Hub : Traits :

Medication for pain relief, constipation, heartburn

269 significantly associated models · 40 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 149771890 151174772 1 1 2.7e-07 2.5e-07 1.0000 100 TARS2
2 1 155739430 157168420 1 1 3.6e-10 6.4e-12 0.0044 83 MEF2D
3 1 173103273 175689679 4 1 9.1e-09 1.1e-09 1.0000 100 RABGAP1L
4 1 242590540 244359621 2 1 4.5e-08 3.1e-08 1.0000 100 SDCCAG8
5 2 26624843 28503968 5 2 4.0e-08 2.0e-07 0.8840 100 CGREF1 NRBP1
6 2 207244783 208729540 1 1 1.8e-07 1.3e-08 0.0122 80 KLF7
7 6 25285943 26689223 1 1 1.2e-13 4.7e-11 0.0112 85 U91328.21
8 6 34065982 35751895 2 2 1.2e-08 8.9e-09 0.2700 96 ANKS1A UHRF1BP1
9 6 96275538 97756290 3 1 4.1e-09 5.9e-10 0.0051 80 FHL5
10 12 56776586 58303535 4 3 2.1e-18 6.0e-18 1.0000 100 LRP1 TMEM194A
11 12 123502044 124005129 1 1 1.7e-07 1.0e-06 0.9200 100 CDK2AP1
12 15 80743350 81292020 1 1 4.8e-09 6.0e-09 1.0000 100 FAM108C1
13 17 42774693 43913030 9 1 1.6e-10 2.5e-09 0.2220 96 LRRC37A4P
14 17 44788310 45285474 2 1 1.4e-07 3.7e-07 1.0000 100 LRRC37A2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 3.04 2 2 4.4 0.00 1.0e+00 CDK2AP1 U91328.21
Depressed Affect (Nagel 2018) 6.38 4 2 4.4 -0.95 4.9e-02 LRRC37A2 LRRC37A4P RABGAP1L SDCCAG8
Intelligence (Savage-Jansen 2018) 2.31 3 1 2.2 0.00 1.0e+00 CDK2AP1 LRRC37A2 RABGAP1L
Neuroticism (Nagel 2018) 5.69 3 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P RABGAP1L
Schizophrenia (2018) 3.76 2 1 2.2 0.00 1.0e+00 CDK2AP1 U91328.21
Worry (Nagel 2018) 3.30 3 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P RABGAP1L
Major Depression (MDD) 2.51 1 0 0.0 0.00 1.0e+00 KLF7
Reaction Time 1.81 1 0 0.0 0.00 1.0e+00 TARS2
Verbal and Numeric Reasoning (VNR) 2.26 2 1 2.2 0.00 1.0e+00 CDK2AP1 U91328.21
Breast Cancer 2.20 2 1 2.2 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Ovarian Cancer 4.57 2 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Coronary Artery Disease (CAD) 3.23 2 0 0.0 0.00 1.0e+00 ANKS1A UHRF1BP1
Fasting Glucose 3.43 1 1 2.2 0.00 1.0e+00 CGREF1
HDL Cholesterol 1.57 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Lupus 1.97 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Neuroticism (2016) 3.49 2 0 0.0 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Primary Biliary Cirrhosis 3.22 2 0 0.0 0.00 1.0e+00 LRP1 LRRC37A2
Schizophrenia (2014) 2.90 4 1 2.2 -0.73 2.7e-01 CDK2AP1 LRRC37A2 NRBP1 SDCCAG8
Triglycerides 5.99 2 2 4.4 0.00 1.0e+00 CGREF1 NRBP1
Blood Eosinophil Count 3.83 8 6 13.3 0.33 4.2e-01 ANKS1A CDK2AP1 KLF7 LRP1 LRRC37A2 LRRC37A4P TARS2 TMEM194A
Blood Platelet Count 4.83 9 6 13.3 -0.51 1.6e-01 CDK2AP1 CGREF1 KLF7 LRRC37A2 LRRC37A4P MEF2D NRBP1 TARS2 UHRF1BP1
Blood Red Count 5.10 4 3 6.7 -0.86 1.4e-01 LRRC37A2 LRRC37A4P NRBP1 RABGAP1L
