	-0.1	-0.6	-0.8	1.4	-0.3	-0.5	-1.8	-0.1	-0.1
Average weekly red wine intake	0.5	0.7	3.3	0.2	0.3	0.6	0.1	0.7	0.4	-0.0	-0.3	0.9	1.1	-1.8	-1.6
Eye problems/disorders: Cataract	0.5	0.6	1.7	-0.9	-0.9	0.2	-0.4	0.3	-0.5	-0.5	1.0	-1.3	-0.9	-0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.9	-0.7	0.5	0.8	0.7	1.4	0.6	0.8	-0.1	-1.7	0.7	-0.2	0.5
Smoking status: Current	0.5	0.8	4.3	-0.8	0.1	0.1	-0.1	-2.1	0.7	0.3	-0.9	-0.8	-1.6	-0.4	0.1
Eye problems/disorders: Glaucoma	0.5	0.6	2.9	-0.3	-0.4	-0.9	0.3	-0.7	0.1	0.2	-1.7	-0.1	-1.6	0.4	0.1
Cholesterol lowering medication	0.5	0.7	2.4	-1.4	-0.1	0.2	0.4	0.6	-0.0	-0.1	-0.1	-1.6	-1.0	-1.2	0.8
Neuroticism (2016)	0.4	0.5	2.5	-0.1	-1.2	-0.9	-0.5	0.3	-0.8	0.3	0.5	0.2	-1.6	0.3	0.3
Triglycerides	0.4	0.7	2.5	-0.0	1.6	0.6	1.2	0.9	1.1	0.4	-0.3	-0.1	1.1	0.7	0.5
Blood Red Count	0.4	4.3	12.5	-1.2	-3.2	-3.5	-2.2	-0.3	-3.2	-2.0	0.1	0.3	-1.2	-0.2	2.5
Leg fat-free mass (left)	0.4	1.9	9.0	-1.5	-0.2	-0.7	-0.8	-0.7	-1.1	-1.7	0.5	0.1	-0.2	2.3	3.0
Hand grip strength (right)	0.4	1.0	3.3	0.1	0.3	1.3	0.2	-0.4	0.9	0.8	-1.8	-1.8	0.6	-1.0	-0.6
Townsend deprivation index at recruitment	0.4	0.6	2.4	0.4	0.5	0.8	0.6	0.4	0.9	1.5	-0.1	-0.4	-1.0	-0.8	-0.9
Relative age voice broke	0.4	0.6	3.3	-0.6	-0.5	0.6	0.8	-0.9	-0.4	0.6	0.0	0.3	-0.4	1.8	0.8
Age when periods started (menarche)	0.4	0.8	5.7	-0.9	0.3	0.2	-0.8	-0.1	-0.1	-2.4	0.7	-0.0	-0.5	1.3	0.6
Medication: Levothyroxine sodium	0.4	0.6	1.7	-0.9	-0.2	-0.5	0.1	0.3	-0.2	1.3	-0.9	-1.1	-0.9	0.3	1.2
Impedance of leg (left)	0.4	2.0	4.6	0.3	1.8	1.8	1.3	1.1	1.9	1.4	1.4	-0.3	1.5	-0.2	-2.2
Number of incorrect matches in round	0.4	0.7	2.3	-0.3	-0.7	-1.3	0.2	-0.2	-1.1	-0.6	0.1	0.6	0.0	1.5	1.5
Alcohol usually taken with meals	0.4	0.6	1.7	1.3	-0.8	0.4	0.4	1.1	0.2	1.0	-0.2	0.1	0.5	-0.5	-1.2
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-0.0	0.0	-0.8	-0.5	-1.0	-0.5	-1.2	1.1	1.2	1.1	-0.7	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	2.3	-0.6	0.4	0.3	0.5	0.3	0.4	1.0	0.2	-0.6	-1.5	-0.3	0.4
Diabetes (self-reported)	0.4	0.7	3.5	-0.0	0.1	1.1	1.9	-0.7	0.9	-0.9	0.7	-0.1	-0.7	0.7	0.3
