Hub : Genes

IL6R

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.2190	0.0820	5.0e-03	0.084	NA	0.035	NA	0.047	6.8e-04	NA	2.2e-02	NA	9.2e-03
2	GTEx	Colon Transverse	0.1760	0.0640	2.6e-03	0.065	NA	0.026	NA	0.059	5.0e-04	NA	2.0e-02	NA	9.2e-04
3	GTEx	Esophagus Muscularis	0.0990	0.0410	3.4e-03	-0.004	NA	-0.003	NA	-0.004	8.6e-01	NA	5.3e-01	NA	7.0e-01
4	GTEx	Testis	0.4950	0.0860	3.5e-07	0.059	NA	0.222	NA	0.183	1.4e-03	NA	3.2e-10	NA	1.5e-08
5	YFS	Blood	0.0363	0.0104	1.9e-07	0.037	0.027	0.034	0.033	0.036	4.0e-12	1.9e-09	1.8e-11	6.4e-11	5.2e-12
6	TCGA	Skin Cutaneous Melanoma	0.1200	0.0550	1.1e-03	0.038	0.114	0.055	NA	0.088	3.4e-02	6.0e-04	1.4e-02	NA	2.4e-03
7	TCGA	Stomach Adenocarcinoma	0.0430	0.0250	5.7e-03	0.004	0.019	0.003	NA	0.008	1.6e-01	1.5e-02	1.8e-01	NA	7.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.2	2.6	-0.9	-1.6	0.5	-1.1	-1.5	0.9	-0.8
Bipolar Disorder or Schizophrenia	0.9	2.2	4.8	-1.4	-2.2	-1.6	-0.7	-2.2	0.6	0.3
Depressed Affect (Nagel 2018)	0.4	0.9	1.4	1.2	1.0	0.6	-1.2	1.1	-0.7	-0.2
Depression (Nagel 2018)	1.2	1.9	2.6	1.5	1.5	0.3	1.3	1.4	-1.6	1.4
Intelligence (Savage-Jansen 2018)	1.2	3.6	6.2	-1.6	-2.1	1.6	-2.5	-1.9	1.8	-1.7
Neuroticism (Nagel 2018)	1.8	4.2	8.3	2.9	2.4	0.7	-0.4	2.4	-2.7	1.3
Schizophrenia (2018)	0.9	1.8	5.6	-1.1	-1.5	-2.4	0.0	-1.6	0.1	1.0
Schizophrenia vs Biploar Disorder	2.4	3.1	8.8	-1.8	-1.9	-3.0	-0.2	-1.7	1.6	-0.8
Worry (Nagel 2018)	3.3	7.0	13.7	2.8	2.9	0.1	0.8	2.3	-3.7	3.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.7	-1.2	-1.6	-1.3	-0.3	-1.3	0.6	-0.5
Alzheimer’s Disease (in father)	1.5	1.6	6.3	-0.5	-1.4	-2.5	-0.3	-0.8	0.9	-1.0
Alzheimer’s Disease (including proxy)	1.3	1.9	5.4	-1.3	-1.9	-2.3	-0.1	-1.4	0.8	-0.6
Crohns Disease (2017)	2.9	6.4	10.2	2.5	3.1	3.0	0.6	3.2	-3.0	0.5
Irritable Bowel Disease (IBD)	0.7	1.7	3.8	1.0	1.6	1.1	0.3	1.8	-1.9	-0.3
Ulcerative Colitis (UC)	0.2	0.4	1.3	0.3	0.5	-0.6	-0.2	0.7	-1.1	-0.4
Major Depression (MDD)	3.8	4.6	18.0	-1.7	-2.0	-4.2	0.5	-2.2	1.4	0.1
Reaction Time	0.2	0.4	1.1	0.6	0.2	1.1	0.4	0.4	-0.5	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	-0.4	-0.5	1.2	-0.9	-0.5	0.1	-0.7
Breast Cancer	0.5	1.1	3.2	-1.0	-1.0	-0.1	-0.7	-0.7	1.8	-1.3
Ovarian Cancer	0.2	0.2	0.5	0.3	0.7	0.1	-0.3	0.4	-0.6	0.5
Prostate Cancer	3.8	5.4	21.3	-1.1	-2.1	-4.6	-2.0	-1.8	1.2	-1.5
Age at First Birth	1.4	2.0	13.8	0.1	-0.1	3.7	-0.4	-0.0	0.3	-0.3
Bipolar Disorder (2011)	2.1	2.0	5.6	1.4	1.1	2.4	-0.2	1.4	-1.8	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.8	-1.1	-0.3	-1.7	0.7	-0.7	0.4	0.9
Coronary Artery Disease (CAD)	6.2	7.3	12.3	2.6	3.5	1.7	1.9	2.4	-3.1	3.2
Crohns Disease (2012)	2.6	4.2	7.5	1.7	2.1	2.5	-1.6	2.5	-2.7	-0.1
Mean Putamen Volume	0.6	0.7	1.7	0.0	-0.4	1.3	-1.1	-0.3	0.6	-1.3
Fasting Glucose	1.0	1.2	2.8	0.8	1.7	-1.0	1.2	1.1	-0.5	0.9
HbA1C	1.1	1.2	4.0	1.1	1.0	2.0	-0.0	0.8	-0.9	0.7
HDL Cholesterol	0.2	0.3	1.0	-0.1	-0.2	1.0	1.0	-0.1	0.2	0.2
LDL Cholesterol	0.4	0.6	2.6	-0.0	-0.5	-1.6	-0.4	-0.3	-0.2	1.1
Lupus	1.1	1.7	3.4	-1.6	-1.6	0.4	0.4	-1.7	1.9	0.2
Neuroticism (2016)	3.5	5.0	7.0	2.6	2.5	1.3	2.2	2.6	-2.5	1.5
Primary Biliary Cirrhosis	0.8	1.1	6.4	0.3	0.1	2.5	-0.8	0.2	-0.7	-0.3
Rheumatoid Arthritis	2.5	3.5	6.1	2.1	1.3	2.3	-1.2	2.5	-1.4	-1.9
