TWAS hub - C1orf43

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1490	0.0680	0.00760	0.006	NA	0.051	NA	0.018	1.4e-01	NA	1.3e-03	NA	3.8e-02
2	GTEx	Breast Mammary Tissue (Female)	0.0619	0.0600	0.16000	-0.003	NA	-0.001	NA	0.003	4.1e-01	NA	3.4e-01	NA	2.6e-01
3	GTEx	Skin Sun Exposed Lower leg	0.0630	0.0270	0.00064	0.073	NA	0.050	NA	0.059	1.3e-06	NA	5.2e-05	NA	1.2e-05
4	GTEx	Thyroid	0.0440	0.0240	0.00760	0.003	NA	0.030	NA	0.027	1.9e-01	NA	2.1e-03	NA	3.8e-03
5	GTEx	Whole Blood	0.0960	0.0490	0.00330	-0.003	NA	0.000	NA	-0.003	8.1e-01	NA	2.8e-01	NA	7.6e-01
6	NTR	Blood	0.0117	0.0054	0.00060	0.014	0.007	0.011	0.006	0.014	1.5e-05	0.0019	1.2e-04	0.0026	1.8e-05
7	TCGA	Rectum Adenocarcinoma	0.1230	0.0730	0.00790	0.053	0.076	0.037	NA	0.058	2.2e-02	0.0077	4.8e-02	NA	1.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Allergy	7.8	18.0	36.6	1.2	4.6	-3.4	-5.5	-6.0	-4.0	-3.0
Age at First Birth	6.8	9.9	20.4	-1.9	-0.2	-3.6	-4.1	-0.8	-4.5	-3.8
Noisy workplace	6.3	7.8	13.7	-0.5	-0.5	3.2	3.5	2.3	3.7	3.6
Prostate Cancer	5.9	8.3	16.4	-0.5	-2.2	3.5	2.9	2.4	4.1	3.2
Hayfever, allergic rhinitis or eczema	5.9	12.9	26.5	-1.9	-4.6	2.4	4.4	5.2	3.0	2.1
Major Depression (MDD)	5.2	6.3	12.3	-0.6	-1.3	2.8	3.5	2.0	3.2	2.9
Allergy or Eczema	5.0	13.0	29.2	-1.3	-4.2	2.4	5.1	5.4	2.7	2.0
Medication: Ventolin 100micrograms inhaler	4.9	6.3	11.3	-0.6	-1.4	3.0	2.8	2.2	3.4	2.9
Medication: Paracetamol	4.9	7.6	15.0	0.5	-0.1	3.6	3.1	-0.2	3.9	3.9
Pain experienced in last month	4.8	8.0	14.6	-1.0	-1.3	-3.4	-3.8	-1.3	-3.6	-3.5
Worry (Nagel 2018)	4.6	9.6	13.1	2.4	3.4	3.4	2.5	2.7	3.3	3.6
Angina	4.6	6.0	9.6	-0.9	2.8	-2.7	-2.5	-1.4	-3.0	-3.1
Nervous feelings	4.4	8.3	14.4	2.4	1.8	3.8	1.6	2.2	3.6	3.8
Suffer from ‘nerves’	4.3	6.8	10.9	1.3	2.4	3.3	2.1	2.0	3.2	3.2
Medication: Paracetamol	4.2	6.9	11.6	2.0	1.2	3.3	3.0	0.9	3.3	3.4
Angina (self-reported)	4.2	5.5	8.4	-0.7	2.9	-2.4	-2.3	-1.7	-2.7	-2.9
Loud music exposure frequency	4.0	4.4	9.6	1.5	1.2	2.5	3.1	0.9	2.4	2.2
Mouth/teeth dental problems: Bleeding gums	3.9	5.1	12.7	-0.2	-0.8	-3.2	-1.3	-0.8	-3.1	-3.6
Medication: Blood pressure	3.9	6.9	15.9	-0.9	-0.8	-3.4	-1.8	-1.6	-4.0	-3.7
Asthma (self-reported)	3.8	7.7	17.1	-0.4	-2.3	2.5	4.1	3.7	2.7	1.9
Pack years of smoking	3.6	5.3	20.5	-4.5	-2.7	-1.3	-1.7	-1.0	-1.4	-1.4
Age when periods started (menarche)	3.5	8.3	15.7	0.6	3.0	-3.4	-2.9	0.5	-3.5	-4.0
Asthma	3.5	6.8	15.1	-0.1	-2.5	2.3	3.9	3.4	2.5	1.8
Medication for cholesterol, blood pressure or diabetes	3.5	5.9	10.2	1.0	-0.0	3.0	2.8	1.9	3.1	3.2
Father’s age at death	3.4	4.5	14.5	-2.9	-3.8	0.9	-0.0	2.2	1.3	1.2
Prospective memory result	3.4	4.2	8.8	-0.1	0.6	2.2	3.0	0.6	2.9	2.6
Wheeze or whistling in the chest in last year	3.4	6.1	21.9	-1.0	-2.7	1.8	4.7	1.6	2.1	1.5
Medication: Aspirin	3.4	4.4	7.8	0.3	1.6	-2.7	-1.7	-1.7	-2.8	-2.7
Mouth/teeth dental problems	3.3	5.0	10.1	-0.4	-0.1	2.8	2.3	2.0	3.2	2.8
Number of live births	3.3	4.6	7.9	1.0	1.2	2.6	1.7	2.3	2.7	2.8
Medication: Bendroflumethiazide	3.3	5.0	12.2	0.5	1.2	-3.1	-1.2	0.5	-3.5	-3.1
Blood Platelet Count	3.2	37.0	68.1	-0.3	-6.7	5.5	6.8	8.2	6.5	5.3
Respiratory disease	3.2	7.0	17.3	-0.4	-3.9	1.3	3.4	4.2	1.6	0.8
Headache pain in last month	3.2	5.6	9.8	0.9	0.7	3.0	3.0	0.2	3.1	3.1
