Hub : Genes

PRDM8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0740 0.0310 0.00160 0.025 0.021 0.024 0.024 0.009 4.1e-04 1.1e-03 5.2e-04 6.2e-04 2.4e-02
2 GTEx Adipose Visceral Omentum 0.2900 0.0890 0.00110 0.010 NA -0.005 NA 0.008 9.4e-02 NA 9.5e-01 NA 1.2e-01
3 GTEx Breast Mammary Tissue 0.2290 0.0830 0.00210 0.065 NA 0.052 NA 0.054 3.1e-04 NA 1.2e-03 NA 9.5e-04
4 GTEx Breast Mammary Tissue (Male) 0.1805 0.1691 0.16000 0.062 NA 0.054 NA 0.026 1.5e-02 NA 2.2e-02 NA 8.3e-02
5 GTEx Breast Mammary Tissue (Female) 0.1205 0.1285 0.13000 0.004 NA 0.058 NA -0.003 2.4e-01 NA 8.0e-03 NA 4.1e-01
6 GTEx Nerve Tibial 0.1358 0.0576 0.00500 0.138 NA 0.095 NA 0.134 5.4e-10 NA 3.0e-07 NA 1.0e-09
7 GTEx Ovary 0.4950 0.0870 0.00012 0.008 NA 0.035 NA 0.161 1.9e-01 NA 4.8e-02 NA 9.4e-05
8 METSIM Adipose 0.0599 0.0222 0.00008 0.009 0.033 0.018 0.033 0.011 1.4e-02 9.1e-06 9.7e-04 9.2e-06 7.0e-03
9 NTR Blood 0.0249 0.0093 0.00027 0.000 0.013 0.005 0.012 0.002 3.9e-01 3.0e-05 6.2e-03 5.4e-05 7.5e-02
10 ROSMAP Brain Pre-frontal Cortex 0.0517 0.0231 0.00460 0.000 0.006 0.005 0.009 0.001 3.8e-01 5.5e-02 6.5e-02 1.9e-02 2.5e-01
11 YFS Blood 0.1310 0.0270 0.00000 0.065 0.075 0.072 0.078 0.071 2.8e-20 2.4e-23 1.9e-22 2.1e-24 3.0e-22
12 TCGA Ovarian Serous Cystadenocarcinoma 0.0690 0.0310 0.00044 0.031 0.026 0.021 NA 0.028 3.4e-03 6.5e-03 1.4e-02 NA 5.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.6 1.0 2.8 1.7 0.7 1.1 1.4 1.4 0.8 0.1 -1.0 1.0 1.2 -0.1 -0.1
Bipolar Disorder or Schizophrenia 0.8 2.1 9.1 3.0 0.8 1.3 1.4 0.2 0.9 -1.0 0.4 1.3 0.5 -2.2 -1.6
Depressed Affect (Nagel 2018) 1.2 2.4 4.6 -0.9 -1.9 -1.5 -0.2 -1.9 -2.1 0.5 2.2 0.1 -1.7 1.6 1.9
Depression (Nagel 2018) 0.7 1.0 2.3 -0.2 -0.8 -1.0 -0.1 -1.5 -1.4 -1.1 1.4 0.8 -0.8 0.3 1.3
Intelligence (Savage-Jansen 2018) 0.7 2.0 7.9 0.2 -1.8 -1.5 -0.6 0.4 -2.1 -1.3 -1.6 0.1 2.8 0.8 1.1
Neuroticism (Nagel 2018) 0.9 2.2 7.0 -0.6 -2.2 -2.0 -0.9 -1.8 -2.6 -0.6 1.9 -0.4 -0.0 0.0 1.4
Schizophrenia (2018) 1.0 2.1 7.5 2.5 0.4 0.8 0.6 -0.9 0.5 -1.4 1.3 0.9 -0.3 -2.7 -2.0
Schizophrenia vs Biploar Disorder 0.3 0.4 1.3 0.6 0.1 0.6 -0.3 0.0 0.5 0.8 -0.5 -0.2 -0.6 -1.2 -0.9
Worry (Nagel 2018) 0.8 1.6 4.0 0.0 -1.6 -1.9 -1.5 -1.0 -2.0 -1.1 0.5 -0.9 1.2 -1.3 0.5
Alzheimer’s Disease (in mother) 2.3 2.6 6.2 -0.8 -2.0 -2.5 -2.2 -1.2 -2.2 -1.1 -2.4 0.5 0.2 1.3 1.0
Alzheimer’s Disease (in father) 1.5 1.6 6.8 1.0 0.9 0.9 0.3 0.4 1.2 0.3 -0.3 -1.1 0.9 -2.6 -2.6
Alzheimer’s Disease (including proxy) 0.6 0.9 4.0 -0.7 -0.7 -1.0 -0.8 -0.4 -0.6 -1.2 -2.0 -1.3 0.6 -0.1 -0.4
Crohns Disease (2017) 1.0 2.1 4.0 -2.0 1.1 1.5 1.4 0.6 2.0 1.4 1.7 -1.0 -1.8 1.7 0.1
Irritable Bowel Disease (IBD) 1.1 2.6 6.8 -2.6 0.7 1.1 1.0 -0.0 1.8 1.7 2.2 -1.7 -2.5 1.3 0.1
Ulcerative Colitis (UC) 0.6 1.1 3.8 -2.0 0.1 0.2 0.1 -0.4 1.0 0.4 1.8 -1.4 -1.7 0.5 -0.0
Major Depression (MDD) 1.1 1.3 5.5 -0.9 -0.8 -1.2 -0.0 -1.3 -0.8 -0.6 0.0 1.1 -0.9 2.4 1.7
Reaction Time 0.5 0.9 2.5 1.4 0.7 0.8 -0.3 -0.1 -0.1 -0.5 -0.2 1.6 -0.9 -1.5 -1.2
Verbal and Numeric Reasoning (VNR) 0.8 1.9 8.7 -0.5 -0.8 -1.5 -0.7 0.5 -1.7 -1.6 -1.4 -0.5 3.0 1.2 1.3
Breast Cancer 1.0 2.3 12.6 0.4 -1.7 -1.6 -0.3 -1.6 -1.8 -1.2 0.4 0.9 3.5 0.9 0.9
Ovarian Cancer 0.1 0.2 0.6 -0.4 -0.0 0.4 0.1 -0.8 0.5 0.4 0.6 -0.3 -0.4 0.6 0.0
Prostate Cancer 1.0 1.3 4.7 2.2 -0.4 -0.1 1.2 0.0 0.8 1.0 0.9 1.7 -0.3 -0.2 -2.1
Age at First Birth 0.8 1.2 7.5 1.0 0.3 -0.4 -0.7 0.5 -0.9 -0.3 -1.1 1.1 2.7 -0.9 -0.6
Bipolar Disorder (2011) 0.6 0.5 2.2 0.4 1.3 0.4 0.1 -0.1 0.3 0.0 1.5 0.2 0.4 -1.4 0.0
Body Mass Index (BMI) (2010) 0.9 1.2 3.4 -1.9 1.5 1.2 0.0 1.3 0.9 0.8 1.2 -0.6 -1.3 0.7 0.8
Coronary Artery Disease (CAD) 0.2 0.3 1.2 0.1 0.3 -0.4 0.5 0.1 -0.0 -1.1 -0.1 0.0 0.9 -0.2 0.7
Crohns Disease (2012) 0.7 1.2 3.5 -1.4 1.5 0.9 0.7 -0.2 1.9 1.0 0.4 -0.8 -1.6 0.9 0.2
Mean Putamen Volume 1.2 1.4 2.9 -0.3 1.7 1.4 1.3 1.3 1.5 -0.1 0.8 -1.0 0.8 -1.5 -1.2
Fasting Glucose 0.2 0.3 1.2 -0.6 -0.6 0.1 -0.4 0.2 -0.4 0.1 -0.3 -0.6 -1.1 0.5 0.7
HbA1C 0.5 0.6 2.2 -1.4 0.2 0.6 -0.6 0.5 0.2 0.2 0.1 -1.3 -1.5 0.0 0.2
HDL Cholesterol 0.2 0.4 1.1 -0.5 -0.8 -0.4 -0.8 0.7 -0.7 -0.2 1.1 0.4 -0.4 -0.5 -0.2
LDL Cholesterol 0.7 1.0 4.4 -1.0 -0.2 -0.3 0.6 0.0 -0.4 -1.3 -1.7 -0.9 0.8 0.7 2.1
Lupus 2.2 3.3 11.7 3.4 0.5 0.2 0.0 0.5 1.0 -1.4 -0.8 1.4 1.8 -3.0 -3.1