Schizophrenia (2014)	1.3	2.8	5.6	-1.6	-2.2	-2.4	0.0	-2.2	0.7	0.9
Triglycerides	0.8	1.3	5.7	-0.1	0.3	-2.4	1.6	-0.4	0.5	0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.3	1.2	1.4	1.4	-0.4	1.5	-0.8	-0.1
Ulcerative Colitis	0.3	0.4	1.3	-0.9	-0.4	-1.2	0.0	-0.8	0.2	0.2
Blood Eosinophil Count	0.1	0.8	2.0	1.4	0.4	-0.6	-0.7	0.5	-1.0	1.1
Blood Platelet Count	2.9	33.7	60.8	-5.6	-7.2	-7.8	-4.8	-6.8	4.7	-0.8
Blood Red Count	0.4	3.8	7.2	2.6	2.0	0.9	1.0	2.5	-2.7	0.9
Blood White Count	0.1	0.8	2.4	0.2	0.0	-1.0	-0.7	0.8	-1.6	-1.0
Heel T-Score	0.0	0.4	1.1	-1.1	-0.1	0.5	0.5	-0.4	-0.1	0.9
BMI	0.5	2.8	5.4	-2.0	-1.8	-0.8	-0.1	-1.3	2.3	-2.2
Height	0.1	2.4	9.8	0.4	-1.1	-1.4	-1.9	0.1	0.1	-3.1
Waist Hip Ratio (WHR)	1.0	4.7	7.6	2.1	1.8	2.8	-1.6	2.5	-2.7	-1.3
Systolic Blood Pressure	0.4	2.2	6.7	-0.9	0.3	1.4	2.1	-1.2	0.3	2.6
Smoking Status	1.7	4.1	7.7	2.5	1.4	-0.6	0.9	2.8	-2.7	-2.1
Allergy or Eczema	11.2	29.5	49.6	-6.2	-6.5	-6.9	1.0	-7.0	5.3	-0.2
Cardiovascular Disease	1.3	4.1	16.7	0.5	1.9	1.8	4.1	0.4	-0.1	2.2
Hypothyroidism (self reported)	2.5	5.7	9.0	2.2	3.0	2.0	2.2	2.8	-2.4	1.8
Respiratory disease	5.7	12.8	24.3	-4.1	-4.9	-3.5	0.3	-4.9	3.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.3	0.1	0.7	0.4	-1.1	1.0	-0.7	-1.5
Lung FEV1/FVC ratio	1.4	6.9	17.2	1.4	3.4	1.4	3.5	1.4	-1.1	4.2
Lung FVC	0.3	1.4	3.2	-1.0	-0.9	0.2	-1.0	-0.8	1.8	-1.7
Neuroticism	1.4	3.3	7.0	2.2	2.0	0.7	-0.7	1.8	-2.6	1.6
Chronotype (morning person)	0.3	0.7	2.2	0.1	0.6	-1.1	1.2	-0.2	0.0	1.5
Hair Pigment	0.1	1.9	4.8	1.0	1.3	-0.3	1.3	1.1	-1.6	2.2
Tanning	0.1	1.2	2.0	-1.1	-1.2	-1.4	-0.7	-0.9	0.8	-1.2
Hand grip strength (left)	0.6	1.6	5.6	-0.7	-1.2	-1.1	-1.4	-0.4	0.3	-2.4
Number of treatments/medications taken	0.4	0.8	4.9	-0.4	0.2	-0.4	2.2	-0.2	0.3	0.4
Average weekly spirits intake	2.9	3.6	6.6	-2.6	-2.0	-0.5	1.3	-2.4	2.4	-1.1
Sensitivity / hurt feelings	0.5	0.8	2.3	1.0	0.5	-0.4	0.7	0.6	-0.9	1.5
Frequency of depressed mood in last 2 weeks	1.3	1.9	4.5	1.2	1.4	-0.4	2.1	1.0	-1.4	1.5
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.1	0.2	-0.9	0.9	0.1	-0.5	0.4
Relative age of first facial hair	0.4	0.8	3.6	0.8	0.6	1.9	0.6	0.5	0.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.7	-0.6	-0.9	-0.4	-0.5	0.7	-0.6
Ever used hormone-replacement therapy (HRT)	1.6	2.0	6.9	0.6	1.6	1.3	2.6	0.7	-0.4	1.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.1	-0.4	-0.6	0.1	0.2	-0.1	-0.2
Systolic blood pressure, automated reading	0.7	2.1	4.5	-2.1	-1.4	0.1	0.9	-2.1	1.5	1.0
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.0	1.1	1.7	1.0	-0.4	1.0	-1.1	1.4
Angina	3.8	5.0	8.8	2.5	3.0	2.6	1.8	2.6	-1.4	1.3
Medication for hormone replacement therapy	0.4	0.4	1.0	-0.1	-0.3	-0.8	0.9	0.2	-1.0	0.4
Vitamin and mineral supplements	1.5	2.0	4.0	1.6	1.7	0.7	0.1	1.8	-2.0	0.7
Supplements: Zinc	0.8	0.8	1.3	-0.8	-1.1	-1.0	-1.1	-0.7	0.5	-0.9
Medication: Co-codamol	0.4	0.5	1.2	-0.4	-0.3	-1.1	1.0	-0.6	0.7	0.2
Medication: Metformin	0.8	1.2	2.4	0.7	1.4	1.2	-0.5	1.3	-1.6	-0.1
Diabetes (father)	0.3	0.4	1.5	-0.6	-0.1	1.2	-0.5	-0.2	0.6	-0.6
Diabetes (mother)	0.5	0.6	3.2	0.6	0.4	1.8	-0.0	0.7	-0.5	-0.3
Severe depression (siblings)	0.4	0.4	1.5	-0.1	-0.8	-1.2	-0.5	-0.1	-0.6	-0.1
Pack years adult smoking proportion	1.5	2.4	9.6	-0.1	-1.0	1.1	-1.7	0.6	-1.2	-3.1
