Best TWAS P=4.45e-42 · Best GWAS P=8.65e-55 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TMEM232 | 0.08 | 0.05 | lasso | 4 | 0.05 | 1.6e-06 | 1.74 | 5.1 | 2.8e-07 | 0.10 | 0.92 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | WDR36 | 0.05 | 0.03 | enet | 13 | 0.01 | 1.0e-02 | -2.98 | -6.8 | 7.9e-12 | 0.44 | 0.14 | 0.42 | FALSE |
3 | GTEx | Adipose Visceral Omentum | WDR36 | 0.11 | 0.08 | lasso | 4 | 0.10 | 8.7e-06 | -4.70 | -6.2 | 5.7e-10 | 0.39 | 0.81 | 0.05 | TRUE |
4 | GTEx | Artery Tibial | WDR36 | 0.11 | 0.05 | lasso | 5 | 0.07 | 3.2e-06 | -4.70 | -6.4 | 1.4e-10 | 0.42 | 0.87 | 0.02 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | WDR36 | 0.32 | 0.12 | lasso | 7 | 0.17 | 4.8e-05 | -4.82 | -6.8 | 7.7e-12 | 0.33 | 0.12 | 0.14 | FALSE |
6 | GTEx | Brain Cerebellum | WDR36 | 0.26 | 0.22 | lasso | 4 | 0.27 | 1.5e-08 | -4.82 | -5.7 | 1.4e-08 | 0.30 | 0.40 | 0.11 | TRUE |
7 | GTEx | Liver | WDR36 | 0.32 | -0.01 | enet | 19 | 0.03 | 5.4e-02 | -3.60 | -8.8 | 2.0e-18 | 0.64 | 0.06 | 0.34 | TRUE |
8 | GTEx | Muscle Skeletal | WDR36 | 0.08 | 0.05 | lasso | 4 | 0.03 | 3.0e-04 | 5.03 | -6.0 | 2.2e-09 | 0.41 | 0.38 | 0.24 | FALSE |
9 | GTEx | Nerve Tibial | SLC25A46 | 0.15 | 0.01 | enet | 18 | 0.07 | 1.2e-05 | 8.38 | -7.3 | 2.4e-13 | 0.00 | 0.52 | 0.02 | FALSE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | WDR36 | 0.17 | 0.09 | lasso | 6 | 0.08 | 2.6e-05 | -6.89 | -7.0 | 2.0e-12 | 0.44 | 0.66 | 0.25 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | WDR36 | 0.13 | 0.03 | lasso | 9 | 0.09 | 8.9e-08 | -6.89 | -6.3 | 2.3e-10 | 0.41 | 0.78 | 0.18 | TRUE |
12 | GTEx | Spleen | SLC25A46 | 0.25 | 0.00 | enet | 6 | 0.02 | 1.3e-01 | 8.38 | -8.2 | 3.7e-16 | 0.01 | 0.07 | 0.05 | TRUE |
13 | GTEx | Testis | WDR36 | 0.61 | 0.37 | lasso | 10 | 0.34 | 5.7e-16 | -6.98 | -9.0 | 3.1e-19 | 0.57 | 1.00 | 0.00 | FALSE |
14 | METSIM | Adipose | CAMK4 | 0.05 | 0.01 | bslmm | 518 | 0.03 | 8.3e-05 | 8.62 | 9.2 | 2.9e-20 | -0.61 | 0.04 | 0.88 | TRUE |
15 | METSIM | Adipose | TMEM232 | 0.04 | 0.06 | lasso | 8 | 0.06 | 9.8e-09 | 6.96 | 6.8 | 1.1e-11 | 0.08 | 1.00 | 0.00 | FALSE |
16 | METSIM | Adipose | TSLP | 0.16 | 0.18 | lasso | 7 | 0.18 | 8.5e-26 | -13.65 | 13.4 | 3.6e-41 | -0.92 | 0.29 | 0.71 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | TSLP | 0.13 | 0.08 | enet | 14 | 0.09 | 4.1e-11 | -12.76 | 10.5 | 1.4e-25 | -0.73 | 1.00 | 0.00 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | CAMK4 | 0.10 | 0.03 | lasso | 4 | 0.04 | 7.8e-06 | 8.63 | -9.4 | 8.3e-21 | 0.59 | 0.90 | 0.08 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | STARD4-AS1 | 0.07 | 0.02 | enet | 19 | 0.03 | 5.0e-05 | -0.32 | -5.2 | 1.7e-07 | 0.39 | 0.06 | 0.81 | FALSE |
20 | YFS | Blood | SLC25A46 | 0.03 | 0.02 | enet | 12 | 0.02 | 9.5e-07 | 8.38 | -12.1 | 1.2e-33 | 0.25 | 0.95 | 0.00 | TRUE |
21 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CAMK4 | 0.04 | 0.04 | blup | 159 | 0.01 | 3.6e-02 | 7.18 | -6.5 | 8.0e-11 | 0.14 | 0.26 | 0.04 | TRUE |
22 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM232 | 0.08 | 0.06 | blup | 158 | 0.07 | 6.4e-07 | 6.95 | 6.3 | 3.7e-10 | 0.08 | 0.98 | 0.00 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSLP | 0.03 | 0.03 | lasso | 2 | 0.03 | 5.5e-07 | -13.68 | 11.8 | 2.5e-32 | -0.84 | 0.00 | 1.00 | FALSE |