Neuroticism (2016) 0.4 0.5 2.5 -0.1 -1.2 -0.9 -0.5 0.3 -0.8 0.3 0.5 0.2 -1.6 0.3 0.3
Primary Biliary Cirrhosis 0.8 1.1 5.9 0.4 -0.7 0.4 -0.1 1.2 -0.2 1.4 -0.1 -0.7 -2.4 -1.1 -1.0
Rheumatoid Arthritis 0.7 1.0 5.3 0.0 0.1 -0.5 1.1 -1.3 0.6 0.2 0.7 1.0 -2.3 1.0 1.0
Schizophrenia (2014) 0.7 1.6 5.6 2.3 1.2 0.7 0.4 -0.0 1.2 -1.2 0.9 0.7 0.3 -2.4 -1.5
Triglycerides 0.4 0.7 2.5 -0.0 1.6 0.6 1.2 0.9 1.1 0.4 -0.3 -0.1 1.1 0.7 0.5
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.1 -0.5 0.6 0.6 -0.9 0.9 0.4 1.1 -0.1 -0.4 0.3 -0.2 -0.4
Ulcerative Colitis 0.8 1.1 4.1 -0.9 0.5 0.2 0.3 -1.4 1.2 1.3 1.2 -1.0 -2.0 -0.1 -0.7
Blood Eosinophil Count 0.2 1.5 7.2 -0.9 -1.0 -0.6 -0.3 -0.0 -1.2 -2.2 2.7 1.0 0.4 1.1 -0.2
Blood Platelet Count 0.1 1.0 5.7 -2.4 0.8 0.3 -0.6 0.1 0.6 0.8 0.8 -1.5 0.3 -1.1 -0.4
Blood Red Count 0.4 4.3 12.5 -1.2 -3.2 -3.5 -2.2 -0.3 -3.2 -2.0 0.1 0.3 -1.2 -0.2 2.5
Blood White Count 0.5 3.4 19.4 -2.1 -1.6 -0.1 -0.2 -0.0 -1.3 -0.9 4.4 -1.1 -3.0 1.0 0.2
Heel T-Score 0.1 0.8 3.7 1.0 -0.3 0.2 0.0 -0.4 0.8 1.4 -1.9 -0.5 0.2 -0.3 -1.1
BMI 0.7 4.1 8.6 -2.0 -1.2 -1.9 -0.8 0.4 -2.0 -2.9 2.8 0.8 -2.8 2.2 2.5
Height 0.3 5.8 15.4 -1.8 -0.9 -2.3 -2.0 -3.9 -1.4 -1.9 0.3 0.1 3.9 3.5 2.9
Waist Hip Ratio (WHR) 0.5 2.1 7.2 -0.4 -1.4 -1.2 -0.6 -2.5 -0.8 2.3 -0.0 -0.5 -2.7 0.9 0.3
Systolic Blood Pressure 2.7 13.5 41.3 0.1 -5.7 -5.2 -5.1 -0.6 -6.4 -4.4 0.5 3.5 0.6 -1.2 0.9
Smoking Status 1.0 2.4 7.2 0.3 -1.7 -2.5 -2.0 -2.7 -1.7 -1.0 -1.0 1.6 -0.7 0.5 0.7
Allergy or Eczema 0.3 0.8 2.2 0.4 1.3 1.1 -0.1 -1.0 0.6 0.0 1.0 -0.2 1.5 -1.4 -0.6
Cardiovascular Disease 2.9 9.5 24.8 -0.9 -4.7 -4.5 -4.0 -0.8 -5.0 -3.8 3.2 1.6 -0.0 -0.4 1.6
Hypothyroidism (self reported) 0.3 0.6 2.5 -0.6 -0.1 0.4 1.1 0.3 0.7 0.0 1.1 -0.5 -1.6 0.8 0.4
Respiratory disease 0.3 0.7 2.5 0.8 0.5 0.3 0.4 -0.7 -0.2 0.7 1.6 0.6 -0.3 -1.2 -1.4
Type 2 Diabetes (T2D) (2018) 0.8 1.5 6.3 -0.8 -0.1 1.2 2.5 -0.0 0.9 -0.3 1.1 -0.8 -2.1 1.3 0.8
Lung FEV1/FVC ratio 0.1 0.7 4.6 -0.2 0.8 -1.2 -2.1 0.6 0.1 -0.7 -0.4 0.7 -0.2 -0.4 0.2
Lung FVC 0.6 3.2 9.5 3.1 0.8 0.5 -0.8 -0.6 -0.5 -2.1 1.0 3.1 2.1 -2.1 -2.0
Neuroticism 1.5 3.5 9.9 -0.8 -2.9 -2.6 -2.0 -2.3 -3.2 0.3 0.7 0.1 -1.2 1.2 2.0
Chronotype (morning person) 0.5 1.1 3.9 -0.3 -1.4 -1.1 0.1 0.3 -0.9 1.1 -0.8 -0.5 -2.0 0.9 1.4
Hair Pigment 0.2 6.3 22.5 2.0 2.9 3.1 0.4 -1.4 3.2 4.7 3.3 1.2 -1.2 -1.0 -1.9
Tanning 0.1 0.9 4.8 -0.7 0.8 -0.2 -0.8 0.3 0.5 -2.2 -0.2 0.5 1.4 0.1 1.1
Hand grip strength (left) 0.5 1.4 3.3 0.7 0.9 1.8 0.6 -0.4 1.5 1.2 -1.7 -1.2 1.0 -1.4 -1.2
Number of treatments/medications taken 2.0 3.6 10.6 -1.4 -3.3 -1.9 -1.8 -1.1 -2.8 -1.4 0.7 0.5 -2.3 1.1 2.1
Average weekly spirits intake 0.8 1.0 5.6 0.4 0.8 0.0 -0.0 1.1 -1.0 -1.2 2.4 0.4 0.6 -0.8 -0.5
Sensitivity / hurt feelings 1.0 1.7 4.3 -2.1 -1.0 -1.2 -1.4 0.2 -1.9 -1.1 1.1 -1.1 0.2 0.8 1.7
Frequency of depressed mood in last 2 weeks 0.8 1.1 4.1 0.2 -0.7 -0.7 -0.4 -1.3 -1.0 0.6 0.6 0.9 -2.0 1.3 1.6
Hearing difficulty/problems: Yes 0.7 1.1 5.9 1.2 -0.0 -0.4 -0.8 -0.4 -0.1 -1.3 0.7 2.4 0.1 -0.7 -1.3
Relative age of first facial hair 1.1 2.3 8.9 0.4 -1.6 -0.9 1.2 -1.2 -1.9 -3.0 0.9 2.2 0.9 1.0 0.5
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 3.9 -0.9 -1.0 -1.9 -1.3 -0.8 -1.8 -1.7 -0.6 1.3 -0.9 0.4 2.0
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.3 -2.1 0.2 -1.0 -2.0 -1.2 -1.2 -1.5 -0.8 -0.6 0.5 -0.3 -0.4
Ever had hysterectomy (womb removed) 0.7 0.8 2.5 -1.6 -1.1 -0.7 -1.4 -0.4 -0.7 -0.0 -0.2 0.2 -0.7 1.2 0.7
Systolic blood pressure, automated reading 1.4 4.1 13.2 0.6 -2.8 -2.7 -2.5 -0.0 -3.6 -2.8 0.7 1.3 -0.0 -2.0 -0.1
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 4.3 -1.3 -0.3 -0.0 0.8 0.3 -0.1 -0.3 2.1 0.5 -1.6 1.8 1.9
Angina 0.5 0.7 3.5 -0.0 -0.3 -1.0 0.0 -0.5 -0.7 -0.9 -0.4 0.3 -1.9 -0.2 1.4
Medication for hormone replacement therapy 1.2 1.3 5.7 -2.4 -0.2 -0.6 -1.3 -0.6 -0.8 -1.6 0.9 -0.2 -0.5 1.4 1.3
Vitamin and mineral supplements 0.6 0.8 3.4 0.3 -0.8 -1.2 -0.3 0.5 -0.6 0.9 -0.9 -0.1 -1.8 -0.8 -0.7
Supplements: Zinc 0.7 0.8 3.7 0.3 -0.5 -0.8 1.0 0.3 -0.7 -1.9 0.6 0.8 -0.4 0.2 1.4
Medication: Co-codamol 0.6 0.7 1.6 -1.2 -0.6 -0.9 -1.1 -1.3 -0.6 0.9 -0.3 -0.9 -0.8 0.5 0.5
Medication: Metformin 0.6 0.9 3.1 -0.9 0.2 0.6 1.8 -0.0 1.0 -0.4 1.3 -1.4 -1.3 -0.1 -0.4
Diabetes (father) 1.7 2.1 4.3 0.5 -1.5 -1.9 -1.3 -1.8 -1.8 -0.7 -1.4 2.1 -0.4 1.7 1.2