Impedance of leg (right)	0.3	1.6	5.3	0.5	0.3	-1.3	2.3	-0.2	-0.8	1.8
Leg fat-free mass (left)	0.4	2.3	7.3	-0.5	-1.1	-0.4	-2.4	-0.2	1.1	-2.7
Trunk fat percentage	0.9	3.8	5.6	-2.4	-2.3	-2.1	-0.3	-2.0	2.2	-1.6
Hand grip strength (right)	0.3	0.7	2.2	-0.9	-1.1	-0.5	-0.6	-0.5	0.2	-1.5
Townsend deprivation index at recruitment	1.2	1.7	4.9	-1.1	-0.6	-1.8	2.2	-1.1	0.7	0.5
Current tobacco smoking	1.3	2.2	4.9	1.5	0.9	0.3	-0.5	2.0	-2.2	-1.7
Average weekly fortified wine intake	0.3	0.4	0.9	0.8	0.9	0.2	0.8	0.6	-0.4	0.3
Maternal smoking around birth	1.9	2.8	4.5	1.9	2.0	0.3	1.3	2.1	-2.0	1.3
Fed-up feelings	0.7	1.3	3.8	1.0	0.8	0.7	-1.9	1.2	-0.7	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	2.5	1.4	1.0	0.2	1.1	1.4	-1.6	0.6
Relative age voice broke	0.9	1.4	4.2	1.1	1.3	2.0	0.6	0.5	-0.2	1.6
Taking other prescription medications	0.7	1.1	5.7	-0.1	0.4	-0.3	2.4	-0.0	-0.1	1.2
Age when periods started (menarche)	1.7	4.2	7.8	1.4	2.6	2.8	2.5	1.2	-0.8	2.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.7	0.1	-0.0	-0.8	-0.0	0.3	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	0.8	1.1	-0.1	1.2	0.7	-0.2	1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.2	0.0	0.2	0.4	1.5	-0.3	1.0	-0.2
Qualifications: CSEs or equivalent	1.4	1.8	3.7	-1.9	-1.1	-1.2	0.9	-1.8	1.4	0.3
Serious illness, injury or assault to yourself	0.7	0.9	1.3	1.2	1.1	1.1	-0.1	1.0	-1.0	0.6
High blood pressure	0.6	1.6	5.2	0.0	0.8	2.3	2.0	-0.1	0.4	1.2
Hayfever, allergic rhinitis or eczema	12.8	27.8	46.5	-5.8	-6.4	-6.8	0.1	-6.8	5.1	-1.0
Multivitamins +/- minerals	1.9	2.4	5.2	-1.8	-1.6	-1.0	0.8	-2.1	2.3	0.3
Stomach or abdominal pain in last month	0.7	0.9	4.2	-0.1	-0.1	-2.0	1.2	-0.5	0.1	0.2
Supplements: Glucosamine	0.3	0.4	1.1	-0.5	-0.5	0.1	-1.1	-0.5	0.8	-0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.4	0.7	1.1	-0.5	-0.1	1.1	-2.1	0.6
Medication: Atenolol	0.5	0.6	2.2	0.2	0.7	0.9	1.5	0.3	0.3	0.4
Medication: Levothyroxine sodium	1.7	2.8	5.8	1.6	1.9	2.4	1.2	2.0	-1.4	0.8
Sitting height	0.2	1.1	2.4	1.6	0.6	0.6	-0.2	1.4	-1.0	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	-0.2	-1.0	-0.9	-0.3	-0.4	0.8	-0.9
High blood pressure (mother)	2.1	3.0	5.8	2.2	2.4	1.7	0.7	1.7	-1.3	1.6
Body mass index (BMI)	0.4	1.8	5.9	-1.1	-1.1	-0.2	-1.1	-0.5	1.6	-2.4
Impedance of leg (left)	0.3	1.6	5.2	0.0	-0.1	-1.7	2.3	-0.6	-0.5	1.6
Leg predicted mass (left)	0.5	2.4	7.6	-0.5	-1.1	-0.3	-2.5	-0.2	1.1	-2.8
Trunk fat mass	0.8	3.6	6.1	-2.0	-2.2	-1.8	-0.9	-1.5	1.9	-2.5
Waist circumference	1.3	4.7	17.1	-1.0	-1.6	-0.0	-3.3	-0.2	1.1	-4.1
Number of incorrect matches in round	0.2	0.4	2.2	-0.2	-0.2	-0.5	1.5	-0.3	0.0	0.3
Past tobacco smoking	0.5	0.9	3.2	-0.1	0.2	1.3	-1.8	-0.3	0.4	1.2
Alcohol usually taken with meals	0.7	1.1	2.9	1.0	1.0	1.7	-0.6	0.9	-1.2	0.6
Nervous feelings	1.6	3.1	7.2	1.8	1.7	-0.5	-0.5	1.7	-2.7	2.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	0.9	0.5	-0.3	1.0	0.8	-1.0	0.0
Hearing difficulty/problems with background noise	0.2	0.3	1.6	-0.1	-0.2	-1.3	0.5	-0.3	-0.2	-0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.7	0.1	0.9	-0.0	1.3	0.1	0.3	0.7
Had menopause	0.2	0.3	1.0	-0.4	-0.5	1.0	-0.2	-0.2	0.4	-0.5
Had other major operations	0.2	0.2	1.0	-0.1	0.3	1.0	0.2	0.2	-0.4	0.3