Blood White Count 2.03 7 2 4.4 -0.70 7.9e-02 CGREF1 LRRC37A2 LRRC37A4P MEF2D NRBP1 TARS2 UHRF1BP1
Heel T-Score 2.00 4 3 6.7 0.25 7.5e-01 CDK2AP1 LRRC37A2 LRRC37A4P MEF2D
BMI 4.15 7 3 6.7 -0.26 5.7e-01 ANKS1A FAM108C1 FHL5 LRP1 MEF2D RABGAP1L UHRF1BP1
Height 2.31 9 8 17.8 0.41 2.8e-01 ANKS1A CDK2AP1 CGREF1 LRP1 LRRC37A2 LRRC37A4P MEF2D NRBP1 UHRF1BP1
Waist Hip Ratio (WHR) 4.95 5 5 11.1 -0.72 1.7e-01 CDK2AP1 LRRC37A2 LRRC37A4P MEF2D UHRF1BP1
Systolic Blood Pressure 3.22 8 3 6.7 -0.59 1.2e-01 CGREF1 FAM108C1 FHL5 LRRC37A2 LRRC37A4P MEF2D NRBP1 SDCCAG8
Allergy or Eczema 2.87 3 1 2.2 0.00 1.0e+00 CDK2AP1 LRP1 TMEM194A
Cardiovascular Disease 3.61 6 2 4.4 -0.97 1.2e-03 ANKS1A CGREF1 FAM108C1 FHL5 SDCCAG8 UHRF1BP1
Hypothyroidism (self reported) 1.29 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Respiratory disease 3.81 5 2 4.4 0.43 4.7e-01 FHL5 LRP1 RABGAP1L TARS2 TMEM194A
Type 2 Diabetes (T2D) (2018) 1.56 1 0 0.0 0.00 1.0e+00 CDK2AP1
Lung FEV1/FVC ratio 3.16 6 1 2.2 0.58 2.2e-01 LRP1 LRRC37A2 LRRC37A4P MEF2D TARS2 TMEM194A
Lung FVC 4.94 3 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P MEF2D
Neuroticism 6.06 3 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P RABGAP1L
Chronotype (morning person) 2.05 1 1 2.2 0.00 1.0e+00 TARS2
Hair Pigment 0.52 7 2 4.4 0.05 9.2e-01 CDK2AP1 CGREF1 LRP1 LRRC37A2 LRRC37A4P NRBP1 TMEM194A
Hand grip strength (left) 3.17 3 2 4.4 0.00 1.0e+00 ANKS1A LRRC37A2 LRRC37A4P
Number of treatments/medications taken 8.09 9 2 4.4 -0.99 6.0e-07 ANKS1A CGREF1 FAM108C1 LRP1 MEF2D NRBP1 RABGAP1L SDCCAG8 U91328.21
Sensitivity / hurt feelings 5.47 2 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Frequency of depressed mood in last 2 weeks 2.88 1 0 0.0 0.00 1.0e+00 LRRC37A2
Relative age of first facial hair 5.72 4 2 4.4 -0.67 3.3e-01 LRRC37A2 LRRC37A4P RABGAP1L TMEM194A
Systolic blood pressure, automated reading 3.20 4 2 4.4 0.11 8.9e-01 FAM108C1 FHL5 LRRC37A2 LRRC37A4P
Vitamin and mineral supplements 5.21 2 2 4.4 0.00 1.0e+00 LRP1 TMEM194A
Impedance of leg (right) 1.92 4 2 4.4 0.19 8.1e-01 FAM108C1 KLF7 TARS2 UHRF1BP1
Leg fat-free mass (left) 2.72 4 3 6.7 -0.22 7.8e-01 CDK2AP1 CGREF1 FAM108C1 UHRF1BP1
Trunk fat percentage 3.64 3 2 4.4 0.00 1.0e+00 ANKS1A LRRC37A2 UHRF1BP1
Hand grip strength (right) 2.80 3 1 2.2 0.00 1.0e+00 LRP1 LRRC37A2 LRRC37A4P
Fed-up feelings 4.13 3 2 4.4 0.00 1.0e+00 CDK2AP1 LRRC37A2 LRRC37A4P
Relative age voice broke 4.20 2 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Taking other prescription medications 3.11 1 0 0.0 0.00 1.0e+00 UHRF1BP1
High blood pressure 3.57 4 1 2.2 -0.98 1.8e-02 CGREF1 FAM108C1 FHL5 SDCCAG8
Hayfever, allergic rhinitis or eczema 2.25 3 1 2.2 0.00 1.0e+00 CDK2AP1 LRP1 TMEM194A
Multivitamins +/- minerals 3.00 2 0 0.0 0.00 1.0e+00 LRP1 TMEM194A
Supplements: Glucosamine 2.18 1 0 0.0 0.00 1.0e+00 TARS2