Diabetes (mother) 0.8 1.0 4.0 0.7 -1.1 0.4 1.1 -0.1 -0.0 1.8 0.2 -0.9 -2.0 0.9 0.3
Severe depression (siblings) 0.5 0.6 2.1 0.3 0.8 0.7 0.6 0.1 0.9 0.6 -0.7 1.5 -0.2 1.1 0.6
Pack years adult smoking proportion 0.7 1.1 6.1 -2.5 0.7 -0.7 -0.7 0.2 0.0 -1.3 0.5 -0.4 -0.9 0.9 1.1
Impedance of leg (right) 0.5 2.3 7.3 0.8 1.2 2.2 1.0 1.2 2.0 1.7 1.4 0.1 1.5 -0.0 -2.7
Leg fat-free mass (left) 0.4 1.9 9.0 -1.5 -0.2 -0.7 -0.8 -0.7 -1.1 -1.7 0.5 0.1 -0.2 2.3 3.0
Trunk fat percentage 0.9 3.7 19.3 -1.6 1.1 0.6 1.2 2.8 0.4 -2.4 4.4 -0.6 -1.0 1.7 1.2
Hand grip strength (right) 0.4 1.0 3.3 0.1 0.3 1.3 0.2 -0.4 0.9 0.8 -1.8 -1.8 0.6 -1.0 -0.6
Townsend deprivation index at recruitment 0.4 0.6 2.4 0.4 0.5 0.8 0.6 0.4 0.9 1.5 -0.1 -0.4 -1.0 -0.8 -0.9
Current tobacco smoking 0.6 1.0 5.6 -1.0 0.3 0.1 -0.2 -2.4 0.8 0.4 -0.5 -0.9 -1.7 -0.4 0.1
Average weekly fortified wine intake 0.6 0.7 4.5 -1.1 0.1 -1.2 -0.7 0.5 0.4 -2.1 -0.3 -0.5 0.5 -0.4 0.1
Maternal smoking around birth 1.4 2.1 8.2 1.1 0.5 -1.1 -0.6 -1.6 -0.3 -2.2 0.6 2.4 2.9 0.5 -0.5
Fed-up feelings 1.7 3.1 7.1 -0.5 -2.7 -1.9 -1.1 -1.2 -2.5 0.4 1.1 0.8 -2.3 2.2 2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 5.9 0.4 0.5 -0.1 0.0 -1.7 -0.4 -1.5 2.4 1.7 0.9 -1.0 -0.2
Relative age voice broke 0.4 0.6 3.3 -0.6 -0.5 0.6 0.8 -0.9 -0.4 0.6 0.0 0.3 -0.4 1.8 0.8
Taking other prescription medications 0.6 0.9 2.4 -0.2 -0.8 -0.8 -0.4 -1.2 -0.5 -1.0 1.5 1.4 -1.6 -0.1 -0.2
Age when periods started (menarche) 0.4 0.8 5.7 -0.9 0.3 0.2 -0.8 -0.1 -0.1 -2.4 0.7 -0.0 -0.5 1.3 0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 3.2 -1.8 0.2 -0.6 -0.7 -0.5 0.5 -0.6 -1.3 -1.1 0.1 1.1 0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.3 10.8 0.6 1.5 2.4 2.7 -0.4 3.3 2.9 -0.2 -1.6 -0.2 0.1 -1.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.9 -1.3 0.9 0.3 -0.1 0.2 0.4 0.9 1.7 -1.7 -0.4 -0.6 -0.4
Qualifications: CSEs or equivalent 0.7 0.9 4.0 -0.8 0.6 0.5 0.5 0.0 1.2 2.0 0.4 0.7 -1.9 0.3 0.3
Serious illness, injury or assault to yourself 0.9 1.1 2.7 0.3 -1.1 -1.0 -0.6 0.3 -1.4 -1.6 -0.8 1.6 0.9 0.4 1.2
High blood pressure 3.5 9.7 26.6 -0.7 -4.7 -4.8 -4.0 -1.2 -5.2 -3.8 2.1 2.2 -0.8 -0.1 1.8
Hayfever, allergic rhinitis or eczema 0.3 0.7 3.2 0.3 1.1 1.1 -0.1 -0.3 0.4 -0.1 0.9 0.1 1.1 -1.8 -0.5
Multivitamins +/- minerals 1.0 1.3 7.4 -0.3 0.6 1.0 0.3 0.2 0.3 -2.0 1.5 0.3 2.7 0.4 0.1
Stomach or abdominal pain in last month 0.9 1.1 3.5 0.6 -0.9 -1.5 -0.4 -1.7 -1.4 -0.2 0.8 -0.1 1.9 0.7 0.7
Supplements: Glucosamine 1.6 2.1 7.4 -1.4 -2.7 -1.6 -1.0 -0.3 -2.7 -0.9 -0.2 -0.4 -1.1 1.4 1.0
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 3.1 -0.7 -0.8 -1.8 -0.6 -0.7 -0.4 -0.3 -0.8 -1.1 0.4 -0.2 1.4
Medication: Atenolol 2.4 3.0 10.4 -0.8 -2.0 -2.0 -2.7 -0.6 -2.1 -3.2 1.9 0.0 0.2 -0.5 0.8
Medication: Levothyroxine sodium 0.4 0.6 1.7 -0.9 -0.2 -0.5 0.1 0.3 -0.2 1.3 -0.9 -1.1 -0.9 0.3 1.2
Sitting height 0.7 4.8 9.5 -0.8 -1.7 -2.3 -2.2 -3.0 -2.1 -2.2 -2.9 1.4 3.1 1.6 2.1
Chronic bronchitis/emphysema (father) 2.4 2.8 12.8 1.6 -0.6 -1.9 -1.1 -1.3 -1.2 -1.9 1.5 3.6 0.0 -1.6 -1.2
High blood pressure (mother) 0.6 0.8 2.7 0.3 -1.6 -1.6 -0.9 -0.5 -0.9 -1.0 -0.1 0.7 -0.5 -0.7 0.4
Body mass index (BMI) 0.7 3.1 12.6 -1.9 0.2 -0.9 0.2 1.2 -0.8 -2.5 3.5 -0.1 -2.0 1.5 2.2
Impedance of leg (left) 0.4 2.0 4.6 0.3 1.8 1.8 1.3 1.1 1.9 1.4 1.4 -0.3 1.5 -0.2 -2.2
Leg predicted mass (left) 0.3 1.8 8.6 -1.4 -0.3 -0.8 -0.8 -0.7 -1.1 -1.7 0.5 0.2 -0.2 2.2 2.9
Trunk fat mass 0.8 3.4 18.0 -1.6 0.9 0.1 0.8 1.9 -0.0 -2.7 4.2 -0.2 -0.7 2.0 1.8
Waist circumference 0.7 2.4 7.8 -1.5 -0.5 -1.2 -0.0 -0.1 -1.0 -1.4 2.8 0.1 -1.8 2.3 2.3
Number of incorrect matches in round 0.4 0.7 2.3 -0.3 -0.7 -1.3 0.2 -0.2 -1.1 -0.6 0.1 0.6 0.0 1.5 1.5
Past tobacco smoking 1.2 2.2 6.1 -1.5 2.3 2.2 0.9 1.2 2.2 0.1 0.4 -2.5 0.9 -0.6 -0.1
Alcohol usually taken with meals 0.4 0.6 1.7 1.3 -0.8 0.4 0.4 1.1 0.2 1.0 -0.2 0.1 0.5 -0.5 -1.2
Nervous feelings 0.8 1.4 5.4 1.7 1.2 -0.0 0.3 -1.2 0.8 -0.1 0.0 -0.8 1.7 -2.3 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.0 1.0 -0.5 0.1 0.8 -0.5 -0.2 0.8 0.1 0.3 -0.4 -0.5 0.3
Hearing difficulty/problems with background noise 0.4 0.7 1.5 -0.0 0.0 -0.8 -0.5 -1.0 -0.5 -1.2 1.1 1.2 1.1 -0.7 -0.6
Hair/balding pattern: Pattern 2 8.5 10.9 21.0 0.9 -3.9 -4.6 -2.7 -2.6 -4.5 -3.4 -2.4 4.5 0.7 3.5 2.9