Pack years adult smoking proportion	3.1	4.7	21.5	-4.6	-2.3	-1.0	-1.3	-0.9	-1.0	-1.3
Vascular/heart problems diagnosed by doctor	3.0	8.3	18.6	-1.8	-1.6	3.5	1.5	2.1	4.3	3.9
Crohns Disease (2017)	2.9	6.4	10.2	-1.7	1.8	-3.2	-3.1	-0.7	-3.0	-3.0
Hair/balding pattern: Pattern 4	2.9	6.9	12.1	-0.0	-0.5	-2.8	-3.3	-2.6	-3.5	-3.2
Rheumatoid Arthritis	2.8	3.9	8.6	-2.5	-0.5	-1.8	-2.9	-1.9	-1.6	-1.6
Ever had prostate specific antigen (PSA) test	2.8	3.2	4.7	0.1	-2.2	1.9	2.1	1.5	2.0	1.9
Tense / ‘highly strung’	2.7	4.5	7.3	0.8	0.8	2.3	2.4	2.3	2.5	2.7
Medication: Aspirin	2.7	3.5	5.8	0.6	1.7	-2.3	-1.5	-1.6	-2.4	-2.4
Fasting Glucose	2.6	3.1	5.9	1.2	2.4	1.7	1.4	1.7	1.9	1.8
Medication for hormone replacement therapy	2.6	2.9	6.6	0.6	0.1	2.6	1.2	-0.1	2.2	2.6
Medication: Atenolol	2.6	3.3	7.2	0.1	1.2	-2.2	-1.6	-1.3	-2.7	-2.3
Pulse wave reflection index	2.6	3.2	7.0	0.2	1.4	-2.0	-1.0	-2.6	-2.3	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.1	5.8	1.0	2.1	1.9	2.4	1.0	1.7	1.8
Guilty feelings	2.6	3.8	8.6	0.6	1.0	2.9	2.2	-0.3	2.3	2.6
Supplements: Zinc	2.5	2.8	5.6	0.3	-1.3	2.1	1.7	0.9	2.0	2.4
Heart disease (mother)	2.5	3.1	13.1	2.4	3.6	0.0	1.4	-0.6	-0.7	-0.2
Loneliness, isolation	2.5	3.5	5.8	1.1	1.7	2.4	1.9	0.1	2.3	2.4
Mother’s age at death	2.5	3.1	12.0	-0.8	-3.5	-1.4	-1.7	-1.8	-0.8	-0.8
Pain type(s) experienced in last month: Hip pain	2.5	3.2	5.8	-1.9	-1.7	1.7	2.4	0.6	2.0	1.7
Medication: Atorvastatin	2.5	3.1	5.2	1.6	1.8	-1.5	-1.6	-1.1	-2.2	-2.3
High blood pressure	2.4	6.7	14.7	1.8	1.4	-2.9	-1.3	-2.5	-3.8	-3.3
Age at first live birth	2.4	4.3	10.9	-0.4	-0.0	-2.8	-1.6	-0.2	-3.3	-2.9
LDL Cholesterol	2.3	3.6	7.2	0.4	0.5	2.5	2.1	0.7	2.7	2.6
Diabetes (mother)	2.3	3.0	6.1	1.0	-0.2	-2.3	-1.4	-0.6	-2.4	-2.5
Medication: Levothyroxine sodium	2.3	3.9	11.1	-0.7	1.8	-1.7	-3.3	-1.4	-1.9	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	5.2	-0.5	0.1	2.0	2.2	1.1	2.3	1.9
Coronary Artery Disease (CAD)	2.2	2.6	14.2	1.3	3.8	0.7	0.9	0.2	0.7	0.7
Hypertension (Self-reported)	2.2	6.2	12.7	2.2	1.5	-2.6	-1.0	-2.5	-3.6	-3.0
Schizophrenia (2014)	2.1	4.7	12.5	0.1	-1.2	1.7	2.7	3.5	2.2	2.1
Triglycerides	2.1	3.5	8.0	0.1	0.7	2.8	1.5	0.4	2.8	2.5
Medication: Co-codamol	2.1	2.4	5.8	0.7	0.2	2.2	1.1	1.2	1.7	2.4
Hypothyroidism/myxoedema (self-reported)	2.1	4.0	10.2	-0.6	1.5	-1.8	-3.2	-1.7	-2.2	-2.1
Illnesses of father: Heart disease	2.1	2.9	13.9	2.2	3.7	0.1	-0.5	-0.7	-0.7	-0.2
Number of operations (self-reported)	2.1	3.1	6.5	-0.8	-1.8	-1.6	-1.8	-2.5	-1.9	-1.5
Schizophrenia (2018)	2.0	4.2	7.2	0.2	-0.6	1.9	2.5	2.7	2.4	2.5
Hypothyroidism (self reported)	2.0	4.6	9.2	1.1	3.0	-1.6	-2.5	-1.9	-2.2	-2.1
Stomach or abdominal pain in last month	2.0	2.4	4.5	-0.6	-0.1	2.1	1.9	1.1	2.0	1.8
Hair/balding pattern: Pattern 3	2.0	2.9	5.2	-1.0	-2.1	-1.8	-2.3	-0.8	-1.7	-1.8
Cardiovascular Disease	1.9	6.3	11.2	1.5	2.6	-2.8	-1.5	-1.8	-3.3	-3.4
Diabetes (self-reported)	1.9	3.0	6.4	-1.2	-0.5	-1.8	-2.5	-1.8	-1.7	-1.8
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	5.0	-1.4	-0.5	1.9	2.2	0.8	1.8	1.7
Mouth/teeth dental problems: Dentures	1.9	3.3	7.1	0.4	0.6	-1.8	-2.3	-2.7	-2.2	-1.5
Age started oral contraceptive pill	1.9	2.4	4.6	-0.2	0.6	-2.0	-1.8	1.0	-2.1	-1.9
Bipolar Disorder or Schizophrenia	1.8	4.5	8.2	-0.8	-1.4	1.7	2.9	2.5	2.3	2.5
