Best TWAS P=6.89e-09 · Best GWAS P=1.65e-08 conditioned to 0.378
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | STAG3L2 | 0.16 | 0.03 | enet | 11 | 0.09 | 1.0e-07 | 3.6 | -5.1 | 2.9e-07 | -0.71 | 0.04 | 0.95 | FALSE |
2 | GTEx | Adipose Subcutaneous | AC004166.6 | 0.09 | 0.08 | lasso | 2 | 0.07 | 3.9e-06 | 5.6 | 5.4 | 5.4e-08 | 0.85 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Subcutaneous | STAG3L1 | 0.30 | 0.24 | enet | 24 | 0.27 | 2.4e-22 | -4.6 | -5.3 | 9.2e-08 | -0.12 | 0.00 | 0.98 | TRUE |
4 | GTEx | Adrenal Gland | STAG3L2 | 0.14 | 0.07 | enet | 3 | 0.11 | 1.2e-04 | 5.1 | -5.3 | 1.5e-07 | -0.92 | 0.02 | 0.77 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | PMS2P5 | 0.16 | 0.06 | lasso | 3 | 0.04 | 1.7e-02 | 5.6 | -5.5 | 4.3e-08 | -0.82 | 0.01 | 0.76 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | PMS2P5 | 0.23 | 0.19 | lasso | 2 | 0.18 | 5.4e-07 | 5.6 | -5.8 | 6.9e-09 | -0.77 | 0.01 | 0.98 | TRUE |
7 | GTEx | Esophagus Mucosa | PMS2P5 | 0.14 | 0.03 | lasso | 4 | 0.04 | 1.7e-03 | 5.6 | -5.7 | 1.2e-08 | -0.79 | 0.01 | 0.87 | FALSE |
8 | GTEx | Esophagus Muscularis | STAG3L2 | 0.23 | 0.09 | enet | 33 | 0.15 | 1.9e-09 | 3.6 | -5.4 | 7.7e-08 | -0.76 | 0.03 | 0.96 | FALSE |
9 | GTEx | Heart Atrial Appendage | PMS2P5 | 0.12 | 0.03 | lasso | 5 | 0.07 | 3.8e-04 | 5.6 | -5.5 | 4.8e-08 | -0.75 | 0.01 | 0.59 | FALSE |
10 | GTEx | Nerve Tibial | STAG3L2 | 0.36 | 0.09 | enet | 13 | 0.24 | 9.5e-17 | 3.6 | -5.4 | 5.3e-08 | -0.75 | 0.02 | 0.97 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | STAG3L2 | 0.15 | 0.05 | enet | 8 | 0.08 | 2.8e-07 | 3.6 | -5.3 | 1.1e-07 | -0.72 | 0.07 | 0.85 | FALSE |
12 | GTEx | Testis | PMS2P5 | 0.22 | 0.13 | lasso | 2 | 0.13 | 3.1e-06 | 5.6 | -5.4 | 7.6e-08 | -0.75 | 0.01 | 0.96 | FALSE |
13 | GTEx | Testis | STAG3L1 | 0.24 | 0.24 | enet | 14 | 0.27 | 1.4e-12 | -4.6 | -5.2 | 2.6e-07 | -0.12 | 0.00 | 0.98 | FALSE |
14 | GTEx | Thyroid | GTF2IRD2B | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.9e-03 | 5.5 | 5.5 | 3.2e-08 | 0.96 | 0.01 | 0.82 | FALSE |
15 | METSIM | Adipose | NCF1 | 0.05 | 0.03 | blup | 130 | 0.04 | 3.9e-07 | 5.6 | 5.4 | 6.8e-08 | 0.71 | 0.01 | 0.99 | FALSE |