Had menopause 0.8 1.0 2.3 -1.5 -0.8 -1.4 -1.2 -0.6 -0.7 -0.2 -0.8 -1.5 -0.3 0.4 1.0
Had other major operations 1.7 2.1 7.5 -1.6 -1.6 -1.3 -2.7 -2.4 -1.0 -1.3 0.1 -0.3 -1.4 0.1 -0.0
Forced vital capacity (FVC) 0.3 1.2 5.5 0.9 0.2 0.5 -0.3 -1.2 -0.6 -0.8 0.7 2.0 2.3 1.0 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 5.9 -0.6 1.1 1.3 1.5 0.4 2.1 2.4 0.1 -1.4 0.1 1.0 -0.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 2.3 -0.6 0.4 0.3 0.5 0.3 0.4 1.0 0.2 -0.6 -1.5 -0.3 0.4
Qualifications: None of the above 0.7 1.4 9.1 -0.3 -0.3 0.2 0.9 -1.5 0.8 1.8 0.2 -0.5 -3.0 0.7 0.4
Financial difficulties in last 2 years 2.5 3.4 9.2 -1.9 -1.6 -2.2 -3.0 0.5 -2.4 0.5 0.5 1.8 -1.2 1.8 2.5
Mouth/teeth dental problems 0.7 1.1 2.9 0.9 -1.5 -0.3 -1.7 -0.2 -1.2 0.5 -1.1 1.6 0.3 1.3 0.0
Heart attack 1.6 2.0 6.5 -0.4 -2.5 -2.4 -1.5 -0.4 -1.9 -1.6 -0.8 0.4 -0.9 -0.5 1.3
Allergy 0.5 1.1 4.2 0.0 -1.4 -1.3 -0.2 0.8 -0.8 0.3 -2.0 0.5 -1.1 1.4 0.8
Pain all over the body in last month 0.8 0.9 3.3 -1.4 -0.6 -0.4 -0.5 0.5 -1.5 -0.7 1.8 1.0 -0.3 -0.4 0.7
Diabetes (self-reported) 0.4 0.7 3.5 -0.0 0.1 1.1 1.9 -0.7 0.9 -0.9 0.7 -0.1 -0.7 0.7 0.3
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 6.0 -0.6 -1.1 -1.1 -1.2 -2.4 -1.5 -0.6 0.8 1.3 -1.1 -0.1 1.3
Medication: Ramipril 1.8 2.4 6.3 -0.6 -2.1 -2.1 -2.3 0.4 -2.5 -2.5 -0.5 1.0 -0.1 0.2 0.4
Medication: Simvastatin 0.5 0.7 2.0 -1.2 -1.4 0.1 -0.6 1.0 -0.7 -1.1 0.3 -1.1 0.1 -0.0 0.7
Fluid intelligence score 1.5 3.2 9.7 0.4 -0.6 -2.5 -1.2 -0.4 -2.2 -1.7 -3.0 -0.0 3.1 0.1 1.6
Illnesses of siblings 2.9 4.1 10.8 1.7 3.0 2.2 2.6 -0.4 2.7 3.3 -1.2 -1.1 0.4 -1.2 -1.7
Neuroticism score 0.8 1.8 5.5 -0.3 -2.1 -1.6 -1.4 -1.0 -2.3 -0.6 1.8 0.4 -0.1 0.4 1.2
Weight 0.6 2.8 9.1 -1.9 0.1 -0.9 -0.1 -0.1 -0.9 -2.4 3.0 0.0 -0.6 2.5 2.8
Impedance of arm (right) 0.2 0.9 2.9 0.8 -0.3 1.2 0.7 1.6 0.7 1.0 0.1 -0.3 0.7 -0.1 -1.7
Arm fat percentage (right) 0.8 3.3 17.0 -1.4 0.2 -0.5 0.9 2.1 -0.4 -2.6 4.1 -0.1 -1.8 1.6 1.4
Trunk fat-free mass 0.3 1.7 4.9 -1.0 -0.4 -1.0 -1.1 -2.2 -1.1 -1.3 0.5 0.5 0.6 1.8 2.2
Hip circumference 0.7 3.1 8.7 -2.1 -0.6 -1.3 -0.3 0.6 -1.3 -2.2 2.6 0.2 -0.6 2.9 3.0
Time employed in main current job 0.8 0.9 3.4 1.3 0.1 0.0 0.5 0.5 -0.1 -0.6 -0.5 -0.6 1.7 -1.9 -0.9
Alcohol intake versus 10 years previously 0.5 0.7 1.7 1.3 0.5 0.5 -0.5 -0.8 1.2 0.7 0.7 0.5 -0.3 -0.8 -1.3
Father’s age at death 1.9 2.5 7.4 1.8 1.3 1.7 0.8 0.0 1.4 1.0 -2.7 -1.0 -0.9 -2.3 -2.1
Worrier / anxious feelings 0.8 1.5 5.6 0.2 -1.9 -1.5 -1.5 0.4 -2.4 -0.4 0.9 -0.3 0.7 -1.5 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 5.1 -0.2 -0.4 -1.7 -1.3 -2.2 -0.9 -1.6 -0.4 1.4 0.0 -0.7 1.3
Falls in the last year 1.1 1.5 5.5 -0.5 -1.2 -0.8 0.3 -0.0 -1.1 -1.4 0.5 -0.9 -1.7 1.7 2.3
Hair/balding pattern: Pattern 3 8.5 12.7 34.7 0.5 4.1 5.9 3.7 2.2 4.8 4.7 2.9 -3.4 -1.7 -2.2 -2.9
Number of live births 1.3 1.8 7.6 -0.4 -0.6 -1.9 -2.8 -0.5 -1.8 -2.0 0.2 0.7 1.1 0.6 0.7
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 3.9 0.6 1.2 0.9 -0.1 -0.0 0.1 -0.8 0.6 1.7 2.0 0.8 0.5
Pulse rate 0.7 1.1 6.4 -1.0 0.8 0.4 0.7 0.6 1.1 1.2 0.8 -1.1 -2.5 0.3 0.4
Happiness 0.2 0.3 0.7 -0.2 -0.1 -0.7 -0.1 0.0 -0.4 0.2 0.5 0.8 -0.7 0.7 0.6
Noisy workplace 0.3 0.4 1.5 -0.2 0.2 1.0 0.1 -0.3 0.4 -0.3 1.2 -0.2 -1.2 0.8 -0.2
Qualifications: A levels/AS levels or equivalent 0.8 1.7 4.0 1.7 2.0 1.2 0.9 1.0 1.2 0.4 -0.7 -0.1 2.0 -1.6 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.6 0.0 -0.3 0.8 0.3 -0.4 0.1 -0.1 0.1 -0.2 -0.5 -0.1 -0.1
Mouth/teeth dental problems: Dentures 0.6 1.0 3.8 -1.4 -1.1 -0.5 0.4 -0.2 -0.4 0.9 -0.1 -2.0 -1.8 -0.4 0.5
Asthma 0.6 1.2 6.2 0.3 -0.1 0.1 0.3 -2.5 -0.2 0.9 1.6 0.2 0.4 -1.4 -1.6
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.6 7.0 0.9 -1.7 -1.9 -0.7 -0.3 -2.6 -0.5 -0.1 2.6 -1.3 0.6 2.6
Medication: Cholesterol lowering 1.3 2.0 5.6 -1.4 -2.4 -0.8 -1.4 -0.3 -1.6 -1.8 0.5 0.4 -0.8 2.2 1.4
Depression (self-reported) 0.9 1.1 3.1 0.0 1.4 1.1 1.8 -0.5 1.5 0.7 1.0 0.3 0.7 1.6 0.3
Medication: Lansoprazole 2.4 2.7 9.1 -1.0 1.1 1.4 3.0 0.9 2.0 2.3 0.5 -1.6 -2.3 0.8 -0.0
Prospective memory result 0.7 0.9 3.6 -1.6 -0.5 0.0 -0.6 -0.7 0.1 -0.7 1.9 1.0 -1.1 0.5 0.5
Lung cancer (father) 1.6 1.8 8.1 0.6 -1.6 -1.8 -1.2 -0.7 -1.7 -2.9 0.5 0.8 1.2 0.1 0.5
