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chr5:130,830,617-132,900,729

Best TWAS P=3.15e-17 · Best GWAS P=1.14e-18 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	7.9	-8.4	3.2e-17	0.18	0.64	0.36	TRUE
54	GTEx	Skin Sun Exposed Lower leg	KIF3A	0.11	0.04	lasso	4	0.04	6.2e-04	-6.5	6.8	1.1e-11	-0.09	0.63	0.03	TRUE
77	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	8.8	-6.7	1.6e-11	0.15	0.04	0.95	TRUE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	-6.0	6.5	9.1e-11	-0.13	0.10	0.35	TRUE
43	GTEx	Nerve Tibial	KIF3A	0.23	0.17	lasso	5	0.15	5.3e-11	-6.0	6.5	1.1e-10	-0.14	1.00	0.00	TRUE
39	GTEx	Muscle Skeletal	SLC22A5	0.10	0.01	lasso	3	0.02	6.6e-03	-2.1	-6.3	3.4e-10	0.49	0.08	0.69	TRUE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	-4.2	-5.2	1.5e-07	0.11	0.53	0.10	TRUE
67	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	8.3	-8.2	1.5e-16	0.27	0.41	0.59	FALSE
74	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	8.3	-8.2	1.6e-16	0.27	0.57	0.43	FALSE
23	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-7.1	-8.2	1.8e-16	0.19	0.94	0.06	FALSE
66	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-7.1	-8.2	2.7e-16	0.06	0.54	0.10	FALSE
60	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	7.2	8.0	1.3e-15	-0.20	0.67	0.30	FALSE
37	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	8.3	-8.0	1.7e-15	0.29	0.59	0.41	FALSE
68	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	7.8	-7.9	2.2e-15	0.11	0.80	0.17	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	8.4	7.8	4.7e-15	-0.29	0.01	0.81	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	-6.6	-7.8	6.1e-15	-0.13	0.09	0.12	FALSE
56	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	7.9	-7.8	7.1e-15	0.28	0.68	0.32	FALSE
57	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	8.3	7.7	1.2e-14	-0.27	0.16	0.58	FALSE
53	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	7.2	-7.7	1.4e-14	0.24	0.78	0.22	FALSE
30	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	8.3	-7.7	1.6e-14	0.25	0.60	0.40	FALSE
75	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	-6.2	7.6	2.2e-14	0.11	0.92	0.08	FALSE
87	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-7.1	-7.6	3.6e-14	0.21	0.03	0.91	FALSE
63	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	5.5	-7.5	4.8e-14	0.30	0.27	0.41	FALSE
92	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-7.1	-7.5	5.0e-14	0.08	0.12	0.44	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	8.3	-7.5	5.8e-14	0.22	0.31	0.38	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-7.6	-7.4	1.5e-13	0.11	0.16	0.05	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	8.3	-7.4	1.6e-13	0.24	0.48	0.16	FALSE
81	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	8.3	-7.3	2.2e-13	0.21	0.40	0.60	FALSE
46	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-4.5	7.3	2.7e-13	-0.28	0.38	0.15	FALSE
14	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	6.9	7.2	4.5e-13	-0.25	0.95	0.05	FALSE
64	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-3.4	-7.2	5.4e-13	0.16	0.79	0.18	FALSE
7	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	7.2	7.2	6.1e-13	-0.20	0.94	0.03	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-7.1	-7.2	8.7e-13	0.16	0.02	0.58	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-6.1	7.1	1.2e-12	0.01	0.72	0.19	FALSE
11	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	6.9	7.1	1.3e-12	-0.24	0.98	0.02	FALSE
10	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	7.1	7.1	1.5e-12	-0.23	0.44	0.11	FALSE
32	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	7.2	7.1	1.7e-12	-0.25	0.87	0.08	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	7.9	-7.0	3.2e-12	0.20	0.37	0.43	FALSE
25	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	8.3	-7.0	3.2e-12	0.21	0.40	0.30	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-5.3	-7.0	3.7e-12	0.24	0.08	0.92	FALSE
41	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-5.5	6.9	4.2e-12	-0.20	0.23	0.06	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	6.9	6.9	4.5e-12	-0.21	0.00	1.00	FALSE
12	GTEx	Artery Tibial	KIF3A	0.11	0.08	lasso	5	0.09	3.2e-07	-6.4	6.9	6.8e-12	-0.12	0.98	0.00	FALSE
69	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-6.2	6.8	1.4e-11	0.02	0.34	0.40	FALSE
8	GTEx	Artery Aorta	KIF3A	0.13	0.07	enet	7	0.07	6.3e-05	-6.0	6.7	1.6e-11	-0.14	0.92	0.01	FALSE
58	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-7.2	-6.7	2.0e-11	0.25	0.16	0.08	FALSE
65	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	6.9	6.7	2.4e-11	-0.14	0.55	0.27	FALSE
2	GTEx	Adipose Subcutaneous	KIF3A	0.08	0.07	lasso	3	0.07	1.2e-06	-6.5	6.7	2.6e-11	-0.07	0.95	0.00	FALSE
22	GTEx	Cells Transformed fibroblasts	SEPT8	0.15	0.12	lasso	4	0.11	6.9e-09	-6.3	6.6	3.5e-11	-0.07	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	8.3	-6.6	3.9e-11	0.33	0.01	0.99	FALSE
29	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	7.2	6.6	4.2e-11	-0.26	0.97	0.03	FALSE
