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chr16:89,013,848-90,172,696

Best TWAS P=3.52e-12 · Best GWAS P=1.95e-12 conditioned to 0.0669

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
36	GTEx	Thyroid	CDK10	0.36	0.16	lasso	9	0.21	9.7e-16	-6.8	-7.0	3.5e-12	0.89	0.00	1.00	TRUE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	CHMP1A	0.05	0.03	blup	38	0.04	1.6e-03	-7.0	6.9	4.5e-12	-0.94	0.01	0.96	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHMP1A	0.04	0.05	enet	3	0.05	2.1e-06	-7.0	6.9	6.2e-12	-0.97	0.00	1.00	FALSE
17	GTEx	Esophagus Mucosa	SPATA33	0.26	0.17	lasso	6	0.16	9.1e-11	-6.8	-6.8	1.1e-11	0.96	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf55	0.03	0.05	enet	6	0.05	3.5e-06	-6.6	6.8	1.2e-11	-0.96	0.01	0.99	FALSE
8	GTEx	Artery Tibial	SPATA33	0.18	0.12	lasso	3	0.10	1.6e-08	-6.8	-6.7	1.7e-11	0.95	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHMP1A	0.04	0.03	enet	9	0.05	7.5e-10	-6.6	6.7	2.6e-11	-0.87	0.01	0.99	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	SPATA33	0.12	0.09	lasso	4	0.10	3.4e-06	-6.6	-6.7	2.9e-11	0.97	0.01	0.99	FALSE
26	GTEx	Pancreas	SPATA33	0.13	0.14	lasso	10	0.11	2.2e-05	-6.9	-6.6	4.5e-11	0.98	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHMP1A	0.04	0.04	lasso	4	0.05	6.3e-06	-7.0	6.6	5.0e-11	-0.94	0.00	0.99	FALSE
2	GTEx	Adipose Subcutaneous	SPATA33	0.17	0.12	lasso	6	0.12	5.6e-10	-6.6	-6.5	8.4e-11	0.96	0.01	0.99	FALSE
31	GTEx	Skin Sun Exposed Lower leg	CHMP1A	0.36	0.11	enet	29	0.19	1.5e-15	4.7	6.5	9.2e-11	-0.79	0.04	0.96	FALSE
18	GTEx	Esophagus Muscularis	SPATA33	0.25	0.18	lasso	11	0.17	1.7e-10	-6.9	-6.4	1.2e-10	0.95	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHMP1A	0.10	0.07	lasso	2	0.09	6.7e-08	4.7	6.4	1.7e-10	-0.88	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	CHMP1A	0.11	0.09	blup	38	0.08	5.1e-08	-7.0	6.4	1.7e-10	-0.79	0.00	1.00	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	CHMP1A	0.25	0.01	enet	21	0.08	5.3e-05	4.7	6.4	1.9e-10	-0.50	0.10	0.82	FALSE
37	GTEx	Whole Blood	SPATA33	0.05	0.02	enet	9	0.02	6.3e-03	-5.8	-6.4	1.9e-10	0.87	0.03	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	SPATA33	0.16	0.10	lasso	3	0.07	1.2e-04	-6.9	-6.3	2.4e-10	0.97	0.01	0.99	FALSE
25	GTEx	Ovary	CDK10	0.45	0.11	lasso	8	0.25	6.8e-07	2.6	-6.3	3.4e-10	0.68	0.03	0.89	FALSE
13	GTEx	Cells Transformed fibroblasts	AC092143.1	0.07	0.00	lasso	6	0.00	5.0e-01	-6.8	-6.3	3.9e-10	0.90	0.02	0.80	FALSE
21	GTEx	Lung	SPATA33	0.15	0.11	enet	9	0.13	5.6e-10	5.4	-6.3	4.0e-10	0.91	0.02	0.98	FALSE
16	GTEx	Esophagus Mucosa	CHMP1A	0.17	0.12	lasso	4	0.16	5.9e-11	4.7	6.2	5.7e-10	-0.73	0.06	0.94	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf55	0.04	0.01	blup	36	0.02	1.7e-03	-6.8	-6.2	5.7e-10	0.92	0.01	0.74	FALSE
23	GTEx	Muscle Skeletal	SPATA33	0.10	0.04	enet	5	0.05	8.3e-06	5.4	-6.2	6.5e-10	0.90	0.01	0.99	FALSE
35	GTEx	Thyroid	SPATA33	0.20	0.18	lasso	6	0.19	2.7e-14	-6.6	-6.1	1.4e-09	0.94	0.01	0.99	FALSE
19	GTEx	Heart Atrial Appendage	CDK10	0.26	0.07	lasso	3	0.13	1.4e-06	-5.8	-5.9	2.8e-09	0.72	0.06	0.86	FALSE
20	GTEx	Heart Left Ventricle	SPATA33	0.07	0.02	enet	6	0.03	6.7e-03	-6.8	-5.9	2.9e-09	0.93	0.01	0.98	FALSE
