Hub : Genes

IL6R

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.2190 0.0820 5.0e-03 0.084 NA 0.035 NA 0.047 6.8e-04 NA 2.2e-02 NA 9.2e-03
2 GTEx Colon Transverse 0.1760 0.0640 2.6e-03 0.065 NA 0.026 NA 0.059 5.0e-04 NA 2.0e-02 NA 9.2e-04
3 GTEx Esophagus Muscularis 0.0990 0.0410 3.4e-03 -0.004 NA -0.003 NA -0.004 8.6e-01 NA 5.3e-01 NA 7.0e-01
4 GTEx Testis 0.4950 0.0860 3.5e-07 0.059 NA 0.222 NA 0.183 1.4e-03 NA 3.2e-10 NA 1.5e-08
5 YFS Blood 0.0363 0.0104 1.9e-07 0.037 0.027 0.034 0.033 0.036 4.0e-12 1.9e-09 1.8e-11 6.4e-11 5.2e-12
6 TCGA Skin Cutaneous Melanoma 0.1200 0.0550 1.1e-03 0.038 0.114 0.055 NA 0.088 3.4e-02 6.0e-04 1.4e-02 NA 2.4e-03
7 TCGA Stomach Adenocarcinoma 0.0430 0.0250 5.7e-03 0.004 0.019 0.003 NA 0.008 1.6e-01 1.5e-02 1.8e-01 NA 7.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.8 1.2 2.6 -0.9 -1.6 0.5 -1.1 -1.5 0.9 -0.8
Bipolar Disorder or Schizophrenia 0.9 2.2 4.8 -1.4 -2.2 -1.6 -0.7 -2.2 0.6 0.3
Depressed Affect (Nagel 2018) 0.4 0.9 1.4 1.2 1.0 0.6 -1.2 1.1 -0.7 -0.2
Depression (Nagel 2018) 1.2 1.9 2.6 1.5 1.5 0.3 1.3 1.4 -1.6 1.4
Intelligence (Savage-Jansen 2018) 1.2 3.6 6.2 -1.6 -2.1 1.6 -2.5 -1.9 1.8 -1.7
Neuroticism (Nagel 2018) 1.8 4.2 8.3 2.9 2.4 0.7 -0.4 2.4 -2.7 1.3
Schizophrenia (2018) 0.9 1.8 5.6 -1.1 -1.5 -2.4 0.0 -1.6 0.1 1.0
Schizophrenia vs Biploar Disorder 2.4 3.1 8.8 -1.8 -1.9 -3.0 -0.2 -1.7 1.6 -0.8
Worry (Nagel 2018) 3.3 7.0 13.7 2.8 2.9 0.1 0.8 2.3 -3.7 3.6
Alzheimer’s Disease (in mother) 1.0 1.2 2.7 -1.2 -1.6 -1.3 -0.3 -1.3 0.6 -0.5
Alzheimer’s Disease (in father) 1.5 1.6 6.3 -0.5 -1.4 -2.5 -0.3 -0.8 0.9 -1.0
Alzheimer’s Disease (including proxy) 1.3 1.9 5.4 -1.3 -1.9 -2.3 -0.1 -1.4 0.8 -0.6
Crohns Disease (2017) 2.9 6.4 10.2 2.5 3.1 3.0 0.6 3.2 -3.0 0.5
Irritable Bowel Disease (IBD) 0.7 1.7 3.8 1.0 1.6 1.1 0.3 1.8 -1.9 -0.3
Ulcerative Colitis (UC) 0.2 0.4 1.3 0.3 0.5 -0.6 -0.2 0.7 -1.1 -0.4
Major Depression (MDD) 3.8 4.6 18.0 -1.7 -2.0 -4.2 0.5 -2.2 1.4 0.1
Reaction Time 0.2 0.4 1.1 0.6 0.2 1.1 0.4 0.4 -0.5 0.7
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.4 -0.4 -0.5 1.2 -0.9 -0.5 0.1 -0.7
Breast Cancer 0.5 1.1 3.2 -1.0 -1.0 -0.1 -0.7 -0.7 1.8 -1.3
Ovarian Cancer 0.2 0.2 0.5 0.3 0.7 0.1 -0.3 0.4 -0.6 0.5
Prostate Cancer 3.8 5.4 21.3 -1.1 -2.1 -4.6 -2.0 -1.8 1.2 -1.5
Age at First Birth 1.4 2.0 13.8 0.1 -0.1 3.7 -0.4 -0.0 0.3 -0.3
Bipolar Disorder (2011) 2.1 2.0 5.6 1.4 1.1 2.4 -0.2 1.4 -1.8 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 2.8 -1.1 -0.3 -1.7 0.7 -0.7 0.4 0.9
Coronary Artery Disease (CAD) 6.2 7.3 12.3 2.6 3.5 1.7 1.9 2.4 -3.1 3.2
Crohns Disease (2012) 2.6 4.2 7.5 1.7 2.1 2.5 -1.6 2.5 -2.7 -0.1
Mean Putamen Volume 0.6 0.7 1.7 0.0 -0.4 1.3 -1.1 -0.3 0.6 -1.3
Fasting Glucose 1.0 1.2 2.8 0.8 1.7 -1.0 1.2 1.1 -0.5 0.9
HbA1C 1.1 1.2 4.0 1.1 1.0 2.0 -0.0 0.8 -0.9 0.7
HDL Cholesterol 0.2 0.3 1.0 -0.1 -0.2 1.0 1.0 -0.1 0.2 0.2
LDL Cholesterol 0.4 0.6 2.6 -0.0 -0.5 -1.6 -0.4 -0.3 -0.2 1.1
Lupus 1.1 1.7 3.4 -1.6 -1.6 0.4 0.4 -1.7 1.9 0.2
Neuroticism (2016) 3.5 5.0 7.0 2.6 2.5 1.3 2.2 2.6 -2.5 1.5
Primary Biliary Cirrhosis 0.8 1.1 6.4 0.3 0.1 2.5 -0.8 0.2 -0.7 -0.3
Rheumatoid Arthritis 2.5 3.5 6.1 2.1 1.3 2.3 -1.2 2.5 -1.4 -1.9
Schizophrenia (2014) 1.3 2.8 5.6 -1.6 -2.2 -2.4 0.0 -2.2 0.7 0.9