Illnesses of mother 0.9 1.1 3.0 -0.0 1.7 1.4 1.4 0.0 1.5 1.1 1.1 -0.9 0.4 -0.6 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 3.6 1.0 0.8 1.1 -0.5 0.5 0.0 -0.6 0.3 1.9 1.4 0.2 -0.7
Pulse wave Arterial Stiffness index 1.4 1.6 4.5 -1.8 -0.7 -1.5 -2.1 -0.0 -1.2 -0.9 1.7 -0.4 -1.0 0.7 1.3
Impedance of arm (left) 0.2 1.1 3.8 1.2 -0.1 1.2 1.1 1.9 0.8 1.1 -0.1 -0.2 0.8 -0.5 -1.6
Arm fat mass (right) 0.6 2.7 12.5 -1.6 0.3 -0.6 0.3 1.1 -0.5 -2.5 3.5 -0.0 -1.4 1.8 1.9
Trunk predicted mass 0.3 1.7 4.6 -0.9 -0.4 -1.0 -1.2 -2.1 -1.1 -1.5 0.6 0.5 0.7 1.7 2.1
Standing height 0.2 1.9 7.9 -0.4 -0.0 -0.1 -0.9 -2.6 -0.3 -0.1 -0.5 0.3 2.8 2.2 1.4
Length of working week for main job 0.3 0.4 1.3 0.9 0.0 0.4 -0.1 -0.5 -0.3 0.4 -0.9 0.8 1.1 -0.5 -0.2
Exposure to tobacco smoke at home 1.3 1.4 9.0 1.6 0.5 -0.1 -0.4 0.7 0.1 -0.3 -0.4 1.8 3.0 -0.5 -0.9
Breastfed as a baby 1.5 1.9 6.9 -0.9 0.2 -1.4 -2.1 -0.8 -1.3 -2.6 -0.1 -0.4 1.3 -2.2 0.2
Tense / ‘highly strung’ 0.7 1.2 3.8 0.8 -1.8 -1.3 -1.7 0.5 -1.9 -0.8 -0.1 0.6 0.3 -0.6 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.9 -0.2 0.3 0.3 0.5 -0.1 0.0 -0.3 1.4 0.6 -1.3 -0.2 -0.4
Hair/balding pattern: Pattern 4 6.4 15.6 32.3 0.0 4.4 5.0 2.2 2.1 5.6 5.7 3.4 -4.7 -0.1 -4.3 -4.2
Birth weight of first child 0.4 0.7 4.4 -0.6 0.1 0.3 0.1 0.5 0.1 -0.8 -1.1 -0.4 2.1 0.6 0.7
Peak expiratory flow (PEF) 0.6 1.4 5.8 0.0 2.4 1.6 -0.0 -0.1 1.3 -0.9 0.7 0.8 1.9 0.8 0.3
Pulse wave reflection index 1.6 2.0 6.2 -1.5 -1.8 -2.1 -2.5 0.1 -2.1 -0.6 -0.5 -0.8 -0.4 0.2 1.1
Ever highly irritable/argumentative for 2 days 1.4 1.7 6.3 -0.0 2.5 0.5 1.5 0.8 1.7 -0.9 -0.4 0.2 2.4 -0.3 0.5
Loud music exposure frequency 1.2 1.3 4.5 1.4 -0.1 0.1 0.4 1.0 -0.2 -1.7 0.4 1.6 2.1 -1.1 -0.8
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 6.1 1.3 1.6 0.3 -0.1 1.0 0.5 -0.5 0.7 0.7 2.5 -1.8 -1.0
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 6.2 0.3 2.5 0.6 2.0 0.6 1.4 -0.8 1.6 0.5 0.6 -1.0 -1.0
Blood clot in the leg (DVT) 0.9 1.1 4.4 -0.2 1.2 0.5 0.8 -0.4 1.0 -1.7 2.1 -0.2 1.1 1.1 0.1
Medication: Paracetamol 0.6 1.0 5.1 -0.3 -1.0 -0.4 -0.8 -1.1 -1.0 1.1 -0.7 0.6 -2.3 0.4 0.7
Headache pain in last month 0.4 0.7 3.2 -0.2 1.1 0.8 0.6 0.1 0.7 0.1 1.8 0.5 -1.3 -0.1 -0.7
Medication for cholesterol, blood pressure or diabetes 4.0 6.6 18.4 1.5 4.3 3.1 3.4 0.9 3.9 2.8 -1.2 -1.7 1.1 -1.9 -2.1
Glaucoma (self-reported) 0.7 0.8 5.1 -0.4 -0.7 -0.8 0.4 -1.1 0.0 0.3 -2.3 -0.3 -0.6 1.0 0.6
Gout (self-reported) 0.8 1.1 3.4 0.5 0.4 1.8 0.9 1.4 1.7 0.9 0.6 -0.4 -0.4 0.8 -1.1
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 3.7 -0.6 -0.3 -0.0 1.4 -0.3 -0.1 0.8 0.4 -1.3 -1.9 1.0 1.2
Medication: Amlodipine 1.8 2.5 5.8 -0.3 -1.6 -2.4 -2.2 -0.5 -2.3 -2.1 -0.7 2.2 0.1 0.7 0.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 -0.5 -0.5 -0.7 -0.1 -1.3 -0.3 -0.8 1.1 0.5 1.0 -0.1 0.4
Birth weight 0.6 1.3 7.2 0.1 -0.9 0.2 -0.7 0.3 -1.2 -1.8 1.0 1.1 2.7 -0.1 0.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 3.2 -0.3 -0.1 -0.0 -0.0 -1.3 0.4 -0.8 0.7 1.8 -1.1 0.5 -0.1
High blood pressure (siblings) 3.2 4.6 13.3 -0.7 -2.7 -2.9 -2.6 1.0 -3.2 -3.7 0.8 1.9 0.6 0.3 1.5
Forced vital capacity (FVC), Best measure 0.4 1.3 6.1 1.3 0.2 0.7 -0.5 -1.0 -0.4 -0.9 0.5 2.5 2.0 0.5 -0.8
Body fat percentage 0.9 3.6 20.4 -1.4 1.1 0.2 1.4 2.5 0.3 -2.5 4.5 -0.3 -0.9 1.7 1.2
Leg fat percentage (right) 0.8 3.0 19.8 -1.3 1.1 -0.1 1.2 1.8 0.4 -1.9 4.5 0.1 -1.0 1.7 1.2
Arm fat-free mass (right) 0.3 1.6 6.1 -1.5 0.5 -0.6 -0.7 -1.5 -0.6 -1.4 1.1 -0.1 0.6 1.9 2.5
Exposure to tobacco smoke outside home 1.6 2.2 4.5 -0.8 -1.6 -1.8 -2.1 -1.2 -1.8 -1.0 -1.2 1.6 -0.9 1.3 1.5
Comparative body size at age 10 0.2 0.6 1.9 -0.8 -0.6 -1.4 -0.2 -0.2 -1.1 -0.4 -0.6 0.3 -0.2 0.7 1.3
Number of full brothers 0.7 0.9 2.3 -1.5 0.5 1.2 -0.2 -1.0 1.5 0.5 1.1 0.9 -0.6 1.1 -0.4
Worry too long after embarrassment 0.6 1.0 2.7 -0.7 -1.0 -0.6 -0.4 -1.0 -1.6 -1.1 1.7 0.0 1.3 -0.3 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 3.2 1.0 0.4 -0.3 1.0 -0.9 0.9 -0.6 1.8 0.0 0.1 0.4 -0.8
Wheeze or whistling in the chest in last year 1.2 2.2 7.0 0.5 -1.6 -1.6 -1.5 -1.3 -1.8 -2.6 0.1 2.6 -0.4 -0.1 0.1
Number of children fathered 1.9 2.2 5.1 -1.5 -1.6 -1.7 -2.2 -2.1 -1.7 -0.7 0.1 1.0 -0.5 1.4 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.7 0.9 -1.3 0.8 0.9 0.1 0.1 0.5 0.8 -0.2 0.5 0.6 -0.4