39	METSIM	Adipose	CHMP1A	0.27	0.05	lasso	9	0.07	1.3e-10	4.7	5.9	3.0e-09	-0.58	0.04	0.96	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPEP1	0.04	0.01	enet	6	0.03	1.0e-04	-5.8	-5.9	3.8e-09	0.66	0.02	0.81	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHMP1A	0.07	0.03	blup	37	0.03	1.3e-04	4.7	5.9	4.3e-09	-0.79	0.00	0.99	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDK10	0.20	0.02	enet	15	0.08	5.3e-04	4.7	-5.8	5.1e-09	0.61	0.02	0.76	FALSE
6	GTEx	Artery Aorta	SPATA2L	0.08	0.00	enet	10	0.05	6.6e-04	3.4	5.8	8.2e-09	-0.62	0.03	0.84	FALSE
24	GTEx	Nerve Tibial	CDK10	0.42	0.28	enet	16	0.35	1.2e-25	5.4	-5.7	1.4e-08	0.72	0.86	0.14	FALSE
11	GTEx	Breast Mammary Tissue (Female)	CDK10	0.07	0.02	lasso	2	0.00	4.6e-01	5.4	-5.7	1.5e-08	0.79	0.03	0.44	FALSE
7	GTEx	Artery Aorta	SPATA33	0.19	0.06	enet	15	0.12	3.7e-07	-6.6	-5.6	1.9e-08	0.86	0.01	0.99	FALSE
22	GTEx	Lung	CDK10	0.25	0.18	lasso	7	0.19	1.0e-14	5.4	-5.6	2.1e-08	0.72	0.49	0.51	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHMP1A	0.07	0.02	blup	38	0.05	3.5e-06	-7.0	5.6	2.2e-08	-0.78	0.01	0.98	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CDK10	0.12	0.08	enet	6	0.01	2.2e-01	-5.4	-5.5	4.2e-08	0.76	0.04	0.36	FALSE
12	GTEx	Cells Transformed fibroblasts	SPATA33	0.11	0.05	enet	22	0.05	1.1e-04	-6.8	-5.5	4.8e-08	0.84	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf7	0.04	0.00	blup	44	0.02	1.6e-03	1.5	5.5	4.8e-08	-0.60	0.02	0.80	FALSE
40	YFS	Blood	SPATA2L	0.11	0.07	bslmm	390	0.12	5.5e-37	-5.4	5.4	6.2e-08	-0.74	0.98	0.02	FALSE
27	GTEx	Pancreas	CDK10	0.18	-0.01	lasso	5	0.02	5.1e-02	5.4	-5.4	6.5e-08	0.65	0.04	0.61	FALSE
32	GTEx	Spleen	CDK10	0.36	0.22	enet	6	0.06	1.3e-02	5.4	-5.4	8.3e-08	0.75	0.15	0.40	FALSE
14	GTEx	Colon Transverse	SPATA33	0.23	0.16	enet	14	0.19	2.2e-09	-6.6	-5.3	1.0e-07	0.87	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SPIRE2	0.04	0.05	lasso	1	0.01	4.9e-02	-5.3	5.3	1.1e-07	-0.67	0.00	0.88	FALSE
34	GTEx	Testis	VPS9D1-AS1	0.14	0.03	lasso	6	0.06	1.7e-03	-4.3	5.3	1.4e-07	-0.57	0.12	0.31	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHMP1A	0.18	0.01	enet	11	0.06	3.8e-04	4.7	5.3	1.4e-07	-0.67	0.01	0.89	FALSE
15	GTEx	Colon Transverse	CDK10	0.34	0.15	lasso	5	0.16	4.2e-08	5.4	-5.2	1.5e-07	0.64	0.67	0.27	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	CDK10	0.08	0.04	lasso	2	0.03	1.1e-04	5.4	-5.2	1.8e-07	0.73	0.20	0.26	FALSE
9	GTEx	Breast Mammary Tissue	CDK10	0.45	0.22	lasso	6	0.23	7.1e-12	5.4	-5.2	1.9e-07	0.80	0.59	0.41	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	CDK10	0.27	0.19	lasso	9	0.28	1.2e-15	5.4	-5.2	1.9e-07	0.65	0.67	0.33	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CHMP1A	0.06	0.05	blup	37	0.05	2.9e-06	4.7	5.2	2.2e-07	-0.84	0.02	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C16orf55	0.06	0.02	lasso	3	0.02	6.2e-04	5.4	-5.2	2.5e-07	0.76	0.08	0.91	FALSE
38	GTEx	Whole Blood	MC1R	0.08	0.00	enet	18	0.00	5.5e-01	3.6	-5.2	2.5e-07	0.43	0.05	0.06	FALSE
3	GTEx	Adipose Subcutaneous	CDK10	0.37	0.20	enet	50	0.26	4.0e-21	5.4	-5.1	2.8e-07	0.60	0.96	0.04	FALSE
5	GTEx	Adipose Visceral Omentum	CDK10	0.43	0.19	lasso	6	0.32	3.6e-17	2.6	-5.1	2.8e-07	0.56	0.99	0.01	FALSE
33	GTEx	Testis	CDK10	0.28	0.14	lasso	6	0.24	4.1e-11	5.4	-5.1	2.9e-07	0.64	0.14	0.86	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	FANCA	0.10	0.05	lasso	6	0.04	7.5e-06	-4.8	-5.1	2.9e-07	0.64	0.03	0.97	FALSE