Triglycerides 0.8 1.3 5.7 -0.1 0.3 -2.4 1.6 -0.4 0.5 0.1
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.3 1.2 1.4 1.4 -0.4 1.5 -0.8 -0.1
Ulcerative Colitis 0.3 0.4 1.3 -0.9 -0.4 -1.2 0.0 -0.8 0.2 0.2
Blood Eosinophil Count 0.1 0.8 2.0 1.4 0.4 -0.6 -0.7 0.5 -1.0 1.1
Blood Platelet Count 2.9 33.7 60.8 -5.6 -7.2 -7.8 -4.8 -6.8 4.7 -0.8
Blood Red Count 0.4 3.8 7.2 2.6 2.0 0.9 1.0 2.5 -2.7 0.9
Blood White Count 0.1 0.8 2.4 0.2 0.0 -1.0 -0.7 0.8 -1.6 -1.0
Heel T-Score 0.0 0.4 1.1 -1.1 -0.1 0.5 0.5 -0.4 -0.1 0.9
BMI 0.5 2.8 5.4 -2.0 -1.8 -0.8 -0.1 -1.3 2.3 -2.2
Height 0.1 2.4 9.8 0.4 -1.1 -1.4 -1.9 0.1 0.1 -3.1
Waist Hip Ratio (WHR) 1.0 4.7 7.6 2.1 1.8 2.8 -1.6 2.5 -2.7 -1.3
Systolic Blood Pressure 0.4 2.2 6.7 -0.9 0.3 1.4 2.1 -1.2 0.3 2.6
Smoking Status 1.7 4.1 7.7 2.5 1.4 -0.6 0.9 2.8 -2.7 -2.1
Allergy or Eczema 11.2 29.5 49.6 -6.2 -6.5 -6.9 1.0 -7.0 5.3 -0.2
Cardiovascular Disease 1.3 4.1 16.7 0.5 1.9 1.8 4.1 0.4 -0.1 2.2
Hypothyroidism (self reported) 2.5 5.7 9.0 2.2 3.0 2.0 2.2 2.8 -2.4 1.8
Respiratory disease 5.7 12.8 24.3 -4.1 -4.9 -3.5 0.3 -4.9 3.4 -0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.3 0.1 0.7 0.4 -1.1 1.0 -0.7 -1.5
Lung FEV1/FVC ratio 1.4 6.9 17.2 1.4 3.4 1.4 3.5 1.4 -1.1 4.2
Lung FVC 0.3 1.4 3.2 -1.0 -0.9 0.2 -1.0 -0.8 1.8 -1.7
Neuroticism 1.4 3.3 7.0 2.2 2.0 0.7 -0.7 1.8 -2.6 1.6
Chronotype (morning person) 0.3 0.7 2.2 0.1 0.6 -1.1 1.2 -0.2 0.0 1.5
Hair Pigment 0.1 1.9 4.8 1.0 1.3 -0.3 1.3 1.1 -1.6 2.2
Tanning 0.1 1.2 2.0 -1.1 -1.2 -1.4 -0.7 -0.9 0.8 -1.2
Hand grip strength (left) 0.6 1.6 5.6 -0.7 -1.2 -1.1 -1.4 -0.4 0.3 -2.4
Number of treatments/medications taken 0.4 0.8 4.9 -0.4 0.2 -0.4 2.2 -0.2 0.3 0.4
Average weekly spirits intake 2.9 3.6 6.6 -2.6 -2.0 -0.5 1.3 -2.4 2.4 -1.1
Sensitivity / hurt feelings 0.5 0.8 2.3 1.0 0.5 -0.4 0.7 0.6 -0.9 1.5
Frequency of depressed mood in last 2 weeks 1.3 1.9 4.5 1.2 1.4 -0.4 2.1 1.0 -1.4 1.5
Hearing difficulty/problems: Yes 0.2 0.3 0.9 0.1 0.2 -0.9 0.9 0.1 -0.5 0.4
Relative age of first facial hair 0.4 0.8 3.6 0.8 0.6 1.9 0.6 0.5 0.1 0.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 -0.7 -0.6 -0.9 -0.4 -0.5 0.7 -0.6
Ever used hormone-replacement therapy (HRT) 1.6 2.0 6.9 0.6 1.6 1.3 2.6 0.7 -0.4 1.4
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 -0.1 -0.4 -0.6 0.1 0.2 -0.1 -0.2
Systolic blood pressure, automated reading 0.7 2.1 4.5 -2.1 -1.4 0.1 0.9 -2.1 1.5 1.0
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.0 1.1 1.7 1.0 -0.4 1.0 -1.1 1.4
Angina 3.8 5.0 8.8 2.5 3.0 2.6 1.8 2.6 -1.4 1.3
Medication for hormone replacement therapy 0.4 0.4 1.0 -0.1 -0.3 -0.8 0.9 0.2 -1.0 0.4
Vitamin and mineral supplements 1.5 2.0 4.0 1.6 1.7 0.7 0.1 1.8 -2.0 0.7
Supplements: Zinc 0.8 0.8 1.3 -0.8 -1.1 -1.0 -1.1 -0.7 0.5 -0.9
Medication: Co-codamol 0.4 0.5 1.2 -0.4 -0.3 -1.1 1.0 -0.6 0.7 0.2
Medication: Metformin 0.8 1.2 2.4 0.7 1.4 1.2 -0.5 1.3 -1.6 -0.1
Diabetes (father) 0.3 0.4 1.5 -0.6 -0.1 1.2 -0.5 -0.2 0.6 -0.6
Diabetes (mother) 0.5 0.6 3.2 0.6 0.4 1.8 -0.0 0.7 -0.5 -0.3
Severe depression (siblings) 0.4 0.4 1.5 -0.1 -0.8 -1.2 -0.5 -0.1 -0.6 -0.1
Pack years adult smoking proportion 1.5 2.4 9.6 -0.1 -1.0 1.1 -1.7 0.6 -1.2 -3.1