Age at first live birth 0.8 1.3 4.7 2.0 0.8 0.1 -0.1 0.5 -0.1 -0.4 -2.2 1.3 2.0 -0.6 -0.6
Pulse wave peak to peak time 1.1 1.4 3.6 1.6 0.6 1.4 1.9 -0.5 1.1 0.9 -1.7 0.3 1.1 -0.3 -1.0
Health satisfaction 0.2 0.3 0.9 0.4 -0.2 -0.7 0.0 -0.9 -0.2 -0.3 -0.6 0.3 -1.0 0.5 0.3
Shortness of breath walking on level ground 0.8 0.9 3.5 -1.0 -0.3 -0.2 0.9 -1.9 -0.2 0.3 1.1 -0.3 -1.0 1.3 1.2
Qualifications: College or University degree 1.0 3.1 14.3 1.9 -0.1 -0.3 -0.8 0.9 -0.6 -1.5 -3.8 -0.1 3.6 -1.4 -0.9
Eye problems/disorders: None of the above 0.9 1.0 3.5 0.2 1.9 1.4 0.1 0.6 1.2 1.1 -1.0 0.9 1.4 0.2 0.0
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.9 1.4 0.4 -0.4 0.3 -0.3 0.1 -0.1 0.9 0.5 -0.6 -0.2 0.1
Emphysema/chronic bronchitis 0.6 0.7 1.5 -0.8 -1.0 -0.4 -1.2 0.1 -0.6 -0.8 1.1 0.0 -1.0 1.2 0.8
Medication for pain relief, constipation, heartburn 3.6 6.2 16.7 0.1 4.1 3.1 2.6 1.3 4.1 1.7 -0.2 -2.7 2.5 -1.0 -2.4
Neck or shoulder pain in last month 1.2 1.7 3.7 -0.6 -1.0 -1.4 0.3 -1.9 -1.6 0.3 1.7 0.6 -1.8 1.5 1.3
Medication: Blood pressure 6.5 11.4 35.3 -1.3 -5.9 -4.3 -4.6 -0.4 -5.6 -2.5 1.3 2.7 -2.2 1.6 2.2
Angina (self-reported) 0.6 0.7 3.9 0.1 -0.5 -0.9 0.1 -0.4 -0.7 -0.7 -0.4 0.4 -2.0 0.1 1.6
Migraine (self-reported) 0.8 1.0 4.4 -0.1 0.8 -0.1 -1.4 -0.6 0.1 -0.9 0.5 0.6 -0.1 -1.8 -2.1
Medication: Ibuprofen 2.3 2.8 7.9 0.4 -1.8 -2.5 -1.0 -0.2 -2.8 -0.9 -0.7 2.2 -0.4 0.7 2.8
Medication: Allopurinol 1.0 1.3 4.7 2.2 -0.6 0.9 0.8 1.1 1.2 1.0 0.7 0.5 -0.5 -0.8 -2.0
Medication: Omeprazole 1.5 1.8 9.6 -0.1 -0.7 -1.9 -1.0 -0.7 -2.1 -3.1 1.3 0.6 0.3 -0.1 0.2
Medication: Seretide 50 evohaler 0.8 0.9 6.4 0.3 -0.5 -1.3 -0.5 -2.5 0.0 -0.4 -1.2 0.3 -0.3 0.6 0.5
Mean time to correctly identify matches 0.4 0.7 3.2 1.2 0.9 0.5 0.2 -0.2 0.0 -0.9 0.3 0.5 -0.0 -1.8 -1.3
Heart disease (mother) 0.4 0.5 1.3 0.9 -0.6 -0.6 -1.2 -0.3 -1.0 -0.2 -0.3 0.7 -0.8 -0.6 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 3.6 1.3 0.3 0.4 0.7 0.9 0.9 0.5 -1.0 -0.6 0.6 -1.2 -1.9
Whole body fat mass 0.7 3.0 16.4 -1.5 1.2 -0.0 0.9 1.5 0.2 -2.5 4.0 -0.3 -0.6 1.8 1.7
Leg fat mass (right) 0.7 2.5 15.0 -1.3 0.7 -0.5 0.6 0.9 -0.2 -2.1 3.9 0.2 -0.8 2.0 1.7
Arm predicted mass (right) 0.4 1.9 6.5 -1.6 0.3 -0.7 -0.8 -1.8 -0.8 -1.6 1.1 0.0 0.4 2.2 2.5
Pulse rate, automated reading 0.6 1.9 8.9 -3.0 0.4 0.4 0.5 1.0 0.4 0.4 -0.5 -1.9 -2.5 0.5 1.3
Alcohol intake frequency. 0.7 1.5 4.3 -1.9 0.9 0.5 1.1 0.7 1.2 1.4 0.6 -2.1 -1.0 0.8 1.4
Comparative height size at age 10 0.1 0.8 2.8 -0.2 -0.1 -0.4 -0.5 -1.7 -0.0 0.9 1.0 -0.3 1.3 1.4 1.0
Number of full sisters 0.7 0.9 2.4 0.5 -1.0 0.7 0.9 -0.7 0.6 1.4 -1.5 0.6 -1.1 1.3 0.3
Suffer from ‘nerves’ 0.5 0.7 3.3 -0.6 -0.9 -0.6 -0.5 -0.7 -0.6 0.2 0.6 -1.8 0.0 0.2 1.5
Overall health rating 0.7 1.4 8.2 -0.9 -0.3 -0.5 -0.5 -2.4 0.1 0.7 0.7 0.3 -2.9 1.0 0.3
Chest pain or discomfort 1.6 2.3 6.4 -0.5 -2.0 -1.9 -0.6 -2.5 -1.9 -0.8 -0.6 1.1 -0.6 1.7 2.1
Had major operations 2.8 3.3 11.5 -1.5 -3.4 -3.0 -1.2 -0.8 -2.9 -1.4 -0.1 0.1 -1.1 0.8 1.5
Age at last live birth 0.6 0.8 3.7 1.0 0.8 -0.5 -0.1 0.5 -0.3 -0.6 -1.9 0.8 1.6 -0.3 0.4
Family relationship satisfaction 0.2 0.2 0.7 0.4 0.3 -0.8 0.6 0.0 -0.1 0.2 0.6 0.1 0.8 -0.4 0.2
Leg pain on walking 1.0 1.2 2.5 -0.3 -1.4 -1.2 -1.0 -1.4 -1.1 -1.6 1.1 0.6 -1.6 0.4 0.6
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 3.0 -1.3 -1.6 -1.6 -1.6 -1.2 -1.6 -0.2 1.6 0.6 -1.7 1.3 1.5
Commuting to job workplace: Car/motor vehicle 0.8 1.0 5.2 -0.4 0.0 0.7 -0.3 0.7 1.1 1.4 0.5 -0.6 -2.3 0.7 -0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 4.0 0.0 0.3 -0.9 -0.0 -2.0 0.0 -1.0 1.0 -0.7 0.2 -1.5 -1.0
Medication: Aspirin 3.9 5.1 15.7 0.2 -4.0 -3.2 -2.4 -1.4 -3.7 -3.2 0.5 1.1 -0.2 -0.1 1.6
Supplements: Vitamin C 0.6 0.7 2.7 -0.5 -0.4 -0.3 -0.3 -0.4 -0.4 0.3 -1.2 0.4 -0.6 1.6 1.6
Knee pain experienced in last month 1.5 2.3 5.9 -0.7 -1.7 -1.8 -0.1 -1.4 -1.6 -0.6 2.4 0.0 -2.0 1.6 2.0
Hypertension (Self-reported) 3.4 9.5 28.1 -0.5 -4.7 -4.8 -4.0 -0.9 -5.3 -3.5 1.9 2.2 -0.3 -0.1 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.3 0.2 -0.6 -0.5 -0.1 -0.6 -0.8 1.4 -0.3 -0.5 -1.8 -0.1 -0.1
Illnesses of father: Heart disease 2.6 3.7 10.7 -1.6 -2.0 -2.5 -2.5 -0.2 -3.3 -2.9 0.1 1.9 -0.2 0.4 1.4