Forced vital capacity (FVC)	0.2	0.9	2.4	0.9	0.2	-1.3	-0.7	0.7	0.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.5	-0.0	-0.7	0.0	-0.5	0.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.5	0.0	-0.4	-1.2	0.4	-0.5	-0.1	0.3
Qualifications: None of the above	1.4	3.0	9.7	0.4	1.7	-1.1	2.3	0.5	-1.1	3.1
Financial difficulties in last 2 years	0.4	0.5	1.6	-0.0	0.3	-0.6	1.3	-0.2	1.0	0.9
Mouth/teeth dental problems	0.9	1.4	7.7	-0.2	-0.4	-2.8	0.9	-0.6	-0.2	0.6
Heart attack	1.4	1.8	4.1	1.2	2.0	1.0	0.8	1.1	-0.4	2.0
Allergy	12.7	29.2	51.4	5.9	6.5	7.2	-0.5	7.1	-5.0	0.3
Pain all over the body in last month	0.5	0.6	1.6	-0.7	-0.1	-0.8	1.3	-0.8	0.6	0.5
Diabetes (self-reported)	1.1	1.7	5.2	0.1	0.6	1.1	-1.9	1.0	-0.9	-2.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.9	0.2	-0.6	-0.9	0.3	-0.1	0.0	-0.5
Medication: Ramipril	0.4	0.5	2.3	-0.0	0.7	-0.2	1.5	0.3	-0.6	0.5
Medication: Simvastatin	0.2	0.4	1.4	0.4	0.7	-1.2	0.5	0.4	-0.1	-0.2
Fluid intelligence score	0.3	0.7	2.7	-0.4	-0.7	1.6	0.3	-0.6	0.5	-0.9
Illnesses of siblings	0.9	1.3	3.8	-0.3	-0.6	-1.9	-2.0	-0.6	0.9	-0.1
Neuroticism score	1.7	3.6	8.0	2.3	2.0	1.1	-0.4	2.1	-2.8	1.4
Weight	0.6	2.9	11.1	-0.9	-1.4	-0.8	-2.0	-0.3	1.4	-3.3
Impedance of arm (right)	0.5	2.2	5.4	-0.8	-0.9	-2.2	0.7	-1.4	-1.0	2.3
Arm fat percentage (right)	0.5	2.1	5.6	-1.4	-1.7	-0.9	-0.9	-1.0	1.4	-2.4
Trunk fat-free mass	0.6	3.2	12.0	0.9	-0.1	0.9	-2.6	1.3	-0.2	-3.5
Hip circumference	0.7	3.2	9.2	-1.1	-1.6	-1.9	-1.9	-0.5	1.6	-3.0
Time employed in main current job	0.3	0.3	1.1	0.5	0.2	0.2	0.8	0.2	-0.1	1.0
Alcohol intake versus 10 years previously	0.5	0.7	2.9	-0.8	-0.1	-1.7	0.3	-0.8	0.6	0.2
Father’s age at death	5.4	7.3	13.8	-2.0	-3.2	-2.2	-3.7	-2.2	2.1	-3.0
Worrier / anxious feelings	1.5	2.8	5.3	1.8	2.0	0.7	1.0	1.2	-2.1	2.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.9	0.7	-0.9	-0.2	0.9	-0.6	-0.6
Falls in the last year	0.6	0.8	3.3	-0.1	-0.5	1.8	-1.1	-0.0	0.3	-1.0
Hair/balding pattern: Pattern 3	1.0	1.6	5.9	0.2	-1.0	1.4	-1.4	0.1	0.4	-2.4
Number of live births	1.1	1.6	4.9	-0.8	0.2	-2.2	0.3	-1.1	1.0	1.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.1	1.4	1.4	-0.8	0.5	1.2	-0.3	0.1
Pulse rate	0.3	0.5	1.7	0.6	0.1	0.5	-0.9	0.5	-1.3	-0.4
Happiness	1.6	2.0	3.4	1.9	1.1	1.8	-1.4	1.3	-1.6	0.2
Noisy workplace	1.8	2.2	5.0	-1.8	-1.0	-2.2	1.1	-1.8	1.2	0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.5	-0.0	-1.1	0.7	-1.9	-0.7	1.0	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	5.4	1.7	1.1	2.3	-0.0	1.6	-1.1	-0.5
Mouth/teeth dental problems: Dentures	0.8	1.4	8.2	-0.2	0.7	2.9	-0.6	0.6	-0.1	-0.7
Asthma	3.4	6.7	13.0	-3.0	-3.3	-3.2	0.5	-3.6	1.9	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.6	-0.0	0.2	-0.2	-0.2	-0.2	0.4	-0.7
Medication: Cholesterol lowering	0.4	0.7	1.4	0.8	1.2	0.3	0.8	1.2	-0.6	0.1
Depression (self-reported)	0.2	0.2	0.6	0.1	-0.1	0.8	0.1	-0.3	0.6	-0.6
Medication: Lansoprazole	0.6	0.7	2.0	-0.3	1.0	0.8	1.4	0.2	0.3	1.0
Prospective memory result	0.4	0.5	2.2	-0.1	0.4	-1.5	0.4	-0.0	-0.2	1.0
Lung cancer (father)	0.3	0.4	1.6	-0.3	-0.7	-0.5	0.5	-0.1	0.2	-1.3
Illnesses of mother	3.8	4.6	9.1	-2.5	-2.1	-3.0	-0.0	-2.5	2.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.5	0.5	0.5	-1.6	0.9	0.2	0.4	0.8
Pulse wave Arterial Stiffness index	2.8	3.3	4.9	1.8	2.2	1.7	2.1	1.9	-1.2	1.5