Diverticular disease/diverticulitis (self-reported) 1.58 1 0 0.0 0.00 1.0e+00 LRRC37A2
Medication: Levothyroxine sodium 2.69 2 1 2.2 0.00 1.0e+00 ANKS1A UHRF1BP1
Sitting height 4.50 7 4 8.9 0.28 5.4e-01 CDK2AP1 CGREF1 FAM108C1 LRP1 LRRC37A2 LRRC37A4P UHRF1BP1
High blood pressure (mother) 2.46 1 0 0.0 0.00 1.0e+00 CGREF1
Body mass index (BMI) 3.39 3 2 4.4 0.00 1.0e+00 ANKS1A FAM108C1 UHRF1BP1
Impedance of leg (left) 1.89 5 1 2.2 0.46 4.4e-01 CDK2AP1 FAM108C1 LRRC37A2 TARS2 UHRF1BP1
Leg predicted mass (left) 2.73 4 3 6.7 -0.22 7.8e-01 CDK2AP1 CGREF1 FAM108C1 UHRF1BP1
Trunk fat mass 3.55 4 2 4.4 -0.63 3.7e-01 ANKS1A FAM108C1 LRRC37A2 UHRF1BP1
Waist circumference 2.79 3 2 4.4 0.00 1.0e+00 ANKS1A FAM108C1 UHRF1BP1
Alcohol usually taken with meals 2.08 1 0 0.0 0.00 1.0e+00 RABGAP1L
Nervous feelings 3.26 2 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Frequency of tenseness / restlessness in last 2 weeks 4.14 2 1 2.2 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Hearing difficulty/problems with background noise 3.13 2 0 0.0 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Hair/balding pattern: Pattern 2 3.19 2 1 2.2 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Had menopause 2.61 2 0 0.0 0.00 1.0e+00 CDK2AP1 NRBP1
Forced vital capacity (FVC) 4.97 4 4 8.9 0.46 5.4e-01 ANKS1A LRRC37A2 LRRC37A4P U91328.21
Ever unenthusiastic/disinterested for a whole week 2.06 1 0 0.0 0.00 1.0e+00 LRRC37A2
Qualifications: None of the above 2.89 1 1 2.2 0.00 1.0e+00 CDK2AP1
Mouth/teeth dental problems 2.18 1 0 0.0 0.00 1.0e+00 SDCCAG8
Allergy 3.09 3 2 4.4 0.00 1.0e+00 CDK2AP1 LRP1 TMEM194A
Hayfever/allergic rhinitis (self-reported) 2.40 1 0 0.0 0.00 1.0e+00 LRP1
Fluid intelligence score 2.50 2 0 0.0 0.00 1.0e+00 CDK2AP1 U91328.21
Neuroticism score 5.30 3 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P RABGAP1L
Weight 3.25 5 2 4.4 -0.44 4.6e-01 ANKS1A CDK2AP1 FAM108C1 RABGAP1L UHRF1BP1
Impedance of arm (right) 1.80 4 1 2.2 0.70 3.0e-01 CGREF1 FAM108C1 LRRC37A2 UHRF1BP1
Arm fat percentage (right) 3.15 2 2 4.4 0.00 1.0e+00 ANKS1A UHRF1BP1
Trunk fat-free mass 2.40 6 4 8.9 -0.03 9.5e-01 CDK2AP1 CGREF1 FAM108C1 LRP1 RABGAP1L UHRF1BP1
Hip circumference 3.83 5 1 2.2 -0.41 4.9e-01 ANKS1A CDK2AP1 FAM108C1 RABGAP1L UHRF1BP1
Time employed in main current job 2.70 1 0 0.0 0.00 1.0e+00 LRRC37A2
Father's age at death 1.58 1 0 0.0 0.00 1.0e+00 CDK2AP1
Worrier / anxious feelings 2.29 2 1 2.2 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Frequency of tiredness / lethargy in last 2 weeks 2.76 1 0 0.0 0.00 1.0e+00 KLF7
Hair/balding pattern: Pattern 3 6.18 2 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Number of live births 2.65 2 0 0.0 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Forced expiratory volume in 1-second (FEV1) 5.16 4 3 6.7 0.42 5.8e-01 ANKS1A LRRC37A2 LRRC37A4P U91328.21
