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chr5:108,927,715-111,770,880

Best TWAS P=4.45e-42 · Best GWAS P=8.65e-55 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TSLP	0.12	0.11	lasso	3	0.08	6.9e-04	-13.70	13.6	4.4e-42	-0.92	0.00	0.97	TRUE
20	YFS	Blood	SLC25A46	0.03	0.02	enet	12	0.02	9.5e-07	8.38	-12.1	1.2e-33	0.25	0.95	0.00	TRUE
41	The Cancer Genome Atlas	Thyroid Carcinoma	TSLP	0.13	0.14	blup	39	0.15	1.4e-14	-12.76	10.1	5.6e-24	-0.75	0.01	0.99	TRUE
14	METSIM	Adipose	CAMK4	0.05	0.01	bslmm	518	0.03	8.3e-05	8.62	9.2	2.9e-20	-0.61	0.04	0.88	TRUE
7	GTEx	Liver	WDR36	0.32	-0.01	enet	19	0.03	5.4e-02	-3.60	-8.8	2.0e-18	0.64	0.06	0.34	TRUE
12	GTEx	Spleen	SLC25A46	0.25	0.00	enet	6	0.02	1.3e-01	8.38	-8.2	3.7e-16	0.01	0.07	0.05	TRUE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CAMK4	0.04	0.04	blup	159	0.01	3.6e-02	7.18	-6.5	8.0e-11	0.14	0.26	0.04	TRUE
11	GTEx	Skin Sun Exposed Lower leg	WDR36	0.13	0.03	lasso	9	0.09	8.9e-08	-6.89	-6.3	2.3e-10	0.41	0.78	0.18	TRUE
3	GTEx	Adipose Visceral Omentum	WDR36	0.11	0.08	lasso	4	0.10	8.7e-06	-4.70	-6.2	5.7e-10	0.39	0.81	0.05	TRUE
6	GTEx	Brain Cerebellum	WDR36	0.26	0.22	lasso	4	0.27	1.5e-08	-4.82	-5.7	1.4e-08	0.30	0.40	0.11	TRUE
16	METSIM	Adipose	TSLP	0.16	0.18	lasso	7	0.18	8.5e-26	-13.65	13.4	3.6e-41	-0.92	0.29	0.71	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSLP	0.06	0.07	blup	39	0.06	6.4e-07	-12.76	12.3	7.1e-35	-0.88	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	TSLP	0.02	0.02	blup	39	0.02	1.9e-03	-13.68	12.3	1.1e-34	-0.88	0.00	0.90	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TSLP	0.04	0.03	enet	6	0.02	1.6e-03	-13.03	12.2	3.9e-34	-0.86	0.01	0.90	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	TSLP	0.03	0.03	lasso	2	0.03	5.5e-07	-13.68	11.8	2.5e-32	-0.84	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	TSLP	0.08	0.01	blup	39	0.03	5.4e-03	-12.76	11.2	5.1e-29	-0.78	0.01	0.74	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TSLP	0.05	0.02	blup	39	0.02	7.9e-04	-12.76	11.0	4.2e-28	-0.77	0.05	0.81	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	TSLP	0.13	0.08	enet	14	0.09	4.1e-11	-12.76	10.5	1.4e-25	-0.73	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	TSLP	0.03	0.01	blup	39	0.02	2.7e-03	-8.73	10.0	1.9e-23	-0.69	0.04	0.53	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	CAMK4	0.10	0.03	lasso	4	0.04	7.8e-06	8.63	-9.4	8.3e-21	0.59	0.90	0.08	FALSE
13	GTEx	Testis	WDR36	0.61	0.37	lasso	10	0.34	5.7e-16	-6.98	-9.0	3.1e-19	0.57	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TSLP	0.03	0.00	enet	7	0.01	3.8e-02	-10.98	8.9	4.6e-19	-0.64	0.02	0.40	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM232	0.09	0.03	blup	160	0.04	3.3e-05	8.55	7.7	1.0e-14	0.06	0.98	0.00	FALSE
9	GTEx	Nerve Tibial	SLC25A46	0.15	0.01	enet	18	0.07	1.2e-05	8.38	-7.3	2.4e-13	0.00	0.52	0.02	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM232	0.17	0.03	blup	162	0.06	1.9e-03	6.99	7.2	6.1e-13	0.09	0.12	0.19	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	WDR36	0.17	0.09	lasso	6	0.08	2.6e-05	-6.89	-7.0	2.0e-12	0.44	0.66	0.25	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	WDR36	0.04	0.04	lasso	1	0.03	3.7e-03	-6.92	-6.9	4.5e-12	0.45	0.17	0.13	FALSE
5	GTEx	Brain Cerebellar Hemisphere	WDR36	0.32	0.12	lasso	7	0.17	4.8e-05	-4.82	-6.8	7.7e-12	0.33	0.12	0.14	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WDR36	0.05	0.03	enet	13	0.01	1.0e-02	-2.98	-6.8	7.9e-12	0.44	0.14	0.42	FALSE
15	METSIM	Adipose	TMEM232	0.04	0.06	lasso	8	0.06	9.8e-09	6.96	6.8	1.1e-11	0.08	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	WDR36	0.08	0.02	blup	73	0.05	1.5e-05	4.92	-6.7	2.1e-11	0.44	0.28	0.33	FALSE
4	GTEx	Artery Tibial	WDR36	0.11	0.05	lasso	5	0.07	3.2e-06	-4.70	-6.4	1.4e-10	0.42	0.87	0.02	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM232	0.08	0.06	blup	158	0.07	6.4e-07	6.95	6.3	3.7e-10	0.08	0.98	0.00	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM232	0.20	0.16	enet	17	0.24	2.3e-23	6.88	6.2	5.5e-10	0.10	1.00	0.00	FALSE
8	GTEx	Muscle Skeletal	WDR36	0.08	0.05	lasso	4	0.03	3.0e-04	5.03	-6.0	2.2e-09	0.41	0.38	0.24	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM232	0.15	0.12	lasso	2	0.16	2.2e-09	6.99	6.0	2.4e-09	0.09	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Esophageal Carcinoma	TMEM232	0.17	0.16	lasso	2	0.13	7.5e-05	5.92	5.7	1.2e-08	0.09	0.68	0.02	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM232	0.07	0.12	lasso	2	0.12	4.7e-13	5.92	5.6	2.1e-08	0.10	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM232	0.07	0.03	blup	159	0.03	2.3e-02	2.86	5.4	7.7e-08	0.08	0.08	0.04	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	STARD4-AS1	0.07	0.02	enet	19	0.03	5.0e-05	-0.32	-5.2	1.7e-07	0.39	0.06	0.81	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM232	0.06	0.06	blup	161	0.08	3.7e-09	6.93	5.1	2.7e-07	0.11	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM232	0.08	0.05	lasso	4	0.05	1.6e-06	1.74	5.1	2.8e-07	0.10	0.92	0.00	FALSE