Impedance of arm (left)	0.6	2.6	9.3	-0.8	-0.4	-2.0	1.3	-1.3	-1.0	3.0
Arm fat mass (right)	0.5	2.2	6.7	-1.1	-1.5	-0.9	-1.3	-0.7	1.4	-2.6
Trunk predicted mass	0.6	3.3	12.4	0.9	-0.2	0.9	-2.7	1.3	-0.2	-3.5
Standing height	0.2	1.6	4.2	0.2	-1.1	-1.4	-2.0	0.0	-0.4	-1.9
Length of working week for main job	0.4	0.4	1.5	0.3	0.1	0.4	-1.2	0.6	-0.6	-0.6
Exposure to tobacco smoke at home	1.0	1.2	2.4	-0.8	-1.4	-1.5	1.5	-0.8	0.6	-0.1
Breastfed as a baby	1.2	1.5	4.3	-0.6	-0.5	2.1	-1.3	-0.3	0.8	-1.8
Tense / ‘highly strung’	0.2	0.3	1.3	0.4	-0.2	-0.5	-0.4	-0.2	-0.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.0	0.9	0.7	1.0	1.4	0.3	-0.7	1.2
Hair/balding pattern: Pattern 4	0.5	1.2	6.8	0.1	0.2	2.6	-1.0	0.4	0.3	-0.8
Birth weight of first child	2.3	4.2	15.2	-1.1	-1.8	-0.7	-2.6	-0.5	1.4	-3.9
Peak expiratory flow (PEF)	1.5	3.6	6.3	2.1	2.5	-0.8	2.0	1.9	-1.7	1.8
Pulse wave reflection index	1.3	1.7	2.7	1.2	1.6	1.3	1.6	1.4	-0.7	0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-0.5	-0.1	-0.9	0.7	-0.8	1.2	-0.7
Loud music exposure frequency	1.5	1.7	2.5	1.4	1.3	-1.2	1.3	1.1	-1.2	1.6
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.7	1.9	0.3	0.7	-0.1	1.1	-0.8	-1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.1	0.2	-0.1	1.1	0.0	0.5	0.3	-0.3
Blood clot in the leg (DVT)	1.1	1.4	2.8	-0.8	-0.4	-1.1	1.0	-1.4	1.3	1.7
Medication: Paracetamol	0.8	1.3	3.6	-0.7	-0.1	-1.9	1.4	-1.1	1.3	0.6
Headache pain in last month	0.4	0.7	4.3	0.6	0.4	-2.1	0.2	0.0	-0.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.9	0.3	-0.0	-1.4	-0.1	-0.2	0.2	0.0
Glaucoma (self-reported)	2.0	2.4	5.2	-1.1	-1.3	0.7	-2.2	-1.3	1.3	-2.3
Gout (self-reported)	2.2	3.0	6.2	-2.5	-2.5	-1.6	-1.0	-1.7	1.0	-1.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.1	1.5	1.7	1.7	1.3	2.0	-1.3	0.4
Medication: Amlodipine	0.2	0.3	1.1	0.2	0.6	1.0	0.2	0.5	-0.4	0.5
Medication: Ventolin 100micrograms inhaler	1.7	2.1	7.9	-0.9	-1.3	-2.8	1.7	-1.2	0.4	0.3
Birth weight	1.5	3.2	11.8	0.7	-0.1	1.9	-2.1	1.3	-0.2	-3.4
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.8	-1.4	-1.7	-1.7	-0.1	-1.3	0.7	-0.5
High blood pressure (siblings)	0.6	0.9	2.7	-0.7	-0.7	0.8	1.6	-1.0	0.9	0.4
Forced vital capacity (FVC), Best measure	0.2	0.7	2.9	-0.1	-0.7	-1.7	-0.4	-0.3	0.8	-0.8
Body fat percentage	0.9	3.4	4.7	-2.2	-2.1	-1.7	-0.2	-1.7	2.2	-2.1
Leg fat percentage (right)	0.5	1.8	5.2	-1.2	-1.3	-0.9	0.1	-0.7	1.8	-2.3
Arm fat-free mass (right)	0.4	1.9	8.8	0.1	-0.4	0.3	-1.7	0.5	0.9	-3.0
Exposure to tobacco smoke outside home	0.9	1.2	3.5	0.2	-1.0	-1.7	-0.7	0.3	-0.4	-1.9
Comparative body size at age 10	0.8	2.1	5.0	0.1	-0.4	2.2	-2.2	0.2	0.7	-2.1
Number of full brothers	0.6	0.8	1.5	0.9	1.2	0.0	0.1	1.2	-1.2	0.4
Worry too long after embarrassment	2.5	4.2	7.9	2.8	2.0	1.8	-0.6	2.5	-2.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.2	0.2	0.3	0.9	0.0	-0.7	0.8
Wheeze or whistling in the chest in last year	2.5	4.5	10.0	-2.4	-3.2	-2.5	0.1	-2.8	1.2	-0.2
Number of children fathered	0.2	0.2	0.6	-0.7	0.3	-0.5	-0.1	-0.2	0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-1.0	-1.1	-0.2	0.1	-1.2	0.3	1.0
Age at first live birth	1.0	1.7	7.7	-0.1	-0.4	2.8	-1.9	-0.4	0.1	0.8
Pulse wave peak to peak time	3.2	3.7	5.5	-1.9	-2.4	-2.0	-2.1	-2.0	1.2	-1.8