Illnesses of siblings: Diabetes 1.4 1.7 8.8 -0.4 -3.0 -0.9 -0.7 -0.7 -1.4 -0.8 -1.1 0.5 -0.7 2.0 1.1
Smoking status: Previous 1.6 2.4 8.1 1.8 -2.2 -2.2 -1.2 -0.7 -2.2 -0.1 -0.1 2.8 -0.4 0.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.0 0.7 0.9 1.3 1.1 1.4 1.3 0.9 -0.6 0.4 1.0 0.6 0.1
Whole body fat-free mass 0.3 1.9 7.3 -1.3 -0.2 -0.9 -1.1 -1.6 -1.2 -1.7 0.5 0.3 0.2 2.2 2.7
Leg fat-free mass (right) 0.4 2.1 10.9 -1.6 -0.2 -1.1 -0.8 -0.8 -1.4 -1.8 0.2 0.0 -0.1 2.1 3.3
Arm fat percentage (left) 0.8 3.0 15.2 -1.2 0.3 -0.4 0.9 2.2 -0.4 -2.4 3.9 -0.1 -1.8 1.4 1.5
Average weekly red wine intake 0.5 0.7 3.3 0.2 0.3 0.6 0.1 0.7 0.4 -0.0 -0.3 0.9 1.1 -1.8 -1.6
Handedness (chirality/laterality): Left-handed 0.6 0.8 4.4 0.5 -2.1 -0.4 -0.2 0.0 -0.5 1.1 -0.2 -0.3 -0.5 -0.3 -1.5
Mood swings 0.8 1.4 4.0 -0.3 -1.9 -0.9 -0.8 -0.8 -1.7 -0.1 0.4 0.6 -0.7 2.0 1.7
Loneliness, isolation 0.6 0.9 2.5 1.6 0.1 1.0 1.4 0.1 0.2 0.6 1.5 1.0 0.6 -0.6 -1.0
Long-standing illness, disability or infirmity 1.4 2.1 5.3 -1.5 -1.5 -1.2 0.0 -1.2 -1.6 -1.8 0.9 0.5 -2.1 1.3 2.3
Ever had bowel cancer screening 1.7 2.0 7.7 -2.8 -1.3 -0.9 -1.4 -0.7 -1.0 -1.0 -1.5 -0.2 -0.1 1.8 2.1
Diabetes diagnosed by doctor 1.0 1.6 7.3 -0.5 0.7 1.9 2.7 0.2 1.8 -0.6 1.3 -0.8 -1.1 0.5 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 4.6 -1.1 -1.0 -1.8 -0.6 -0.9 -1.3 -0.1 -0.1 -0.3 0.1 1.9 2.1
Friendships satisfaction 0.3 0.4 2.1 0.2 -0.2 -0.3 0.1 0.2 -0.6 0.6 -1.4 -0.6 0.5 0.7 0.9
Qualifications: nursing, teaching 0.3 0.4 1.0 -1.0 0.6 -0.3 -0.8 0.7 0.0 -0.4 -0.3 0.9 0.6 0.9 0.4
Commuting to job workplace: Walk 0.3 0.3 0.9 0.9 -0.0 -0.9 0.0 -0.5 -0.8 -0.1 0.7 0.5 -0.3 -0.3 0.2
Eye problems/disorders: Cataract 0.5 0.6 1.7 -0.9 -0.9 0.2 -0.4 0.3 -0.5 -0.5 1.0 -1.3 -0.9 -0.7 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.9 -0.7 0.5 0.8 0.7 1.4 0.6 0.8 -0.1 -1.7 0.7 -0.2 0.5
Medication for cholesterol 1.2 1.8 4.2 2.1 1.6 1.7 2.0 0.0 1.9 1.2 -0.2 0.4 0.9 0.2 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 9.1 -2.5 -1.2 -1.0 -0.8 0.6 -0.8 1.3 -0.7 -0.6 -1.7 3.0 2.5
Back pain experienced in last month 2.3 3.3 8.6 -1.5 -1.7 -1.5 -1.0 -2.3 -2.3 -1.7 -0.5 0.4 -0.8 2.9 2.9
Mineral and other dietary supplements 1.0 1.4 5.9 0.4 2.4 1.0 0.3 1.8 1.7 0.5 1.2 0.8 0.9 -0.1 -0.8
Breast cancer (self-reported) 0.3 0.4 1.3 -0.4 -0.7 -0.1 -0.9 -1.2 -0.8 -0.3 0.6 0.1 -0.7 -0.2 -0.3
Asthma (self-reported) 0.7 1.3 6.5 0.4 -0.1 -0.1 0.1 -2.5 -0.3 0.7 1.6 0.1 0.3 -1.8 -1.6
Osteoporosis (self-reported) 0.6 0.8 1.9 -0.4 -1.1 -0.9 -1.2 0.6 -1.4 -1.2 -0.8 -0.9 0.3 -0.4 0.5
Osteoarthritis (self-reported) 1.7 2.2 6.6 -2.5 -0.4 -1.3 -1.2 -1.1 -1.6 -1.3 1.1 -0.7 -1.6 0.3 2.6
Medication: Aspirin 3.6 4.7 13.6 0.0 -3.7 -2.9 -2.6 -0.9 -3.5 -3.3 0.7 1.1 -0.1 -0.2 1.6
Medication: Gliclazide 0.6 0.6 2.2 0.3 0.3 0.3 1.2 -1.0 0.8 0.5 -0.9 0.2 -1.5 0.8 0.5
Illnesses of father: None of the above (group 1) 1.3 1.6 5.2 0.3 0.6 2.3 1.0 0.9 1.7 1.6 -0.9 -2.0 0.4 0.9 0.0
Smoking status: Current 0.5 0.8 4.3 -0.8 0.1 0.1 -0.1 -2.1 0.7 0.3 -0.9 -0.8 -1.6 -0.4 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.0 1.4 -0.7 0.2 -1.4 0.1 -0.5 -0.2 -1.3 1.2 -0.8 -0.8 -0.8
Whole body water mass 0.3 1.9 6.4 -1.3 -0.3 -0.9 -1.2 -1.7 -1.2 -1.8 0.5 0.4 0.3 2.0 2.5
Leg predicted mass (right) 0.4 2.1 10.6 -1.6 -0.1 -1.2 -0.8 -0.8 -1.3 -1.8 0.2 0.0 -0.1 2.0 3.2
Arm fat mass (left) 0.7 2.7 15.2 -1.6 0.6 -0.3 0.5 1.4 -0.4 -2.4 3.9 -0.2 -1.2 1.5 1.7
Number of self-reported non-cancer illnesses 1.1 2.0 8.5 -0.7 -1.4 -1.6 -0.9 -2.4 -1.3 -2.9 1.0 0.6 0.1 -0.0 0.9
Average weekly champagne plus white wine intake 1.3 1.8 4.8 -1.6 -1.5 -1.2 -1.1 -1.0 -1.4 0.1 -0.8 -0.1 -1.2 2.1 2.2
Miserableness 0.4 0.7 4.2 0.6 0.8 0.8 0.6 -0.2 0.5 -0.5 2.1 0.4 0.5 -0.5 -0.6
Guilty feelings 1.8 2.7 8.5 0.9 -2.6 -2.6 -1.2 -0.6 -2.9 -1.4 1.3 2.1 -0.3 -0.1 0.7
Wears glasses or contact lenses 0.7 0.8 2.4 0.1 -1.1 -1.6 -0.6 -1.2 -1.0 0.1 -0.9 -0.7 0.7 0.9 0.6
Ever taken oral contraceptive pill 0.6 0.7 4.4 0.9 0.1 0.4 0.2 -0.1 -0.2 -1.5 0.2 0.7 2.1 -0.5 -0.4
Hearing aid user 1.0 1.1 11.0 -0.1 -0.1 -0.1 -0.1 0.7 -1.0 -3.3 0.5 0.2 0.6 -0.7 -0.1
Mother’s age at death 0.8 1.1 2.6 0.3 1.6 0.3 0.8 1.5 1.5 0.5 -1.3 -0.9 1.2 -0.7 -0.5
Financial situation satisfaction 0.2 0.3 0.8 -0.4 -0.8 -0.0 0.0 0.6 -0.7 -0.4 0.5 0.1 -0.8 0.9 0.3
