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chr5:34,920,257-36,848,558

Best TWAS P=1.07e-41 · Best GWAS P=4.5e-45 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	LMBRD2	0.19	0.01	lasso	6	0.02	6.9e-02	-4.9	5.3	1.1e-07	-0.32	0.07	0.50	TRUE
2	GTEx	Brain Frontal Cortex BA9	SPEF2	0.39	0.23	enet	27	0.22	1.8e-06	-4.3	-5.3	1.4e-07	0.49	0.81	0.02	FALSE
3	GTEx	Cells Transformed fibroblasts	SPEF2	0.26	0.01	enet	56	0.04	2.6e-04	-4.3	-7.4	1.1e-13	0.34	0.12	0.71	FALSE
4	GTEx	Lung	LMBRD2	0.13	0.03	enet	27	0.06	3.1e-05	-4.5	6.1	1.1e-09	-0.39	0.78	0.11	TRUE
5	GTEx	Testis	IL7R	0.25	0.19	lasso	6	0.18	2.1e-08	6.5	6.8	1.2e-11	-0.33	0.99	0.00	TRUE
6	METSIM	Adipose	SPEF2	0.06	0.01	blup	522	0.03	4.0e-05	3.7	-6.4	1.6e-10	0.36	0.74	0.02	TRUE
7	ROSMAP	Brain Pre-frontal Cortex	CAPSL	0.05	0.02	lasso	6	0.03	2.9e-04	6.1	-6.4	1.6e-10	0.55	0.29	0.42	TRUE
8	YFS	Blood	IL7R	0.03	0.01	bslmm	467	0.01	8.1e-05	3.5	5.7	1.1e-08	-0.39	0.82	0.05	TRUE
9	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UGT3A2	0.04	0.00	blup	52	0.01	4.9e-02	-4.9	7.6	2.9e-14	-0.35	0.02	0.23	TRUE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	UGT3A2	0.06	0.02	blup	52	0.05	9.7e-10	3.5	6.1	9.5e-10	-0.30	0.97	0.02	FALSE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	UGT3A2	0.11	0.08	lasso	5	0.04	2.9e-03	-4.9	5.3	9.0e-08	-0.31	0.33	0.27	FALSE
12	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL7R	0.04	0.03	lasso	3	0.02	9.8e-04	-14.1	-13.5	1.1e-41	0.96	0.00	0.99	TRUE
13	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UGT3A2	0.05	0.03	blup	52	0.04	2.8e-05	-4.9	5.4	5.7e-08	-0.22	0.06	0.60	TRUE
14	The Cancer Genome Atlas	Rectum Adenocarcinoma	UGT3A2	0.29	0.26	lasso	4	0.26	1.0e-06	-4.9	5.7	1.5e-08	-0.32	0.03	0.91	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	UGT3A2	0.05	0.00	blup	52	0.02	3.4e-03	3.6	6.4	1.3e-10	-0.34	0.02	0.13	TRUE