Health satisfaction	0.1	0.1	0.3	-0.3	-0.1	-0.1	-0.4	-0.3	0.3	-0.5
Shortness of breath walking on level ground	0.4	0.5	1.6	0.5	0.5	0.6	-1.3	0.8	-0.0	-0.5
Qualifications: College or University degree	0.6	2.0	5.7	1.6	0.8	2.4	-1.8	1.0	-1.0	0.0
Eye problems/disorders: None of the above	1.3	1.5	2.4	1.5	1.3	1.0	1.4	1.1	-0.7	1.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	3.1	-0.0	0.3	-0.3	1.8	0.2	-0.4	0.4
Emphysema/chronic bronchitis	2.1	2.4	5.2	-1.5	-2.3	-1.1	-0.8	-1.6	1.2	-1.9
Medication for pain relief, constipation, heartburn	0.2	0.4	1.2	-0.4	-1.0	-0.1	-1.1	-0.2	-0.2	-0.4
Neck or shoulder pain in last month	0.6	0.8	2.6	0.2	0.5	-1.5	1.6	0.0	0.3	0.7
Medication: Blood pressure	0.5	0.9	3.8	-0.4	-0.7	1.9	-1.2	-0.2	0.3	-0.6
Angina (self-reported)	4.2	5.5	9.9	2.6	3.1	2.6	1.6	2.8	-1.6	1.5
Migraine (self-reported)	0.7	0.9	2.6	0.8	0.4	-1.6	-0.2	0.8	0.0	-1.4
Medication: Ibuprofen	1.3	1.6	3.5	-1.1	-1.1	-1.3	-0.5	-1.1	1.5	-1.9
Medication: Allopurinol	0.5	0.6	2.0	-1.4	-0.9	-1.2	-0.3	-0.5	-0.1	-0.1
Medication: Omeprazole	0.2	0.3	1.1	0.1	-0.0	-1.1	0.5	-0.1	0.0	0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.2	-0.5	0.5	0.7	-0.1	-0.4	-0.1
Mean time to correctly identify matches	0.2	0.4	2.3	0.3	-0.1	1.5	-0.4	0.2	-0.2	0.6
Heart disease (mother)	4.6	5.7	9.5	1.9	3.1	2.5	2.0	2.0	-1.9	3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	0.8	0.7	-1.2	0.2	1.0	-1.1	-0.2
Whole body fat mass	0.8	3.2	6.0	-1.9	-2.1	-1.5	-0.9	-1.4	2.0	-2.4
Leg fat mass (right)	0.9	3.5	9.2	-1.7	-2.0	-1.2	-1.0	-1.2	2.2	-3.0
Arm predicted mass (right)	0.4	1.9	8.9	0.2	-0.3	0.2	-1.8	0.6	0.8	-3.0
Pulse rate, automated reading	0.3	1.1	4.9	-0.6	-1.0	-2.2	-0.6	-1.0	-0.1	0.0
Alcohol intake frequency.	0.8	1.9	3.6	-1.3	-1.4	-1.6	-0.6	-1.8	1.9	-0.2
Comparative height size at age 10	0.8	4.3	13.0	-2.2	-2.4	-3.6	-1.0	-1.9	0.9	-1.0
Number of full sisters	0.6	0.7	2.7	0.6	0.8	-0.4	0.3	0.9	-1.7	0.4
Suffer from ‘nerves’	2.9	4.5	9.5	2.4	2.2	0.3	0.8	2.2	-3.1	2.4
Overall health rating	0.2	0.3	1.1	0.4	0.3	-1.1	0.5	0.3	-0.8	0.3
Chest pain or discomfort	0.5	0.8	4.4	0.3	0.6	-0.4	2.1	0.3	-0.1	0.5
Had major operations	3.1	3.6	5.8	-2.4	-2.4	-1.3	-1.2	-2.4	2.1	-0.9
Age at last live birth	0.8	1.1	2.3	-0.4	-0.4	1.5	-1.1	-1.0	1.0	1.4
Family relationship satisfaction	0.2	0.3	0.8	-0.3	-0.9	0.4	-0.8	-0.5	0.3	-0.1
Leg pain on walking	0.7	0.8	2.0	-0.8	-0.5	-1.4	0.1	-0.8	1.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.4	-1.2	-0.7	-1.1	1.5	-0.8	1.4	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.8	-0.5	0.2	0.5	1.3	-0.6	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.6	-0.5	-0.7	0.8	-1.6	-0.0	-0.2	-1.6
Medication: Aspirin	2.7	3.6	6.1	2.2	2.5	2.5	-0.5	2.3	-1.6	-0.2
Supplements: Vitamin C	1.3	1.5	2.7	-1.1	-1.3	-0.8	-1.1	-1.3	1.6	-1.1
Knee pain experienced in last month	0.2	0.4	0.8	-0.3	-0.5	0.9	-0.8	-0.1	0.4	-0.8
Hypertension (Self-reported)	0.6	1.7	4.8	-0.0	0.9	1.9	2.2	-0.0	0.2	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	8.9	0.9	1.6	-0.3	3.0	1.0	-0.6	2.2
Illnesses of father: Heart disease	7.9	11.0	16.2	3.6	4.0	4.0	0.8	3.5	-3.1	3.1
Illnesses of siblings: Diabetes	0.8	1.0	2.1	1.2	1.5	1.3	0.3	1.2	-0.3	-0.1
