[Hub]/) : Traits : Hayfever, allergic rhinitis or eczema :

chr5:108,927,715-111,770,880

Best TWAS P=4.45e-42 · Best GWAS P=8.65e-55 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TMEM232 0.08 0.05 lasso 4 0.05 1.6e-06 1.74 5.1 2.8e-07 0.10 0.92 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex WDR36 0.05 0.03 enet 13 0.01 1.0e-02 -2.98 -6.8 7.9e-12 0.44 0.14 0.42 FALSE
3 GTEx Adipose Visceral Omentum WDR36 0.11 0.08 lasso 4 0.10 8.7e-06 -4.70 -6.2 5.7e-10 0.39 0.81 0.05 TRUE
4 GTEx Artery Tibial WDR36 0.11 0.05 lasso 5 0.07 3.2e-06 -4.70 -6.4 1.4e-10 0.42 0.87 0.02 FALSE
5 GTEx Brain Cerebellar Hemisphere WDR36 0.32 0.12 lasso 7 0.17 4.8e-05 -4.82 -6.8 7.7e-12 0.33 0.12 0.14 FALSE
6 GTEx Brain Cerebellum WDR36 0.26 0.22 lasso 4 0.27 1.5e-08 -4.82 -5.7 1.4e-08 0.30 0.40 0.11 TRUE
7 GTEx Liver WDR36 0.32 -0.01 enet 19 0.03 5.4e-02 -3.60 -8.8 2.0e-18 0.64 0.06 0.34 TRUE
8 GTEx Muscle Skeletal WDR36 0.08 0.05 lasso 4 0.03 3.0e-04 5.03 -6.0 2.2e-09 0.41 0.38 0.24 FALSE
9 GTEx Nerve Tibial SLC25A46 0.15 0.01 enet 18 0.07 1.2e-05 8.38 -7.3 2.4e-13 0.00 0.52 0.02 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic WDR36 0.17 0.09 lasso 6 0.08 2.6e-05 -6.89 -7.0 2.0e-12 0.44 0.66 0.25 FALSE
11 GTEx Skin Sun Exposed Lower leg WDR36 0.13 0.03 lasso 9 0.09 8.9e-08 -6.89 -6.3 2.3e-10 0.41 0.78 0.18 TRUE
12 GTEx Spleen SLC25A46 0.25 0.00 enet 6 0.02 1.3e-01 8.38 -8.2 3.7e-16 0.01 0.07 0.05 TRUE
13 GTEx Testis WDR36 0.61 0.37 lasso 10 0.34 5.7e-16 -6.98 -9.0 3.1e-19 0.57 1.00 0.00 FALSE
14 METSIM Adipose CAMK4 0.05 0.01 bslmm 518 0.03 8.3e-05 8.62 9.2 2.9e-20 -0.61 0.04 0.88 TRUE
15 METSIM Adipose TMEM232 0.04 0.06 lasso 8 0.06 9.8e-09 6.96 6.8 1.1e-11 0.08 1.00 0.00 FALSE
16 METSIM Adipose TSLP 0.16 0.18 lasso 7 0.18 8.5e-26 -13.65 13.4 3.6e-41 -0.92 0.29 0.71 FALSE
17 ROSMAP Brain Pre-frontal Cortex TSLP 0.13 0.08 enet 14 0.09 4.1e-11 -12.76 10.5 1.4e-25 -0.73 1.00 0.00 FALSE
18 ROSMAP Brain Pre-frontal Cortex CAMK4 0.10 0.03 lasso 4 0.04 7.8e-06 8.63 -9.4 8.3e-21 0.59 0.90 0.08 FALSE
19 ROSMAP Brain Pre-frontal Cortex STARD4-AS1 0.07 0.02 enet 19 0.03 5.0e-05 -0.32 -5.2 1.7e-07 0.39 0.06 0.81 FALSE
20 YFS Blood SLC25A46 0.03 0.02 enet 12 0.02 9.5e-07 8.38 -12.1 1.2e-33 0.25 0.95 0.00 TRUE
21 The Cancer Genome Atlas Bladder Urothelial Carcinoma CAMK4 0.04 0.04 blup 159 0.01 3.6e-02 7.18 -6.5 8.0e-11 0.14 0.26 0.04 TRUE
22 The Cancer Genome Atlas Bladder Urothelial Carcinoma TMEM232 0.08 0.06 blup 158 0.07 6.4e-07 6.95 6.3 3.7e-10 0.08 0.98 0.00 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma TSLP 0.03 0.03 lasso 2 0.03 5.5e-07 -13.68 11.8 2.5e-32 -0.84 0.00 1.00 FALSE