Birth weight of first child	0.4	0.7	4.4	-0.6	0.1	0.3	0.1	0.5	0.1	-0.8	-1.1	-0.4	2.1	0.6	0.7
Headache pain in last month	0.4	0.7	3.2	-0.2	1.1	0.8	0.6	0.1	0.7	0.1	1.8	0.5	-1.3	-0.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.5	-0.5	-0.7	-0.1	-1.3	-0.3	-0.8	1.1	0.5	1.0	-0.1	0.4
Forced vital capacity (FVC), Best measure	0.4	1.3	6.1	1.3	0.2	0.7	-0.5	-1.0	-0.4	-0.9	0.5	2.5	2.0	0.5	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.7	0.9	-1.3	0.8	0.9	0.1	0.1	0.5	0.8	-0.2	0.5	0.6	-0.4
Mean time to correctly identify matches	0.4	0.7	3.2	1.2	0.9	0.5	0.2	-0.2	0.0	-0.9	0.3	0.5	-0.0	-1.8	-1.3
Heart disease (mother)	0.4	0.5	1.3	0.9	-0.6	-0.6	-1.2	-0.3	-1.0	-0.2	-0.3	0.7	-0.8	-0.6	-0.6
Arm predicted mass (right)	0.4	1.9	6.5	-1.6	0.3	-0.7	-0.8	-1.8	-0.8	-1.6	1.1	0.0	0.4	2.2	2.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.0	0.7	0.9	1.3	1.1	1.4	1.3	0.9	-0.6	0.4	1.0	0.6	0.1
Leg fat-free mass (right)	0.4	2.1	10.9	-1.6	-0.2	-1.1	-0.8	-0.8	-1.4	-1.8	0.2	0.0	-0.1	2.1	3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.0	1.4	-0.7	0.2	-1.4	0.1	-0.5	-0.2	-1.3	1.2	-0.8	-0.8	-0.8
Leg predicted mass (right)	0.4	2.1	10.6	-1.6	-0.1	-1.2	-0.8	-0.8	-1.3	-1.8	0.2	0.0	-0.1	2.0	3.2
Miserableness	0.4	0.7	4.2	0.6	0.8	0.8	0.6	-0.2	0.5	-0.5	2.1	0.4	0.5	-0.5	-0.6
Basal metabolic rate	0.4	2.0	7.3	-1.4	-0.1	-0.9	-0.8	-1.2	-1.1	-1.8	1.2	0.4	0.0	2.3	2.7
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	0.6	0.1	0.6	-0.3	0.0	0.5	0.8	-0.5	-0.2	-0.6	-1.2	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-0.5	0.6	0.6	-0.9	0.9	0.4	1.1	-0.1	-0.4	0.3	-0.2	-0.4
Height	0.3	5.8	15.4	-1.8	-0.9	-2.3	-2.0	-3.9	-1.4	-1.9	0.3	0.1	3.9	3.5	2.9
Allergy or Eczema	0.3	0.8	2.2	0.4	1.3	1.1	-0.1	-1.0	0.6	0.0	1.0	-0.2	1.5	-1.4	-0.6
Hypothyroidism (self reported)	0.3	0.6	2.5	-0.6	-0.1	0.4	1.1	0.3	0.7	0.0	1.1	-0.5	-1.6	0.8	0.4
Respiratory disease	0.3	0.7	2.5	0.8	0.5	0.3	0.4	-0.7	-0.2	0.7	1.6	0.6	-0.3	-1.2	-1.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.2	0.3	1.1	1.1	-0.1	-0.3	0.4	-0.1	0.9	0.1	1.1	-1.8	-0.5