Frequency of depressed mood in last 2 weeks	1.8	2.5	4.0	1.4	1.6	1.9	1.5	0.7	2.0	1.5
Fluid intelligence score	1.8	3.7	8.6	-0.4	-0.9	-1.7	-2.4	-1.1	-2.9	-2.5
Chronic bronchitis/emphysema (mother)	1.8	2.0	5.9	-0.8	-1.5	1.4	2.4	0.7	1.3	1.2
Exposure to tobacco smoke outside home	1.8	2.4	9.8	-0.9	-1.6	0.9	3.1	-0.4	1.2	1.1
Number of full brothers	1.8	2.2	7.5	1.1	1.2	1.3	2.7	-0.0	1.5	1.2
HDL Cholesterol	1.7	2.8	6.3	0.5	0.5	-2.5	-1.0	-0.6	-2.5	-2.3
Ever used hormone-replacement therapy (HRT)	1.7	2.2	5.5	2.3	2.4	-0.1	-0.6	-1.8	-0.9	-0.2
Relative age voice broke	1.7	2.7	4.1	2.0	1.8	-1.9	-0.1	-0.5	-2.0	-1.9
Hair/balding pattern: Pattern 2	1.7	2.1	3.6	1.2	1.6	1.5	1.6	-0.7	1.3	1.9
Medication: Cholesterol lowering	1.7	2.6	4.2	-0.5	1.2	-1.8	-2.0	-1.7	-1.5	-2.0
Comparative body size at age 10	1.7	4.8	10.4	-1.2	-1.4	-2.6	-3.2	-1.7	-2.5	-2.1
Emphysema/chronic bronchitis	1.7	1.9	6.4	-2.4	-2.5	0.3	0.8	0.6	0.6	0.2
Alzheimer’s Disease (in father)	1.6	1.8	3.4	-0.7	-1.7	1.6	1.8	-0.1	1.4	1.2
Relative age of first facial hair	1.6	3.3	8.0	0.2	0.4	-2.6	-0.6	-1.0	-2.6	-2.8
Current tobacco smoking	1.6	2.6	14.2	-3.8	-0.5	-0.9	-0.5	-1.0	-0.5	-1.3
Chronic bronchitis/emphysema (father)	1.6	1.9	3.1	-1.5	-1.8	-1.4	0.2	-0.5	-1.6	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	3.5	-1.4	0.4	-1.4	-1.9	-0.6	-1.6	-1.4
Pulse wave peak to peak time	1.6	1.9	6.0	-0.5	-2.5	1.2	0.7	1.1	1.5	1.3
Hearing aid user	1.6	1.8	6.5	0.1	2.5	-0.8	-1.9	-1.1	-0.4	-0.9
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.0	0.9	2.2	-1.4	-1.1	-0.0	-1.9	-1.4
Heart attack	1.5	1.9	6.6	1.1	2.6	-1.1	-0.7	0.1	-1.6	-1.3
Illnesses of siblings	1.5	2.1	5.1	-0.7	-0.5	1.6	1.0	0.6	2.2	2.2
Impedance of arm (left)	1.5	6.9	26.3	2.0	1.1	1.8	2.4	5.1	2.4	1.2
Neck or shoulder pain in last month	1.5	2.1	6.7	0.2	1.0	1.3	2.6	1.0	1.5	1.5
Number of full sisters	1.5	1.8	3.8	0.2	0.8	1.7	1.2	0.3	1.9	2.0
Illnesses of siblings: Diabetes	1.5	1.8	3.2	1.8	1.1	-1.2	-0.5	-1.7	-1.4	-1.3
Back pain experienced in last month	1.5	2.2	5.1	-0.9	-0.2	1.6	2.2	1.0	1.9	1.6
Osteoporosis (self-reported)	1.5	1.9	8.9	-0.6	0.8	-0.6	-1.5	-3.0	-0.5	-0.6
Average weekly beer plus cider intake	1.5	2.1	6.7	2.3	-0.1	0.9	2.6	0.1	1.1	0.9
Ever depressed for a whole week	1.5	1.8	5.2	-2.3	-1.4	-1.0	0.9	0.5	-1.1	-1.6
Intelligence (Savage-Jansen 2018)	1.4	4.4	10.8	0.8	-2.0	-2.0	-2.0	-0.9	-3.3	-2.5
Gout (self-reported)	1.4	1.9	6.7	-2.3	-2.6	0.0	0.4	-0.9	-0.2	0.0
Had major operations	1.4	1.7	4.3	-0.3	-2.1	-1.4	-0.6	-0.2	-1.3	-1.7
Eye problems/disorders: Cataract	1.4	1.7	3.2	0.5	-1.4	-1.8	-1.2	1.3	-1.2	-1.4
Wears glasses or contact lenses	1.4	1.7	4.0	-0.4	-1.4	-1.2	-2.0	0.7	-1.4	-1.2
Ever taken oral contraceptive pill	1.4	1.6	2.6	1.6	0.7	1.2	1.5	0.2	1.5	1.3
Lung FVC	1.3	6.6	15.0	-1.2	-1.2	-3.0	-3.9	-0.0	-2.8	-3.4
Average weekly spirits intake	1.3	1.6	3.4	-0.5	-1.5	-1.2	-1.9	-0.7	-1.4	-1.2
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	4.8	1.1	2.2	0.8	1.0	-0.1	1.2	1.0
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	4.0	-0.5	0.9	1.6	0.2	0.2	2.0	1.7
Impedance of arm (right)	1.3	5.9	30.9	0.9	0.5	1.2	2.0	5.6	1.8	0.5
Lung cancer (father)	1.3	1.5	4.0	-2.0	-1.3	-0.5	-0.3	2.0	-0.3	-0.6