Qualifications: A levels/AS levels or equivalent 3.22 2 1 2.2 0.00 1.0e+00 CDK2AP1 SDCCAG8
Asthma 4.05 4 1 2.2 0.81 1.9e-01 LRP1 TARS2 TMEM194A U91328.21
Medication: Ibuprofen (e.g. Nurofen) 10.72 7 1 2.2 -0.99 2.5e-06 FHL5 LRP1 LRRC37A2 MEF2D TARS2 TMEM194A U91328.21
Medication: Cholesterol lowering 2.27 2 0 0.0 0.00 1.0e+00 CGREF1 MEF2D
Forced expiratory volume in 1-second (FEV1), Best measure 4.72 4 3 6.7 0.43 5.7e-01 ANKS1A LRRC37A2 LRRC37A4P U91328.21
Impedance of arm (left) 2.01 4 1 2.2 0.68 3.2e-01 CGREF1 FAM108C1 LRRC37A2 UHRF1BP1
Arm fat mass (right) 3.28 3 2 4.4 0.00 1.0e+00 ANKS1A FAM108C1 UHRF1BP1
Trunk predicted mass 2.41 6 4 8.9 -0.04 9.5e-01 CDK2AP1 CGREF1 FAM108C1 LRP1 RABGAP1L UHRF1BP1
Standing height 2.06 8 4 8.9 0.39 3.4e-01 ANKS1A CDK2AP1 CGREF1 KLF7 LRP1 LRRC37A2 LRRC37A4P U91328.21
Exposure to tobacco smoke at home 1.66 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Breastfed as a baby 1.76 1 0 0.0 0.00 1.0e+00 CDK2AP1
Tense / 'highly strung' 3.05 1 1 2.2 0.00 1.0e+00 RABGAP1L
Seen doctor (GP) for nerves, anxiety, tension or depression 2.05 1 0 0.0 0.00 1.0e+00 U91328.21
Hair/balding pattern: Pattern 4 9.46 2 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Peak expiratory flow (PEF) 3.54 4 2 4.4 0.44 5.6e-01 LRRC37A2 LRRC37A4P TARS2 U91328.21
Qualifications: O levels/GCSEs or equivalent 3.23 1 1 2.2 0.00 1.0e+00 CDK2AP1
Medication: Paracetamol 16.36 12 7 15.6 -0.98 6.3e-09 CGREF1 FAM108C1 FHL5 LRP1 LRRC37A2 LRRC37A4P MEF2D NRBP1 RABGAP1L SDCCAG8 TMEM194A U91328.21
Headache pain in last month 19.03 10 7 15.6 -0.96 4.3e-06 FHL5 LRP1 LRRC37A2 LRRC37A4P MEF2D RABGAP1L SDCCAG8 TARS2 TMEM194A U91328.21
Medication for cholesterol, blood pressure or diabetes 2.76 1 0 0.0 0.00 1.0e+00 FAM108C1
Gout (self-reported) 3.46 1 1 2.2 0.00 1.0e+00 CGREF1
Hypothyroidism/myxoedema (self-reported) 1.65 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Medication: Amlodipine 3.08 1 0 0.0 0.00 1.0e+00 FAM108C1
High blood pressure (siblings) 3.23 2 0 0.0 0.00 1.0e+00 CGREF1 FAM108C1
Forced vital capacity (FVC), Best measure 4.59 4 3 6.7 0.49 5.1e-01 ANKS1A LRRC37A2 LRRC37A4P U91328.21
Body fat percentage 3.69 3 2 4.4 0.00 1.0e+00 ANKS1A LRP1 UHRF1BP1
Leg fat percentage (right) 3.97 5 2 4.4 -0.50 3.9e-01 ANKS1A FHL5 LRP1 TARS2 UHRF1BP1
Arm fat-free mass (right) 2.35 4 3 6.7 -0.13 8.7e-01 CDK2AP1 CGREF1 FAM108C1 UHRF1BP1
Exposure to tobacco smoke outside home 2.90 2 0 0.0 0.00 1.0e+00 LRRC37A4P SDCCAG8
Comparative body size at age 10 2.23 3 1 2.2 0.00 1.0e+00 TARS2 U91328.21 UHRF1BP1
Number of full brothers 2.31 1 0 0.0 0.00 1.0e+00 LRRC37A2
Worry too long after embarrassment 1.85 1 0 0.0 0.00 1.0e+00 LRRC37A2
Qualifications: College or University degree 3.24 5 4 8.9 1.00 3.4e-04 CDK2AP1 LRRC37A2 LRRC37A4P RABGAP1L SDCCAG8
