Best TWAS P=1.71e-35 · Best GWAS P=9.65e-30 conditioned to 0.153
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KIAA1109 | 0.09 | 0.08 | bslmm | 390 | 0.08 | 8.9e-10 | 11.0 | -7.9 | 2.3e-15 | -0.68 | 0.04 | 0.96 | FALSE |
2 | GTEx | Artery Aorta | KIAA1109 | 0.11 | 0.00 | lasso | 7 | 0.01 | 5.1e-02 | 11.2 | -9.3 | 1.5e-20 | -0.65 | 0.06 | 0.63 | FALSE |
3 | GTEx | Artery Tibial | KIAA1109 | 0.16 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | 10.7 | -10.4 | 2.7e-25 | -0.79 | 0.03 | 0.95 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | KIAA1109 | 0.22 | 0.07 | lasso | 7 | 0.03 | 5.9e-02 | 10.7 | -10.5 | 8.7e-26 | -0.71 | 0.04 | 0.44 | FALSE |
5 | GTEx | Colon Transverse | KIAA1109 | 0.25 | -0.01 | enet | 16 | 0.00 | 4.1e-01 | 10.9 | -11.1 | 1.6e-28 | -0.92 | 0.02 | 0.77 | TRUE |
6 | ROSMAP | Brain Pre-frontal Cortex | KIAA1109 | 0.08 | 0.08 | lasso | 7 | 0.07 | 2.5e-09 | 10.7 | -10.5 | 1.4e-25 | -0.79 | 0.04 | 0.96 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | SPATA5 | 0.05 | 0.01 | bslmm | 485 | 0.01 | 1.2e-02 | 3.8 | -7.4 | 1.1e-13 | -0.12 | 0.16 | 0.06 | TRUE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1109 | 0.03 | 0.03 | lasso | 1 | 0.02 | 1.2e-05 | 10.7 | -10.7 | 9.1e-27 | -0.77 | 0.16 | 0.75 | FALSE |
9 | The Cancer Genome Atlas | Esophageal Carcinoma | KIAA1109 | 0.32 | 0.02 | blup | 45 | 0.02 | 7.4e-02 | 10.9 | -12.4 | 1.7e-35 | -0.51 | 0.01 | 0.46 | TRUE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA1109 | 0.05 | 0.05 | enet | 8 | 0.04 | 1.3e-05 | 10.7 | -8.1 | 7.7e-16 | -0.80 | 0.02 | 0.94 | TRUE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1109 | 0.06 | 0.05 | lasso | 2 | 0.03 | 7.1e-05 | 10.7 | -11.0 | 6.1e-28 | -0.79 | 0.31 | 0.53 | TRUE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1109 | 0.05 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | 10.9 | -11.4 | 2.5e-30 | -0.90 | 0.01 | 0.98 | FALSE |