Smoking status: Previous	0.6	0.9	2.1	-0.6	-0.8	-1.4	1.2	-0.5	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.5	0.9	0.2	-0.2	-2.1	1.1	-1.6	-1.1
Whole body fat-free mass	0.5	2.8	11.3	0.2	-0.7	0.4	-2.6	0.6	0.5	-3.4
Leg fat-free mass (right)	0.5	2.7	8.0	-0.6	-1.2	-0.5	-2.7	-0.3	1.1	-2.8
Arm fat percentage (left)	0.5	2.0	3.7	-1.6	-1.6	-1.1	-0.7	-1.1	1.5	-1.9
Average weekly red wine intake	0.2	0.3	0.7	-0.2	-0.5	0.9	0.4	-0.5	0.4	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	4.0	-0.1	0.2	0.0	2.0	-0.1	-0.1	0.8
Mood swings	0.4	0.7	1.2	1.0	1.1	0.8	-0.1	0.9	-1.0	0.3
Loneliness, isolation	1.1	1.5	3.5	1.2	1.6	-0.2	0.5	1.2	-1.3	1.9
Long-standing illness, disability or infirmity	0.3	0.4	0.9	0.6	0.6	0.3	0.0	0.9	-0.7	-0.9
Ever had bowel cancer screening	1.4	1.6	6.3	-0.9	-0.8	-0.3	-0.0	-1.4	2.5	-1.3
Diabetes diagnosed by doctor	0.5	0.9	1.4	0.5	1.0	0.3	-1.2	1.1	-0.9	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.1	0.4	0.3	-1.0	-0.6	0.4	-0.5	0.5
Friendships satisfaction	0.2	0.3	1.0	1.0	0.0	0.2	0.5	0.5	-0.6	0.1
Qualifications: nursing, teaching	1.6	2.5	11.3	0.0	-0.6	0.3	-3.4	-0.2	0.8	-2.2
Commuting to job workplace: Walk	0.8	0.8	2.7	-0.6	-1.0	0.4	-1.6	-0.4	-0.1	-1.2
Eye problems/disorders: Cataract	0.7	0.8	2.1	-1.4	-1.1	-0.3	-0.1	-0.8	0.8	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.7	0.2	-0.2	1.3	-0.4	0.2	0.5	-0.9
Medication for cholesterol	1.1	1.6	3.6	-0.6	-1.6	0.1	-1.9	-0.8	0.8	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	4.2	-0.3	-0.2	-0.5	2.0	-0.5	0.0	1.2
Back pain experienced in last month	0.4	0.5	1.4	0.5	0.3	-1.0	0.1	0.8	-1.2	-0.5
Mineral and other dietary supplements	0.3	0.4	1.0	0.0	-0.4	-1.0	-0.8	0.1	-0.6	-0.7
Breast cancer (self-reported)	0.8	1.0	3.2	-0.4	-0.7	-1.8	-0.7	-0.8	1.1	-0.9
Asthma (self-reported)	3.2	6.4	12.0	-2.7	-3.1	-3.4	0.9	-3.5	1.6	0.8
Osteoporosis (self-reported)	1.6	2.0	3.7	1.9	1.6	1.6	-1.3	1.6	-1.0	-0.3
Osteoarthritis (self-reported)	0.9	1.2	3.1	1.4	0.8	0.2	-0.1	1.8	-1.5	-0.7
Medication: Aspirin	1.8	2.3	5.3	1.6	2.0	2.3	-0.6	1.7	-1.1	-0.1
Medication: Gliclazide	2.2	2.5	5.2	1.6	1.0	0.8	-2.3	1.9	-1.6	-1.4
Illnesses of father: None of the above (group 1)	1.6	2.0	3.6	-1.9	-1.3	-1.9	0.9	-1.6	1.3	-0.5
Smoking status: Current	1.5	2.4	5.7	1.8	1.3	0.5	0.0	2.1	-2.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	4.3	1.9	2.1	1.2	0.3	2.0	-0.7	0.6
Whole body water mass	0.5	2.7	10.8	0.3	-0.6	0.3	-2.6	0.6	0.5	-3.3
Leg predicted mass (right)	0.5	2.7	8.2	-0.6	-1.3	-0.6	-2.7	-0.3	1.1	-2.9
Arm fat mass (left)	0.5	1.9	5.9	-1.1	-1.4	-0.9	-1.2	-0.6	1.3	-2.4
Number of self-reported non-cancer illnesses	1.1	2.0	5.4	-1.4	-0.8	-0.9	2.3	-1.5	1.2	1.1
Average weekly champagne plus white wine intake	1.3	1.8	5.5	1.1	0.4	0.9	-2.3	1.4	-1.5	-1.0
Miserableness	0.8	1.3	4.0	1.0	-0.4	-0.1	-2.0	0.7	-0.5	-1.8
Guilty feelings	1.6	2.4	5.9	2.4	1.5	0.4	-0.3	2.1	-2.0	0.2
Wears glasses or contact lenses	0.9	1.0	1.8	-1.3	-1.2	0.1	-0.3	-1.4	1.3	-0.3
Ever taken oral contraceptive pill	0.8	0.9	2.6	-1.0	-0.3	-0.6	1.4	-0.8	0.1	1.6
Hearing aid user	3.5	3.9	6.2	1.6	2.5	1.6	2.4	1.9	-1.7	2.0
Mother’s age at death	4.5	5.7	15.9	-1.2	-2.5	0.4	-3.3	-1.1	1.9	-4.0
Financial situation satisfaction	0.3	0.3	1.0	0.2	0.4	0.0	-0.8	0.4	-1.0	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.7	0.3	-0.1	-0.8	-0.0	0.2	0.2	-0.5