Impedance of leg (right) 0.3 1.6 5.3 0.5 0.3 -1.3 2.3 -0.2 -0.8 1.8
Leg fat-free mass (left) 0.4 2.3 7.3 -0.5 -1.1 -0.4 -2.4 -0.2 1.1 -2.7
Trunk fat percentage 0.9 3.8 5.6 -2.4 -2.3 -2.1 -0.3 -2.0 2.2 -1.6
Hand grip strength (right) 0.3 0.7 2.2 -0.9 -1.1 -0.5 -0.6 -0.5 0.2 -1.5
Townsend deprivation index at recruitment 1.2 1.7 4.9 -1.1 -0.6 -1.8 2.2 -1.1 0.7 0.5
Current tobacco smoking 1.3 2.2 4.9 1.5 0.9 0.3 -0.5 2.0 -2.2 -1.7
Average weekly fortified wine intake 0.3 0.4 0.9 0.8 0.9 0.2 0.8 0.6 -0.4 0.3
Maternal smoking around birth 1.9 2.8 4.5 1.9 2.0 0.3 1.3 2.1 -2.0 1.3
Fed-up feelings 0.7 1.3 3.8 1.0 0.8 0.7 -1.9 1.2 -0.7 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 2.5 1.4 1.0 0.2 1.1 1.4 -1.6 0.6
Relative age voice broke 0.9 1.4 4.2 1.1 1.3 2.0 0.6 0.5 -0.2 1.6
Taking other prescription medications 0.7 1.1 5.7 -0.1 0.4 -0.3 2.4 -0.0 -0.1 1.2
Age when periods started (menarche) 1.7 4.2 7.8 1.4 2.6 2.8 2.5 1.2 -0.8 2.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.7 0.1 -0.0 -0.8 -0.0 0.3 0.3 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.4 0.8 1.1 -0.1 1.2 0.7 -0.2 1.1
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 2.2 0.0 0.2 0.4 1.5 -0.3 1.0 -0.2
Qualifications: CSEs or equivalent 1.4 1.8 3.7 -1.9 -1.1 -1.2 0.9 -1.8 1.4 0.3
Serious illness, injury or assault to yourself 0.7 0.9 1.3 1.2 1.1 1.1 -0.1 1.0 -1.0 0.6
High blood pressure 0.6 1.6 5.2 0.0 0.8 2.3 2.0 -0.1 0.4 1.2
Hayfever, allergic rhinitis or eczema 12.8 27.8 46.5 -5.8 -6.4 -6.8 0.1 -6.8 5.1 -1.0
Multivitamins +/- minerals 1.9 2.4 5.2 -1.8 -1.6 -1.0 0.8 -2.1 2.3 0.3
Stomach or abdominal pain in last month 0.7 0.9 4.2 -0.1 -0.1 -2.0 1.2 -0.5 0.1 0.2
Supplements: Glucosamine 0.3 0.4 1.1 -0.5 -0.5 0.1 -1.1 -0.5 0.8 -0.5
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 4.4 0.7 1.1 -0.5 -0.1 1.1 -2.1 0.6
Medication: Atenolol 0.5 0.6 2.2 0.2 0.7 0.9 1.5 0.3 0.3 0.4
Medication: Levothyroxine sodium 1.7 2.8 5.8 1.6 1.9 2.4 1.2 2.0 -1.4 0.8
Sitting height 0.2 1.1 2.4 1.6 0.6 0.6 -0.2 1.4 -1.0 -1.2
Chronic bronchitis/emphysema (father) 0.4 0.5 1.0 -0.2 -1.0 -0.9 -0.3 -0.4 0.8 -0.9
High blood pressure (mother) 2.1 3.0 5.8 2.2 2.4 1.7 0.7 1.7 -1.3 1.6
Body mass index (BMI) 0.4 1.8 5.9 -1.1 -1.1 -0.2 -1.1 -0.5 1.6 -2.4
Impedance of leg (left) 0.3 1.6 5.2 0.0 -0.1 -1.7 2.3 -0.6 -0.5 1.6
Leg predicted mass (left) 0.5 2.4 7.6 -0.5 -1.1 -0.3 -2.5 -0.2 1.1 -2.8
Trunk fat mass 0.8 3.6 6.1 -2.0 -2.2 -1.8 -0.9 -1.5 1.9 -2.5
Waist circumference 1.3 4.7 17.1 -1.0 -1.6 -0.0 -3.3 -0.2 1.1 -4.1
Number of incorrect matches in round 0.2 0.4 2.2 -0.2 -0.2 -0.5 1.5 -0.3 0.0 0.3
Past tobacco smoking 0.5 0.9 3.2 -0.1 0.2 1.3 -1.8 -0.3 0.4 1.2
Alcohol usually taken with meals 0.7 1.1 2.9 1.0 1.0 1.7 -0.6 0.9 -1.2 0.6
Nervous feelings 1.6 3.1 7.2 1.8 1.7 -0.5 -0.5 1.7 -2.7 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.1 0.9 0.5 -0.3 1.0 0.8 -1.0 0.0
Hearing difficulty/problems with background noise 0.2 0.3 1.6 -0.1 -0.2 -1.3 0.5 -0.3 -0.2 -0.1
Hair/balding pattern: Pattern 2 0.3 0.4 1.7 0.1 0.9 -0.0 1.3 0.1 0.3 0.7
Had menopause 0.2 0.3 1.0 -0.4 -0.5 1.0 -0.2 -0.2 0.4 -0.5
Had other major operations 0.2 0.2 1.0 -0.1 0.3 1.0 0.2 0.2 -0.4 0.3