Tinnitus: Yes, now most or all of the time 1.4 1.6 5.0 0.5 0.3 -2.1 -1.7 -0.3 -1.4 -2.2 1.4 1.4 -0.4 -0.3 0.3
Commuting to job workplace: Public transport 0.7 0.8 4.7 0.1 0.4 0.4 0.9 -0.7 0.2 -0.8 -1.3 -0.7 2.2 -0.2 0.5
Eye problems/disorders: Glaucoma 0.5 0.6 2.9 -0.3 -0.4 -0.9 0.3 -0.7 0.1 0.2 -1.7 -0.1 -1.6 0.4 0.1
Medication: Blood pressure 1.5 2.9 7.7 0.3 -1.8 -2.8 -2.1 -1.5 -2.5 -2.6 0.2 0.8 0.1 -1.9 -0.1
Pain type(s) experienced in last month: Hip pain 1.4 1.7 4.2 -0.5 -1.9 -0.9 -0.2 -0.7 -2.0 -0.8 -1.7 0.5 0.2 1.9 1.9
Supplements: Fish oil (including cod liver oil) 0.8 1.0 3.4 -0.3 -1.9 -0.5 -0.2 -1.7 -0.9 -0.9 -1.3 -1.0 -0.9 -0.2 0.5
High cholesterol (Self-reported) 0.6 1.1 3.3 -1.4 -1.4 -0.5 -0.1 -0.3 -1.4 -1.1 -0.2 -1.1 -0.7 0.7 1.8
Medication: Bendroflumethiazide 1.8 2.7 10.8 -0.6 -3.3 -2.2 -2.1 -0.7 -2.8 -0.4 -0.1 0.6 -1.4 -0.1 1.0
Medication: Paracetamol 1.3 2.1 4.6 -1.3 -1.5 -0.9 -1.7 -1.4 -1.5 0.8 -1.5 1.0 -2.1 1.6 1.5
Medication: Lisinopril 1.7 2.2 5.6 -1.2 -2.4 -2.1 -1.0 -1.0 -2.4 -1.2 -0.4 0.9 -0.8 1.0 1.9
Medication: Atorvastatin 0.7 0.9 3.4 -0.8 -0.9 -0.5 0.2 0.2 -0.7 -1.8 1.4 0.9 -0.9 0.8 0.9
Illnesses of father: High blood pressure 0.7 0.9 2.8 -1.1 -0.9 -1.2 -0.9 -0.0 -1.7 -0.9 0.4 0.6 -0.2 -0.0 1.6
Alcohol drinker status: Never 1.4 1.7 5.1 -2.3 -0.8 -0.1 -0.2 0.8 -0.5 1.9 -0.8 -1.6 -1.9 1.2 1.3
Ever smoked 1.0 1.7 5.0 1.3 -2.2 -2.0 -0.1 -1.4 -1.9 -0.1 -0.5 1.3 -1.0 1.1 0.6
Basal metabolic rate 0.4 2.0 7.3 -1.4 -0.1 -0.9 -0.8 -1.2 -1.1 -1.8 1.2 0.4 0.0 2.3 2.7
Leg fat percentage (left) 0.9 3.3 19.0 -1.6 1.3 -0.4 1.4 1.8 0.3 -2.2 4.4 -0.2 -1.0 1.6 1.6
Arm fat-free mass (left) 0.3 1.8 4.7 -1.7 0.6 -0.4 -0.5 -1.4 -0.4 -1.8 1.5 -0.2 0.6 2.0 2.2
Number of operations (self-reported) 3.1 4.6 14.5 -1.0 -3.8 -3.1 -3.0 -1.8 -3.3 -1.5 -0.9 1.0 -1.9 0.2 0.2
Average weekly beer plus cider intake 0.7 1.0 4.5 0.7 1.2 -0.1 0.5 -0.3 0.4 -1.4 2.1 0.8 0.9 -0.9 -0.8
Irritability 0.3 0.6 1.8 0.7 -1.3 -0.4 -0.3 -0.1 -1.3 -0.0 -0.0 0.5 1.3 0.6 0.7
Risk taking 1.8 2.6 6.9 -0.1 -1.2 -1.8 -1.7 -0.1 -1.8 -2.3 1.3 2.6 1.0 1.8 1.3
Ever had prostate specific antigen (PSA) test 2.2 2.5 7.0 2.2 -2.1 -1.4 -1.7 0.6 -2.1 -0.1 -1.5 2.6 0.1 -1.2 -0.7
Fractured/broken bones in last 5 years 0.7 0.8 3.2 -0.8 0.6 -0.2 -0.9 -0.7 0.5 0.3 1.5 0.9 -1.8 1.0 0.2
Age started oral contraceptive pill 0.3 0.3 2.4 -0.4 -0.1 0.5 0.3 -0.6 -0.0 -0.2 0.2 -1.5 0.2 -0.6 -0.6
Diastolic blood pressure, automated reading 1.1 3.5 13.5 -0.2 -1.9 -2.4 -1.6 0.7 -2.9 -3.7 1.7 1.3 0.9 -1.3 0.9
Ever depressed for a whole week 0.6 0.7 3.4 0.1 -0.9 -1.0 -0.6 -0.5 -0.9 0.8 -0.3 0.2 -1.9 0.3 0.8
Unable to work because of sickness or disability 1.8 2.3 5.0 -1.8 -1.5 -2.2 -1.5 -0.1 -2.2 -1.5 -0.1 0.0 -1.8 1.0 1.9
Commuting to job workplace: Cycle 1.5 1.8 7.0 0.3 -1.8 -1.2 -0.7 -0.4 -2.6 -2.5 0.7 0.5 1.4 -0.4 0.6
Myopia 1.2 1.7 7.8 -0.7 -1.4 -0.1 0.4 1.9 -0.2 1.3 -2.8 -1.7 0.5 0.7 1.1
Vascular/heart problems diagnosed by doctor 3.2 8.7 22.5 1.0 4.4 4.6 3.6 1.3 4.7 3.7 -2.0 -1.5 1.2 0.3 -2.1
Cholesterol lowering medication 0.5 0.7 2.4 -1.4 -0.1 0.2 0.4 0.6 -0.0 -0.1 -0.1 -1.6 -1.0 -1.2 0.8
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 7.7 -1.1 -1.0 -2.3 -1.6 -1.2 -2.4 -2.8 1.3 0.7 -0.5 0.4 0.7
Pain experienced in last month 1.3 2.1 6.2 0.5 1.4 1.3 -0.0 1.6 1.2 -0.3 -1.8 -0.6 2.5 -2.4 -1.4
Supplements: Calcium 0.8 0.8 3.6 0.1 -0.1 -1.1 -1.2 -0.5 -0.9 -1.9 -0.3 1.2 0.9 -0.5 0.3
Basal cell carcinoma (self-reported) 1.7 2.1 12.0 -0.1 -1.0 -1.7 -1.8 -1.4 -1.4 -0.2 -3.5 0.8 -0.6 0.6 0.7
Heart attack/myocardial infarction (self-reported) 1.7 2.2 6.9 -0.5 -2.6 -2.4 -1.7 -0.4 -1.9 -1.6 -0.7 0.3 -1.2 -0.4 1.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 4.5 -0.1 1.2 0.4 0.5 -0.7 1.1 -1.8 2.1 0.0 1.1 0.9 -0.1
Heart disease (siblings) 0.6 0.8 3.0 -0.4 -1.1 -0.5 -0.2 -0.5 -0.7 -0.5 1.7 0.7 -1.7 0.1 -0.2
Alcohol drinker status: Previous 1.1 1.3 4.3 -1.0 -1.0 -0.9 0.0 -0.7 -1.0 0.0 -1.4 -0.4 -2.1 1.2 1.6
Pack years of smoking 0.7 1.1 5.4 -2.3 0.4 -1.0 -1.0 -0.1 -0.3 -1.9 0.2 -0.2 -0.5 0.6 1.0
Impedance of whole body 0.3 1.7 4.6 0.7 0.8 1.9 1.4 1.6 1.5 1.5 0.8 -0.5 1.1 -0.3 -2.1
Leg fat mass (left) 0.7 2.7 15.0 -1.4 1.1 -0.5 0.8 0.9 -0.1 -2.2 3.9 -0.0 -0.8 1.8 1.9
Arm predicted mass (left) 0.3 1.7 4.0 -1.4 0.7 -0.6 -0.6 -1.8 -0.5 -1.8 1.6 0.0 0.7 1.9 2.0