24 | The Cancer Genome Atlas | Colon Adenocarcinoma | TSLP | 0.08 | 0.01 | blup | 39 | 0.03 | 5.4e-03 | -12.76 | 11.2 | 5.1e-29 | -0.78 | 0.01 | 0.74 | FALSE |
25 | The Cancer Genome Atlas | Esophageal Carcinoma | TMEM232 | 0.17 | 0.16 | lasso | 2 | 0.13 | 7.5e-05 | 5.92 | 5.7 | 1.2e-08 | 0.09 | 0.68 | 0.02 | FALSE |
26 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TSLP | 0.03 | 0.00 | enet | 7 | 0.01 | 3.8e-02 | -10.98 | 8.9 | 4.6e-19 | -0.64 | 0.02 | 0.40 | FALSE |
27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM232 | 0.07 | 0.12 | lasso | 2 | 0.12 | 4.7e-13 | 5.92 | 5.6 | 2.1e-08 | 0.10 | 1.00 | 0.00 | FALSE |
28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSLP | 0.05 | 0.02 | blup | 39 | 0.02 | 7.9e-04 | -12.76 | 11.0 | 4.2e-28 | -0.77 | 0.05 | 0.81 | FALSE |
29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TMEM232 | 0.15 | 0.12 | lasso | 2 | 0.16 | 2.2e-09 | 6.99 | 6.0 | 2.4e-09 | 0.09 | 1.00 | 0.00 | FALSE |
30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM232 | 0.09 | 0.03 | blup | 160 | 0.04 | 3.3e-05 | 8.55 | 7.7 | 1.0e-14 | 0.06 | 0.98 | 0.00 | FALSE |
31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSLP | 0.06 | 0.07 | blup | 39 | 0.06 | 6.4e-07 | -12.76 | 12.3 | 7.1e-35 | -0.88 | 0.01 | 0.99 | FALSE |
32 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSLP | 0.02 | 0.02 | blup | 39 | 0.02 | 1.9e-03 | -13.68 | 12.3 | 1.1e-34 | -0.88 | 0.00 | 0.90 | FALSE |
33 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TSLP | 0.04 | 0.03 | enet | 6 | 0.02 | 1.6e-03 | -13.03 | 12.2 | 3.9e-34 | -0.86 | 0.01 | 0.90 | FALSE |
34 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMEM232 | 0.17 | 0.03 | blup | 162 | 0.06 | 1.9e-03 | 6.99 | 7.2 | 6.1e-13 | 0.09 | 0.12 | 0.19 | FALSE |
35 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TMEM232 | 0.07 | 0.03 | blup | 159 | 0.03 | 2.3e-02 | 2.86 | 5.4 | 7.7e-08 | 0.08 | 0.08 | 0.04 | FALSE |
36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM232 | 0.06 | 0.06 | blup | 161 | 0.08 | 3.7e-09 | 6.93 | 5.1 | 2.7e-07 | 0.11 | 1.00 | 0.00 | FALSE |
37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TSLP | 0.03 | 0.01 | blup | 39 | 0.02 | 2.7e-03 | -8.73 | 10.0 | 1.9e-23 | -0.69 | 0.04 | 0.53 | FALSE |
38 | The Cancer Genome Atlas | Stomach Adenocarcinoma | WDR36 | 0.04 | 0.04 | lasso | 1 | 0.03 | 3.7e-03 | -6.92 | -6.9 | 4.5e-12 | 0.45 | 0.17 | 0.13 | FALSE |
39 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TSLP | 0.12 | 0.11 | lasso | 3 | 0.08 | 6.9e-04 | -13.70 | 13.6 | 4.4e-42 | -0.92 | 0.00 | 0.97 | TRUE |
40 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM232 | 0.20 | 0.16 | enet | 17 | 0.24 | 2.3e-23 | 6.88 | 6.2 | 5.5e-10 | 0.10 | 1.00 | 0.00 | FALSE |
41 | The Cancer Genome Atlas | Thyroid Carcinoma | TSLP | 0.13 | 0.14 | blup | 39 | 0.15 | 1.4e-14 | -12.76 | 10.1 | 5.6e-24 | -0.75 | 0.01 | 0.99 | TRUE |
42 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR36 | 0.08 | 0.02 | blup | 73 | 0.05 | 1.5e-05 | 4.92 | -6.7 | 2.1e-11 | 0.44 | 0.28 | 0.33 | FALSE |