Pulse wave Arterial Stiffness index	1.3	1.5	5.1	0.3	2.3	-1.0	-0.5	-1.0	-1.3	-1.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.4	0.1	-1.4	-1.4	-1.8	0.5	-1.1	-1.5
Average weekly red wine intake	1.3	2.0	7.8	-2.8	-0.7	-1.1	-1.0	0.7	-1.1	-1.3
Medication: Blood pressure	1.3	2.5	10.2	2.5	3.2	-0.3	-0.5	-0.4	-0.7	-0.4
Alzheimer’s Disease (including proxy)	1.2	1.8	3.8	-1.5	-1.7	0.9	1.9	0.9	1.1	0.8
Irritable Bowel Disease (IBD)	1.2	2.8	4.9	-1.7	0.7	-2.2	-1.3	-1.6	-1.9	-1.8
Hand grip strength (right)	1.2	3.2	11.6	-3.4	-1.6	-1.6	-1.1	0.5	-0.9	-1.8
High blood pressure (mother)	1.2	1.7	7.5	1.8	2.7	0.1	0.7	-0.8	0.2	0.1
Qualifications: None of the above	1.2	2.5	6.5	1.7	2.5	0.4	0.6	2.4	1.1	0.5
Neuroticism score	1.2	2.5	4.6	1.1	1.9	2.1	0.7	0.5	1.7	2.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.6	0.7	0.3	1.5	1.1	-0.8	1.5	1.9
Glaucoma (self-reported)	1.2	1.4	3.1	-0.4	-1.8	-1.3	0.1	-1.3	-1.2	-1.3
High blood pressure (siblings)	1.2	1.8	4.8	0.1	-0.2	-1.5	-0.5	0.7	-2.1	-2.2
Commuting to job workplace: Walk	1.2	1.3	3.0	-0.2	-1.7	-1.4	-0.9	0.6	-0.9	-1.4
Smoking status: Current	1.2	1.9	11.0	-3.3	0.0	-0.7	-0.5	-0.8	-0.3	-1.0
Risk taking	1.2	1.8	2.9	-0.8	-0.8	1.7	1.5	0.4	1.7	1.7
Fractured/broken bones in last 5 years	1.2	1.6	7.8	-0.5	0.5	-0.5	-2.8	-1.4	-0.5	-0.0
Neuroticism (Nagel 2018)	1.1	2.5	4.0	1.1	2.0	1.9	1.5	0.6	1.6	2.0
Schizophrenia vs Biploar Disorder	1.1	1.5	4.2	0.3	-1.7	0.8	0.5	2.1	1.0	1.0
Neuroticism (2016)	1.1	1.6	7.3	-0.1	2.7	0.8	1.4	-0.9	0.4	0.6
Smoking Status	1.1	2.7	9.7	-3.1	-0.4	0.3	0.7	-2.7	0.9	-0.4
Lung FEV1/FVC ratio	1.1	5.5	21.6	1.7	4.7	2.1	-0.1	1.2	1.6	2.4
Chronotype (morning person)	1.1	2.6	4.3	0.6	1.2	1.5	1.9	2.1	1.7	1.8
Alcohol intake versus 10 years previously	1.1	1.7	3.0	1.7	0.6	1.5	1.1	0.7	1.6	1.5
Worrier / anxious feelings	1.1	2.1	6.2	1.9	2.5	1.2	0.2	1.4	0.8	0.9
Illnesses of mother	1.1	1.4	3.2	-0.8	-1.5	0.8	-0.4	1.8	1.2	1.2
Birth weight of first child	1.1	1.9	7.8	-1.3	-2.8	-0.4	-0.2	-1.9	-0.2	-0.3
Peak expiratory flow (PEF)	1.1	2.6	4.7	-0.2	2.1	1.9	0.0	1.7	2.2	1.5
Birth weight	1.1	2.5	10.3	-0.1	-1.8	-0.4	-1.3	-3.2	-1.0	-1.0
Medication for pain relief, constipation, heartburn	1.1	1.8	2.6	-1.6	-1.5	-1.2	-1.6	0.1	-1.3	-1.4
Medication: Ibuprofen	1.1	1.3	3.2	-0.1	-1.1	1.3	0.9	-0.6	1.4	1.8
Pulse rate, automated reading	1.1	3.5	5.5	1.8	-0.9	2.1	1.9	1.9	2.3	1.9
Medication for cholesterol	1.1	1.7	6.0	-2.5	-2.1	-0.9	-0.2	0.1	-0.4	-0.6
Cholesterol lowering medication	1.1	1.6	5.6	2.4	1.7	1.2	0.3	-0.7	0.5	0.7
Impedance of whole body	1.1	5.4	17.0	2.0	1.1	2.0	1.9	4.1	2.5	1.4
Alzheimer’s Disease (in mother)	1.0	1.1	2.5	-1.3	-1.6	0.4	1.6	0.6	0.7	0.4
Qualifications: CSEs or equivalent	1.0	1.3	2.5	0.6	-0.0	1.4	1.2	0.6	1.5	1.6
Exposure to tobacco smoke at home	1.0	1.1	2.0	1.2	-0.9	1.2	0.3	0.7	1.4	1.2
Medication: Omeprazole	1.0	1.2	5.1	-0.7	-0.0	1.0	2.2	0.7	1.0	0.6
Diastolic blood pressure, automated reading	1.0	3.0	5.7	2.4	1.3	-1.8	-1.4	-0.5	-2.1	-1.9
Supplements: Calcium	1.0	1.1	2.9	0.8	-0.5	-1.3	0.2	0.9	-1.7	-1.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.9	-0.4	-1.1	-1.0	-1.5	-1.3	-2.2	-1.9
Waist circumference	0.9	3.4	9.1	-1.5	-3.0	1.4	-0.7	-2.6	1.0	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.2	1.1	0.7	1.3	1.4	0.4	1.5	1.4
Hip circumference	0.9	3.9	6.0	-1.7	-2.3	2.4	0.7	-1.1	2.4	2.4
