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chr4:122,377,715-124,935,698

Best TWAS P=1.71e-35 · Best GWAS P=9.65e-30 conditioned to 0.153

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	The Cancer Genome Atlas	Esophageal Carcinoma	KIAA1109	0.32	0.02	blup	45	0.02	7.4e-02	10.9	-12.4	1.7e-35	-0.51	0.01	0.46	TRUE
5	GTEx	Colon Transverse	KIAA1109	0.25	-0.01	enet	16	0.00	4.1e-01	10.9	-11.1	1.6e-28	-0.92	0.02	0.77	TRUE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA1109	0.06	0.05	lasso	2	0.03	7.1e-05	10.7	-11.0	6.1e-28	-0.79	0.31	0.53	TRUE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA1109	0.05	0.05	enet	8	0.04	1.3e-05	10.7	-8.1	7.7e-16	-0.80	0.02	0.94	TRUE
7	ROSMAP	Brain Pre-frontal Cortex	SPATA5	0.05	0.01	bslmm	485	0.01	1.2e-02	3.8	-7.4	1.1e-13	-0.12	0.16	0.06	TRUE
12	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1109	0.05	0.04	enet	3	0.05	5.4e-06	10.9	-11.4	2.5e-30	-0.90	0.01	0.98	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1109	0.03	0.03	lasso	1	0.02	1.2e-05	10.7	-10.7	9.1e-27	-0.77	0.16	0.75	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	KIAA1109	0.22	0.07	lasso	7	0.03	5.9e-02	10.7	-10.5	8.7e-26	-0.71	0.04	0.44	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	KIAA1109	0.08	0.08	lasso	7	0.07	2.5e-09	10.7	-10.5	1.4e-25	-0.79	0.04	0.96	FALSE
3	GTEx	Artery Tibial	KIAA1109	0.16	0.07	lasso	6	0.05	5.1e-05	10.7	-10.4	2.7e-25	-0.79	0.03	0.95	FALSE
2	GTEx	Artery Aorta	KIAA1109	0.11	0.00	lasso	7	0.01	5.1e-02	11.2	-9.3	1.5e-20	-0.65	0.06	0.63	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KIAA1109	0.09	0.08	bslmm	390	0.08	8.9e-10	11.0	-7.9	2.3e-15	-0.68	0.04	0.96	FALSE