Commuting to job workplace: Public transport	0.8	0.9	1.6	1.3	0.7	-0.6	-0.3	1.1	-1.2	1.1
Eye problems/disorders: Glaucoma	1.1	1.4	4.8	-0.7	-0.7	-0.1	-1.4	-0.9	0.8	-2.2
Medication: Blood pressure	2.2	4.2	11.0	0.8	2.4	0.7	3.2	0.7	-0.8	3.3
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.6	-1.7	-1.3	-2.1	-0.8	-1.3	1.3	-2.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.2	0.5	0.2	1.2	0.2	0.1	0.8
High cholesterol (Self-reported)	0.7	1.2	2.5	1.3	1.6	-0.1	1.0	1.3	-0.7	1.0
Medication: Bendroflumethiazide	0.6	1.0	2.1	-0.8	0.2	1.4	1.1	-0.8	0.1	1.5
Medication: Paracetamol	1.2	1.9	6.6	-1.0	-0.8	-2.6	0.0	-1.2	1.7	-1.0
Medication: Lisinopril	0.1	0.1	0.2	-0.1	0.1	0.1	-0.4	-0.2	0.5	0.3
Medication: Atorvastatin	3.6	4.4	6.9	2.3	2.6	2.2	-0.8	2.5	-2.2	1.6
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.5	-0.4	0.6	-0.6	-0.3	0.3	-0.1
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	-0.4	-0.3	0.5	-0.1	-0.3	0.5
Ever smoked	0.5	0.9	2.5	-0.1	-0.6	-1.3	1.4	0.1	-0.4	-1.6
Basal metabolic rate	0.5	2.7	11.0	-0.1	-0.9	-0.2	-2.5	0.3	0.8	-3.3
Leg fat percentage (left)	0.6	2.2	5.7	-1.4	-1.5	-1.0	0.1	-0.8	1.9	-2.4
Arm fat-free mass (left)	0.6	2.9	13.8	-0.0	-0.8	-0.0	-2.0	0.3	1.2	-3.7
Number of operations (self-reported)	1.3	2.0	3.0	-1.6	-1.7	0.8	-1.2	-1.5	1.6	-1.2
Average weekly beer plus cider intake	0.5	0.7	1.4	-0.8	-0.5	-1.2	0.7	-0.9	1.0	0.1
Irritability	0.8	1.4	3.4	1.0	0.8	1.8	-1.7	0.9	-1.1	0.1
Risk taking	0.7	1.0	3.0	-0.5	-1.0	-0.7	0.1	-0.9	1.2	-1.7
Ever had prostate specific antigen (PSA) test	2.2	2.6	6.4	-0.7	-1.5	-2.5	-2.1	-0.6	1.0	-1.8
Fractured/broken bones in last 5 years	0.5	0.6	1.8	-0.3	0.1	1.3	-0.4	-0.4	1.1	-1.1
Age started oral contraceptive pill	1.2	1.5	8.7	0.9	0.7	3.0	-0.5	0.6	-0.4	0.3
Diastolic blood pressure, automated reading	0.4	1.3	5.0	-0.3	0.5	1.1	1.5	-0.5	-0.2	2.2
Ever depressed for a whole week	2.1	2.7	6.4	-2.0	-1.9	-1.2	-0.4	-2.5	1.6	0.1
Unable to work because of sickness or disability	0.3	0.4	0.7	0.8	0.7	-0.2	0.8	0.5	-0.4	0.7
Commuting to job workplace: Cycle	1.5	1.8	3.4	1.6	1.0	1.8	-1.2	1.4	-1.0	-1.2
Myopia	1.4	2.1	6.7	-1.4	-0.6	-0.0	2.6	-1.8	0.9	1.4
Vascular/heart problems diagnosed by doctor	0.6	1.8	5.0	-0.1	-0.8	-2.2	-2.0	0.1	-0.4	-1.6
Cholesterol lowering medication	1.1	1.7	4.4	1.8	2.1	0.4	-0.2	1.6	-0.9	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.6	-0.5	-0.9	0.8	-0.7	0.3	1.1
Pain experienced in last month	0.7	1.2	4.6	-0.3	-1.0	2.2	-0.9	0.1	0.1	-1.4
Supplements: Calcium	0.6	0.7	1.1	-1.0	-0.9	0.7	-0.5	-1.0	0.9	-0.7
Basal cell carcinoma (self-reported)	0.4	0.5	3.1	-0.2	-0.4	-0.0	-0.3	0.0	0.4	-1.8
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.2	0.8	1.7	1.0	0.6	0.7	-0.0	1.8
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.6	-1.0	-0.5	-1.1	1.3	-1.6	1.6	1.4
Heart disease (siblings)	2.3	2.9	5.2	1.4	1.8	2.3	1.4	1.5	-2.0	1.3
Alcohol drinker status: Previous	0.5	0.6	2.7	-0.5	-0.3	-1.0	1.6	-0.3	0.1	0.2
Pack years of smoking	1.9	2.8	12.2	-0.3	-1.3	1.4	-1.7	0.4	-0.8	-3.5
Impedance of whole body	0.5	2.8	8.0	-0.4	-0.2	-2.2	2.1	-1.1	-0.8	2.8
Leg fat mass (left)	0.9	3.5	9.2	-1.7	-1.9	-1.3	-0.9	-1.1	2.2	-3.0
Arm predicted mass (left)	0.5	2.5	11.2	0.4	-0.4	0.3	-2.2	0.8	0.6	-3.4