Best TWAS P=1.32e-15 · Best GWAS P=1.32e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ACE | 0.08 | 0.05 | lasso | 4 | 0.04 | 1.0e-05 | 4.7 | 5.9 | 3.2e-09 | 0.82 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Colon Transverse | ACE | 0.31 | 0.28 | lasso | 2 | 0.28 | 1.8e-13 | 8.0 | -7.8 | 9.5e-15 | -0.98 | 0.00 | 1.00 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ACE | 0.02 | 0.01 | enet | 3 | 0.01 | 1.3e-03 | 7.1 | 7.7 | 1.1e-14 | 0.93 | 0.00 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | ACE | 0.34 | 0.22 | lasso | 5 | 0.22 | 6.5e-13 | 7.1 | -7.8 | 5.1e-15 | -0.94 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CYB561 | 0.17 | 0.01 | enet | 6 | 0.08 | 2.0e-05 | 7.2 | -5.5 | 4.8e-08 | -0.58 | 0.01 | 0.44 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ACE | 0.16 | 0.08 | lasso | 2 | 0.07 | 5.8e-05 | 7.1 | -7.9 | 3.8e-15 | -0.96 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ACE | 0.13 | 0.14 | lasso | 1 | 0.10 | 6.6e-05 | 8.0 | -8.0 | 1.3e-15 | -1.00 | 0.00 | 1.00 | TRUE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ACE | 0.16 | 0.14 | lasso | 6 | 0.13 | 5.1e-04 | 8.0 | -7.6 | 3.3e-14 | -0.95 | 0.00 | 0.88 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ACE | 0.06 | 0.03 | blup | 53 | 0.02 | 9.3e-03 | 7.2 | -5.4 | 7.6e-08 | -0.72 | 0.02 | 0.95 | FALSE |