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chr2:197,134,790-200,117,777

Best TWAS P=1.71e-15 · Best GWAS P=1.37e-14 conditioned to 0.00198

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Breast Mammary Tissue (Female)	SF3B1	0.05	-0.01	lasso	3	-0.01	8.1e-01	7.2	8.0	1.7e-15	0.68	0.05	0.17	TRUE
29	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	7.4	7.9	2.0e-15	0.74	0.03	0.50	FALSE
14	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	7.2	7.9	3.5e-15	0.88	0.07	0.53	FALSE
3	GTEx	Breast Mammary Tissue	SF3B1	0.06	0.06	lasso	4	0.03	6.6e-03	7.2	7.8	5.9e-15	0.64	0.12	0.76	FALSE
18	GTEx	Thyroid	SF3B1	0.04	0.02	enet	14	0.02	2.0e-02	6.7	7.8	7.7e-15	0.76	0.08	0.85	FALSE
9	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	7.6	7.7	1.2e-14	0.91	0.06	0.94	FALSE
19	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	6.9	7.7	1.6e-14	0.81	0.16	0.59	FALSE
13	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	7.3	-7.4	1.2e-13	-0.91	0.05	0.94	FALSE
15	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	7.3	-7.4	1.7e-13	-0.86	0.06	0.45	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SF3B1	0.06	0.07	enet	10	0.07	2.5e-09	7.3	7.3	2.4e-13	0.51	0.12	0.88	FALSE
17	GTEx	Testis	SF3B1	0.10	0.07	enet	17	0.08	2.6e-04	7.3	7.2	4.2e-13	0.57	0.16	0.82	FALSE
28	YFS	Blood	PLCL1	0.10	0.10	lasso	9	0.14	1.5e-43	7.7	7.2	7.0e-13	0.88	0.04	0.96	FALSE
6	GTEx	Esophagus Mucosa	SF3B1	0.04	0.02	lasso	4	0.01	5.7e-02	7.1	7.2	7.1e-13	0.51	0.14	0.57	FALSE
21	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	7.4	7.1	9.2e-13	0.97	0.05	0.95	FALSE
10	GTEx	Nerve Tibial	SF3B1	0.06	0.09	lasso	8	0.08	3.3e-06	7.2	7.1	1.2e-12	0.57	0.41	0.59	FALSE
11	GTEx	Pituitary	HSPD1	0.10	0.03	enet	12	0.06	1.3e-02	3.8	6.8	1.2e-11	0.48	0.08	0.37	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	SF3B1	0.02	0.01	blup	336	0.01	6.2e-03	6.7	6.5	7.2e-11	0.52	0.23	0.62	FALSE
2	GTEx	Adipose Subcutaneous	RFTN2	0.14	0.10	enet	11	0.13	5.3e-11	7.6	6.1	1.3e-09	0.91	0.03	0.97	FALSE
7	GTEx	Esophagus Muscularis	SF3B1	0.06	0.02	lasso	4	0.03	1.0e-02	6.5	6.0	1.4e-09	0.45	0.14	0.32	FALSE
22	NTR	Blood	ANKRD44	0.03	0.00	bslmm	417	0.02	2.7e-06	6.7	-6.1	1.4e-09	-0.50	0.15	0.75	FALSE
16	GTEx	Testis	ANKRD44	0.33	0.35	enet	15	0.36	6.2e-17	6.1	6.0	1.6e-09	0.39	1.00	0.00	FALSE
8	GTEx	Lung	SF3B1	0.06	0.04	enet	23	0.02	2.2e-02	7.1	6.0	1.7e-09	0.48	0.15	0.75	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	MARS2	0.15	0.14	lasso	4	0.07	2.6e-03	-5.8	-5.9	3.0e-09	-0.70	0.07	0.62	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	MARS2	0.05	0.03	enet	14	0.05	2.2e-07	-6.1	-5.8	8.1e-09	-0.79	0.10	0.90	FALSE
20	GTEx	Thyroid	RFTN2	0.04	0.01	enet	11	0.01	9.5e-02	7.3	5.7	1.4e-08	0.84	0.12	0.65	FALSE
23	NTR	Blood	PLCL1	0.02	0.01	enet	14	0.02	1.9e-06	7.3	5.6	1.8e-08	0.76	0.08	0.90	FALSE
27	YFS	Blood	ANKRD44	0.02	0.00	blup	416	0.01	6.3e-04	1.6	-5.5	3.9e-08	-0.40	0.14	0.49	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	RFTN2	0.03	0.04	blup	351	0.03	1.5e-04	6.6	-5.5	4.0e-08	-0.26	0.81	0.14	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	SF3B1	0.08	0.00	enet	19	0.01	1.6e-01	7.4	5.2	1.5e-07	0.34	0.13	0.61	FALSE