Forced vital capacity (FVC) 0.2 0.9 2.4 0.9 0.2 -1.3 -0.7 0.7 0.2 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.6 -0.5 -0.0 -0.7 0.0 -0.5 0.5 0.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.5 0.0 -0.4 -1.2 0.4 -0.5 -0.1 0.3
Qualifications: None of the above 1.4 3.0 9.7 0.4 1.7 -1.1 2.3 0.5 -1.1 3.1
Financial difficulties in last 2 years 0.4 0.5 1.6 -0.0 0.3 -0.6 1.3 -0.2 1.0 0.9
Mouth/teeth dental problems 0.9 1.4 7.7 -0.2 -0.4 -2.8 0.9 -0.6 -0.2 0.6
Heart attack 1.4 1.8 4.1 1.2 2.0 1.0 0.8 1.1 -0.4 2.0
Allergy 12.7 29.2 51.4 5.9 6.5 7.2 -0.5 7.1 -5.0 0.3
Pain all over the body in last month 0.5 0.6 1.6 -0.7 -0.1 -0.8 1.3 -0.8 0.6 0.5
Diabetes (self-reported) 1.1 1.7 5.2 0.1 0.6 1.1 -1.9 1.0 -0.9 -2.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.9 0.2 -0.6 -0.9 0.3 -0.1 0.0 -0.5
Medication: Ramipril 0.4 0.5 2.3 -0.0 0.7 -0.2 1.5 0.3 -0.6 0.5
Medication: Simvastatin 0.2 0.4 1.4 0.4 0.7 -1.2 0.5 0.4 -0.1 -0.2
Fluid intelligence score 0.3 0.7 2.7 -0.4 -0.7 1.6 0.3 -0.6 0.5 -0.9
Illnesses of siblings 0.9 1.3 3.8 -0.3 -0.6 -1.9 -2.0 -0.6 0.9 -0.1
Neuroticism score 1.7 3.6 8.0 2.3 2.0 1.1 -0.4 2.1 -2.8 1.4
Weight 0.6 2.9 11.1 -0.9 -1.4 -0.8 -2.0 -0.3 1.4 -3.3
Impedance of arm (right) 0.5 2.2 5.4 -0.8 -0.9 -2.2 0.7 -1.4 -1.0 2.3
Arm fat percentage (right) 0.5 2.1 5.6 -1.4 -1.7 -0.9 -0.9 -1.0 1.4 -2.4
Trunk fat-free mass 0.6 3.2 12.0 0.9 -0.1 0.9 -2.6 1.3 -0.2 -3.5
Hip circumference 0.7 3.2 9.2 -1.1 -1.6 -1.9 -1.9 -0.5 1.6 -3.0
Time employed in main current job 0.3 0.3 1.1 0.5 0.2 0.2 0.8 0.2 -0.1 1.0
Alcohol intake versus 10 years previously 0.5 0.7 2.9 -0.8 -0.1 -1.7 0.3 -0.8 0.6 0.2
Father’s age at death 5.4 7.3 13.8 -2.0 -3.2 -2.2 -3.7 -2.2 2.1 -3.0
Worrier / anxious feelings 1.5 2.8 5.3 1.8 2.0 0.7 1.0 1.2 -2.1 2.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.8 0.9 0.7 -0.9 -0.2 0.9 -0.6 -0.6
Falls in the last year 0.6 0.8 3.3 -0.1 -0.5 1.8 -1.1 -0.0 0.3 -1.0
Hair/balding pattern: Pattern 3 1.0 1.6 5.9 0.2 -1.0 1.4 -1.4 0.1 0.4 -2.4
Number of live births 1.1 1.6 4.9 -0.8 0.2 -2.2 0.3 -1.1 1.0 1.8
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.1 1.4 1.4 -0.8 0.5 1.2 -0.3 0.1
Pulse rate 0.3 0.5 1.7 0.6 0.1 0.5 -0.9 0.5 -1.3 -0.4
Happiness 1.6 2.0 3.4 1.9 1.1 1.8 -1.4 1.3 -1.6 0.2
Noisy workplace 1.8 2.2 5.0 -1.8 -1.0 -2.2 1.1 -1.8 1.2 0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.5 -0.0 -1.1 0.7 -1.9 -0.7 1.0 -1.2
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 5.4 1.7 1.1 2.3 -0.0 1.6 -1.1 -0.5
Mouth/teeth dental problems: Dentures 0.8 1.4 8.2 -0.2 0.7 2.9 -0.6 0.6 -0.1 -0.7
Asthma 3.4 6.7 13.0 -3.0 -3.3 -3.2 0.5 -3.6 1.9 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.6 -0.0 0.2 -0.2 -0.2 -0.2 0.4 -0.7
Medication: Cholesterol lowering 0.4 0.7 1.4 0.8 1.2 0.3 0.8 1.2 -0.6 0.1
Depression (self-reported) 0.2 0.2 0.6 0.1 -0.1 0.8 0.1 -0.3 0.6 -0.6
Medication: Lansoprazole 0.6 0.7 2.0 -0.3 1.0 0.8 1.4 0.2 0.3 1.0
Prospective memory result 0.4 0.5 2.2 -0.1 0.4 -1.5 0.4 -0.0 -0.2 1.0
Lung cancer (father) 0.3 0.4 1.6 -0.3 -0.7 -0.5 0.5 -0.1 0.2 -1.3
Illnesses of mother 3.8 4.6 9.1 -2.5 -2.1 -3.0 -0.0 -2.5 2.5 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.5 0.5 0.5 -1.6 0.9 0.2 0.4 0.8
Pulse wave Arterial Stiffness index 2.8 3.3 4.9 1.8 2.2 1.7 2.1 1.9 -1.2 1.5
