Best TWAS P=1.3e-09 · Best GWAS P=6.4e-09 conditioned to 0.293
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CISD2 | 0.02 | 0.00 | blup | 322 | 0.00 | 2.7e-01 | -4.9 | 5.2 | 2.0e-07 | 0.62 | 0.15 | 0.38 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MANBA | 0.08 | 0.04 | bslmm | 390 | 0.03 | 9.6e-05 | -4.4 | 5.4 | 5.6e-08 | 0.48 | 0.64 | 0.32 | FALSE |
| 3 | GTEx | Muscle Skeletal | CISD2 | 0.03 | 0.02 | enet | 15 | 0.03 | 7.9e-04 | -4.4 | -5.1 | 3.1e-07 | -0.50 | 0.22 | 0.72 | FALSE |
| 4 | GTEx | Pancreas | MANBA | 0.14 | 0.14 | enet | 5 | 0.06 | 1.8e-03 | 5.2 | -5.3 | 1.4e-07 | -0.52 | 0.09 | 0.85 | FALSE |
| 5 | METSIM | Adipose | SLC9B1 | 0.02 | 0.03 | lasso | 8 | 0.02 | 1.2e-04 | 5.3 | 5.3 | 1.2e-07 | 0.52 | 0.09 | 0.87 | FALSE |
| 6 | YFS | Blood | MANBA | 0.09 | 0.10 | lasso | 3 | 0.10 | 5.2e-30 | 5.3 | 5.3 | 1.3e-07 | 0.52 | 0.09 | 0.91 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MANBA | 0.03 | 0.03 | blup | 71 | 0.04 | 2.0e-05 | 4.7 | 5.3 | 1.1e-07 | 0.61 | 0.40 | 0.49 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NFKB1 | 0.10 | 0.06 | blup | 90 | 0.07 | 2.2e-03 | 5.3 | -6.1 | 1.3e-09 | -0.87 | 0.04 | 0.88 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | NFKB1 | 0.06 | 0.09 | enet | 7 | 0.09 | 9.1e-09 | 5.1 | 5.2 | 2.6e-07 | 0.79 | 0.15 | 0.85 | FALSE |