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chr5:108,927,715-111,770,880

Best TWAS P=2.04e-45 · Best GWAS P=4.28e-60 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	METSIM	Adipose	TSLP	0.16	0.18	lasso	7	0.18	8.5e-26	14.33	-14.1	2.0e-45	-0.92	0.28	0.72	TRUE
19	YFS	Blood	SLC25A46	0.03	0.02	enet	12	0.02	9.5e-07	-8.32	12.5	5.6e-36	0.25	0.95	0.00	TRUE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TSLP	0.05	0.02	blup	39	0.02	7.9e-04	13.52	-12.3	5.5e-35	-0.77	0.05	0.78	TRUE
16	ROSMAP	Brain Pre-frontal Cortex	TSLP	0.13	0.08	enet	14	0.09	4.1e-11	13.48	-11.2	4.4e-29	-0.73	1.00	0.00	TRUE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TSLP	0.03	0.00	enet	7	0.01	3.8e-02	12.17	-8.9	7.8e-19	-0.64	0.02	0.28	TRUE
5	GTEx	Brain Cerebellar Hemisphere	WDR36	0.32	0.12	lasso	7	0.17	4.8e-05	4.89	7.5	8.5e-14	0.33	0.11	0.14	TRUE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CAMK4	0.04	0.04	blup	159	0.01	3.6e-02	-7.78	7.2	4.8e-13	0.14	0.26	0.04	TRUE
14	METSIM	Adipose	TMEM232	0.04	0.06	lasso	8	0.06	9.8e-09	-7.36	-7.2	6.3e-13	0.08	1.00	0.00	TRUE
28	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM232	0.15	0.12	lasso	2	0.16	2.2e-09	-7.64	-6.6	4.2e-11	0.09	1.00	0.00	TRUE
38	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TSLP	0.12	0.11	lasso	3	0.08	6.9e-04	14.30	-14.1	5.5e-45	-0.92	0.01	0.90	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TSLP	0.04	0.03	enet	6	0.02	1.6e-03	13.82	-12.9	4.6e-38	-0.86	0.02	0.85	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSLP	0.06	0.07	blup	39	0.06	6.4e-07	13.52	-12.8	1.5e-37	-0.88	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	TSLP	0.02	0.02	blup	39	0.02	1.9e-03	14.34	-12.5	4.0e-36	-0.88	0.01	0.79	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	TSLP	0.03	0.03	lasso	2	0.03	5.5e-07	14.34	-12.4	1.8e-35	-0.84	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	TSLP	0.08	0.01	blup	39	0.03	5.4e-03	13.52	-12.0	2.6e-33	-0.78	0.02	0.59	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	TSLP	0.13	0.14	blup	39	0.15	1.4e-14	13.52	-10.5	5.7e-26	-0.75	0.04	0.96	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	CAMK4	0.10	0.03	lasso	4	0.04	7.8e-06	-10.07	10.5	1.0e-25	0.59	0.90	0.08	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	TSLP	0.03	0.01	blup	39	0.02	2.7e-03	9.38	-10.3	5.3e-25	-0.69	0.06	0.33	FALSE
13	METSIM	Adipose	CAMK4	0.05	0.01	bslmm	518	0.03	8.3e-05	-10.09	-9.6	7.7e-22	-0.61	0.04	0.88	FALSE
12	GTEx	Testis	WDR36	0.61	0.37	lasso	10	0.34	5.7e-16	7.18	8.8	9.0e-19	0.57	1.00	0.00	FALSE
7	GTEx	Liver	WDR36	0.32	-0.01	enet	19	0.03	5.4e-02	3.42	8.5	2.2e-17	0.64	0.06	0.34	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM232	0.09	0.03	blup	160	0.04	3.3e-05	-8.62	-8.2	1.8e-16	0.06	0.98	0.00	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM232	0.17	0.03	blup	162	0.06	1.9e-03	-7.64	-7.8	5.4e-15	0.09	0.12	0.19	FALSE
11	GTEx	Spleen	SLC25A46	0.25	0.00	enet	6	0.02	1.3e-01	-8.30	7.8	7.3e-15	0.01	0.07	0.05	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	WDR36	0.04	0.04	lasso	1	0.03	3.7e-03	7.10	7.1	1.2e-12	0.45	0.17	0.13	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	WDR36	0.17	0.09	lasso	6	0.08	2.6e-05	7.12	7.1	1.3e-12	0.44	0.66	0.25	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WDR36	0.05	0.03	enet	13	0.01	1.0e-02	2.49	6.9	4.6e-12	0.44	0.14	0.42	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM232	0.20	0.16	enet	17	0.24	2.3e-23	-7.30	-6.8	8.8e-12	0.10	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM232	0.08	0.06	blup	158	0.07	6.4e-07	-7.51	-6.8	1.5e-11	0.08	0.98	0.00	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	WDR36	0.08	0.02	blup	73	0.05	1.5e-05	-3.96	6.2	4.8e-10	0.44	0.28	0.33	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM232	0.08	0.05	lasso	4	0.05	1.6e-06	-3.17	-6.2	6.4e-10	0.10	0.92	0.00	FALSE
24	The Cancer Genome Atlas	Esophageal Carcinoma	TMEM232	0.17	0.16	lasso	2	0.13	7.5e-05	-6.25	-6.1	1.4e-09	0.09	0.68	0.02	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM232	0.07	0.12	lasso	2	0.12	4.7e-13	-6.25	-6.0	2.2e-09	0.10	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM232	0.07	0.03	blup	159	0.03	2.3e-02	-3.12	-5.9	3.6e-09	0.08	0.08	0.04	FALSE
8	GTEx	Nerve Tibial	SLC25A46	0.15	0.01	enet	18	0.07	1.2e-05	-8.32	5.9	3.8e-09	0.00	0.52	0.02	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM232	0.06	0.06	blup	161	0.08	3.7e-09	-7.47	-5.9	4.5e-09	0.11	1.00	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	STARD4-AS1	0.07	0.02	enet	19	0.03	5.0e-05	0.22	5.8	5.3e-09	0.39	0.06	0.81	FALSE
3	GTEx	Adipose Visceral Omentum	WDR36	0.11	0.08	lasso	4	0.10	8.7e-06	3.89	5.7	1.0e-08	0.39	0.81	0.05	FALSE
4	GTEx	Artery Tibial	WDR36	0.11	0.05	lasso	5	0.07	3.2e-06	3.89	5.6	2.3e-08	0.42	0.87	0.02	FALSE
6	GTEx	Brain Cerebellum	WDR36	0.26	0.22	lasso	4	0.27	1.5e-08	4.89	5.5	3.4e-08	0.30	0.40	0.11	FALSE
10	GTEx	Skin Sun Exposed Lower leg	WDR36	0.13	0.03	lasso	9	0.09	8.9e-08	7.12	5.4	6.2e-08	0.41	0.78	0.18	FALSE