Impedance of arm (left) 0.6 2.6 9.3 -0.8 -0.4 -2.0 1.3 -1.3 -1.0 3.0
Arm fat mass (right) 0.5 2.2 6.7 -1.1 -1.5 -0.9 -1.3 -0.7 1.4 -2.6
Trunk predicted mass 0.6 3.3 12.4 0.9 -0.2 0.9 -2.7 1.3 -0.2 -3.5
Standing height 0.2 1.6 4.2 0.2 -1.1 -1.4 -2.0 0.0 -0.4 -1.9
Length of working week for main job 0.4 0.4 1.5 0.3 0.1 0.4 -1.2 0.6 -0.6 -0.6
Exposure to tobacco smoke at home 1.0 1.2 2.4 -0.8 -1.4 -1.5 1.5 -0.8 0.6 -0.1
Breastfed as a baby 1.2 1.5 4.3 -0.6 -0.5 2.1 -1.3 -0.3 0.8 -1.8
Tense / ‘highly strung’ 0.2 0.3 1.3 0.4 -0.2 -0.5 -0.4 -0.2 -0.4 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.0 0.9 0.7 1.0 1.4 0.3 -0.7 1.2
Hair/balding pattern: Pattern 4 0.5 1.2 6.8 0.1 0.2 2.6 -1.0 0.4 0.3 -0.8
Birth weight of first child 2.3 4.2 15.2 -1.1 -1.8 -0.7 -2.6 -0.5 1.4 -3.9
Peak expiratory flow (PEF) 1.5 3.6 6.3 2.1 2.5 -0.8 2.0 1.9 -1.7 1.8
Pulse wave reflection index 1.3 1.7 2.7 1.2 1.6 1.3 1.6 1.4 -0.7 0.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.5 -0.5 -0.1 -0.9 0.7 -0.8 1.2 -0.7
Loud music exposure frequency 1.5 1.7 2.5 1.4 1.3 -1.2 1.3 1.1 -1.2 1.6
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.7 1.9 0.3 0.7 -0.1 1.1 -0.8 -1.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 1.1 0.2 -0.1 1.1 0.0 0.5 0.3 -0.3
Blood clot in the leg (DVT) 1.1 1.4 2.8 -0.8 -0.4 -1.1 1.0 -1.4 1.3 1.7
Medication: Paracetamol 0.8 1.3 3.6 -0.7 -0.1 -1.9 1.4 -1.1 1.3 0.6
Headache pain in last month 0.4 0.7 4.3 0.6 0.4 -2.1 0.2 0.0 -0.4 0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.9 0.3 -0.0 -1.4 -0.1 -0.2 0.2 0.0
Glaucoma (self-reported) 2.0 2.4 5.2 -1.1 -1.3 0.7 -2.2 -1.3 1.3 -2.3
Gout (self-reported) 2.2 3.0 6.2 -2.5 -2.5 -1.6 -1.0 -1.7 1.0 -1.1
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 4.1 1.5 1.7 1.7 1.3 2.0 -1.3 0.4
Medication: Amlodipine 0.2 0.3 1.1 0.2 0.6 1.0 0.2 0.5 -0.4 0.5
Medication: Ventolin 100micrograms inhaler 1.7 2.1 7.9 -0.9 -1.3 -2.8 1.7 -1.2 0.4 0.3
Birth weight 1.5 3.2 11.8 0.7 -0.1 1.9 -2.1 1.3 -0.2 -3.4
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.8 -1.4 -1.7 -1.7 -0.1 -1.3 0.7 -0.5
High blood pressure (siblings) 0.6 0.9 2.7 -0.7 -0.7 0.8 1.6 -1.0 0.9 0.4
Forced vital capacity (FVC), Best measure 0.2 0.7 2.9 -0.1 -0.7 -1.7 -0.4 -0.3 0.8 -0.8
Body fat percentage 0.9 3.4 4.7 -2.2 -2.1 -1.7 -0.2 -1.7 2.2 -2.1
Leg fat percentage (right) 0.5 1.8 5.2 -1.2 -1.3 -0.9 0.1 -0.7 1.8 -2.3
Arm fat-free mass (right) 0.4 1.9 8.8 0.1 -0.4 0.3 -1.7 0.5 0.9 -3.0
Exposure to tobacco smoke outside home 0.9 1.2 3.5 0.2 -1.0 -1.7 -0.7 0.3 -0.4 -1.9
Comparative body size at age 10 0.8 2.1 5.0 0.1 -0.4 2.2 -2.2 0.2 0.7 -2.1
Number of full brothers 0.6 0.8 1.5 0.9 1.2 0.0 0.1 1.2 -1.2 0.4
Worry too long after embarrassment 2.5 4.2 7.9 2.8 2.0 1.8 -0.6 2.5 -2.6 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.2 0.2 0.3 0.9 0.0 -0.7 0.8
Wheeze or whistling in the chest in last year 2.5 4.5 10.0 -2.4 -3.2 -2.5 0.1 -2.8 1.2 -0.2
Number of children fathered 0.2 0.2 0.6 -0.7 0.3 -0.5 -0.1 -0.2 0.8 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.5 -1.0 -1.1 -0.2 0.1 -1.2 0.3 1.0
Age at first live birth 1.0 1.7 7.7 -0.1 -0.4 2.8 -1.9 -0.4 0.1 0.8
Pulse wave peak to peak time 3.2 3.7 5.5 -1.9 -2.4 -2.0 -2.1 -2.0 1.2 -1.8
