Best TWAS P=2.55e-10 · Best GWAS P=3.34e-10 conditioned to 0.0616
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FADS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.2e-19 | -6.2 | 6.2 | 7.1e-10 | -0.98 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FEN1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 1.1e-07 | -6.2 | -6.1 | 1.1e-09 | 0.98 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Aorta | FADS2 | 0.18 | 0.17 | lasso | 3 | 0.14 | 3.2e-08 | -4.7 | -5.2 | 1.7e-07 | 0.68 | 0.13 | 0.87 | FALSE |
| 4 | GTEx | Artery Tibial | FADS2 | 0.08 | 0.02 | lasso | 4 | 0.02 | 6.9e-03 | -5.6 | -5.2 | 2.5e-07 | 0.80 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Artery Tibial | TMEM258 | 0.08 | 0.05 | lasso | 5 | 0.02 | 1.1e-02 | -6.1 | -6.1 | 9.0e-10 | 0.97 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Brain Cerebellum | FADS1 | 0.35 | 0.24 | enet | 16 | 0.30 | 2.1e-09 | -6.0 | 5.8 | 7.6e-09 | -0.92 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Brain Cerebellum | FADS3 | 0.26 | 0.18 | lasso | 4 | 0.14 | 5.7e-05 | -6.0 | 6.1 | 9.0e-10 | -0.93 | 0.02 | 0.90 | FALSE |
| 8 | GTEx | Colon Transverse | FADS2 | 0.18 | 0.11 | lasso | 7 | 0.16 | 8.1e-08 | -4.7 | -6.1 | 8.7e-10 | 0.76 | 0.03 | 0.96 | FALSE |
| 9 | GTEx | Heart Left Ventricle | FADS2 | 0.17 | 0.12 | enet | 3 | 0.13 | 1.5e-07 | -4.9 | -5.3 | 1.2e-07 | 0.71 | 0.22 | 0.77 | FALSE |
| 10 | GTEx | Muscle Skeletal | FADS2 | 0.08 | 0.04 | lasso | 2 | 0.03 | 5.9e-04 | -6.0 | -6.0 | 1.8e-09 | 0.90 | 0.03 | 0.97 | FALSE |
| 11 | GTEx | Pancreas | FADS1 | 0.17 | 0.13 | lasso | 6 | 0.12 | 1.2e-05 | -6.0 | 6.2 | 6.0e-10 | -0.92 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Spleen | FADS2 | 0.30 | 0.27 | lasso | 3 | 0.27 | 1.6e-07 | -4.7 | -5.3 | 1.1e-07 | 0.72 | 0.08 | 0.90 | FALSE |
| 13 | NTR | Blood | C11orf10 | 0.06 | 0.08 | bslmm | 399 | 0.08 | 1.3e-24 | -5.6 | -6.1 | 1.3e-09 | 0.92 | 0.05 | 0.95 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | TMEM258 | 0.14 | 0.16 | lasso | 4 | 0.15 | 4.7e-19 | -5.6 | -5.6 | 2.0e-08 | 0.94 | 0.05 | 0.95 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | FADS1 | 0.08 | 0.08 | enet | 10 | 0.09 | 1.5e-11 | -6.1 | 6.0 | 2.7e-09 | -0.97 | 0.01 | 0.99 | FALSE |
| 16 | YFS | Blood | FADS1 | 0.11 | 0.08 | lasso | 8 | 0.09 | 6.1e-29 | -4.7 | -5.6 | 2.3e-08 | 0.77 | 0.97 | 0.03 | FALSE |
| 17 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FADS1 | 0.06 | 0.03 | lasso | 4 | 0.04 | 7.4e-03 | -6.0 | 6.3 | 2.5e-10 | -0.83 | 0.01 | 0.77 | TRUE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | FADS2 | 0.30 | 0.21 | lasso | 2 | 0.22 | 6.7e-13 | -4.7 | -5.4 | 5.3e-08 | 0.76 | 0.65 | 0.35 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FADS2 | 0.26 | 0.29 | enet | 15 | 0.29 | 2.9e-33 | -4.7 | -5.3 | 1.3e-07 | 0.73 | 0.97 | 0.03 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FADS2 | 0.33 | 0.27 | lasso | 9 | 0.35 | 9.3e-21 | -4.7 | -5.7 | 1.2e-08 | 0.79 | 0.39 | 0.61 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FADS2 | 0.02 | 0.01 | blup | 71 | 0.02 | 1.9e-03 | -6.0 | -5.4 | 5.9e-08 | 0.91 | 0.02 | 0.78 | FALSE |
| 22 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FADS2 | 0.47 | 0.34 | lasso | 5 | 0.30 | 7.9e-08 | -4.7 | -5.1 | 3.1e-07 | 0.68 | 0.04 | 0.94 | FALSE |
| 23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FADS2 | 0.15 | 0.05 | blup | 71 | 0.11 | 2.5e-08 | -4.7 | -5.7 | 1.0e-08 | 0.72 | 0.04 | 0.95 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf10 | 0.02 | 0.02 | blup | 44 | 0.02 | 1.8e-03 | -4.8 | -5.9 | 3.2e-09 | 0.95 | 0.02 | 0.74 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | FADS2 | 0.30 | 0.33 | lasso | 8 | 0.33 | 5.6e-33 | -4.7 | -5.4 | 6.0e-08 | 0.71 | 0.97 | 0.03 | FALSE |