Best TWAS P=2.45e-10 · Best GWAS P=2.55e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ANAPC7 | 0.09 | 0.02 | blup | 232 | 0.04 | 3.3e-06 | -3.1 | -5.4 | 5.3e-08 | 0.48 | 0.20 | 0.22 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | ATP2A2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 4.9e-03 | -5.4 | -5.5 | 4.4e-08 | 0.89 | 0.05 | 0.74 | FALSE |
3 | GTEx | Adipose Subcutaneous | FAM216A | 0.04 | 0.01 | lasso | 3 | 0.00 | 1.4e-01 | -5.9 | 6.3 | 2.4e-10 | -0.95 | 0.02 | 0.84 | TRUE |
4 | GTEx | Adipose Visceral Omentum | FAM216A | 0.09 | 0.03 | lasso | 3 | 0.03 | 7.6e-03 | -5.8 | 5.8 | 5.0e-09 | -0.98 | 0.04 | 0.79 | FALSE |
5 | GTEx | Artery Tibial | ATP2A2 | 0.11 | 0.00 | enet | 26 | 0.03 | 1.4e-03 | -5.8 | 5.6 | 1.8e-08 | -0.54 | 0.05 | 0.36 | FALSE |
6 | GTEx | Esophagus Muscularis | PPTC7 | 0.10 | 0.07 | enet | 10 | 0.07 | 2.6e-05 | -5.9 | -5.8 | 5.9e-09 | 0.97 | 0.02 | 0.98 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | FAM216A | 0.11 | 0.09 | lasso | 2 | 0.06 | 3.2e-04 | -5.5 | 5.4 | 5.2e-08 | -0.91 | 0.03 | 0.94 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | FAM216A | 0.03 | 0.01 | lasso | 4 | 0.00 | 6.5e-01 | -5.8 | 5.6 | 2.4e-08 | -0.96 | 0.09 | 0.59 | FALSE |
9 | YFS | Blood | ANAPC7 | 0.02 | 0.01 | blup | 228 | 0.01 | 8.0e-05 | -5.7 | -5.2 | 2.7e-07 | 0.93 | 0.05 | 0.95 | FALSE |
10 | YFS | Blood | ANKRD13A | 0.01 | 0.00 | bslmm | 297 | 0.00 | 1.1e-02 | 3.1 | -5.6 | 1.7e-08 | 0.26 | 0.17 | 0.02 | TRUE |
11 | YFS | Blood | HVCN1 | 0.01 | 0.01 | bslmm | 214 | 0.01 | 4.0e-03 | -4.0 | 5.1 | 2.7e-07 | -0.90 | 0.06 | 0.90 | FALSE |
12 | YFS | Blood | PPP1CC | 0.02 | 0.02 | enet | 14 | 0.02 | 1.1e-06 | -6.2 | -5.9 | 4.5e-09 | 0.91 | 0.02 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C12orf24 | 0.02 | 0.02 | lasso | 2 | 0.01 | 4.8e-04 | -5.7 | 5.7 | 9.6e-09 | -0.97 | 0.00 | 1.00 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VPS29 | 0.05 | 0.04 | lasso | 3 | 0.05 | 1.5e-05 | -5.7 | -5.3 | 1.5e-07 | 0.92 | 0.00 | 0.99 | FALSE |