Health satisfaction 0.1 0.1 0.3 -0.3 -0.1 -0.1 -0.4 -0.3 0.3 -0.5
Shortness of breath walking on level ground 0.4 0.5 1.6 0.5 0.5 0.6 -1.3 0.8 -0.0 -0.5
Qualifications: College or University degree 0.6 2.0 5.7 1.6 0.8 2.4 -1.8 1.0 -1.0 0.0
Eye problems/disorders: None of the above 1.3 1.5 2.4 1.5 1.3 1.0 1.4 1.1 -0.7 1.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 3.1 -0.0 0.3 -0.3 1.8 0.2 -0.4 0.4
Emphysema/chronic bronchitis 2.1 2.4 5.2 -1.5 -2.3 -1.1 -0.8 -1.6 1.2 -1.9
Medication for pain relief, constipation, heartburn 0.2 0.4 1.2 -0.4 -1.0 -0.1 -1.1 -0.2 -0.2 -0.4
Neck or shoulder pain in last month 0.6 0.8 2.6 0.2 0.5 -1.5 1.6 0.0 0.3 0.7
Medication: Blood pressure 0.5 0.9 3.8 -0.4 -0.7 1.9 -1.2 -0.2 0.3 -0.6
Angina (self-reported) 4.2 5.5 9.9 2.6 3.1 2.6 1.6 2.8 -1.6 1.5
Migraine (self-reported) 0.7 0.9 2.6 0.8 0.4 -1.6 -0.2 0.8 0.0 -1.4
Medication: Ibuprofen 1.3 1.6 3.5 -1.1 -1.1 -1.3 -0.5 -1.1 1.5 -1.9
Medication: Allopurinol 0.5 0.6 2.0 -1.4 -0.9 -1.2 -0.3 -0.5 -0.1 -0.1
Medication: Omeprazole 0.2 0.3 1.1 0.1 -0.0 -1.1 0.5 -0.1 0.0 0.8
Medication: Seretide 50 evohaler 0.2 0.2 0.5 -0.2 -0.5 0.5 0.7 -0.1 -0.4 -0.1
Mean time to correctly identify matches 0.2 0.4 2.3 0.3 -0.1 1.5 -0.4 0.2 -0.2 0.6
Heart disease (mother) 4.6 5.7 9.5 1.9 3.1 2.5 2.0 2.0 -1.9 3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.4 0.8 0.7 -1.2 0.2 1.0 -1.1 -0.2
Whole body fat mass 0.8 3.2 6.0 -1.9 -2.1 -1.5 -0.9 -1.4 2.0 -2.4
Leg fat mass (right) 0.9 3.5 9.2 -1.7 -2.0 -1.2 -1.0 -1.2 2.2 -3.0
Arm predicted mass (right) 0.4 1.9 8.9 0.2 -0.3 0.2 -1.8 0.6 0.8 -3.0
Pulse rate, automated reading 0.3 1.1 4.9 -0.6 -1.0 -2.2 -0.6 -1.0 -0.1 0.0
Alcohol intake frequency. 0.8 1.9 3.6 -1.3 -1.4 -1.6 -0.6 -1.8 1.9 -0.2
Comparative height size at age 10 0.8 4.3 13.0 -2.2 -2.4 -3.6 -1.0 -1.9 0.9 -1.0
Number of full sisters 0.6 0.7 2.7 0.6 0.8 -0.4 0.3 0.9 -1.7 0.4
Suffer from ‘nerves’ 2.9 4.5 9.5 2.4 2.2 0.3 0.8 2.2 -3.1 2.4
Overall health rating 0.2 0.3 1.1 0.4 0.3 -1.1 0.5 0.3 -0.8 0.3
Chest pain or discomfort 0.5 0.8 4.4 0.3 0.6 -0.4 2.1 0.3 -0.1 0.5
Had major operations 3.1 3.6 5.8 -2.4 -2.4 -1.3 -1.2 -2.4 2.1 -0.9
Age at last live birth 0.8 1.1 2.3 -0.4 -0.4 1.5 -1.1 -1.0 1.0 1.4
Family relationship satisfaction 0.2 0.3 0.8 -0.3 -0.9 0.4 -0.8 -0.5 0.3 -0.1
Leg pain on walking 0.7 0.8 2.0 -0.8 -0.5 -1.4 0.1 -0.8 1.3 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.4 -1.2 -0.7 -1.1 1.5 -0.8 1.4 -0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.8 -0.5 0.2 0.5 1.3 -0.6 0.6 0.7
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.6 -0.5 -0.7 0.8 -1.6 -0.0 -0.2 -1.6
Medication: Aspirin 2.7 3.6 6.1 2.2 2.5 2.5 -0.5 2.3 -1.6 -0.2
Supplements: Vitamin C 1.3 1.5 2.7 -1.1 -1.3 -0.8 -1.1 -1.3 1.6 -1.1
Knee pain experienced in last month 0.2 0.4 0.8 -0.3 -0.5 0.9 -0.8 -0.1 0.4 -0.8
Hypertension (Self-reported) 0.6 1.7 4.8 -0.0 0.9 1.9 2.2 -0.0 0.2 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 8.9 0.9 1.6 -0.3 3.0 1.0 -0.6 2.2
Illnesses of father: Heart disease 7.9 11.0 16.2 3.6 4.0 4.0 0.8 3.5 -3.1 3.1
Illnesses of siblings: Diabetes 0.8 1.0 2.1 1.2 1.5 1.3 0.3 1.2 -0.3 -0.1