Leg predicted mass (left)	0.3	1.8	8.6	-1.4	-0.3	-0.8	-0.8	-0.7	-1.1	-1.7	0.5	0.2	-0.2	2.2	2.9
Forced vital capacity (FVC)	0.3	1.2	5.5	0.9	0.2	0.5	-0.3	-1.2	-0.6	-0.8	0.7	2.0	2.3	1.0	0.4
Trunk fat-free mass	0.3	1.7	4.9	-1.0	-0.4	-1.0	-1.1	-2.2	-1.1	-1.3	0.5	0.5	0.6	1.8	2.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.9	0.6	1.2	0.9	-0.1	-0.0	0.1	-0.8	0.6	1.7	2.0	0.8	0.5
Noisy workplace	0.3	0.4	1.5	-0.2	0.2	1.0	0.1	-0.3	0.4	-0.3	1.2	-0.2	-1.2	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.6	1.0	0.8	1.1	-0.5	0.5	0.0	-0.6	0.3	1.9	1.4	0.2	-0.7
Trunk predicted mass	0.3	1.7	4.6	-0.9	-0.4	-1.0	-1.2	-2.1	-1.1	-1.5	0.6	0.5	0.7	1.7	2.1
Length of working week for main job	0.3	0.4	1.3	0.9	0.0	0.4	-0.1	-0.5	-0.3	0.4	-0.9	0.8	1.1	-0.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.9	-0.2	0.3	0.3	0.5	-0.1	0.0	-0.3	1.4	0.6	-1.3	-0.2	-0.4
Arm fat-free mass (right)	0.3	1.6	6.1	-1.5	0.5	-0.6	-0.7	-1.5	-0.6	-1.4	1.1	-0.1	0.6	1.9	2.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.9	1.4	0.4	-0.4	0.3	-0.3	0.1	-0.1	0.9	0.5	-0.6	-0.2	0.1
Whole body fat-free mass	0.3	1.9	7.3	-1.3	-0.2	-0.9	-1.1	-1.6	-1.2	-1.7	0.5	0.3	0.2	2.2	2.7
Friendships satisfaction	0.3	0.4	2.1	0.2	-0.2	-0.3	0.1	0.2	-0.6	0.6	-1.4	-0.6	0.5	0.7	0.9
Qualifications: nursing, teaching	0.3	0.4	1.0	-1.0	0.6	-0.3	-0.8	0.7	0.0	-0.4	-0.3	0.9	0.6	0.9	0.4
Commuting to job workplace: Walk	0.3	0.3	0.9	0.9	-0.0	-0.9	0.0	-0.5	-0.8	-0.1	0.7	0.5	-0.3	-0.3	0.2
Breast cancer (self-reported)	0.3	0.4	1.3	-0.4	-0.7	-0.1	-0.9	-1.2	-0.8	-0.3	0.6	0.1	-0.7	-0.2	-0.3
Whole body water mass	0.3	1.9	6.4	-1.3	-0.3	-0.9	-1.2	-1.7	-1.2	-1.8	0.5	0.4	0.3	2.0	2.5
Arm fat-free mass (left)	0.3	1.8	4.7	-1.7	0.6	-0.4	-0.5	-1.4	-0.4	-1.8	1.5	-0.2	0.6	2.0	2.2
Irritability	0.3	0.6	1.8	0.7	-1.3	-0.4	-0.3	-0.1	-1.3	-0.0	-0.0	0.5	1.3	0.6	0.7
Age started oral contraceptive pill	0.3	0.3	2.4	-0.4	-0.1	0.5	0.3	-0.6	-0.0	-0.2	0.2	-1.5	0.2	-0.6	-0.6
Impedance of whole body	0.3	1.7	4.6	0.7	0.8	1.9	1.4	1.6	1.5	1.5	0.8	-0.5	1.1	-0.3	-2.1
