[Hub]/) : Traits : High blood pressure :

chr11:15,741,673-18,106,069

Best TWAS P=8.72e-09 · Best GWAS P=8.55e-18 conditioned to 2.08e-10

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Skin Not Sun Exposed Suprapubic KCNJ11 0.18 0.07 lasso 6 0.12 7.0e-07 5.1 -5.1 2.9e-07 -0.06 0.02 0.98 FALSE
2 GTEx Skin Sun Exposed Lower leg KCNJ11 0.23 0.09 lasso 10 0.12 1.7e-10 4.9 -5.2 1.8e-07 -0.04 0.01 0.99 FALSE
3 GTEx Thyroid NUCB2 0.07 0.02 lasso 4 0.02 1.3e-02 -4.1 -5.2 2.1e-07 -0.05 0.16 0.08 FALSE
4 The Cancer Genome Atlas Bladder Urothelial Carcinoma DKFZp686O24166 0.04 0.00 blup 71 0.02 7.1e-03 -3.8 -5.3 1.0e-07 -0.03 0.01 0.71 FALSE
5 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DKFZp686O24166 0.03 0.01 blup 72 0.03 2.4e-04 5.0 -5.3 1.4e-07 -0.04 0.01 0.94 FALSE
6 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NUCB2 0.10 0.04 enet 8 0.05 2.6e-06 -3.2 -5.5 4.9e-08 -0.06 0.44 0.27 TRUE
7 The Cancer Genome Atlas Pancreatic Adenocarcinoma SOX6 0.12 -0.01 blup 250 0.02 3.1e-02 1.4 -5.8 8.7e-09 -0.46 0.05 0.13 TRUE