55	GTEx	Skin Sun Exposed Lower leg	SEPT8	0.46	0.35	lasso	6	0.33	3.2e-28	-6.3	-6.5	5.8e-11	0.05	1.00	0.00	FALSE
21	GTEx	Cells Transformed fibroblasts	KIF3A	0.15	0.16	enet	7	0.15	2.6e-11	-6.0	6.5	6.4e-11	-0.12	1.00	0.00	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	SEPT8	0.15	0.17	lasso	2	0.17	1.4e-09	-6.0	-6.5	6.7e-11	0.13	0.99	0.00	FALSE
16	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-5.6	6.5	7.2e-11	-0.29	0.49	0.09	FALSE
80	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-5.4	-6.5	9.4e-11	0.38	1.00	0.00	FALSE
62	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	6.9	6.4	1.2e-10	-0.20	0.57	0.29	FALSE
33	GTEx	Esophagus Muscularis	KIF3A	0.31	0.17	lasso	5	0.20	2.2e-12	-6.0	6.4	1.4e-10	-0.12	1.00	0.00	FALSE
73	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	4.9	-6.4	1.5e-10	0.09	0.91	0.05	FALSE
70	METSIM	Adipose	KIF3A	0.08	0.08	lasso	15	0.07	4.0e-11	-5.7	6.3	2.8e-10	-0.09	1.00	0.00	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-5.3	-6.3	2.9e-10	0.31	0.20	0.80	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-5.3	-6.3	3.1e-10	0.33	0.88	0.10	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	6.9	6.3	3.9e-10	-0.21	0.01	0.99	FALSE
45	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	5.5	6.2	5.3e-10	-0.23	0.94	0.04	FALSE
71	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	6.9	6.1	1.1e-09	-0.25	1.00	0.00	FALSE
26	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-5.6	6.0	1.8e-09	-0.28	0.95	0.00	FALSE
93	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-4.0	-6.0	2.5e-09	0.20	0.03	0.84	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-4.8	-5.9	4.3e-09	0.24	1.00	0.00	FALSE
94	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-4.8	-5.8	5.4e-09	0.31	0.16	0.84	FALSE
40	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-5.2	5.8	7.1e-09	-0.29	1.00	0.00	FALSE
95	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	-7.1	-5.8	7.5e-09	0.03	0.09	0.68	FALSE
38	GTEx	Lung	AC004041.2	0.13	0.08	lasso	9	0.08	8.8e-07	-6.2	-5.8	7.7e-09	-0.10	0.96	0.01	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-5.1	-5.7	1.1e-08	0.09	0.15	0.72	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-5.1	-5.7	1.1e-08	0.16	1.00	0.00	FALSE
48	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-5.6	5.7	1.2e-08	-0.31	0.95	0.04	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-5.5	-5.7	1.3e-08	0.16	1.00	0.00	FALSE
42	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-5.3	5.7	1.6e-08	-0.30	1.00	0.00	FALSE
99	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-5.8	-5.7	1.6e-08	0.07	0.09	0.11	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-5.5	-5.6	2.0e-08	0.14	1.00	0.00	FALSE
72	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	5.4	-5.5	2.9e-08	0.22	0.90	0.03	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-5.4	-5.5	3.0e-08	0.14	1.00	0.00	FALSE
34	GTEx	Heart Atrial Appendage	KIF3A	0.11	0.00	enet	18	0.01	1.8e-01	-5.1	5.5	3.2e-08	-0.25	0.13	0.09	FALSE
15	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-5.2	5.5	3.3e-08	-0.31	1.00	0.00	FALSE
44	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-5.3	5.5	4.0e-08	-0.30	1.00	0.00	FALSE
20	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-5.5	-5.5	4.1e-08	0.14	0.85	0.01	FALSE
59	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-4.8	5.5	4.4e-08	-0.25	1.00	0.00	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-5.3	5.5	4.5e-08	-0.30	0.90	0.04	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-4.7	5.5	4.5e-08	-0.21	0.64	0.05	FALSE
9	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-5.6	5.4	7.2e-08	-0.30	0.56	0.15	FALSE
24	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-5.6	5.4	8.0e-08	-0.38	0.25	0.14	FALSE
4	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-5.4	5.3	8.7e-08	-0.31	1.00	0.00	FALSE
76	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	4.9	-5.3	8.8e-08	0.06	0.75	0.12	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-5.3	-5.3	9.1e-08	0.31	0.31	0.36	FALSE
36	GTEx	Lung	RAD50	0.12	0.09	lasso	11	0.08	1.3e-06	-6.2	-5.3	9.3e-08	-0.15	0.91	0.03	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-4.6	-5.3	1.0e-07	0.02	0.96	0.00	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-5.7	-5.3	1.2e-07	0.26	0.82	0.04	FALSE
6	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-5.3	5.3	1.4e-07	-0.31	0.71	0.07	FALSE
5	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-5.2	5.2	1.9e-07	-0.31	0.59	0.04	FALSE
31	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-5.6	5.2	1.9e-07	-0.31	0.98	0.00	FALSE
61	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-5.2	5.2	2.0e-07	-0.31	0.90	0.01	FALSE
18	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	8.3	-5.2	2.1e-07	0.32	0.38	0.47	FALSE
35	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	-5.6	5.2	2.1e-07	-0.31	1.00	0.00	FALSE
47	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-4.7	5.2	2.3e-07	-0.28	0.71	0.02	FALSE