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chr5:130,830,617-132,425,049

Best TWAS P=1.39e-08 · Best GWAS P=4.4e-08 conditioned to 0.211

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	-5.0	5.7	1.4e-08	0.85	0.02	0.97	TRUE
4	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	-5.1	-5.6	2.3e-08	-0.74	0.02	0.98	FALSE
21	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	4.6	5.6	2.6e-08	0.72	0.25	0.74	FALSE
13	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	5.5	5.5	2.9e-08	0.96	0.04	0.74	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	4.8	5.5	3.3e-08	0.84	0.04	0.96	FALSE
19	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	-5.2	5.5	4.6e-08	0.78	0.03	0.97	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	4.6	5.4	5.6e-08	0.80	0.06	0.94	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	-5.3	5.4	6.2e-08	0.75	0.04	0.94	FALSE
16	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	-4.8	5.4	6.6e-08	0.62	0.05	0.89	FALSE
17	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	-5.3	-5.4	7.4e-08	-0.61	0.02	0.97	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	-5.2	-5.3	8.7e-08	-0.86	0.01	0.85	FALSE
9	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	4.6	-5.3	1.1e-07	-0.77	0.08	0.65	FALSE
12	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	-5.2	5.3	1.1e-07	0.74	0.02	0.98	FALSE
14	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	-5.0	-5.3	1.1e-07	-0.74	0.03	0.97	FALSE
15	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	-5.3	-5.3	1.1e-07	-0.67	0.02	0.97	FALSE
18	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	-5.3	5.3	1.1e-07	0.76	0.01	0.98	FALSE
20	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	-5.3	5.3	1.1e-07	0.76	0.02	0.98	FALSE
2	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	-5.2	-5.3	1.3e-07	-0.68	0.04	0.90	FALSE
5	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	4.9	5.3	1.3e-07	0.88	0.07	0.93	FALSE
3	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	-5.3	-5.3	1.4e-07	-0.67	0.02	0.98	FALSE
8	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	4.6	-5.3	1.4e-07	-0.64	0.20	0.79	FALSE
1	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	-5.2	5.2	2.3e-07	0.73	0.03	0.95	FALSE
6	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	-5.3	5.2	2.4e-07	0.80	0.04	0.94	FALSE
7	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	-5.3	5.2	2.5e-07	0.74	0.02	0.97	FALSE