Best TWAS P=2.14e-18 · Best GWAS P=5.98e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STAT6 | 0.11 | 0.08 | lasso | 3 | 0.11 | 9.1e-14 | 4.6 | 6.4 | 1.4e-10 | 0.52 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Artery Tibial | LRP1 | 0.15 | 0.12 | lasso | 2 | 0.10 | 3.9e-08 | 8.6 | -8.7 | 2.1e-18 | -1.00 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Artery Tibial | STAT6 | 0.08 | 0.03 | enet | 4 | 0.02 | 1.3e-02 | 6.1 | 5.8 | 7.6e-09 | 0.61 | 0.23 | 0.24 | FALSE |
| 4 | GTEx | Lung | TMEM194A | 0.30 | 0.01 | enet | 4 | 0.02 | 2.2e-02 | 6.2 | 5.2 | 1.8e-07 | 0.26 | 0.15 | 0.03 | TRUE |
| 5 | METSIM | Adipose | NXPH4 | 0.04 | 0.01 | bslmm | 354 | 0.02 | 1.7e-04 | 6.8 | -5.9 | 2.7e-09 | -0.47 | 0.04 | 0.58 | FALSE |
| 6 | METSIM | Adipose | STAT6 | 0.08 | 0.02 | blup | 343 | 0.03 | 5.0e-06 | 6.1 | -5.8 | 6.8e-09 | -0.53 | 0.42 | 0.55 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | STAT6 | 0.04 | 0.01 | blup | 47 | 0.01 | 2.3e-02 | 6.8 | 8.0 | 1.8e-15 | 0.79 | 0.02 | 0.73 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM194A | 0.15 | 0.07 | blup | 43 | 0.09 | 1.9e-09 | 4.4 | 6.2 | 4.5e-10 | 0.42 | 0.26 | 0.67 | TRUE |