Best TWAS P=1.56e-40 · Best GWAS P=1.63e-40 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STAT6 | 0.11 | 0.08 | lasso | 3 | 0.11 | 9.1e-14 | -4.8 | -8.0 | 1.5e-15 | 0.52 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Artery Tibial | LRP1 | 0.15 | 0.12 | lasso | 2 | 0.10 | 3.9e-08 | -13.3 | 13.3 | 1.6e-40 | -1.00 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Artery Tibial | STAT6 | 0.08 | 0.03 | enet | 4 | 0.02 | 1.3e-02 | -9.7 | -8.7 | 3.4e-18 | 0.61 | 0.23 | 0.24 | FALSE |
| 4 | GTEx | Muscle Skeletal | RAB5B | 0.29 | 0.32 | lasso | 4 | 0.33 | 1.3e-33 | -5.2 | 5.3 | 1.1e-07 | 0.00 | 0.04 | 0.96 | TRUE |
| 5 | GTEx | Muscle Skeletal | AC034102.1 | 0.28 | 0.31 | lasso | 4 | 0.31 | 2.3e-31 | -5.1 | 5.3 | 1.1e-07 | 0.00 | 0.04 | 0.96 | FALSE |
| 6 | METSIM | Adipose | NXPH4 | 0.04 | 0.01 | bslmm | 354 | 0.02 | 1.7e-04 | -11.1 | 7.2 | 7.0e-13 | -0.47 | 0.04 | 0.58 | FALSE |
| 7 | METSIM | Adipose | STAT6 | 0.08 | 0.02 | blup | 343 | 0.03 | 5.0e-06 | -9.7 | 8.5 | 2.5e-17 | -0.53 | 0.42 | 0.55 | FALSE |
| 8 | NTR | Blood | NACA2 | 0.02 | 0.02 | blup | 328 | 0.02 | 8.9e-08 | 2.9 | -5.3 | 9.9e-08 | 0.27 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERBB3 | 0.07 | 0.02 | blup | 29 | 0.05 | 2.1e-06 | -5.5 | -5.2 | 1.5e-07 | 0.02 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | STAT6 | 0.04 | 0.01 | blup | 47 | 0.01 | 2.3e-02 | -11.1 | -11.0 | 2.5e-28 | 0.79 | 0.02 | 0.73 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM194A | 0.15 | 0.07 | blup | 43 | 0.09 | 1.9e-09 | -8.0 | -6.6 | 4.9e-11 | 0.42 | 0.26 | 0.67 | FALSE |