Arm predicted mass (left)	0.3	1.7	4.0	-1.4	0.7	-0.6	-0.6	-1.8	-0.5	-1.8	1.6	0.0	0.7	1.9	2.0
Coronary Artery Disease (CAD)	0.2	0.3	1.2	0.1	0.3	-0.4	0.5	0.1	-0.0	-1.1	-0.1	0.0	0.9	-0.2	0.7
Fasting Glucose	0.2	0.3	1.2	-0.6	-0.6	0.1	-0.4	0.2	-0.4	0.1	-0.3	-0.6	-1.1	0.5	0.7
HDL Cholesterol	0.2	0.4	1.1	-0.5	-0.8	-0.4	-0.8	0.7	-0.7	-0.2	1.1	0.4	-0.4	-0.5	-0.2
Blood Eosinophil Count	0.2	1.5	7.2	-0.9	-1.0	-0.6	-0.3	-0.0	-1.2	-2.2	2.7	1.0	0.4	1.1	-0.2
Hair Pigment	0.2	6.3	22.5	2.0	2.9	3.1	0.4	-1.4	3.2	4.7	3.3	1.2	-1.2	-1.0	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	1.0	-0.5	0.1	0.8	-0.5	-0.2	0.8	0.1	0.3	-0.4	-0.5	0.3
Impedance of arm (right)	0.2	0.9	2.9	0.8	-0.3	1.2	0.7	1.6	0.7	1.0	0.1	-0.3	0.7	-0.1	-1.7
Happiness	0.2	0.3	0.7	-0.2	-0.1	-0.7	-0.1	0.0	-0.4	0.2	0.5	0.8	-0.7	0.7	0.6
Impedance of arm (left)	0.2	1.1	3.8	1.2	-0.1	1.2	1.1	1.9	0.8	1.1	-0.1	-0.2	0.8	-0.5	-1.6
Standing height	0.2	1.9	7.9	-0.4	-0.0	-0.1	-0.9	-2.6	-0.3	-0.1	-0.5	0.3	2.8	2.2	1.4
Comparative body size at age 10	0.2	0.6	1.9	-0.8	-0.6	-1.4	-0.2	-0.2	-1.1	-0.4	-0.6	0.3	-0.2	0.7	1.3
Health satisfaction	0.2	0.3	0.9	0.4	-0.2	-0.7	0.0	-0.9	-0.2	-0.3	-0.6	0.3	-1.0	0.5	0.3
Family relationship satisfaction	0.2	0.2	0.7	0.4	0.3	-0.8	0.6	0.0	-0.1	0.2	0.6	0.1	0.8	-0.4	0.2
Financial situation satisfaction	0.2	0.3	0.8	-0.4	-0.8	-0.0	0.0	0.6	-0.7	-0.4	0.5	0.1	-0.8	0.9	0.3
Ovarian Cancer	0.1	0.2	0.6	-0.4	-0.0	0.4	0.1	-0.8	0.5	0.4	0.6	-0.3	-0.4	0.6	0.0
Blood Platelet Count	0.1	1.0	5.7	-2.4	0.8	0.3	-0.6	0.1	0.6	0.8	0.8	-1.5	0.3	-1.1	-0.4
Heel T-Score	0.1	0.8	3.7	1.0	-0.3	0.2	0.0	-0.4	0.8	1.4	-1.9	-0.5	0.2	-0.3	-1.1
Lung FEV1/FVC ratio	0.1	0.7	4.6	-0.2	0.8	-1.2	-2.1	0.6	0.1	-0.7	-0.4	0.7	-0.2	-0.4	0.2
Tanning	0.1	0.9	4.8	-0.7	0.8	-0.2	-0.8	0.3	0.5	-2.2	-0.2	0.5	1.4	0.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.6	0.0	-0.3	0.8	0.3	-0.4	0.1	-0.1	0.1	-0.2	-0.5	-0.1	-0.1
Comparative height size at age 10	0.1	0.8	2.8	-0.2	-0.1	-0.4	-0.5	-1.7	-0.0	0.9	1.0	-0.3	1.3	1.4	1.0

Hub : Genes

PRDM8

Models

Trait associations