Best TWAS P=8.72e-09 · Best GWAS P=8.55e-18 conditioned to 2.08e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Skin Not Sun Exposed Suprapubic | KCNJ11 | 0.18 | 0.07 | lasso | 6 | 0.12 | 7.0e-07 | 5.1 | -5.1 | 2.9e-07 | -0.06 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | KCNJ11 | 0.23 | 0.09 | lasso | 10 | 0.12 | 1.7e-10 | 4.9 | -5.2 | 1.8e-07 | -0.04 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Thyroid | NUCB2 | 0.07 | 0.02 | lasso | 4 | 0.02 | 1.3e-02 | -4.1 | -5.2 | 2.1e-07 | -0.05 | 0.16 | 0.08 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DKFZp686O24166 | 0.04 | 0.00 | blup | 71 | 0.02 | 7.1e-03 | -3.8 | -5.3 | 1.0e-07 | -0.03 | 0.01 | 0.71 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DKFZp686O24166 | 0.03 | 0.01 | blup | 72 | 0.03 | 2.4e-04 | 5.0 | -5.3 | 1.4e-07 | -0.04 | 0.01 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NUCB2 | 0.10 | 0.04 | enet | 8 | 0.05 | 2.6e-06 | -3.2 | -5.5 | 4.9e-08 | -0.06 | 0.44 | 0.27 | TRUE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SOX6 | 0.12 | -0.01 | blup | 250 | 0.02 | 3.1e-02 | 1.4 | -5.8 | 8.7e-09 | -0.46 | 0.05 | 0.13 | TRUE |