Smoking status: Previous 0.6 0.9 2.1 -0.6 -0.8 -1.4 1.2 -0.5 0.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.5 0.9 0.2 -0.2 -2.1 1.1 -1.6 -1.1
Whole body fat-free mass 0.5 2.8 11.3 0.2 -0.7 0.4 -2.6 0.6 0.5 -3.4
Leg fat-free mass (right) 0.5 2.7 8.0 -0.6 -1.2 -0.5 -2.7 -0.3 1.1 -2.8
Arm fat percentage (left) 0.5 2.0 3.7 -1.6 -1.6 -1.1 -0.7 -1.1 1.5 -1.9
Average weekly red wine intake 0.2 0.3 0.7 -0.2 -0.5 0.9 0.4 -0.5 0.4 0.5
Handedness (chirality/laterality): Left-handed 0.6 0.7 4.0 -0.1 0.2 0.0 2.0 -0.1 -0.1 0.8
Mood swings 0.4 0.7 1.2 1.0 1.1 0.8 -0.1 0.9 -1.0 0.3
Loneliness, isolation 1.1 1.5 3.5 1.2 1.6 -0.2 0.5 1.2 -1.3 1.9
Long-standing illness, disability or infirmity 0.3 0.4 0.9 0.6 0.6 0.3 0.0 0.9 -0.7 -0.9
Ever had bowel cancer screening 1.4 1.6 6.3 -0.9 -0.8 -0.3 -0.0 -1.4 2.5 -1.3
Diabetes diagnosed by doctor 0.5 0.9 1.4 0.5 1.0 0.3 -1.2 1.1 -0.9 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.1 0.4 0.3 -1.0 -0.6 0.4 -0.5 0.5
Friendships satisfaction 0.2 0.3 1.0 1.0 0.0 0.2 0.5 0.5 -0.6 0.1
Qualifications: nursing, teaching 1.6 2.5 11.3 0.0 -0.6 0.3 -3.4 -0.2 0.8 -2.2
Commuting to job workplace: Walk 0.8 0.8 2.7 -0.6 -1.0 0.4 -1.6 -0.4 -0.1 -1.2
Eye problems/disorders: Cataract 0.7 0.8 2.1 -1.4 -1.1 -0.3 -0.1 -0.8 0.8 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.7 0.2 -0.2 1.3 -0.4 0.2 0.5 -0.9
Medication for cholesterol 1.1 1.6 3.6 -0.6 -1.6 0.1 -1.9 -0.8 0.8 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 4.2 -0.3 -0.2 -0.5 2.0 -0.5 0.0 1.2
Back pain experienced in last month 0.4 0.5 1.4 0.5 0.3 -1.0 0.1 0.8 -1.2 -0.5
Mineral and other dietary supplements 0.3 0.4 1.0 0.0 -0.4 -1.0 -0.8 0.1 -0.6 -0.7
Breast cancer (self-reported) 0.8 1.0 3.2 -0.4 -0.7 -1.8 -0.7 -0.8 1.1 -0.9
Asthma (self-reported) 3.2 6.4 12.0 -2.7 -3.1 -3.4 0.9 -3.5 1.6 0.8
Osteoporosis (self-reported) 1.6 2.0 3.7 1.9 1.6 1.6 -1.3 1.6 -1.0 -0.3
Osteoarthritis (self-reported) 0.9 1.2 3.1 1.4 0.8 0.2 -0.1 1.8 -1.5 -0.7
Medication: Aspirin 1.8 2.3 5.3 1.6 2.0 2.3 -0.6 1.7 -1.1 -0.1
Medication: Gliclazide 2.2 2.5 5.2 1.6 1.0 0.8 -2.3 1.9 -1.6 -1.4
Illnesses of father: None of the above (group 1) 1.6 2.0 3.6 -1.9 -1.3 -1.9 0.9 -1.6 1.3 -0.5
Smoking status: Current 1.5 2.4 5.7 1.8 1.3 0.5 0.0 2.1 -2.4 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.0 4.3 1.9 2.1 1.2 0.3 2.0 -0.7 0.6
Whole body water mass 0.5 2.7 10.8 0.3 -0.6 0.3 -2.6 0.6 0.5 -3.3
Leg predicted mass (right) 0.5 2.7 8.2 -0.6 -1.3 -0.6 -2.7 -0.3 1.1 -2.9
Arm fat mass (left) 0.5 1.9 5.9 -1.1 -1.4 -0.9 -1.2 -0.6 1.3 -2.4
Number of self-reported non-cancer illnesses 1.1 2.0 5.4 -1.4 -0.8 -0.9 2.3 -1.5 1.2 1.1
Average weekly champagne plus white wine intake 1.3 1.8 5.5 1.1 0.4 0.9 -2.3 1.4 -1.5 -1.0
Miserableness 0.8 1.3 4.0 1.0 -0.4 -0.1 -2.0 0.7 -0.5 -1.8
Guilty feelings 1.6 2.4 5.9 2.4 1.5 0.4 -0.3 2.1 -2.0 0.2
Wears glasses or contact lenses 0.9 1.0 1.8 -1.3 -1.2 0.1 -0.3 -1.4 1.3 -0.3
Ever taken oral contraceptive pill 0.8 0.9 2.6 -1.0 -0.3 -0.6 1.4 -0.8 0.1 1.6
Hearing aid user 3.5 3.9 6.2 1.6 2.5 1.6 2.4 1.9 -1.7 2.0
Mother’s age at death 4.5 5.7 15.9 -1.2 -2.5 0.4 -3.3 -1.1 1.9 -4.0
Financial situation satisfaction 0.3 0.3 1.0 0.2 0.4 0.0 -0.8 0.4 -1.0 0.6
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.7 0.3 -0.1 -0.8 -0.0 0.2 0.2 -0.5