Mean time to correctly identify matches	0.9	1.6	3.4	1.6	0.2	-1.8	-0.2	-0.6	-1.8	-1.4
Family relationship satisfaction	0.9	1.2	2.9	-0.3	-0.9	-1.6	-0.1	-0.1	-1.4	-1.7
Qualifications: nursing, teaching	0.9	1.4	2.1	-1.1	-1.4	-1.3	-0.5	0.5	-1.4	-1.5
Myopia	0.9	1.3	2.3	-1.5	0.4	-1.1	-0.5	0.7	-1.5	-1.5
Crohns Disease (2012)	0.8	1.3	2.2	-1.5	0.7	-1.1	-1.3	-0.4	-1.3	-1.3
Mean Putamen Volume	0.8	0.9	2.5	1.0	-0.6	-0.4	-0.7	-1.6	-1.4	-0.4
Hand grip strength (left)	0.8	2.0	8.8	-3.0	-1.8	-0.7	0.4	0.9	0.2	-0.9
Average weekly fortified wine intake	0.8	0.9	2.5	0.6	0.7	0.8	1.6	0.9	1.1	0.8
Past tobacco smoking	0.8	1.4	5.5	1.6	0.6	-0.1	-0.9	2.4	-0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	3.9	-1.1	-0.1	0.8	2.0	-0.6	0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.4	0.7	-0.1	1.5	1.2	-1.6	1.2	1.0
Happiness	0.8	1.0	1.8	-1.2	0.6	-0.9	-1.0	0.2	-1.0	-1.3
Medication: Amlodipine	0.8	1.1	2.9	0.2	0.6	-1.4	-0.1	-0.5	-1.7	-1.5
Number of children fathered	0.8	0.9	2.3	0.5	0.5	1.0	-0.6	-1.2	0.8	1.5
Knee pain experienced in last month	0.8	1.3	3.1	-0.4	-0.8	1.2	1.8	-1.1	0.6	1.3
Osteoarthritis (self-reported)	0.8	1.0	3.5	-1.9	-0.2	0.3	1.8	-0.5	-0.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.0	1.4	1.8	-0.4	-2.2	1.2	-0.3	-0.7
Ever smoked	0.8	1.3	5.6	-2.4	-1.0	-0.2	1.0	-0.9	0.2	-0.9
Leg fat percentage (left)	0.8	2.8	5.6	-0.2	-1.8	1.7	-0.9	-2.4	1.5	2.1
Arm fat-free mass (left)	0.8	4.1	11.8	-3.3	-2.1	0.2	-1.0	-3.4	-0.3	0.2
Bipolar Disorder (2018)	0.7	1.1	2.2	-1.4	-1.5	0.4	1.5	0.5	0.6	1.0
Depression (Nagel 2018)	0.7	1.1	1.8	1.3	1.3	1.0	0.5	-1.0	1.0	0.8
Reaction Time	0.7	1.3	2.8	0.8	0.3	-1.7	0.9	-0.5	-1.5	-1.5
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.6	1.3	0.7	-0.8	-1.2	-1.1	-0.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.4	5.7	0.3	-0.1	-0.6	-1.7	-2.4	-0.5	-0.6
Neuroticism	0.7	1.8	3.5	1.1	1.9	1.7	0.7	0.2	1.2	1.7
Ever had hysterectomy (womb removed)	0.7	0.8	2.5	0.2	-0.2	0.9	-0.2	-1.6	0.6	1.2
Medication: Metformin	0.7	1.0	2.8	0.3	1.1	-0.9	-0.7	-1.7	-1.1	-0.8
Trunk fat-free mass	0.7	4.2	15.3	-3.9	-1.6	-0.3	-0.5	-3.3	-0.6	-0.2
Trunk predicted mass	0.7	4.0	14.6	-3.8	-1.6	-0.1	-0.4	-3.2	-0.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.6	0.7	-0.0	0.4	1.1	1.6	0.6	0.8
Medication: Allopurinol	0.7	0.9	3.6	-1.9	-1.2	0.4	0.5	-0.9	-0.1	0.4
Alcohol intake frequency.	0.7	1.7	3.1	0.1	-0.8	1.8	1.4	1.1	1.5	1.7
Comparative height size at age 10	0.7	4.1	5.9	-2.0	-1.9	2.3	2.0	0.4	2.4	2.3
Breast cancer (self-reported)	0.7	0.8	2.4	0.6	-0.9	-0.1	1.5	-1.4	0.1	0.1
Leg fat mass (left)	0.7	2.7	5.6	-1.2	-2.4	1.5	-0.5	-2.2	1.2	1.8
Arm predicted mass (left)	0.7	3.5	11.7	-3.0	-1.8	0.3	-0.6	-3.4	-0.1	0.4
Lupus	0.6	1.0	2.8	0.4	-0.8	-1.1	-0.5	-0.1	-1.7	-1.3
Sensitivity / hurt feelings	0.6	1.1	2.9	1.4	1.2	0.4	1.0	1.7	0.1	0.1
Severe depression (siblings)	0.6	0.6	1.6	0.4	-0.6	0.6	0.8	0.8	1.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	0.6	-0.0	1.1	-0.2	-0.8	1.0	1.3
Serious illness, injury or assault to yourself	0.6	0.7	1.4	-0.2	1.1	0.6	1.2	-0.8	0.2	1.0
Multivitamins +/- minerals	0.6	0.7	1.4	-0.0	-0.6	0.9	0.8	1.2	0.5	1.2
Hearing difficulty/problems with background noise	0.6	0.9	2.2	-0.4	-0.2	0.8	1.4	0.5	1.5	0.9