24 The Cancer Genome Atlas Colon Adenocarcinoma TSLP 0.08 0.01 blup 39 0.03 5.4e-03 -12.76 11.2 5.1e-29 -0.78 0.01 0.74 FALSE
25 The Cancer Genome Atlas Esophageal Carcinoma TMEM232 0.17 0.16 lasso 2 0.13 7.5e-05 5.92 5.7 1.2e-08 0.09 0.68 0.02 FALSE
26 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TSLP 0.03 0.00 enet 7 0.01 3.8e-02 -10.98 8.9 4.6e-19 -0.64 0.02 0.40 FALSE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM232 0.07 0.12 lasso 2 0.12 4.7e-13 5.92 5.6 2.1e-08 0.10 1.00 0.00 FALSE
28 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TSLP 0.05 0.02 blup 39 0.02 7.9e-04 -12.76 11.0 4.2e-28 -0.77 0.05 0.81 FALSE
29 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM232 0.15 0.12 lasso 2 0.16 2.2e-09 6.99 6.0 2.4e-09 0.09 1.00 0.00 FALSE
30 The Cancer Genome Atlas Brain Lower Grade Glioma TMEM232 0.09 0.03 blup 160 0.04 3.3e-05 8.55 7.7 1.0e-14 0.06 0.98 0.00 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma TSLP 0.06 0.07 blup 39 0.06 6.4e-07 -12.76 12.3 7.1e-35 -0.88 0.01 0.99 FALSE
32 The Cancer Genome Atlas Lung Adenocarcinoma TSLP 0.02 0.02 blup 39 0.02 1.9e-03 -13.68 12.3 1.1e-34 -0.88 0.00 0.90 FALSE
33 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TSLP 0.04 0.03 enet 6 0.02 1.6e-03 -13.03 12.2 3.9e-34 -0.86 0.01 0.90 FALSE
34 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM232 0.17 0.03 blup 162 0.06 1.9e-03 6.99 7.2 6.1e-13 0.09 0.12 0.19 FALSE
35 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TMEM232 0.07 0.03 blup 159 0.03 2.3e-02 2.86 5.4 7.7e-08 0.08 0.08 0.04 FALSE
36 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM232 0.06 0.06 blup 161 0.08 3.7e-09 6.93 5.1 2.7e-07 0.11 1.00 0.00 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma TSLP 0.03 0.01 blup 39 0.02 2.7e-03 -8.73 10.0 1.9e-23 -0.69 0.04 0.53 FALSE
38 The Cancer Genome Atlas Stomach Adenocarcinoma WDR36 0.04 0.04 lasso 1 0.03 3.7e-03 -6.92 -6.9 4.5e-12 0.45 0.17 0.13 FALSE
39 The Cancer Genome Atlas Testicular Germ Cell Tumors TSLP 0.12 0.11 lasso 3 0.08 6.9e-04 -13.70 13.6 4.4e-42 -0.92 0.00 0.97 TRUE
40 The Cancer Genome Atlas Thyroid Carcinoma TMEM232 0.20 0.16 enet 17 0.24 2.3e-23 6.88 6.2 5.5e-10 0.10 1.00 0.00 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma TSLP 0.13 0.14 blup 39 0.15 1.4e-14 -12.76 10.1 5.6e-24 -0.75 0.01 0.99 TRUE
42 The Cancer Genome Atlas Thyroid Carcinoma WDR36 0.08 0.02 blup 73 0.05 1.5e-05 4.92 -6.7 2.1e-11 0.44 0.28 0.33 FALSE