Emphysema/chronic bronchitis 2.77 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Medication: Blood pressure 2.61 1 1 2.2 0.00 1.0e+00 FAM108C1
Migraine (self-reported) 10.45 4 3 6.7 -0.99 7.7e-03 FHL5 LRP1 MEF2D TMEM194A
Medication: Ibuprofen 8.23 3 1 2.2 0.00 1.0e+00 LRP1 MEF2D TMEM194A
Medication: Allopurinol 2.03 1 0 0.0 0.00 1.0e+00 CGREF1
Medication: Omeprazole 3.55 2 0 0.0 0.00 1.0e+00 TARS2 UHRF1BP1
Mean time to correctly identify matches 1.62 1 0 0.0 0.00 1.0e+00 KLF7
Whole body fat mass 3.50 3 2 4.4 0.00 1.0e+00 ANKS1A FAM108C1 UHRF1BP1
Leg fat mass (right) 3.88 3 2 4.4 0.00 1.0e+00 ANKS1A FAM108C1 UHRF1BP1
Arm predicted mass (right) 2.38 4 3 6.7 -0.16 8.4e-01 CDK2AP1 CGREF1 FAM108C1 UHRF1BP1
Pulse rate, automated reading 2.09 3 2 4.4 0.00 1.0e+00 MEF2D RABGAP1L UHRF1BP1
Alcohol intake frequency. 5.16 5 3 6.7 -0.94 1.7e-02 CDK2AP1 CGREF1 LRP1 LRRC37A2 LRRC37A4P
Comparative height size at age 10 2.68 6 4 8.9 0.21 6.9e-01 CDK2AP1 CGREF1 FAM108C1 LRRC37A2 LRRC37A4P U91328.21
Overall health rating 3.54 3 0 0.0 0.00 1.0e+00 KLF7 SDCCAG8 UHRF1BP1
Medication: Aspirin 4.46 2 0 0.0 0.00 1.0e+00 KLF7 MEF2D
Supplements: Vitamin C 2.68 1 0 0.0 0.00 1.0e+00 LRRC37A2
Knee pain experienced in last month 3.69 2 0 0.0 0.00 1.0e+00 RABGAP1L SDCCAG8
Hypertension (Self-reported) 3.62 4 2 4.4 -0.98 1.8e-02 CGREF1 FAM108C1 FHL5 SDCCAG8
Illnesses of father: Heart disease 2.11 1 0 0.0 0.00 1.0e+00 LRRC37A2
Whole body fat-free mass 2.53 5 3 6.7 -0.01 9.9e-01 CDK2AP1 CGREF1 FAM108C1 KLF7 UHRF1BP1
Leg fat-free mass (right) 2.72 4 3 6.7 -0.20 8.0e-01 CDK2AP1 FAM108C1 KLF7 UHRF1BP1
Arm fat percentage (left) 3.20 2 2 4.4 0.00 1.0e+00 ANKS1A UHRF1BP1
Average weekly red wine intake 2.06 1 0 0.0 0.00 1.0e+00 CDK2AP1
Handedness (chirality/laterality): Left-handed 2.99 1 1 2.2 0.00 1.0e+00 LRRC37A2
Mood swings 5.35 2 2 4.4 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Loneliness, isolation 2.99 1 0 0.0 0.00 1.0e+00 LRRC37A2
Long-standing illness, disability or infirmity 2.59 2 0 0.0 0.00 1.0e+00 KLF7 UHRF1BP1
Friendships satisfaction 1.59 1 0 0.0 0.00 1.0e+00 TARS2
Qualifications: nursing, teaching 2.53 1 1 2.2 0.00 1.0e+00 CDK2AP1
Mouth/teeth dental problems: Mouth ulcers 3.72 3 1 2.2 0.00 1.0e+00 LRRC37A2 LRRC37A4P SDCCAG8
Medication for cholesterol 3.43 2 0 0.0 0.00 1.0e+00 CGREF1 FAM108C1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.44 1 0 0.0 0.00 1.0e+00 CGREF1
Mineral and other dietary supplements 2.65 1 0 0.0 0.00 1.0e+00 LRP1
Asthma (self-reported) 4.09 5 1 2.2 0.73 1.6e-01 CDK2AP1 LRP1 TARS2 TMEM194A U91328.21
Osteoarthritis (self-reported) 2.50 1 0 0.0 0.00 1.0e+00 TARS2
Medication: Aspirin 4.07 2 0 0.0 0.00 1.0e+00 KLF7 MEF2D
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.93 3 3 6.7 0.00 1.0e+00 LRRC37A2 LRRC37A4P U91328.21
