Best TWAS P=2.7e-14 · Best GWAS P=2.14e-15 conditioned to 0.00368
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TLR1 | 0.08 | 0.07 | lasso | 2 | 0.07 | 1.3e-08 | -6.9 | -7.3 | 2.1e-13 | 0.83 | 0.19 | 0.81 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | TLR6 | 0.28 | 0.19 | lasso | 5 | 0.17 | 1.7e-12 | -6.4 | 6.5 | 6.5e-11 | -0.71 | 0.95 | 0.05 | FALSE |
| 3 | GTEx | Esophagus Mucosa | TLR1 | 0.20 | 0.02 | lasso | 6 | 0.04 | 9.8e-04 | -6.4 | 7.1 | 1.4e-12 | -0.78 | 0.04 | 0.95 | FALSE |
| 4 | GTEx | Esophagus Muscularis | TLR1 | 0.21 | 0.02 | enet | 46 | 0.06 | 2.3e-04 | -6.1 | 5.5 | 3.8e-08 | -0.56 | 0.07 | 0.80 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | TLR6 | 0.29 | 0.03 | lasso | 11 | 0.08 | 4.8e-05 | 3.1 | 6.3 | 2.6e-10 | -0.68 | 0.15 | 0.82 | FALSE |
| 6 | GTEx | Testis | FAM114A1 | 0.37 | 0.20 | lasso | 7 | 0.20 | 2.2e-09 | -6.3 | -5.5 | 2.9e-08 | 0.71 | 0.46 | 0.53 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | TLR1 | 0.08 | 0.02 | blup | 514 | 0.03 | 2.3e-05 | -6.8 | -5.1 | 3.0e-07 | 0.68 | 0.15 | 0.83 | FALSE |
| 8 | YFS | Blood | TLR1 | 0.08 | 0.05 | bslmm | 525 | 0.07 | 1.2e-20 | -7.5 | 6.1 | 1.3e-09 | -0.54 | 0.04 | 0.96 | FALSE |
| 9 | YFS | Blood | TLR6 | 0.05 | 0.04 | bslmm | 505 | 0.06 | 1.3e-18 | -6.8 | 5.6 | 1.8e-08 | -0.61 | 0.80 | 0.20 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TLR6 | 0.03 | 0.02 | lasso | 2 | 0.01 | 3.5e-02 | -6.4 | 6.4 | 1.6e-10 | -0.71 | 0.05 | 0.18 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TLR1 | 0.04 | 0.03 | lasso | 4 | 0.03 | 8.2e-05 | -7.5 | 7.6 | 2.7e-14 | -0.83 | 0.04 | 0.96 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TLR10 | 0.09 | 0.06 | lasso | 2 | 0.06 | 2.3e-04 | -5.8 | 5.8 | 5.4e-09 | -0.68 | 0.12 | 0.29 | FALSE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TLR1 | 0.14 | 0.07 | enet | 12 | 0.10 | 1.7e-05 | -6.8 | 7.3 | 3.5e-13 | -0.85 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TLR1 | 0.03 | 0.03 | enet | 23 | 0.03 | 1.5e-04 | -7.5 | 5.5 | 3.6e-08 | -0.69 | 0.03 | 0.90 | FALSE |
| 15 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TLR1 | 0.13 | 0.13 | enet | 3 | 0.08 | 2.6e-03 | -4.6 | 5.8 | 8.8e-09 | -0.71 | 0.02 | 0.61 | FALSE |