Best TWAS P=8.01e-34 · Best GWAS P=2.67e-30 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KIAA1109 | 0.09 | 0.08 | bslmm | 390 | 0.08 | 8.9e-10 | -11.3 | 8.4 | 3.0e-17 | -0.91 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | KIAA1109 | 0.11 | 0.00 | lasso | 7 | 0.01 | 5.1e-02 | -11.4 | 10.1 | 5.7e-24 | -0.88 | 0.03 | 0.82 | FALSE |
3 | GTEx | Artery Tibial | KIAA1109 | 0.16 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | -11.1 | 10.9 | 1.0e-27 | -0.97 | 0.01 | 0.98 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | KIAA1109 | 0.22 | 0.07 | lasso | 7 | 0.03 | 5.9e-02 | -11.1 | 10.7 | 6.3e-27 | -0.97 | 0.02 | 0.67 | FALSE |
5 | GTEx | Colon Transverse | KIAA1109 | 0.25 | -0.01 | enet | 16 | 0.00 | 4.1e-01 | -10.9 | 11.2 | 7.0e-29 | -0.86 | 0.02 | 0.76 | FALSE |
6 | GTEx | Colon Transverse | BBS12 | 0.12 | 0.05 | enet | 29 | 0.12 | 3.2e-06 | 1.9 | -5.3 | 1.3e-07 | 0.52 | 0.07 | 0.28 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | KIAA1109 | 0.08 | 0.08 | lasso | 7 | 0.07 | 2.5e-09 | -11.1 | 10.9 | 1.0e-27 | -0.98 | 0.01 | 0.99 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | SPATA5 | 0.05 | 0.01 | bslmm | 485 | 0.01 | 1.2e-02 | -3.1 | 6.6 | 3.2e-11 | -0.13 | 0.17 | 0.05 | TRUE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1109 | 0.03 | 0.03 | lasso | 1 | 0.02 | 1.2e-05 | -11.1 | 11.1 | 1.1e-28 | -0.99 | 0.05 | 0.92 | FALSE |
10 | The Cancer Genome Atlas | Esophageal Carcinoma | KIAA1109 | 0.32 | 0.02 | blup | 45 | 0.02 | 7.4e-02 | -10.9 | 12.1 | 8.0e-34 | -0.66 | 0.01 | 0.47 | TRUE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA1109 | 0.05 | 0.05 | enet | 8 | 0.04 | 1.3e-05 | -11.1 | 8.2 | 1.7e-16 | -0.93 | 0.02 | 0.95 | TRUE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1109 | 0.06 | 0.05 | lasso | 2 | 0.03 | 7.1e-05 | -11.1 | 11.3 | 1.6e-29 | -0.99 | 0.06 | 0.91 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1109 | 0.05 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | -10.9 | 11.7 | 1.6e-31 | -0.95 | 0.01 | 0.98 | TRUE |