Medication: Ramipril	0.6	0.7	1.1	0.5	1.0	-0.8	-1.0	-0.8	-1.1	-0.6
Weight	0.6	3.1	5.2	-2.2	-2.2	1.5	-0.1	-2.3	1.2	1.7
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.4	-0.4	-1.5	-1.1	-0.8	-0.6	-1.3	-1.5
Arm fat-free mass (right)	0.6	3.2	11.0	-2.9	-1.5	0.0	-0.9	-3.3	-0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.4	1.2	0.6	1.2	0.7	0.7	0.5	0.9
Health satisfaction	0.6	0.7	2.8	0.2	-0.3	0.2	1.5	-1.7	0.0	0.1
Shortness of breath walking on level ground	0.6	0.7	4.3	-0.3	-0.1	-0.5	-0.1	-2.1	-0.4	-0.6
Leg fat mass (right)	0.6	2.3	5.6	-1.5	-2.4	1.0	-0.6	-2.1	0.8	1.3
Arm predicted mass (right)	0.6	3.0	10.2	-2.9	-1.4	0.1	-0.8	-3.2	-0.3	0.2
Chest pain or discomfort	0.6	0.9	2.4	-1.4	0.9	0.3	1.6	1.0	0.1	-0.2
Smoking status: Previous	0.6	0.9	4.0	-0.3	-0.8	0.3	1.0	-2.0	0.8	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	3.9	-0.2	0.3	0.1	1.0	2.0	0.5	-0.1
Long-standing illness, disability or infirmity	0.6	1.0	1.8	-1.2	0.3	0.9	0.9	-1.3	0.7	1.2
Illnesses of father: High blood pressure	0.6	0.7	1.7	0.5	-0.8	0.8	0.9	-1.3	0.3	0.8
Irritability	0.6	1.1	2.3	1.0	0.8	-1.0	-0.4	-1.3	-1.5	-0.9
Unable to work because of sickness or disability	0.6	0.7	1.6	0.7	1.1	0.7	0.3	1.3	0.8	0.8
Commuting to job workplace: Cycle	0.6	0.8	3.6	-1.9	0.1	0.5	-0.1	-0.9	0.4	0.6
Heart disease (siblings)	0.6	0.7	3.6	1.0	1.9	0.3	-0.2	-0.3	0.2	0.2
Primary Biliary Cirrhosis	0.5	0.8	2.6	-0.8	0.2	-0.6	-0.9	-1.6	-0.9	-0.4
Systolic Blood Pressure	0.5	2.5	9.0	3.0	1.4	-1.0	-0.4	0.7	-1.8	-1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.4	-0.5	-0.4	0.6	-0.4	-0.8	1.1	1.2
Trunk fat percentage	0.5	2.1	4.3	0.1	-2.1	1.8	-0.3	0.2	1.9	1.9
Townsend deprivation index at recruitment	0.5	0.7	2.9	0.6	0.2	-0.3	1.0	1.7	-0.2	-0.6
Maternal smoking around birth	0.5	0.7	3.7	-0.2	1.9	0.0	0.5	0.6	-0.2	-0.5
Fed-up feelings	0.5	0.8	2.3	-1.4	-0.1	-0.2	-1.5	-1.2	-0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.9	1.2	0.3	0.5	-0.1	-1.4	0.1	0.3
Trunk fat mass	0.5	2.3	5.6	-1.1	-2.4	1.6	-0.4	-0.8	1.6	1.8
Number of incorrect matches in round	0.5	0.8	2.0	-0.3	0.6	0.8	0.5	0.8	1.3	1.4
Had menopause	0.5	0.6	1.2	0.7	-0.4	-0.9	-1.0	0.6	-1.1	-0.7
Pain all over the body in last month	0.5	0.5	2.9	0.1	0.3	0.4	-0.4	1.7	0.4	0.4
Blood clot in the leg (DVT)	0.5	0.7	1.7	1.3	1.0	0.6	0.7	0.9	0.3	0.7
Body fat percentage	0.5	1.9	4.2	-0.2	-2.0	1.6	-0.7	-0.7	1.6	1.8
Leg fat percentage (right)	0.5	1.9	4.3	-0.6	-1.6	1.2	-1.1	-2.1	1.1	1.6
Eye problems/disorders: None of the above	0.5	0.6	3.0	-0.4	1.7	0.8	-0.2	-0.5	-0.0	0.5
Migraine (self-reported)	0.5	0.7	1.5	0.9	0.2	1.2	0.1	-0.3	1.1	1.1
Age at last live birth	0.5	0.7	2.1	0.3	0.3	-1.0	-0.3	0.4	-1.5	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	0.8	-0.6	0.8	0.8	-0.4	1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.5	-1.6	-0.8	0.9	1.2	0.1	1.3	0.7
Whole body fat-free mass	0.5	3.1	10.9	-3.3	-1.9	0.0	-0.2	-2.7	-0.3	0.1
Diabetes diagnosed by doctor	0.5	0.8	2.0	-0.2	0.3	-0.9	-1.4	-1.2	-0.7	-0.9
Friendships satisfaction	0.5	0.7	2.6	-1.2	-0.2	0.4	-0.3	1.6	0.4	-0.3
Whole body water mass	0.5	3.1	10.8	-3.3	-1.8	0.1	-0.3	-2.7	-0.3	0.1
Arm fat mass (left)	0.5	1.9	3.5	-1.2	-1.9	1.5	-0.1	-1.4	1.2	1.5
Basal metabolic rate	0.5	2.9	8.9	-3.0	-2.0	0.6	0.0	-2.5	0.3	0.7