Commuting to job workplace: Public transport 0.8 0.9 1.6 1.3 0.7 -0.6 -0.3 1.1 -1.2 1.1
Eye problems/disorders: Glaucoma 1.1 1.4 4.8 -0.7 -0.7 -0.1 -1.4 -0.9 0.8 -2.2
Medication: Blood pressure 2.2 4.2 11.0 0.8 2.4 0.7 3.2 0.7 -0.8 3.3
Pain type(s) experienced in last month: Hip pain 2.0 2.5 4.6 -1.7 -1.3 -2.1 -0.8 -1.3 1.3 -2.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.4 0.2 0.5 0.2 1.2 0.2 0.1 0.8
High cholesterol (Self-reported) 0.7 1.2 2.5 1.3 1.6 -0.1 1.0 1.3 -0.7 1.0
Medication: Bendroflumethiazide 0.6 1.0 2.1 -0.8 0.2 1.4 1.1 -0.8 0.1 1.5
Medication: Paracetamol 1.2 1.9 6.6 -1.0 -0.8 -2.6 0.0 -1.2 1.7 -1.0
Medication: Lisinopril 0.1 0.1 0.2 -0.1 0.1 0.1 -0.4 -0.2 0.5 0.3
Medication: Atorvastatin 3.6 4.4 6.9 2.3 2.6 2.2 -0.8 2.5 -2.2 1.6
Illnesses of father: High blood pressure 0.2 0.2 0.4 0.5 -0.4 0.6 -0.6 -0.3 0.3 -0.1
Alcohol drinker status: Never 0.1 0.1 0.3 -0.1 -0.4 -0.3 0.5 -0.1 -0.3 0.5
Ever smoked 0.5 0.9 2.5 -0.1 -0.6 -1.3 1.4 0.1 -0.4 -1.6
Basal metabolic rate 0.5 2.7 11.0 -0.1 -0.9 -0.2 -2.5 0.3 0.8 -3.3
Leg fat percentage (left) 0.6 2.2 5.7 -1.4 -1.5 -1.0 0.1 -0.8 1.9 -2.4
Arm fat-free mass (left) 0.6 2.9 13.8 -0.0 -0.8 -0.0 -2.0 0.3 1.2 -3.7
Number of operations (self-reported) 1.3 2.0 3.0 -1.6 -1.7 0.8 -1.2 -1.5 1.6 -1.2
Average weekly beer plus cider intake 0.5 0.7 1.4 -0.8 -0.5 -1.2 0.7 -0.9 1.0 0.1
Irritability 0.8 1.4 3.4 1.0 0.8 1.8 -1.7 0.9 -1.1 0.1
Risk taking 0.7 1.0 3.0 -0.5 -1.0 -0.7 0.1 -0.9 1.2 -1.7
Ever had prostate specific antigen (PSA) test 2.2 2.6 6.4 -0.7 -1.5 -2.5 -2.1 -0.6 1.0 -1.8
Fractured/broken bones in last 5 years 0.5 0.6 1.8 -0.3 0.1 1.3 -0.4 -0.4 1.1 -1.1
Age started oral contraceptive pill 1.2 1.5 8.7 0.9 0.7 3.0 -0.5 0.6 -0.4 0.3
Diastolic blood pressure, automated reading 0.4 1.3 5.0 -0.3 0.5 1.1 1.5 -0.5 -0.2 2.2
Ever depressed for a whole week 2.1 2.7 6.4 -2.0 -1.9 -1.2 -0.4 -2.5 1.6 0.1
Unable to work because of sickness or disability 0.3 0.4 0.7 0.8 0.7 -0.2 0.8 0.5 -0.4 0.7
Commuting to job workplace: Cycle 1.5 1.8 3.4 1.6 1.0 1.8 -1.2 1.4 -1.0 -1.2
Myopia 1.4 2.1 6.7 -1.4 -0.6 -0.0 2.6 -1.8 0.9 1.4
Vascular/heart problems diagnosed by doctor 0.6 1.8 5.0 -0.1 -0.8 -2.2 -2.0 0.1 -0.4 -1.6
Cholesterol lowering medication 1.1 1.7 4.4 1.8 2.1 0.4 -0.2 1.6 -0.9 0.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.3 -0.6 -0.5 -0.9 0.8 -0.7 0.3 1.1
Pain experienced in last month 0.7 1.2 4.6 -0.3 -1.0 2.2 -0.9 0.1 0.1 -1.4
Supplements: Calcium 0.6 0.7 1.1 -1.0 -0.9 0.7 -0.5 -1.0 0.9 -0.7
Basal cell carcinoma (self-reported) 0.4 0.5 3.1 -0.2 -0.4 -0.0 -0.3 0.0 0.4 -1.8
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.2 0.8 1.7 1.0 0.6 0.7 -0.0 1.8
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 2.6 -1.0 -0.5 -1.1 1.3 -1.6 1.6 1.4
Heart disease (siblings) 2.3 2.9 5.2 1.4 1.8 2.3 1.4 1.5 -2.0 1.3
Alcohol drinker status: Previous 0.5 0.6 2.7 -0.5 -0.3 -1.0 1.6 -0.3 0.1 0.2
Pack years of smoking 1.9 2.8 12.2 -0.3 -1.3 1.4 -1.7 0.4 -0.8 -3.5
Impedance of whole body 0.5 2.8 8.0 -0.4 -0.2 -2.2 2.1 -1.1 -0.8 2.8
Leg fat mass (left) 0.9 3.5 9.2 -1.7 -1.9 -1.3 -0.9 -1.1 2.2 -3.0
Arm predicted mass (left) 0.5 2.5 11.2 0.4 -0.4 0.3 -2.2 0.8 0.6 -3.4