Whole body water mass 2.53 5 3 6.7 -0.01 9.9e-01 CDK2AP1 CGREF1 FAM108C1 KLF7 UHRF1BP1
Leg predicted mass (right) 2.74 5 3 6.7 -0.10 8.7e-01 CDK2AP1 CGREF1 FAM108C1 KLF7 UHRF1BP1
Arm fat mass (left) 3.23 3 2 4.4 0.00 1.0e+00 ANKS1A FAM108C1 UHRF1BP1
Number of self-reported non-cancer illnesses 4.32 4 0 0.0 -1.00 1.2e-03 ANKS1A CGREF1 KLF7 UHRF1BP1
Average weekly champagne plus white wine intake 3.64 2 0 0.0 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Miserableness 4.48 3 1 2.2 0.00 1.0e+00 LRRC37A2 LRRC37A4P SDCCAG8
Guilty feelings 2.81 2 0 0.0 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Medication: Blood pressure 3.84 3 0 0.0 0.00 1.0e+00 FAM108C1 LRRC37A2 LRRC37A4P
Pain type(s) experienced in last month: Hip pain 2.54 1 0 0.0 0.00 1.0e+00 TARS2
Supplements: Fish oil (including cod liver oil) 2.87 2 0 0.0 0.00 1.0e+00 KLF7 LRP1
High cholesterol (Self-reported) 3.53 1 1 2.2 0.00 1.0e+00 CGREF1
Medication: Bendroflumethiazide 2.39 1 0 0.0 0.00 1.0e+00 FAM108C1
Medication: Paracetamol 13.58 9 4 8.9 -0.98 2.0e-06 CGREF1 FHL5 LRP1 LRRC37A2 LRRC37A4P RABGAP1L SDCCAG8 TARS2 U91328.21
Medication: Atorvastatin 2.04 1 0 0.0 0.00 1.0e+00 CGREF1
Ever smoked 1.57 1 0 0.0 0.00 1.0e+00 CDK2AP1
Basal metabolic rate 2.69 5 3 6.7 -0.09 8.9e-01 CDK2AP1 CGREF1 FAM108C1 RABGAP1L UHRF1BP1
Leg fat percentage (left) 3.98 3 2 4.4 0.00 1.0e+00 ANKS1A LRP1 UHRF1BP1
Arm fat-free mass (left) 2.49 5 3 6.7 -0.04 9.5e-01 CDK2AP1 CGREF1 FAM108C1 RABGAP1L UHRF1BP1
Irritability 2.79 2 1 2.2 0.00 1.0e+00 LRRC37A2 LRRC37A4P
Risk taking 1.81 2 0 0.0 0.00 1.0e+00 SDCCAG8 U91328.21
Ever had prostate specific antigen (PSA) test 2.16 1 0 0.0 0.00 1.0e+00 U91328.21
Fractured/broken bones in last 5 years 2.02 1 0 0.0 0.00 1.0e+00 LRRC37A2
Diastolic blood pressure, automated reading 4.60 5 4 8.9 -0.96 8.2e-03 CDK2AP1 FAM108C1 FHL5 SDCCAG8 U91328.21
Ever depressed for a whole week 1.97 1 0 0.0 0.00 1.0e+00 LRRC37A2
Unable to work because of sickness or disability 1.55 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Commuting to job workplace: Cycle 2.13 1 0 0.0 0.00 1.0e+00 UHRF1BP1
Myopia 3.28 2 0 0.0 0.00 1.0e+00 LRP1 LRRC37A2
Vascular/heart problems diagnosed by doctor 3.60 5 1 2.2 0.98 2.9e-03 CGREF1 FAM108C1 FHL5 MEF2D SDCCAG8
Pain experienced in last month 7.70 5 1 2.2 1.00 9.6e-05 ANKS1A FHL5 KLF7 LRP1 RABGAP1L
Impedance of whole body 2.11 5 2 4.4 0.34 5.8e-01 CGREF1 FAM108C1 LRRC37A2 TARS2 UHRF1BP1
Leg fat mass (left) 3.81 3 2 4.4 0.00 1.0e+00 ANKS1A FAM108C1 UHRF1BP1
Arm predicted mass (left) 2.57 5 3 6.7 -0.05 9.4e-01 CDK2AP1 CGREF1 FAM108C1 RABGAP1L UHRF1BP1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.172 1.8
GTEx Adipose Visceral Omentum 5 0.246 1.9
GTEx Adrenal Gland 2 0.137 1.8