Ovarian Cancer	0.4	0.6	1.0	-0.1	0.9	1.0	0.9	0.1	0.6	1.0
Waist Hip Ratio (WHR)	0.4	1.7	9.0	0.8	0.0	-0.1	-1.2	-3.0	-0.5	-0.4
Body mass index (BMI)	0.4	1.7	5.7	-0.8	-1.6	0.9	-0.7	-2.4	0.6	1.2
Financial difficulties in last 2 years	0.4	0.5	1.7	1.3	0.7	0.0	0.8	-0.8	-0.4	0.0
Arm fat percentage (right)	0.4	1.4	3.7	-0.9	-1.9	1.3	-0.3	-0.7	1.2	1.3
Pulse rate	0.4	0.7	1.6	-0.4	-0.1	1.0	0.7	1.3	1.2	0.7
Medication: Lansoprazole	0.4	0.5	1.4	-0.0	1.2	-0.2	-0.6	-0.6	-0.8	-0.6
Arm fat mass (right)	0.4	1.7	3.7	-1.5	-1.9	1.1	-0.2	-1.3	0.9	1.2
Standing height	0.4	3.5	12.3	-3.5	-1.5	1.6	1.8	0.3	1.6	1.2
Length of working week for main job	0.4	0.5	2.2	-0.9	-0.5	-0.0	0.1	-1.5	-0.1	-0.1
Breastfed as a baby	0.4	0.5	1.0	0.9	-0.8	-0.9	-0.1	0.0	-1.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.0	-0.2	1.3	0.9	1.4	0.5	0.1	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	1.0	-0.1	0.6	0.6	-1.0	0.6	0.6
Worry too long after embarrassment	0.4	0.7	2.4	0.8	1.6	1.1	-0.4	-0.2	0.5	0.6
Qualifications: College or University degree	0.4	1.3	4.5	-0.7	0.3	-1.1	-0.6	-0.7	-2.1	-1.4
Whole body fat mass	0.4	1.8	5.1	-1.1	-2.3	1.3	-0.5	-1.2	1.1	1.4
Overall health rating	0.4	0.9	1.9	0.5	0.3	1.4	0.9	-1.0	1.0	0.9
Leg pain on walking	0.4	0.4	0.7	-0.8	-0.6	-0.8	0.8	-0.4	-0.4	-0.7
Arm fat percentage (left)	0.4	1.7	3.0	-0.4	-1.7	1.6	-0.2	-0.7	1.6	1.7
Number of self-reported non-cancer illnesses	0.4	0.7	2.5	1.4	0.4	0.2	1.6	-0.6	0.0	0.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	-0.4	-1.3	-0.7	0.7	-0.5	-0.6	-0.5
Medication: Lisinopril	0.4	0.5	1.6	0.7	-0.5	0.5	-0.6	-1.3	0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.7	-0.9	-0.1	0.5	1.3	0.8	0.5	0.2
Alcohol drinker status: Previous	0.4	0.4	1.1	-1.1	-0.5	0.7	0.1	0.6	0.8	0.5
Depressed Affect (Nagel 2018)	0.3	0.5	1.5	-0.2	0.4	0.7	-0.5	-1.2	0.6	0.9
Ulcerative Colitis (UC)	0.3	0.5	1.1	-0.8	-0.0	0.2	0.9	-1.0	0.6	0.7
Bipolar Disorder (2011)	0.3	0.2	0.6	0.2	0.7	-0.1	0.7	-0.7	-0.2	-0.2
Body Mass Index (BMI) (2010)	0.3	0.5	3.0	-0.2	0.2	-0.3	0.1	1.7	0.1	-0.2
Heel T-Score	0.3	2.5	7.8	0.6	-0.1	2.4	-1.0	0.5	1.6	2.8
Hearing difficulty/problems: Yes	0.3	0.5	1.3	-1.1	0.7	0.2	-0.1	1.2	0.5	0.6
Vitamin and mineral supplements	0.3	0.4	1.4	0.6	1.2	-0.3	-0.5	-0.7	-0.0	-0.6
Diabetes (father)	0.3	0.4	2.3	0.6	-0.2	-0.3	-0.2	-1.5	-0.5	0.1
Leg fat-free mass (left)	0.3	1.5	5.2	-2.3	-1.8	0.4	0.4	-1.4	0.1	0.4
Taking other prescription medications	0.3	0.4	1.4	-0.8	1.2	0.2	0.8	0.2	-0.1	-0.0
Supplements: Glucosamine	0.3	0.4	0.8	-0.7	-0.9	0.4	-0.4	-0.8	0.6	0.7
Leg predicted mass (left)	0.3	1.6	5.5	-2.3	-1.9	0.3	0.4	-1.4	0.1	0.4
Alcohol usually taken with meals	0.3	0.5	1.6	0.6	1.3	0.5	0.0	0.3	0.3	1.0
Had other major operations	0.3	0.4	1.6	0.6	0.6	0.1	-0.3	-1.3	-0.3	0.2
Falls in the last year	0.3	0.4	0.9	-0.8	-0.6	-0.4	-0.4	-0.9	-0.9	-0.4
Depression (self-reported)	0.3	0.4	1.0	1.0	0.0	-0.4	0.3	-0.4	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.6	0.2	0.8	1.0	-0.4	1.9	0.9	0.5
Medication: Seretide 50 evohaler	0.3	0.4	1.1	-0.1	-0.9	0.3	1.1	0.6	0.5	0.4
Supplements: Vitamin C	0.3	0.3	1.2	-0.6	-1.1	0.4	-0.1	-0.2	0.3	0.8
Leg fat-free mass (right)	0.3	1.9	4.9	-2.2	-2.1	0.7	0.7	-1.5	0.4	0.7
Ever had bowel cancer screening	0.3	0.3	1.9	1.4	-0.2	0.3	-0.4	0.1	0.0	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.8	-0.1	0.2	0.0	0.6	-1.3	0.3	0.0
