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chr4:122,377,715-124,935,698

Best TWAS P=8.01e-34 · Best GWAS P=2.67e-30 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	The Cancer Genome Atlas	Esophageal Carcinoma	KIAA1109	0.32	0.02	blup	45	0.02	7.4e-02	-10.9	12.1	8.0e-34	-0.66	0.01	0.47	TRUE
13	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1109	0.05	0.04	enet	3	0.05	5.4e-06	-10.9	11.7	1.6e-31	-0.95	0.01	0.98	TRUE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA1109	0.05	0.05	enet	8	0.04	1.3e-05	-11.1	8.2	1.7e-16	-0.93	0.02	0.95	TRUE
8	ROSMAP	Brain Pre-frontal Cortex	SPATA5	0.05	0.01	bslmm	485	0.01	1.2e-02	-3.1	6.6	3.2e-11	-0.13	0.17	0.05	TRUE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA1109	0.06	0.05	lasso	2	0.03	7.1e-05	-11.1	11.3	1.6e-29	-0.99	0.06	0.91	FALSE
5	GTEx	Colon Transverse	KIAA1109	0.25	-0.01	enet	16	0.00	4.1e-01	-10.9	11.2	7.0e-29	-0.86	0.02	0.76	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1109	0.03	0.03	lasso	1	0.02	1.2e-05	-11.1	11.1	1.1e-28	-0.99	0.05	0.92	FALSE
3	GTEx	Artery Tibial	KIAA1109	0.16	0.07	lasso	6	0.05	5.1e-05	-11.1	10.9	1.0e-27	-0.97	0.01	0.98	FALSE
7	ROSMAP	Brain Pre-frontal Cortex	KIAA1109	0.08	0.08	lasso	7	0.07	2.5e-09	-11.1	10.9	1.0e-27	-0.98	0.01	0.99	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	KIAA1109	0.22	0.07	lasso	7	0.03	5.9e-02	-11.1	10.7	6.3e-27	-0.97	0.02	0.67	FALSE
2	GTEx	Artery Aorta	KIAA1109	0.11	0.00	lasso	7	0.01	5.1e-02	-11.4	10.1	5.7e-24	-0.88	0.03	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KIAA1109	0.09	0.08	bslmm	390	0.08	8.9e-10	-11.3	8.4	3.0e-17	-0.91	0.01	0.99	FALSE
6	GTEx	Colon Transverse	BBS12	0.12	0.05	enet	29	0.12	3.2e-06	1.9	-5.3	1.3e-07	0.52	0.07	0.28	FALSE