GTEx Artery Aorta 6 0.202 1.8
GTEx Artery Coronary 5 0.423 1.9
GTEx Artery Tibial 10 0.266 1.9
GTEx Brain Caudate basal ganglia 4 0.435 1.7
GTEx Brain Cerebellar Hemisphere 4 0.269 1.8
GTEx Brain Cerebellum 5 0.252 1.9
GTEx Brain Cortex 4 0.386 1.9
GTEx Brain Frontal Cortex BA9 4 0.433 1.8
GTEx Brain Hippocampus 3 0.573 1.8
GTEx Brain Hypothalamus 3 0.508 1.7
GTEx Brain Nucleus accumbens basal ganglia 4 0.462 1.9
GTEx Brain Putamen basal ganglia 4 0.641 1.9
GTEx Breast Mammary Tissue 6 0.304 1.8
GTEx Breast Mammary Tissue (Male) 6 0.503 1.8
GTEx Breast Mammary Tissue (Female) 6 0.365 1.8
GTEx Cells EBV-transformed lymphocytes 5 0.351 1.9
GTEx Cells Transformed fibroblasts 6 0.143 1.8
GTEx Colon Sigmoid 6 0.410 1.8
GTEx Colon Transverse 5 0.242 1.9
GTEx Esophagus Gastroesophageal Junction 6 0.415 1.8
GTEx Esophagus Mucosa 8 0.241 1.8
GTEx Esophagus Muscularis 9 0.278 1.8
GTEx Heart Atrial Appendage 5 0.317 1.7
GTEx Heart Left Ventricle 5 0.327 1.8
GTEx Liver 2 0.279 1.9
GTEx Lung 9 0.313 1.8
GTEx Muscle Skeletal 6 0.208 1.8
GTEx Nerve Tibial 8 0.185 1.7
GTEx Ovary 4 0.441 1.8
GTEx Pancreas 5 0.306 1.9
GTEx Pituitary 3 0.269 1.8
GTEx Prostate 3 0.359 1.9
GTEx Skin Not Sun Exposed Suprapubic 5 0.203 1.9
GTEx Skin Sun Exposed Lower leg 10 0.275 1.8
GTEx Small Intestine Terminal Ileum 3 0.651 2.1
GTEx Spleen 2 0.142 1.8
GTEx Stomach 6 0.413 1.9
GTEx Testis 7 0.222 1.8
GTEx Thyroid 7 0.175 1.7
GTEx Uterus 6 1.058 2.0
GTEx Vagina 4 0.630 1.9
GTEx Whole Blood 5 0.251 1.7
METSIM Adipose 3 0.065 1.6
NTR Blood 4 0.167 1.6
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.6
YFS Blood 0 0.000 1.6
CommonMind Brain Pre-frontal Cortex 4 0.074 1.7
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.7
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.6
The Cancer Genome Atlas Esophageal Carcinoma 1 0.146 1.8
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.7
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 2 0.049 1.6
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.5
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.6
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.7
The Cancer Genome Atlas Lung Adenocarcinoma 3 0.102 1.7
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.7
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.6
The Cancer Genome Atlas Pancreatic Adenocarcinoma 3 0.181 1.7
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.6
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.6
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.7
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.7
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.6
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.6
The Cancer Genome Atlas Thyroid Carcinoma 4 0.078 1.6
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.8