Medication: Gliclazide	0.3	0.3	1.3	0.4	-0.3	-0.5	0.3	-1.1	-0.5	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	-1.2	-0.3	-0.3	-0.1	1.0	0.4	-0.1
Leg predicted mass (right)	0.3	1.8	5.2	-2.3	-2.1	0.6	0.7	-1.4	0.3	0.6
Miserableness	0.3	0.6	2.1	-1.2	-1.4	-0.1	0.5	-0.1	0.2	-0.3
Financial situation satisfaction	0.3	0.4	1.5	1.2	0.3	-0.6	0.2	-0.4	-0.5	-0.7
Commuting to job workplace: Public transport	0.3	0.4	1.2	0.3	0.6	0.6	0.4	1.1	0.5	0.5
Alcohol drinker status: Never	0.3	0.3	1.8	0.4	-0.4	-0.1	-0.3	-1.3	-0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	1.0	0.9	0.2	0.1	0.8	-0.0	0.5
Breast Cancer	0.2	0.4	0.8	-0.7	-0.8	-0.4	-0.9	-0.7	-0.2	-0.1
Blood Eosinophil Count	0.2	1.7	7.2	-0.4	-0.2	1.3	2.7	1.5	0.6	0.7
BMI	0.2	1.1	3.9	-0.2	-1.8	-0.2	-0.7	-2.0	-0.3	0.1
Height	0.2	4.3	14.4	-3.8	-1.9	1.2	2.5	0.0	1.5	1.2
Tanning	0.2	2.3	5.0	0.5	-1.4	2.0	1.0	0.2	2.0	2.2
Systolic blood pressure, automated reading	0.2	0.7	3.5	1.9	-0.5	0.2	-0.1	1.0	-0.1	0.6
Impedance of leg (right)	0.2	0.8	3.6	0.3	1.0	0.4	0.5	1.9	0.8	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.4	0.4	0.7	0.6	-0.7	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.3	0.8	0.9	-0.1	0.5	0.5	0.8
Impedance of leg (left)	0.2	1.1	2.6	0.8	0.5	1.2	0.7	1.6	1.5	0.7
Forced vital capacity (FVC)	0.2	0.6	3.3	-1.8	-0.5	0.4	-0.7	-0.0	0.4	-0.3
Time employed in main current job	0.2	0.2	0.7	0.4	0.4	-0.1	-0.6	0.8	0.2	-0.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-0.9	1.0	1.0	-0.5	0.8	0.9	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.3	-1.1	-0.2	-0.1	-0.2	0.4	-0.4	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.7	1.7	-1.1	-1.0	0.4	-0.8	1.3	0.5	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.0	0.1	1.0	-0.3	-0.6	0.2	-0.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.0	-0.1	1.0	0.2	-0.7	0.1	-0.2	0.2
Mood swings	0.2	0.4	0.8	0.3	0.8	0.7	-0.0	-0.4	0.6	0.9
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.2	-0.4	0.2	0.2	0.7	0.8	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.2	-0.1	1.1	0.1	-0.3	0.4	0.1	0.3
High cholesterol (Self-reported)	0.2	0.4	1.8	0.6	1.4	0.5	-0.2	-0.6	0.5	-0.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	0.3	-0.6	0.5	0.6	0.0	0.7	0.7
HbA1C	0.1	0.1	0.6	-0.1	0.1	0.3	0.1	-0.8	0.2	-0.0
Ulcerative Colitis	0.1	0.2	0.3	0.4	-0.1	0.2	0.5	0.5	0.5	0.5
Blood Red Count	0.1	1.1	3.4	-1.1	1.3	-0.2	-0.7	1.8	0.1	-0.6
Blood White Count	0.1	0.9	2.0	-1.1	-0.8	0.9	0.6	0.5	1.4	1.1
Number of treatments/medications taken	0.1	0.3	0.8	-0.1	0.9	-0.2	0.1	-0.8	-0.3	-0.4
Sitting height	0.1	1.0	5.5	-2.4	-0.2	-0.4	0.6	-0.4	-0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.9	-0.1	0.6	-0.2	0.5	0.4	0.7
Medication: Simvastatin	0.1	0.1	0.5	0.1	0.7	0.3	-0.1	-0.1	0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	0.3	-0.4	-0.3	-0.9	-0.1	-0.6	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.9	0.4	0.2	0.1	0.1	0.9	-0.2	0.2
Mineral and other dietary supplements	0.1	0.2	0.8	-0.2	-0.9	-0.2	0.3	0.4	0.0	-0.6
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.1	-0.6	-0.1	-0.5	-0.3	0.3	0.5
Hair Pigment	0.0	0.5	1.2	0.3	1.1	0.7	-0.7	-0.8	0.5	0.8

Hub : Genes

C1orf43

Models

Trait associations