Best TWAS P=5.95e-38 · Best GWAS P=2.28e-40 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | SPEF2 | 0.39 | 0.23 | enet | 27 | 0.22 | 1.8e-06 | 4.9 | 5.5 | 3.1e-08 | 0.49 | 0.81 | 0.02 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SPEF2 | 0.26 | 0.01 | enet | 56 | 0.04 | 2.6e-04 | 2.9 | 7.0 | 2.8e-12 | 0.34 | 0.12 | 0.70 | FALSE |
| 3 | GTEx | Testis | IL7R | 0.25 | 0.19 | lasso | 6 | 0.18 | 2.1e-08 | -5.3 | -5.5 | 3.2e-08 | -0.33 | 0.99 | 0.00 | TRUE |
| 4 | METSIM | Adipose | SPEF2 | 0.06 | 0.01 | blup | 522 | 0.03 | 4.0e-05 | -4.2 | 6.7 | 1.7e-11 | 0.36 | 0.74 | 0.02 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CAPSL | 0.05 | 0.02 | lasso | 6 | 0.03 | 2.9e-04 | -5.5 | 5.7 | 1.4e-08 | 0.55 | 0.29 | 0.42 | FALSE |
| 6 | YFS | Blood | IL7R | 0.03 | 0.01 | bslmm | 467 | 0.01 | 8.1e-05 | -4.4 | -6.7 | 2.7e-11 | -0.39 | 0.82 | 0.05 | FALSE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UGT3A2 | 0.04 | 0.00 | blup | 52 | 0.01 | 4.9e-02 | 4.0 | -6.7 | 2.6e-11 | -0.35 | 0.02 | 0.23 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UGT3A2 | 0.06 | 0.02 | blup | 52 | 0.05 | 9.7e-10 | -3.5 | -5.4 | 8.5e-08 | -0.30 | 0.97 | 0.02 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL7R | 0.04 | 0.03 | lasso | 3 | 0.02 | 9.8e-04 | 13.3 | 12.9 | 5.9e-38 | 0.96 | 0.00 | 0.99 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | UGT3A2 | 0.05 | 0.00 | blup | 52 | 0.02 | 3.4e-03 | -2.9 | -5.4 | 7.1e-08 | -0.34 | 0.02 | 0.13 | FALSE |